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Histological and biochemical alterations in early-stage lobar ischemia-reperfusion in rat liver 被引量:16
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作者 Hossein Ali Arab Farhang Sasani +2 位作者 Mohammad Hossein Rafiee Ahmad Fatemi Abbas Javaheri 《World Journal of Gastroenterology》 SCIE CAS CSCD 2009年第16期1951-1957,共7页
AIM: To investigate the structural and biochemical changes in the early stage of reperfusion in the rat livers exposed to lobar ischemia-reperfusion (IR). METHODS: The median and left lobes of the liver were subje... AIM: To investigate the structural and biochemical changes in the early stage of reperfusion in the rat livers exposed to lobar ischemia-reperfusion (IR). METHODS: The median and left lobes of the liver were subjected to 60 min ischemia followed by 5, 10, 30, 45, 60 and 120 min reperfusion. Blood samples were taken at different time intervals to test enzyme activities and biochemical alterations induced by reperfusion. At the end of each reperfusion period, the animals were killed by euthanasia and tissue samples were taken for histological examination and immunohistochemistry. RESULTS: Cell vacuolation, bleb formation and focal hepatitis were the most important changes occur during ischemia. While some changes including bleb formation were removed during reperfusion, other alterations including portal hepatitis, inflammation and the induction of apoptosis were seen during this stage. The occurrence of apoptosis, as demonstrated by apoptotic cells and bodies, was the most important histological change during reperfusion. The severity of apoptosis was dependent on the time of reperfusion, and by increasing the time of reperfusion, the numbers of apoptotic bodies was significantly enhanced. The amounts of lactate dehydrogenase, alanine aminotransferase, aspartate aminotransfrase, creatinine and urea were significantly increased in serum obtained from animals exposed to hepatic IR. CONCLUSION: Inflammation and subsequent apoptotic cell death were the most important changes in early-stage hepatic reperfusion injury, and the number of apoptotic bodies increased with time of reperfusion. 展开更多
关键词 lobar ischemia Liver Reperfusion injury Apoptosis IMMUNOHISTOCHEMISTRY
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Acute lobar nephritis in children:Not so easy to recognize and manage 被引量:2
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作者 Cristina Bibalo Andrea Apicella +6 位作者 Veronica Guastalla Pierluigi Marzuillo Floriana Zennaro Carmela Tringali Andrea Taddio Claudio Germani Egidio Barbi 《World Journal of Clinical Pediatrics》 2016年第1期136-142,共7页
Acute lobar nephritis(ALN)is a localized non-liquefactive inflammatory renal bacterial infection,which typically involves one or more lobes.ALN is considered to be a midpoint in the spectrum of upper urinary tract inf... Acute lobar nephritis(ALN)is a localized non-liquefactive inflammatory renal bacterial infection,which typically involves one or more lobes.ALN is considered to be a midpoint in the spectrum of upper urinary tract infection,a spectrum ranging from uncomplicated pyelonephritis to intrarenal abscess.This condition may be difficult to recognize due to the lack of specific symptoms and laboratory findings.Therefore the disease is probably underdiagnosed.Computed tomography scanning represents the diagnostic gold standard for ALN,but magnetic resonance imagine could be considered in order to limit irradiation.The diagnosis is relevant since initial intravenous antibiotic therapy and overall length of treatment should not be shorter than 3 wk.We review the literature and analyze the ALN clinical presentation starting from four cases with the aim to give to the clinicians the elements to suspect and recognize the ALN in children. 展开更多
关键词 ACUTE lobar NEPHRITIS CHILDREN Computed tomography Magnetic resonance IMAGINE Upper urinary TRACT infection
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Lobar lung transplantation from deceased donors: A systematic review 被引量:1
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作者 Michael Eberlein Robert M Reed +9 位作者 Mayy Chahla Servet Bolukbas Amy Blevins Dirk Van Raemdonck Alessia Stanzi Ilhan Inci Silvana Marasco Norihisa Shigemura Clemens Aigner Tobias Deuse 《World Journal of Transplantation》 2017年第1期70-80,共11页
