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Long-term mechanical loading aggravates osteoarthritis through a pro-apoptotic inflammatory microenvironment 被引量:1
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作者 Shiyun Shen Tianshun Fang +8 位作者 Jiabao Dong Junjie Li Miyang Xu Jian Wu Jiangfeng Zhang Jianyou Li Wei Liu Wei Zhou Xiongfeng Li 《Journal of Biomedical Research》 2026年第2期134-146,共13页
Articular cartilage maintains joint homeostasis by adapting to mechanical loading,but both insufficient and excessive loading can impair cartilage integrity.Whether mechanical activity should be restricted in early os... Articular cartilage maintains joint homeostasis by adapting to mechanical loading,but both insufficient and excessive loading can impair cartilage integrity.Whether mechanical activity should be restricted in early osteoarthritis(OA),particularly among exercise enthusiasts,remains controversial.Here,we established in vitro and in vivo models of prolonged moderate mechanical loading(7.5%strain,1 Hz)and analyzed human cartilage from weight-bearing and non-weight-bearing regions using RNA sequencing.Prolonged exposure(≥12 h)significantly increased chondrocyte apoptosis(2.3-fold),reduced expression of the chondrogenic transcription factor SOX9 and the matrix markers COL2A1,and elevated nerve growth factor(NGF)expression(1.8-fold),accompanied by enrichment of neural sensitization and inflammatory pathways.Immunofluorescence staining revealed NGF accumulation in mechanically stressed cartilage.Unlike high-intensity stress,which led to immediate apoptosis,moderate loading induced a delayed pro-apoptotic response after 12 h.These findings indicate that prolonged moderate mechanical loading may promote chondrocyte apoptosis through an NGFmediated inflammatory microenvironment and provide mechanistic evidence suggesting that patients with early OA may benefit from limiting high-impact or prolonged moderate-intensity exercise sessions to prevent cartilage damage and guide rehabilitation. 展开更多
关键词 OSTEOARTHRITIS mechanical loading
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痤疮灵颗粒联合挑治和红蓝光治疗中重度寻常痤疮的疗效及对患者外周血IL-8、TNF-α、SIL-2R的影响
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作者 章若画 闵仲生 +2 位作者 刘岩 熊玉洁 吉津 《中国美容医学》 2026年第2期111-115,共5页
目的:探讨痤疮灵颗粒联合挑治和红蓝光治疗中重度寻常痤疮的疗效及对患者外周血白细胞介素(IL)-8、肿瘤坏死因子(TNF)-α、可溶性白细胞介素-2受体(SIL-2R)的影响。方法:选取2021年10月-2024年10月收治的中重度寻常痤疮患者100例,随机... 目的:探讨痤疮灵颗粒联合挑治和红蓝光治疗中重度寻常痤疮的疗效及对患者外周血白细胞介素(IL)-8、肿瘤坏死因子(TNF)-α、可溶性白细胞介素-2受体(SIL-2R)的影响。方法:选取2021年10月-2024年10月收治的中重度寻常痤疮患者100例,随机分为两组,各50例。对照组给予挑治和红蓝光治疗,观察组在对照组基础上加用痤疮灵颗粒治疗。比较两组疗效、皮损积分、皮肤屏障功能、外周血IL-8、TNF-α、SIL-2R水平、不良反应及复发率。结果:观察组治疗总有效率(90.00%)高于对照组(74.00%)(P<0.05)。治疗后,两组皮损积分均降低,且组间比较观察组更低(P<0.05)。治疗后,两组皮肤角质层含水量均增加,皮脂分泌量均减少,且相较于对照组,观察组皮肤角质层含水量更高,皮脂分泌量更低(P<0.05)。治疗后,两组外周血IL-8、TNF-α、SIL-2R水平均降低,且组间比较观察组更低(P<0.05)。两组不良反应差异无统计学意义(P>0.05)。停止治疗3个月后,观察组复发率(6.00%)低于对照组(24.00%)(P<0.05)。结论:痤疮灵颗粒联合挑治和红蓝光治疗中重度寻常痤疮的效果确切,可以减轻皮损积分,改善皮肤屏障功能,降低外周血IL-8、TNF-α、SIL-2R水平,降低复发率。 展开更多
关键词 痤疮灵颗粒 挑治 红蓝光 寻常痤疮 白细胞介素-8(IL-8) 肿瘤坏死因子-α(TNF-α) 可溶性白细胞介素-2受体(sil-2R)
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Vat photopolymerization of silica-based ceramic cores using high solid loading slurry with performance optimization
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作者 Yong-kang Yang Bo-ran Wang +4 位作者 Zi-qi Jia Shu-xin Niu Xin Li Ya-jie Guo Xi-qing Xu 《China Foundry》 2025年第5期555-564,共10页
Vat photopolymerization(VPP)3D printing is an optimized technology for complex-shaped ceramic cores,in which the solid loading of ceramic slurries greatly infiuences the microstructure and property of the final cerami... Vat photopolymerization(VPP)3D printing is an optimized technology for complex-shaped ceramic cores,in which the solid loading of ceramic slurries greatly infiuences the microstructure and property of the final ceramic parts.However,the high solid loading of slurries is highly limited by the high viscosity.In this study,silica-based ceramic core slurries with solid loading up to 68vol.%were achieved by the composition design to optimize the performance,considering the curing,rheological,and double bond conversion rate.The slurries demonstrate superior curing and rheological performance with mass ratio of monomers being 3:2 and mass fraction of BYK111 being 4wt.%.Afterwards,the impact of solid loading on the morphology and mechanical properties was investigated.As the solid loading increases,the microstructure becomes gradually dense,leading to an improved flexural strength of 19.5 MPa.Additionally,the sintering shrinkage becomes more uniform,satisfying the casting requirements effectively.This work serves as a guide for the preparation of ceramic slurries with a high solid loading. 展开更多
