Objectives: To estimate the cost effectiveness of fluvoxamine against desvenlafaxine in Chinese patients with major depressive disorder (MDD). Methods: A cost effectiveness of treating Chinese patients with MDD for 6 ...Objectives: To estimate the cost effectiveness of fluvoxamine against desvenlafaxine in Chinese patients with major depressive disorder (MDD). Methods: A cost effectiveness of treating Chinese patients with MDD for 6 months maintenance period has been estimated by a decision tree model. The relative effectiveness on relapse rates came from a recent network meta analysis by Kishi et al. (2023) along with local drug cost data based on WHO defined daily dose (DDD) and relapse cost for the 6 months estimated from various sources were used in the model. Based on the Quality Adjusted Life Years (QALY) gain reported by Sobocki et al. (2007), QALY loss from a relapse was estimated. Univariate sensitivity analyses were presented by a Tornado diagram and extensive probabilistic sensitivity analysis based on 10,000 simulations was performed. The most recent cost effectiveness threshold of 1.5 times GDP suggested by Cai et al. (2022) was applied. Results: Fluvoxamine dominated desvenlafaxine (cost savings of 4003 CNY and 0.01 QALY higher in 6 months). The most sensitive parameters were relapse rates followed by desvenlafaxine cost and utility loss of relapse. However, the default result of fluvoxamine dominance was not changed for any univariate sensitivity analysis. The probabilistic sensitivity result showed the cost effectiveness acceptability at 1.5 times GDP as 99.93%. Conclusions: The cost effectiveness of fluvoxamine against desvenlafaxine among Chinese patients with MDD in a 6-month maintenance period was cost saving with better effectiveness (i.e., dominating) with low uncertainty.展开更多
目的评估中药联合选择性5-羟色胺再摄取抑制剂(SSRIs)治疗抑郁症的疗效及安全性。方法系统检索中国知网、万方、维普、PubMed、Embase、Web of Science、Cochrane Library数据库中涉及中药联合SSRIs治疗抑郁症的随机对照试验,检索时限...目的评估中药联合选择性5-羟色胺再摄取抑制剂(SSRIs)治疗抑郁症的疗效及安全性。方法系统检索中国知网、万方、维普、PubMed、Embase、Web of Science、Cochrane Library数据库中涉及中药联合SSRIs治疗抑郁症的随机对照试验,检索时限为建库至2025年1月10日。使用Cochrane偏倚风险评估工具,对纳入文献质量进行评价,同时使用RevMan 5.4.1和Stata 14.0软件对提取的数据进行Meta分析。结果共纳入20篇文献,2116例患者。结果显示,中药联合SSRIs治疗抑郁症在降低汉密尔顿抑郁量表(HAMD)评分[均数差(MD)=-2.63,95%置信区间(CI)(-3.55,-1.71),P<0.00001]、提高临床有效率[相对危险度(RR)=1.18,95%CI(1.13,1.22),P<0.00001]和临床治愈率[RR=1.46,95%CI(1.25,1.70),P<0.00001]及降低临床不良反应发生率[RR=0.48,95%CI(0.37,0.62),P<0.00001]方面,均显著优于单用SSRIs治疗。结论中药联合SSRIs治疗抑郁症可显著增强治疗效果,降低HAMD评分,提高临床有效率和治愈率,减少不良反应发生率。展开更多
As we know,English writing is an important part of communicative competence.But for many English majors,it is hard to express their thoughts clearly.In order to find out the main problems and corresponding measures,th...As we know,English writing is an important part of communicative competence.But for many English majors,it is hard to express their thoughts clearly.In order to find out the main problems and corresponding measures,the author analyzes many compositions written by English majors.With some academic opinions and the author’s own analysis,some problems existing in students’writing are listed.According to the problems,the author summarizes some influencing factors.Finally,the author gives some relevant solutions.Through analyzing those samples,the author hopes it has some help for English majors’writing.展开更多
This study aims to find if, and to what extent, Chinese students'metacognitive strategy use associates with their reading ability in English. Sixty-four sophomore English majors participated in the study. The quan...This study aims to find if, and to what extent, Chinese students'metacognitive strategy use associates with their reading ability in English. Sixty-four sophomore English majors participated in the study. The quantitative analyses of the data generated the following major findings: Of the five metacognitive strategy categories, the selective attention strategy category is most favored by the students, and the evaluating strategy category is least favored by them. Metacognitive strategies have meaningfully positive effect on English reading.展开更多