AIM To systematically review reports on deceased-donor-lobar lung transplantation(dd LLTx) and uniformly describe sizematching using the donor-to-recipient predicted-total lung-capacity(pT LC) ratio. METHODS We set ou... AIM To systematically review reports on deceased-donor-lobar lung transplantation(dd LLTx) and uniformly describe sizematching using the donor-to-recipient predicted-total lung-capacity(pT LC) ratio. METHODS We set out to systematically review reports on ddL LTx and uniformly describe size matching using the donorto-recipient pT LC ratio and to summarize reported oneyear survival data of ddL LTx and conventional-LTx. We searched in Pub Med, CINAHL via EBSCO, Cochrane Database of Systematic Reviews via Wiley(CDSR),Database of Abstracts of Reviews of Effects via Wiley(DARE), Cochrane Central Register of Controlled Trials via Wiley(CENTRAL), Scopus(which includes EMBASE abstracts), and Web of Science for original reports on ddL LTx. RESULTS Nine observational cohort studies reporting on 301 ddL LTx met our inclusion criteria for systematic review of size matching, and eight for describing one-year-survival. The dd LLTx-group was often characterized by high acuity;however there was heterogeneity in transplant indications and pre-operative characteristics between studies. Data to calculate the pT LC ratio was available for 242 ddL LTx(80%). The mean pT LCratio before lobar resection was1.25 ± 0.3 and the transplanted pT LCratio after lobar resection was 0.76 ± 0.2. One-year survival in the ddL LTxgroup ranged from 50%-100%, compared to 72%-88%in the conventional-LTx group. In the largest study ddL LTx(n = 138) was associated with a lower one-year-survival compared to conventional-LTx(n = 539)(65.1% vs84.1%, P < 0.001). CONCLUSION Further investigations of optimal donor-to-recipient size matching parameters for ddL LTx could improve outcomes of this important surgical option. 展开更多
关键词 lobar LUNG TRANSPLANTATION from deceased DONORS CADAVERIC lobar LUNG TRANSPLANTATION LUNG size matching Primary GRAFT dysfunction Survival
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Analysis of effect of terbutaline sulfate combined with shunning on acute attack of asthma complicated with lobar pneumonia in children
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作者 Xin Shao Jun Qian Hui-Dong Cai 《Journal of Hainan Medical University》 2020年第6期59-62,共4页
Objective:To explore the effect of terbutaline sulfate combined with shunning on acute attack of asthma complicated with lobar pneumonia in children.Methods:One hundred and fifty children with acute attack of asthma a... Objective:To explore the effect of terbutaline sulfate combined with shunning on acute attack of asthma complicated with lobar pneumonia in children.Methods:One hundred and fifty children with acute attack of asthma and lobar pneumonia were randomly divided into routine group(seventy-five cases)and combined group(seventy-five cases).The routine group was given routine treatment.The study group was treated with routine therapy plus terbutaline sulfate plus shunning.The changes of pulmonary function and serum inflammatory factors before and after treatment,clinical effect and safety were compared between the two groups.Results:Respiratory time/inspiratory time(Ti/Te),peak time ratio(TPTEF/TE),peak volume ratio(VPEF/VE),tidal volume per kilogram(Vt/kg)were increased in both groups after treatment(P<0.05),which in the combined group were higher than the routine group after treatment(P<0.05).After treatment,serum levels of tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)and interleukin-8(IL-8)in both groups decreased significantly(P<0.05),and those in the combined group were lower than those in the routine group(P<0.05).There was a significant difference in clinical effect distribution between the two groups(P<0.05).The total effective rate of the combined group was higher than that of the routine group(P<0.05).The incidence of adverse reactions in the combined group was slightly higher than that in the routine group(P>0.05).Conclusion:On the basis of routine treatment,terbutaline sulfate combined with shunning can significantly improve pulmonary function and serum inflammatory factors in children with acute attack of asthma and lobar pneumonia,with ideal effect and safe. 展开更多
关键词 TERBUTALINE SULFATE Shunning Acute ASTHMA attack lobar PNEUMONIA
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Recurrent Lobar Torsion
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作者 Hassan Alghamdi 《Open Journal of Thoracic Surgery》 2013年第4期103-106,共4页
We report a first case of 180° left upper lobe lung torsion followed by a 90° lobar torsion in the same lobe after a left lower lobectomy.