关键词 ceramic core additive manufacturing mechanical performance solid loading VISCOSITY vat photopolymerization
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以往使用数据用于SIL验证的探讨
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作者 孙金晓 宋艳 崔姊一 《石油化工自动化》 2026年第1期43-47,共5页
仪表设备的失效数据对于评估安全仪表系统(SIS)的安全完整性等级(SIL)至关重要,获取失效数据是SIL验证工作的重要内容。以往使用数据记录了仪表设备在实际运行中的失效情况,为SIL验证提供相对准确的失效数据。根据现行的行业标准要求,... 仪表设备的失效数据对于评估安全仪表系统(SIS)的安全完整性等级(SIL)至关重要,获取失效数据是SIL验证工作的重要内容。以往使用数据记录了仪表设备在实际运行中的失效情况,为SIL验证提供相对准确的失效数据。根据现行的行业标准要求,介绍了获取以往使用数据的要求和利用以往使用数据进行失效概率计算的方法,给出了实际应用案例,为使用以往使用数据进行SIL验证提供了参考。 展开更多
关键词 失效数据 以往使用 sil验证 点估计方法 贝叶斯方法
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封闭园区商用车自动驾驶SIL仿真测试
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作者 邢斯琦 张倩 王永昌 《汽车实用技术》 2026年第5期20-24,87,共6页
随着商用车高级别自动驾驶车辆在封闭园区中的应用落地,自动驾驶系统迭代升级频率逐步加快,为解决新自动驾驶系统上车前功能完备性验证、问题场景迭代优化验证、功能边界场景挖掘、落地场景适配等问题,对自动驾驶仿真系统提出了新的要... 随着商用车高级别自动驾驶车辆在封闭园区中的应用落地,自动驾驶系统迭代升级频率逐步加快,为解决新自动驾驶系统上车前功能完备性验证、问题场景迭代优化验证、功能边界场景挖掘、落地场景适配等问题,对自动驾驶仿真系统提出了新的要求。文章搭建了智能驾驶车辆决策、规划、控制、调度算法仿真测试系统,用以完成代码开发优化迭代升级后的安全完整性等级(SIL)仿真测试,提高自动驾驶系统应用落地效率。 展开更多
关键词 sil仿真测试 动力学特性仿真 功能场景 问题场景 运营场景 仿真测试问题管理系统
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Design of Virtual Driving Test Environment for Collecting and Validating Bad Weather SiLS Data Based on Multi-Source Images Using DCU with V2X-Car Edge Cloud
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作者 Sun Park JongWon Kim 《Computers, Materials & Continua》 2026年第3期448-467,共20页
In real-world autonomous driving tests,unexpected events such as pedestrians or wild animals suddenly entering the driving path can occur.Conducting actual test drives under various weather conditions may also lead to... In real-world autonomous driving tests,unexpected events such as pedestrians or wild animals suddenly entering the driving path can occur.Conducting actual test drives under various weather conditions may also lead to dangerous situations.Furthermore,autonomous vehicles may operate abnormally in bad weather due to limitations of their sensors and GPS.Driving simulators,which replicate driving conditions nearly identical to those in the real world,can drastically reduce the time and cost required for market entry validation;consequently,they have become widely used.In this paper,we design a virtual driving test environment capable of collecting and verifying SiLS data under adverse weather conditions using multi-source images.The proposed method generates a virtual testing environment that incorporates various events,including weather,time of day,and moving objects,that cannot be easily verified in real-world autonomous driving tests.By setting up scenario-based virtual environment events,multi-source image analysis and verification using real-world DCUs(Data Concentrator Units)with V2X-Car edge cloud can effectively address risk factors that may arise in real-world situations.We tested and validated the proposed method with scenarios employing V2X communication and multi-source image analysis. 展开更多
关键词 Virtual driving test DCU bad weather silS autonomous environment V2X-Car edge cloud
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Analysis of loading characteristics of windshield wiper structure on high-speed train
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作者 Honglei Yuan Quanwei Che Sicong Zhao 《High-Speed Railway》 2026年第1期33-40,共8页
This paper studies the structural response of high-speed train wipers under the combined action of complex flow fields and scraping actions.The stress concentration areas are determined through simulation analysis,and... This paper studies the structural response of high-speed train wipers under the combined action of complex flow fields and scraping actions.The stress concentration areas are determined through simulation analysis,and the stress and aerodynamic load measurement points are reasonably arranged accordingly.The actual measurement is carried out in combination with the operating conditions of the existing lines.The stress variations and spectral characteristics of the train under different speed levels(80,160,180,200 km/h),tunnel entry