Environmental stress is used as an indicator of the overall pressure on regional environmental systems caused by the output of various pollutants as a result of human activities. Based on the pollutant emissions and s...Environmental stress is used as an indicator of the overall pressure on regional environmental systems caused by the output of various pollutants as a result of human activities. Based on the pollutant emissions and socioeconomic databases of the counties in Beijing–Tianjin–Hebei region, this paper comprehensively calculates the environmental stress index(ESI) for the urban agglomeration using the entropy weight method(EWM) at the county scale and analyzes the spatiotemporal patterns and the differences among the four types of major functional zones(MFZ) for the period 2012–2016. In addition, the socioeconomic driving forces of environmental stress are quantitatively estimated using the geographically weighted regression(GWR) method based on the STIRPAT model framework. The results show that:(1) The level of environmental stress in the Beijing–Tianjin–Hebei region was significantly alleviated during that time period, with a decrease in ESI of 54.68% by 2016. This decrease was most significant in Beijing, Tangshan, Tianjin, Shijiazhuang, and other central urban areas, as well as the Binhai New Area. The level of environmental stress in counties decreased gradually from the central urban areas to the suburban areas, and the high-level stress counties were eliminated by 2016.(2) The spatial spillover effect of environmental stress increased further at the county scale from 2012 to 2016, and spatial locking and path dependence emerged in the cities of Tangshan and Tianjin.(3) Urbanized zones(development-optimized and development-prioritized zones) were the major areas bearing environmental pollution in the Beijing–Tianjin–Hebei region in that time period. The ESI accounted for 65.98% of the whole region, where there was a need to focus on the prevention and control of environmental pollution.(4) The driving factors of environmental stress at the county scale included population size and the level of economic development. In addition, the technical capacity of environmental waste disposal, the intensity of agricultural production input, the intensity of territorial development, and the level of urbanization also had a certain degree of influence.(5) There was spatial heterogeneity in the effects of the various driving factors on the level of environmental stress. Thus, it was necessary to adopt differentiated environmental governance and reduction countermeasures in respect of emission sources, according to the intensity and spatiotemporal differences in the driving forces in order to improve the accuracy and adaptability of environmental collaborative control in the Beijing–Tianjin–Hebei region.展开更多
文摘Objectives: To estimate the cost effectiveness of fluvoxamine against desvenlafaxine in Chinese patients with major depressive disorder (MDD). Methods: A cost effectiveness of treating Chinese patients with MDD for 6 months maintenance period has been estimated by a decision tree model. The relative effectiveness on relapse rates came from a recent network meta analysis by Kishi et al. (2023) along with local drug cost data based on WHO defined daily dose (DDD) and relapse cost for the 6 months estimated from various sources were used in the model. Based on the Quality Adjusted Life Years (QALY) gain reported by Sobocki et al. (2007), QALY loss from a relapse was estimated. Univariate sensitivity analyses were presented by a Tornado diagram and extensive probabilistic sensitivity analysis based on 10,000 simulations was performed. The most recent cost effectiveness threshold of 1.5 times GDP suggested by Cai et al. (2022) was applied. Results: Fluvoxamine dominated desvenlafaxine (cost savings of 4003 CNY and 0.01 QALY higher in 6 months). The most sensitive parameters were relapse rates followed by desvenlafaxine cost and utility loss of relapse. However, the default result of fluvoxamine dominance was not changed for any univariate sensitivity analysis. The probabilistic sensitivity result showed the cost effectiveness acceptability at 1.5 times GDP as 99.93%. Conclusions: The cost effectiveness of fluvoxamine against desvenlafaxine among Chinese patients with MDD in a 6-month maintenance period was cost saving with better effectiveness (i.e., dominating) with low uncertainty.