关键词 COMPLICATION lobar LEFT Upper LOBE RECURRENT TORSION
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Congenital Lobar Emphysema in an Infant: A Case Report from the University Hospital of Mali
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作者 Bourama Kané Korotoumou Wéllé Diallo +4 位作者 Aboubacar Sangaré Garan Dabo Mamadou Traoré Mohamed Maba Traoré Mariam Maiga 《Open Journal of Pediatrics》 2022年第2期453-459,共7页
Congenital lobar emphysema is characterized by distress due to hyperinflation of the affected lung lobe(s). We report the case of a 2-month-old infant with congenital left lower lobe emphysema. A 2-month-old female in... Congenital lobar emphysema is characterized by distress due to hyperinflation of the affected lung lobe(s). We report the case of a 2-month-old infant with congenital left lower lobe emphysema. A 2-month-old female infant, born at term without incident, was hospitalized for respiratory distress. On a postnatal day 15, respiratory distress occurred. On admission, he weighed 3400 g and was apyretic. He had a polypnea of 58 cycles/min and a oxygen saturation of hemoglobin of 90% on room air. A chest radiograph revealed hyperclarity of the left lung. Chest CT revealed left lower lobe emphysema. He underwent a left lower lobectomy. The postoperative course was uneventful. He was discharged from the hospital 7 days after surgery without sequelae. Physicians should be aware that congenital lobar emphysema can present with respiratory distress in infants. A chest CT scan confirms the diagnosis. Surgical treatment is effective. 展开更多
关键词 Congenital lobar Emphysema INFANT PEDIATRICS Mali Hospital
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Curative effect of small-dose glucocorticoids + azithromycin treatment of lobar pneumonia
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作者 Li Zhang 《Journal of Hainan Medical University》 2018年第12期46-49,共4页
Objective: To study the effect of small-dose glucocorticoids + azithromycin therapy on inflammatory response and stress response in children with lobar pneumonia. Methods:Children with mycoplasma pneumoniae lobar pneu... Objective: To study the effect of small-dose glucocorticoids + azithromycin therapy on inflammatory response and stress response in children with lobar pneumonia. Methods:Children with mycoplasma pneumoniae lobar pneumonia who were treated in the First People's Hospital of Ziyang between January 2015 and January 2018 were chosen as the research subjects and randomly divided into two groups: GCs group were treated with low-dose glucocorticoids + azithromycin, and control group were treated with azithromycin. The inflammatory response indicators and stress response indicators in serum and peripheral blood were measured before treatment as well as 3 d and 5 d after treatment. Results: Compared with those of same group before treatment, peripheral blood TLR4, NF-κB, NOX2, p38MAPK, iNOS, GRP78, PERK, ATF4, CHOP and Caspase-12 expression intensity as well as serum TNF-α, HMGB-1, ICAM-1, NO, MDA and 8-OhdG levels of both groups were significantly decreased after treatment, and peripheral blood TLR4, NF-κB, NOX2, p38MAPK, iNOS, GRP78, PERK, ATF4, CHOP and Caspase-12 expression intensity as well as serum TNF-α, HMGB-1, ICAM-1, NO, MDA and 8-OhdG levels of GCs group after treatment were significantly lower than those of control group. Conclusion: Small-dose glucocorticoid +azithromycin therapy is more effective than azithromycin therapy to suppress the inflammatory and stress response in children with lobar pneumonia. 展开更多