and exit,and scraper action conditions were compared and analyzed.The stress amplification factors under tunnel intersection and scraper action were obtained,providing boundary conditions for the design of wipers for highspeed s.The research results show that the maximum stress of the wiper structure obtained through simulation calculation is concentrated at the connection of the wiper arm.Structural stress increases with the rise of speed grade.The stress increases by 1.11 times when the tunnel meets.When the scraper operates,the stress on the scraper arm increases by 4.1–7.6 times.Due to the broadband excitation effect of the aerodynamic load,the spectral energy of the structure is relatively high at the natural frequency,which excites the natural mode of the wiper. 展开更多
关键词 High-speed train WIPER Load characteristic STRENGTH Natural frequency
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城市轨道交通信号系统SIL4云技术的研究
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作者 张猛 徐志军 《科技与创新》 2026年第5期127-129,共3页
随着新一代数字信息科技的发展,轨道交通数字化转型进程不断加快,轨道交通信号系统也随之引入更灵活、更具可扩展性的云计算新技术。SIL4(安全完整性等级4级)是CENELEC(欧洲电工标准化委员会)功能安全规范中定义的最高安全完整性等级,... 随着新一代数字信息科技的发展,轨道交通数字化转型进程不断加快,轨道交通信号系统也随之引入更灵活、更具可扩展性的云计算新技术。SIL4(安全完整性等级4级)是CENELEC(欧洲电工标准化委员会)功能安全规范中定义的最高安全完整性等级,适用于轨道交通信号系统中列车防护、列车自动驾驶、联锁等安全设备的关键应用场景。为解决云计算分布式架构特点与SIL4高安全要求之间的技术矛盾,SIL4云技术应运而生,旨在通过私有云环境提供可认证的IT平台,满足轨道交通系统的安全性与可靠性需求。研究详细阐述了云平台的技术架构与实施细节,同时分析了当前面临的挑战、未来发展方向以及国产化发展过程中应注意的要点,为云信号系统的发展提供了决策参考与技术支撑。 展开更多
关键词 新一代数字信息科技 城市轨道交通 云计算 sil4
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Multi-pass intermittent local loading process of large-scale rib-web component:Forming characteristics and implementing apparatus
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作者 Dawei ZHANG Peng DONG +2 位作者 Jingxiang LI Zijian YU Shengdun ZHAO 《Chinese Journal of Aeronautics》 2026年第1期601-625,共25页
The multi-pass intermittent local loading process,which features a more flexible processing path,can further enhance the second material distribution during local loading,improve the formability of components,and redu... The multi-pass intermittent local loading process,which features a more flexible processing path,can further enhance the second material distribution during local loading,improve the formability of components,and reduce forming loads.However,the absence of compatible forming equipment makes it difficult to control the constraint in the unloaded zones during the forming process.This difficulty complicates coordination and control of deformation,particularly for asymmetric rib-web components.Additionally,the current implementation involves multi-fire heating,a long process flow,and high energy consumption,which limits the popularization and application of the local loading process.In this study,a new multi-pass local loading hydraulic forming apparatus that can quickly and reliably switch between heavy-load deformation and low-load constraint for different local loading sub-dies was developed.A 10-tonne laboratory prototype was developed,and the forming characteristics during the forming process as well as the response characteristics of the hydraulic system during the multi-pass intermittent local loading of rib-web component were investigated using numerical simulations and physical experiments.Results indicated that,compared to a whole loading process with the same initial geometry of billet,the total forming load(i.e.,the sum of loaded and restrained loads)is reduced by more than 40%with the local loading process,and by nearly 50%with multi-pass local loading.The multi-pass local loading process allows for more effective control of material flow compared to single-pass local loading,leading to improved cavity filling and reduced flow line disturbance.For a large-scale,complex titanium alloy bulkhead,the cavity filling problem was addressed by optimizing the multi-pass local loading path with an unequal thickness billet.The dynamic performance of the multi-pass local loading hydraulic system was found to be robust,with stable pressure transitions during motion and load switching for the sub-die(s).The dynamic characteristic of the hydraulic cylinder when switching from non-moving/unloaded state to a moving/loading state are consistent whether a load is present or not.However,the dynamic characteristics differ when switching from a moving/loading state to non-moving/unloaded state,showing opposite behavior.The developed hydraulic drive mechanism provides a way for implementation of multi-pass local loading without auxiliary operation and extra heating.The results of the study provide a foundation for the industrial production of large-scale,complex components with reduced force requirement and low-energy consumption. 展开更多
