摘要
目的:运用Meta分析方法对奥硝唑与其他抗菌药物治疗妇科常见阴道感染的临床效果进行评价,为其提供循证医学证据。方法:全面检索奥硝唑与其他抗菌药物治疗妇科阴道感染的临床研究文献,按照Meta分析方法,运用Rev Man5.1软件对符合条件的所有结果进行分析。结果:共纳入13篇文献,总样本量1553例,其中,试验组777例,对照组776例。Meta分析结果显示,有效性、临床治愈率、安全性及细菌清除率的合并0R值分别为2.83(P<0.000 01)、2.11(P=0.04)、0.25(P<0.000 1)、1.11(P=0.79),表明奥硝唑的疗效优于对照组,并且不良反应的发生率低于对照组,细菌清除率差异没有统计学意义。结论:在治疗妇科阴道感染中,奥硝唑的疗效和安全性优于其他抗菌药物。
Objective： To evaluate the efficacy and safety of omidazole in the treatment of gynecological infections and provide evidence for the clinical therapy. Methods： Literatures on randomized controlled trials of omidazole in the treatment of gynecological infections were collected.Data were analyzed by Rev Man 5.1 software. Results： A total of 13 randomized controlled trials involving 1553 patients （E/C 777/776） with gynecological infections were included.The efficacy, clinical treatment success, safety and bacterial clearance were evaluated.Results of recta-analysis showed that ornidazole was more effective than the other antibiotics in the treatment of gynecological infections, the values of combined OR for efficacy and clinical cure rate were 2.83 （P 〈 0.000 01） and 2.11 （P = 0.04）. However, there was less adverse reactions in ornidazole group than in the control group, the value of combined OR was 0.25 （P 〈 0.000 1）. There were no statistically difference in clinical treatment success and bacterial eradication rate between the two groups. Conclusion： The efficacy and safety of omidazole were superior to the other antibiotics in the treatmerit of gynecological infections.
出处
《中国药物应用与监测》
CAS
2013年第1期7-12,共6页
Chinese Journal of Drug Application and Monitoring
基金
国家科技部十二五重大专项滚动课题项目(2012ZX09303004)
关键词
奥硝唑
妇科阴道感染
随机对照试验
META分析
Omidazole, Gynecological vaginal infection
Randomized controlled trial
Mcta-analysis