关键词 lobar PNEUMONIA GLUCOCORTICOIDS AZITHROMYCIN INFLAMMATORY RESPONSE Stress RESPONSE
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Resection and yttrium-90 radioembolization as sequential downstaging to living donor liver transplantation for large,multifocal hepatocellular carcinoma with lobar portal vein tumor thrombosis
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作者 Chao-Long Chen Leona Bettina P.Dungca +2 位作者 Chee-Chien Yong Itsuko Chih-Yi Chen Yu-Fan Cheng 《Hepatobiliary Surgery and Nutrition》 2025年第5期869-873,共5页
Hepatocellular carcinoma(HCC)is a leading cause of cancer-related mortality,with unfavorable outcomes associated with extensive tumor burden,multifocality,poor differentiation,and portal vein tumor thrombosis(PVTT).PV... Hepatocellular carcinoma(HCC)is a leading cause of cancer-related mortality,with unfavorable outcomes associated with extensive tumor burden,multifocality,poor differentiation,and portal vein tumor thrombosis(PVTT).PVTT occurs in 10-40%of HCC cases and portends a dismal median survival of 2-4 months without treatment. 展开更多
关键词 Large hepatocellular carcinoma(large HCC) lobar portal vein tumor thrombosis(lobar PVTT) RESECTION DOWNSTAGING living donor liver transplantation(LDLT)
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不同时机下支气管肺泡灌洗治疗儿童肺炎支原体大叶性肺炎的临床效果对比
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作者 刘丹丹 关静 +2 位作者 冯毅 贾玉涛 马国瑞 《河南医学研究》 2026年第3期496-500,共5页
目的对比不同时机下支气管肺泡灌洗治疗儿童肺炎支原体大叶性肺炎的临床效果。方法依据支气管肺泡灌洗治疗时机将150例肺炎支原体大叶性肺炎患儿分为5~8 d、9~14 d和>14 d 3组。比较3组治疗8~10 d的临床疗效、临床指标、肺功能指标... 目的对比不同时机下支气管肺泡灌洗治疗儿童肺炎支原体大叶性肺炎的临床效果。方法依据支气管肺泡灌洗治疗时机将150例肺炎支原体大叶性肺炎患儿分为5~8 d、9~14 d和>14 d 3组。比较3组治疗8~10 d的临床疗效、临床指标、肺功能指标、不良反应及预后情况。结果5~8 d组和9~14 d组总有效率高于>14 d组,患儿体温恢复正常时间、肺部啰音及咳嗽消失时间均短于>14 d组,住院时间短于>14 d组(P<0.05),5~8 d组和9~14 d组上述指标差异无统计学意义(P>0.05)。5~8 d组和9~14 d组患儿用力肺活量(FVC)、呼气峰流速(PEF)及第1秒用力呼气容积占用力肺活量比值(FEV 1/FVC)均高于>14 d组,5~8 d组患儿PEF、FEV 1/FVC高于9~14 d组(P<0.05)。3组不良反应发生率差异无统计学意义(P>0.05)。5~8 d组、9~14 d组患儿出现管腔通气不良、增生、狭窄和闭塞等占比低于>14 d组,而5~8 d组和9~14 d组差异无统计学意义(P>0.05)。结论采用支气管肺泡灌洗治疗儿童肺炎支原体大叶性肺炎时,病程14 d内尤其5~8 d内实施支气管肺泡灌洗是改善预后的关键,可更好地促进临床各项症状的缓解和消失,改善肺功能,延迟干预可能降低临床治疗效果。 展开更多
关键词 肺炎支原体 大叶性肺炎 儿童 支气管肺泡灌洗 治疗时机 临床效果
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Potential common pathogenesis of several neurodegenerative diseases
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作者 Ting Fan Jiaman Peng +3 位作者 Huiting Liang Wenzhi Chen Junlin Wang Renshi Xu 《Neural Regeneration Research》 2026年第3期972-988,共17页
With the gradual advancement of research methods and technologies,various biological processes have been identified as playing roles in the pathogenesis of neurodegenerative diseases.However,current descriptions of th... With the gradual advancement of research methods and technologies,various biological processes have been identified as playing roles in the pathogenesis of neurodegenerative diseases.However,current descriptions of these biological processes do not fully explain the onset,progression,and development of these conditions.Therefore,exploration of the pathogenesis of neurodegenerative diseases remains a