关键词 Forming characteristics Hydraulic system Intermittent local loading process Material flow Rib-web component
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Acoustic emission characteristics of rock salt under multistage creep-fatigue loading at various temperatures
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作者 Hang Li Chunhe Yang +5 位作者 Hongling Ma Jiangyu Fang Rui Liang Wentao Li Kai Zhao J.J.K.Daemen 《Journal of Rock Mechanics and Geotechnical Engineering》 2026年第1期364-379,共16页
With the growing global demand for energy,deep underground salt caverns are emerging as a potential solution for large-scale energy storage.In this study,multistage cyclic loading tests were conducted on rock salt at ... With the growing global demand for energy,deep underground salt caverns are emerging as a potential solution for large-scale energy storage.In this study,multistage cyclic loading tests were conducted on rock salt at different temperatures in combination with real-time acoustic emission(AE)monitoring.The results show that the cumulative AE count increases stepwise with increasing cyclic stress.The peak frequency is concentrated primarily in the medium-frequency range,exhibiting a band distribution across low-,medium-,and high-frequency ranges.As the temperature increases,the proportion of low-frequency signals decreases from 14.32%to 5.76%,whereas the proportion of medium-frequency signals increases from 85.48%to 94.1%.The proportion of high-frequency signals remains relatively constant between 0.1%and 0.2%.The amplitude-count relationship of the AE signals demonstrates a strong negative power-law correlation.Furthermore,with increasing temperature,the negative power-law exponent of the amplitude gradually decreases,with the b value decreasing from 1.096 to 0.837 and the a value decreasing from 7.4871 to 6.6982.Under all four temperature conditions,the dominant failure mode in rock salt is tensile cracking.However,as the temperature increases,the proportion of tensile cracks decreases from 88.59%to 75.12%,whereas the proportion of shear cracks at 80℃is nearly double that at 20℃.This finding indicates that as the temperature increases,the ductility of the material increases,and the crack propagation mode shifts from tensile to shear.This research provides valuable insights for the design and stability assessment of salt cavern reservoirs for deep underground energy storage systems. 展开更多
关键词 Rock salt Cyclic loading Temperature Acoustic emission(AE) Crack type
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Damage behavior of soaked sandstone subjected to cyclic loadings
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作者 Zhenhui Bi Lei Wang +3 位作者 Chunhe Yang Yintong Guo Wuhao Guo Mingnan Xu 《Journal of Rock Mechanics and Geotechnical Engineering》 2026年第2期1090-1107,共18页
Large-scale geological energy storage plays a crucial role in balancing the intermittency of renewable energy.As an energy storage medium,soaked sandstone has a wide range of applications in geological energy storage.... Large-scale geological energy storage plays a crucial role in balancing the intermittency of renewable energy.As an energy storage medium,soaked sandstone has a wide range of applications in geological energy storage.Understanding the damage characteristics in soaked sandstones is essential for ensuring the stability and longevity of these energy storage systems.This study involved multi-stage cyclic loading tests conducted on soaked sandstone to explore the damage evolution throughout the loading process.The findingsreveal several important insights:(1)The plastic hysteresis loops observed during multi-stage cyclic loading evolved from dense to sparse.An increase in stress level led to greater damage in the rock,as evidenced by an increase in accumulated peak/plastic strains.(2)Energy density and stress level are related by quadratic polynomial relationships.The elastic and dissipated energy densities are related by a linear law.The average energy storage coefficientdecreased by up to 24.1%with increasing stress amplitude,reflectingchanges in energy dynamics within the samples.