文摘Majority(MAJ)运算和反相(INV)运算组成完备集,数字逻辑电路可以用基于"MAJ/INV"的MI(Majority-Inverter)逻辑来实现。三输入MAJ门是MI逻辑电路的一种基本门电路单元。本文设计了一种基于碳纳米管场效应晶体管(Carbon Nanotube Field Effect Transistor,CNFET)的三输入MAJ门电路,并用所设计的MAJ门实现三个多输入组合逻辑电路。实验结果表明,在采用相同的器件和工艺的条件下,与现有的设计相比,所设计的MAJ门在功耗和功耗延时积上的改进最高分别达到32.5%和45.3%。
文摘As we know,English writing is an important part of communicative competence.But for many English majors,it is hard to express their thoughts clearly.In order to find out the main problems and corresponding measures,the author analyzes many compositions written by English majors.With some academic opinions and the author’s own analysis,some problems existing in students’writing are listed.According to the problems,the author summarizes some influencing factors.Finally,the author gives some relevant solutions.Through analyzing those samples,the author hopes it has some help for English majors’writing.
文摘This study aims to find if, and to what extent, Chinese students'metacognitive strategy use associates with their reading ability in English. Sixty-four sophomore English majors participated in the study. The quantitative analyses of the data generated the following major findings: Of the five metacognitive strategy categories, the selective attention strategy category is most favored by the students, and the evaluating strategy category is least favored by them. Metacognitive strategies have meaningfully positive effect on English reading.
基金National Natural Science Foundation of China,No.41971164, No.42071148Strategic Priority Research Program of the Chinese Academy of Sciences,Grant No.XDA23020101。
文摘Environmental stress is used as an indicator of the overall pressure on regional environmental systems caused by the output of various pollutants as a result of human activities. Based on the pollutant emissions and socioeconomic databases of the counties in Beijing–Tianjin–Hebei region, this paper comprehensively calculates the environmental stress index(ESI) for the urban agglomeration using the entropy weight method(EWM) at the county scale and analyzes the spatiotemporal patterns and the differences among the four types of major functional zones(MFZ) for the period 2012–2016. In addition, the socioeconomic driving forces of environmental stress are quantitatively estimated using the geographically weighted regression(GWR) method based on the STIRPAT model framework. The results show that:(1) The level of environmental stress in the Beijing–Tianjin–Hebei region was significantly alleviated during that time period, with a decrease in ESI of 54.68% by 2016. This decrease was most significant in Beijing, Tangshan, Tianjin, Shijiazhuang, and other central urban areas, as well as the Binhai New Area. The level of environmental stress in counties decreased gradually from the central urban areas to the suburban areas, and the high-level stress counties were eliminated by 2016.(2) The spatial spillover effect of environmental stress increased further at the county scale from 2012 to 2016, and spatial locking and path dependence emerged in the cities of Tangshan and Tianjin.(3) Urbanized zones(development-optimized and development-prioritized zones) were the major areas bearing environmental pollution in the Beijing–Tianjin–Hebei region in that time period. The ESI accounted for 65.98% of the whole region, where there was a need to focus on the prevention and control of environmental pollution.(4) The driving factors of environmental stress at the county scale included population size and the level of economic development. In addition, the technical capacity of environmental waste disposal, the intensity of agricultural production input, the intensity of territorial development, and the level of urbanization also had a certain degree of influence.(5) There was spatial heterogeneity in the effects of the various driving factors on the level of environmental stress. Thus, it was necessary to adopt differentiated environmental governance and reduction countermeasures in respect of emission sources, according to the intensity and spatiotemporal differences in the driving forces in order to improve the accuracy and adaptability of environmental collaborative control in the Beijing–Tianjin–Hebei region.