valuable area of research.This review summarizes the potential common pathogeneses of Alzheimer’s disease,Parkinson’s disease,amyotrophic lateral sclerosis,Huntington’s disease,frontotemporal lobar dementia,and Lewy body disease.Research findings have indicated that several common biological processes,including aging,genetic factors,progressive neuronal dysfunction,neuronal death and apoptosis,protein misfolding and aggregation,neuroinflammation,mitochondrial dysfunction,axonal transport defects,and gut microbiota dysbiosis,are involved in the pathogenesis of these six neurodegenerative diseases.Based on current information derived from diverse areas of research,these biological processes may form complex pathogenic networks that lead to distinctive types of neuronal death in neurodegenerative diseases.Furthermore,promoting the regeneration of damaged neurons may be achievable through the repair of affected neural cells if the underlying pathogenesis can be prevented or reversed.Hence,these potential common biological processes may represent only very small,limited elements within numerous intricate pathogenic networks associated with neurodegenerative diseases.In clinical treatment,interfering with any single biological process has proven insufficient to completely halt the progression of neurodegenerative diseases.Therefore,future research on the pathogenesis of neurodegenerative diseases should focus on uncovering the complex pathogenic networks,rather than isolating individual biological processes.Based on this,therapies that aim to block or reverse various targets involved in the potential pathogenic mechanisms of neurodegenerative diseases may be promising directions,as current treatment methods that focus on halting a single pathogenic factor have not achieved satisfactory efficacy. 展开更多
关键词 aging Alzheimer’s disease amyotrophic lateral sclerosis frontotemporal lobar dementia genetics Huntington’s disease Lewy body disease Parkinson’s disease progressive neuron dysfunction and death protein misfolding
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Mucoepidermoid Carcinomas Presented as Lobar Pneumonia 被引量:3
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作者 Tong Zhou Ying Liu +1 位作者 Tong-Tong Li Zhen-Xiang Yu 《Chinese Medical Journal》 SCIE CAS CSCD 2018年第1期107-108,共2页
Mucoepidermoid carcinomas (MECs) had always been recognized as salivary gland tumors mainly steming from parotid and submandibular salivary glands. Eater, studies showed that MECs can occur in bronchus, esophagus, l... Mucoepidermoid carcinomas (MECs) had always been recognized as salivary gland tumors mainly steming from parotid and submandibular salivary glands. Eater, studies showed that MECs can occur in bronchus, esophagus, lacrimal glands, pancreas, thymus, and thyroid gland. MECs in bronchus are usually centrally located and are proposed to originate from submucosal minor salivary-type glands in large airways. 展开更多
关键词 Mucoepidermoid Carcinomas lobar Pneumonia
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First successful bilateral living-donor lobar lung transplantation in China 被引量:2
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作者 CHEN Qian-kun JIANG Ge-ning DING Jia-an GAO Wen CHEN Chang ZHOU Xiao 《Chinese Medical Journal》 SCIE CAS CSCD 2010年第11期1477-1478,共2页