(3)AE counts,amplitude,and frequency provided critical insights into rock damage and fracture patterns.The greater the loading rate and stress amplitude,the lower the proportion of high-amplitude,high-peak frequency,and shear-type fractures.Increasing stress amplitude caused a maximum 16.63%reduction in the AE bvalue,indicating shifts in fracture behavior under varying stress conditions.(4)The increase in loading rate and stress amplitude promotes the transformation of micropores and mesopores to macropores/microcracks.(5)Damage variables,definedin terms of cumulative dissipation energy,aligned closely with the fatigue damage model under multi-stage cyclic loading.Accelerated damage primarily occurred during the finalstages of fatigue loading,highlighting critical periods in the degradation of soaked sandstones.This study can offer guidance for designing operational parameters for energy storage geological bodies dominated by soaked sandstones. 展开更多
关键词 Soaked sandstone Multi-stage cyclic loading Energy density Acoustic emission MICROSTRUCTURE Damage evaluation
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Pull-out capacity and energy absorption of cable bolts under impact loading
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作者 Adel Mottahedi Naj Aziz +1 位作者 Alex Remennikov Ali Mirzaghorbanali 《International Journal of Mining Science and Technology》 2026年第1期23-42,共20页
This study investigates the performance of high-strength cable bolts under impact loading conditions representative of rock bursts in underground environments.Although widely used,the dynamic behaviour of these cable ... This study investigates the performance of high-strength cable bolts under impact loading conditions representative of rock bursts in underground environments.Although widely used,the dynamic behaviour of these cable bolts has received limited experimental attention,and their effectiveness in seismically active zones remains a subject of ongoing debate.To address this gap,a reverse pull-out test machine integrated with a drop hammer rig was employed.Tests were conducted on 70-t SUMO bulbed and non-bulbed cable bolts with encapsulation lengths of 300 and 450 mm,subjected to an impact energy of 14.52 k J.Results indicate that non-bulbed cables,despite showing lower initial peak loads(average 218 vs.328 k N for bulbed cables at 300 mm encapsulation),demonstrated superior energy absorption(average 11.26 vs.8.75 k J)and displacement capacity(average 48.40 vs.36.25 mm).Increasing the encapsulation length for bulbed cables led to a reduction in initial peak load but improved displacement and energy absorption.The dominant failure mechanism was debonding at the cable-grout interface,characterised by frictional sliding and cable rotation.These findings provide new insights into the energy dissipation mechanisms of cables and support the development of more resilient ground support systems for dynamically active conditions. 展开更多
关键词 Rock reinforcement Cable bolt Impact loading Pull-out testing Mine seismicity Rock burst
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Effect of initial fracture angle on the failure pattern and gas flow channel of sandstone under multistage loading
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作者 Quanle Zou Feixiang Lv +4 位作者 Zihan Chen Qingsong Li Jianjun Zhao Qican Ran Qingmiao Li 《Journal of Rock Mechanics and Geotechnical Engineering》 2026年第3期2142-2157,共16页
After coal seam mining,the overlying rock strata above the goaf are subjected to long-term stress and eventually undergo failure.Under mining-induced disturbances,the strata develop fractures at various angles,which s... After coal seam mining,the overlying rock strata above the goaf are subjected to long-term stress and eventually undergo failure.Under mining-induced disturbances,the strata develop fractures at various angles,which significantly influence failure modes and the morphology of gas flow channels.This study employed multistage loading experiments,numerical simulations,three-dimensional reconstruction,and image recognition to investigate the fragmentation process of rocks with different initial fracture angles under multistage loading.The results show that variations in the initial fracture angle affect the transmission of contact forces among rock particles.As the angle increases,the transmission pattern shifts from a uniform distribution