Lung transplantation has been performed internationally as an effective treatment for a variety of end-stage lung'diseases. A great disparity between the supply of donor organs and the demand of potential recipients ... Lung transplantation has been performed internationally as an effective treatment for a variety of end-stage lung'diseases. A great disparity between the supply of donor organs and the demand of potential recipients has resulted in longer waiting time and annual increases in deaths on the lung transplant waiting list. Living-donor lobar lung transplantation (LDLLT) has become an established strategy to deal with the shortage of cadaveric donors. Encouraged by Starnes et al and Date et al, we began to apply the operation to a critically ill patient with bronchopulmonary dysplasia (BPD) firstly at Shanghai Pulmonary Hospital in China. 展开更多
关键词 living-donor lobar lung transplantation end-stage lung disease
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肺炎支原体感染性大叶性肺炎患儿血清CRP,D-二聚体,LDH和SAA表达与病情关系
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作者 陶亚男 毛庆东 陈启锋 《中国病原生物学杂志》 北大核心 2026年第1期41-45,共5页
目的探讨肺炎支原体感染性大叶性肺炎(MP-LP)患儿血清C反应蛋白(CRP),D-二聚体(D-Dimer),乳酸脱氢酶(LDH)和淀粉样蛋白A(SAA)水平与病情严重程度的相关性。方法采用前瞻性研究,纳入98例MP-LP患儿作为研究组,依据病情严重程度分为轻症组(... 目的探讨肺炎支原体感染性大叶性肺炎(MP-LP)患儿血清C反应蛋白(CRP),D-二聚体(D-Dimer),乳酸脱氢酶(LDH)和淀粉样蛋白A(SAA)水平与病情严重程度的相关性。方法采用前瞻性研究,纳入98例MP-LP患儿作为研究组,依据病情严重程度分为轻症组(n=58)与重症组(n=40)。同期选取100例普通肺炎支原体肺炎患儿作为对照组。收集患儿临床资料,并检测各组血清CRP、D-Dimer、LDH、SAA水平;多因素Logistic回归分析MP-LP患儿病情加重的风险因素;绘制受试者工作特征曲线(ROC)分析血清CRP、D-Dimer、LDH、SAA水平对MP-LP的诊断效能及病情评估价值。结果研究组血清CRP、D-Dimer、LDH、SAA水平均显著高于对照组(P<0.05)。与轻症组相比,重症组血清CRP、D-Dimer、LDH、SAA水平显著升高(P<0.05)。多因素Logistic回归分析显示,血清CRP、D-Dimer、LDH、SAA水平升高均为MP-LP患儿病情进展为重症的危险因素(P<0.05)。ROC曲线分析表明,血清CRP、D-Dimer、LDH、SAA单独诊断MP-LP的AUC分别为0.792、0.751、0.772、0.787,联合诊断的AUC为0.924,显著优于各指标单独诊断(Z_(联合-CRP)=4.158、Z_(联合-D-Dimer)=4.866、Z_(联合-LDH)=4.662、Z_(联合-SAA)=4.751,均P<0.01)。在病情评估方面,四项指标单独评估的AUC分别为0.802、0.812、0.810、0.778,联合评估的AUC为0.919,显著优于各指标单独评估(Z_(联合-CRP)=2.258、Z_(联合-D-Dimer)=2.696、Z_(联合-LDH)=2.340、Z_(联合-SAA)=2.622,均P<0.05)。结论血清CRP、D-Dimer、LDH及SAA水平与MP-LP患儿病情严重程度相关,联合检测可提高诊断和病情评估效能,为临床早期干预及机制研究提供参考。 展开更多
关键词 肺炎支原体 大叶性肺炎 C反应蛋白 D-二聚体 乳酸脱氢酶 淀粉样蛋白A 病情
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血清IL-8、sB7-H3、CXCL16水平在大叶性肺炎患儿疗程中的变化
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作者 杨照玉 呂民英 《医学检验与临床》 2026年第2期19-23,共5页
目的:通过分析血清IL-8、sB7-H3、CXCL16水平在大叶性肺炎患儿疗程中的动态变化及患儿发生治疗无效的影响因素,探讨血清IL-8、sB7-H3、CXCL16对大叶性肺炎患儿治疗效果的预测价值。方法:回顾性选取我院2023年1月-2025年1月106例大叶性... 目的:通过分析血清IL-8、sB7-H3、CXCL16水平在大叶性肺炎患儿疗程中的动态变化及患儿发生治疗无效的影响因素,探讨血清IL-8、sB7-H3、CXCL16对大叶性肺炎患儿治疗效果的预测价值。方法:回顾性选取我院2023年1月-2025年1月106例大叶性肺炎患儿为观察组,依照1:1选例原则,选取同期健康体检儿童106例为对照组,比较2组血清IL-8、sB7-H3、CXCL16水平,比较观察组不同治疗时间下血清IL-8、sB7-H3、CXCL16水平,单因素分析治疗2个疗程后治疗无效的影响因素,logistic回归分析各因素是否为大叶性肺炎患儿治疗无效的独立危险因素。结果:观察组血清IL-8、sB7-H3、CXCL16水平高于对照组,差异有统计学意义(P<0.05);治疗前血清IL-8、sB7-H3、CXCL16水平>治疗1个疗程>治疗2个疗程>治疗3个疗程,差异有统计学意义(P<0.05);治疗无效患者血清IL-8、sB7-H3、CXCL16水平高于治疗有效患者,差异有统计学意义(P0.05);治疗无效患儿胸腔积液、肺外并发症、心动过速、IL-8≥39.80pg/mL、sB7-H3≥117.16pg/mL、CXCL16≥1.32ng/mL发生率均高于治疗有效患儿,且各指标均为患儿发生治疗无效的危险因素,差异有统计学意义(P0.05)。结论:血清IL-8、sB7-H3、CXCL16水平在大叶性肺炎患儿疗程中变化显著,可为临床预测患儿治疗效果提供参考。 展开更多
关键词 IL-8 sB7-H3 CXCL16 大叶性肺炎 儿童
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硫酸特布他林雾化和甲泼尼龙琥珀酸钠共用治疗儿童大叶性肺炎的效果
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作者 张雷 李俊霞 《临床研究》 2026年第1期71-75,共5页
目的探讨硫酸特布他林雾化吸入用溶液联合注射用甲泼尼龙琥珀酸钠对儿童大叶性肺炎的影响。方法选择2023年1月至2024年7月襄城县人民医院收治的100例大叶性肺炎患儿。采用SPSS 27.0生成随机数,按1∶1简单随机分配至观察组和对照组(各50... 目的探讨硫酸特布他林雾化吸入用溶液联合注射用甲泼尼龙琥珀酸钠对儿童大叶性肺炎的影响。方法选择2023年1月至2024年7月襄城县人民医院收治的100例大叶性肺炎患儿。采用SPSS 27.0生成随机数,按1∶1简单随机分配至观察组和对照组(各50例)。对照组给予注射用青霉素钠联合注射用阿奇霉素静脉滴注,观察组在对照组治疗基础上加用硫酸特布他林雾化吸入用溶液雾化吸入联合注射用甲泼尼龙琥珀酸钠静脉滴注。两组均连续治疗5 d,治疗开始后第20 d复查影像学判定疗效。比较两组退热时间及咳嗽咯痰、胸痛、肺部体征、啰音消失时间,血清C反应蛋白(CRP)、降钙素原(PCT)及白细胞介素-6(IL-6)水平,以及不良反应发生情况。结果治疗后,观察组治疗有效率高于对照组,退热时间及咳嗽咯痰、胸痛、肺部体征、啰音消失时间均少于对照组,差异均有统计学意义(P<0.05)。治疗后,两组CRP、PCT和IL-6水平均降低,且观察组低于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论硫酸特布他林雾化吸入用溶液联合注射用甲泼尼龙琥珀酸钠辅助治疗儿童大叶性肺炎可提高临床疗效,缩短病程,减轻炎症反应,且安全性较高。 展开更多
关键词 特布他林雾化 甲泼尼龙 大叶性肺炎 炎性因子
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止嗽散合玉屏风散联合常规西药治疗大叶性肺炎患儿的效果
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作者 王锦鹏 尤伟 《中国民康医学》 2026年第4期125-127,共3页
目的:观察止嗽散合玉屏风散联合常规西药治疗大叶性肺炎患儿的效果。方法:选取2022年1月至2024年1月该院收治的96例大叶性肺炎患儿进行前瞻性研究,按照随机数字表法将其分为对照组和观察组各48例。对照组采用常规西药(头孢吡肟+布地奈德... 目的:观察止嗽散合玉屏风散联合常规西药治疗大叶性肺炎患儿的效果。方法:选取2022年1月至2024年1月该院收治的96例大叶性肺炎患儿进行前瞻性研究,按照随机数字表法将其分为对照组和观察组各48例。对照组采用常规西药(头孢吡肟+布地奈德+乙酰半胱氨酸)治疗,观察组在对照组基础上联合止嗽散合玉屏风散治疗,两组均治疗7 d。比较两组临床疗效,临床症状(咳嗽、肺部啰音、咳痰)消失时间,治疗前后炎性因子[C反应蛋白(CRP)、白细胞介素(IL)-6、IL-8]水平,以及不良反应发生率。结果:观察组治疗总有效率为95.83%,高于对照组的81.25%,差异有统计学意义(P<0.05);观察组咳嗽、咳痰、肺部啰音等临床症状消失时间均短于对照组,差异有统计学意义(P<0.05);治疗后,两组CRP、IL-6、IL-8水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:止嗽散合玉屏风散联合常规西药治疗大叶性肺炎患儿可提高治疗总有效率,缩短临床症状消失时间,降低炎性因子水平,效果优于单纯常规西药治疗。 展开更多
关键词 大叶性肺炎 儿童 止嗽散 玉屏风散 炎性因子 不良反应
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哌拉西林钠他唑巴坦钠联合甲泼尼龙琥珀酸钠治疗儿童大叶性肺炎临床疗效
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作者 郭闪闪 杨栋 《四川生理科学杂志》 2026年第3期629-631,637,共4页
目的:探究哌拉西林钠他唑巴坦钠联合甲泼尼龙琥珀酸钠治疗儿童大叶性肺炎临床疗效。方法:选取2023年10月至2025年8月我院收治的100例大叶性肺炎患儿,采用随机数字表法分为对照组和实验组,每组50例。对照组给予哌拉西林钠他唑巴坦钠(100 ... 目的:探究哌拉西林钠他唑巴坦钠联合甲泼尼龙琥珀酸钠治疗儿童大叶性肺炎临床疗效。方法:选取2023年10月至2025年8月我院收治的100例大叶性肺炎患儿,采用随机数字表法分为对照组和实验组,每组50例。对照组给予哌拉西林钠他唑巴坦钠(100 mg·kg^(-1)q8h,最大剂量≤4.5 g)静滴及布地奈德混悬液(1 mg)联合特布他林溶液(5 mg)压缩雾化吸入(2次·d^(-1));实验组在对照组基础上加用甲泼尼龙琥珀酸钠静滴(1 mg·kg^(-1),q12h,最大剂量≤40 mg),治疗7 d。治疗前后采集静脉血以免疫比浊法测定C反应蛋白(C-Reactive Protein,CRP)水平,酶联免疫吸附测定(Enzyme-Linked Immunosorbent Assay,ELISA)白细胞介素-6(Interleukin-6,IL-6)水平;记录症状改善时间,并于疗程结束时依据影像学吸收程度和症状变化评估疗效。结果:实验组总有效率明显优于对照组(P<0.05);症状改善方面,实验组患儿也能更快恢复体温,且肺部啰音和咳嗽的消失更快,同时,实验组患儿静脉血IL-6、CRP值的变化均明显优于对照组(P<0.05);两组患儿的总不良反应率比较,无统计学意义(P>0.05)。结论:多药联合治疗儿童大叶性肺炎临床疗效显著,可有效改善患儿的症状和体征,疗程短,值得在临床推广。 展开更多
关键词 哌拉西林钠他唑巴坦钠 甲泼尼龙琥珀酸钠 儿童大叶性肺炎 临床疗效
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Micro-particle deposition and lobar distribution of mass flow in human upper respiratory tract model 被引量:2
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作者 HUANG JianHua ZHANG LianZhong 《Chinese Science Bulletin》 SCIE EI CAS 2011年第4期380-385,共6页
A representative human upper respiratory tract model consisting of oropharyngeal and asymmetric tracheobronchial(TB) airways from the trachea(G0) to the main lobar bronchi(G2) was constructed. Laminar-to-turbulent air... A representative human upper respiratory tract model consisting of oropharyngeal and asymmetric tracheobronchial(TB) airways from the trachea(G0) to the main lobar bronchi(G2) was constructed. Laminar-to-turbulent airflow for typical inhalation modes as well as micro-particle transportation,wall deposition and mass flow to lobes was simulated using the CFX10.0 software from Ansys Inc. The numerical particle deposition efficiency of the oropharynx region and two generations(G1 and G2) of TB airways shows great agreement with the experimental data obtained from realistic casts. The particle deposition pattern indicates that inertial impaction is the primary mechanism in the human upper airway,and turbulence dispersion performs crescent influence especially for small particles. The initial positions of particles with different fates are confined to specifically concentrated zones. The particle mass distributions of five lobes are close to airflow distributions. The upper lobes receive fewer particles than lower lobes and the right middle lobe receives the least. 展开更多
关键词 微观粒子 呼吸道模型 沉积效率 质量流量 ANSYS公司 人类 航空公司
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复方鲜竹沥液联合支气管肺泡灌洗术对儿童重症肺炎支原体感染性大叶性肺炎的疗效 被引量:3
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作者 刘冬梅 王敬敏 +2 位作者 徐琳 王亚楠 侯秀玲 《广东医学》 2025年第5期641-647,共7页
目的 分析复方鲜竹沥液联合支气管肺泡灌洗术(BAL)治疗儿童重症肺炎支原体(MP)感染性大叶性肺炎的临床疗效,以及对患儿免疫炎症状态的影响,为临床提供参考依据。方法 选取2022年1月至2024年1月收治的104例重症MP感染性大叶性肺炎患儿,... 目的 分析复方鲜竹沥液联合支气管肺泡灌洗术(BAL)治疗儿童重症肺炎支原体(MP)感染性大叶性肺炎的临床疗效,以及对患儿免疫炎症状态的影响,为临床提供参考依据。方法 选取2022年1月至2024年1月收治的104例重症MP感染性大叶性肺炎患儿,按随机数字表法平均分为两组。对照组接受BAL治疗,在此基础上观察组联合复方鲜竹沥液治疗。连续治疗2周后评价两组临床疗效。比较两组治疗前后主要症状积分、肺炎胸片吸收评价量表(PCRAES)、临床肺部感染评分(CPIS),以及免疫炎症指标[补体C3、C4、CD3*人类白细胞抗原-DR(CD3*HLA-DR)、自然杀伤细胞(NK细胞)、血清淀粉样蛋白A(SAA)、白细胞介素(IL)-33、可溶性细胞间黏附分子-1(sICAM-1)]水平。统计两组不良反应情况。结果 总有效率:观察组[94.23%(49/52)]高于对照组[80.77%(42/52),P<0.05]。两组主要症状(发热、咳嗽、痰量、痰液性质、胸痛、肺部啰音)积分比较,治疗后均低于同组治疗前(P<0.05),且治疗后观察组低于对照组(P<0.05)。治疗后,两组PCRAES、CPIS评分和血清补体C3、C4、SAA、IL-33、sICAM-1水平均显著降低(P<0.05),外周血CD3*HLA-DR、NK细胞水平均显著升高(P<0.05),以观察组为甚(P<0.05)。观察组不良反应率[7.69%(4/52)]较对照组[5.77%(3/52)],差异无统计学意义(P>0.05)。结论 在BAL基础上联合复方鲜竹沥液治疗能有效提高儿童重症MP感染性大叶性肺炎的临床疗效,能更好地促进患儿症状改善及肺部感染减轻,其作用可能与进一步纠正机体免疫功能紊乱、抑制炎症反应有关。 展开更多
关键词 儿童 免疫炎症反应 重症肺炎 复方鲜竹沥液 肺炎支原体 支气管肺泡灌洗术 大叶性肺炎
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桑菊清解汤在儿童大叶性肺炎治疗中的作用观察
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作者 王文英 王莹莹 商亚敏 《中华中医药学刊》 北大核心 2025年第11期221-225,共5页
目的探究桑菊清解汤联合抗感染、退热、补液、雾化吸入等对症支持疗法对儿童大叶性肺炎疗效。方法采用随机分组法将198例大叶性肺炎儿童分为观察组与对照组。每组99例。对照组给予抗感染、退热、补液、雾化吸入等对症支持治疗,观察组在... 目的探究桑菊清解汤联合抗感染、退热、补液、雾化吸入等对症支持疗法对儿童大叶性肺炎疗效。方法采用随机分组法将198例大叶性肺炎儿童分为观察组与对照组。每组99例。对照组给予抗感染、退热、补液、雾化吸入等对症支持治疗,观察组在对照组基础上加用桑菊清解汤。比较两组治疗前后超敏C反应蛋白(high-sensitivity C-reactive protein,hs-CRP)、白细胞(white blood cells,WBC)、血沉(erythrocyte sedimentation rate,ESR)、白细胞介素-6(interleukin-6,IL-6)、呼气峰流量(peak expiratory flow,PEF)、第1秒用力呼吸容积(forced respiratory volume in 1 second,FEV1)、FEV1与用力肺活量比值(FEV1 versus forced vital capacity,FEV1/FVC)。分析两组患儿的咳嗽消失时长、退热时长、喘息消失时长、咳痰消失时长以及住院的具体天数。对比两组患儿临床方面的疗效和不良反应出现概率。结果总有效率方面,治疗后对照组患儿(84.85%,84/99)相较于观察组患儿(97.98%,97/99)更低(P<0.05)。咳嗽、喘息、咳痰和哮鸣音积分方面,治疗前两组患儿对比差异无统计学意义(P>0.05),治疗后上述积分相较于治疗前出现了明显的下降情况,且相较于对照组,观察组患儿更低(P<0.05)。观察组患儿咳嗽消失时长、退热时长、喘息消失时长、咳痰消失时长以及住院的具体天数均明显低于对照组(P<0.05)。IL-6、WBC、hs-CRP和ESR的浓度水平方面,两组患儿治疗前对比差异无统计学意义(P>0.05),相较于治疗前,两组患儿治疗后上述指标的浓度水平改变明显(P<0.05),且观察组治疗后较对照组全部出现了下降情况(P<0.05)。FEV1、PEF和FEV1/FVC水平方面,两组患儿治疗前对比差异无统计学意义(P>0.05),相较于治疗前,两组患儿治疗后上述指标水平差异明显(P<0.05),且观察组治疗后这些指标较对照组高(P<0.05)。治疗后,观察组总不良反应发生率为5.05%(5/99)略低于对照组7.07%(7/99)(P>0.05)。结论桑菊清解汤联合抗感染、退热、补液、雾化吸入等对症支持疗法能有效缩短病程治疗时间、降低不良反应发生率、改善患儿肺功能和血清炎症因子水平,提高儿童大叶性肺炎临床疗效。 展开更多
关键词 桑菊清解汤 儿童大叶性肺炎 临床疗效 雾化吸入 补液 退热
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