to one extending along the direction of the fracture.Rocks with small initial fracture angles tend to experience tensile-dominated failure,with most of the material subjected to longitudinal loading,resulting in reduced strength.Fractures propagate from the central region of the initial fracture,producing a complex internal fracture network.The proportion of fracture channels varies considerably across regions,creating multiple zones of velocity variation in the gas flow.In contrast,rocks with large initial fracture angles are more susceptible to shear failure,with the primary load-bearing zones aligned along the inclined fracture direction.As a result,the influence on surrounding regions is limited,improving the rock's load-bearing capacity under multistage loading.In these cases,the distribution and proportion of fracture channels become more uniform,promoting more stable gas flow within the channels.Overall,these findings provide theoretical insights into how initial fracture angles govern rock failure patterns and gas flow characteristics. 展开更多
关键词 Multistage loading Initial fracture angle Failure pattern Gas flow characteristics Three-dimensional fracture reconstruction
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Rutting performance of geosynthetic reinforced unbound pavements subjected to repetitive loading:A review
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作者 Arnold Fernando Shehan Mithila +1 位作者 Shiran Jayakody Chaminda Gallage 《Journal of Road Engineering》 2026年第1期34-50,共17页
The growing demands on global infrastructure highlight the critical need for durable and efficient pavement systems,particularly under the stress of repetitive heavy traffic loads.The use of geosynthetics within the p... The growing demands on global infrastructure highlight the critical need for durable and efficient pavement systems,particularly under the stress of repetitive heavy traffic loads.The use of geosynthetics within the pavement structure increases the load-carrying capacity of unbound pavement layers by providing lateral restraint,improving vertical stress distribution,and enhancing bearing capacity.Such reinforcement typically aims to either improve the service life of pavements or achieve equivalent performance with a reduced granular cover.Previous and ongoing research quantifies geosynthetic performance in pavement reinforcement using various testing methods.Among these,laboratory model box tests subjected to cyclic loading are pivotal,as they closely replicate real-world traffic conditions.Hence,these studies are essential for understanding how geosynthetics distribute loads and enhance pavement durability.This facilitates the development of optimized geosynthetic design and installation practices,accelerating the loading process to simulate years of traffic wear in a shorter period.This review discusses the improved rutting resistance of unbound pavements reinforced with geosynthetic materials,specifically drawing on data from cyclic plate load tests conducted on laboratory model boxes,as highlighted in the literature.Key variables such as optimum geosynthetic placement,geosynthetic material properties,performance of different geosynthetic materials and the effects of aperture shape and size on rutting resistance are discussed.Furthermore,the review assesses various predictive rutting models,analysing their applicability and accuracy in forecasting the rutting performance of geosynthetic-reinforced unbound pavements.This comprehensive literature review aids pavement engineers and researchers,in guiding the selection and design of geosynthetics to optimize pavement durability and functionality under repetitive traffic loads. 展开更多
关键词 GEOSYNTHETICS Unbound pavements Laboratory model box tests Cyclic loading Rutting resistance Predictive rutting models
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Energy absorption behavior and damage constitutive model of frozen moraine soil under impact loading
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作者 XIE Qijun SU Lijun +1 位作者 ZHAO Bo ZHANG Fulai 《Journal of Mountain Science》 2026年第3期1288-1301,共14页
Frozen moraine soils are widely distributed across the Tianshan Mountains,the Qinghai-Tibetan Plateau,and other high-altitude regions.Engineering activities,particularly blasting,often induce degradation of the soil m... Frozen moraine soils are widely distributed across the Tianshan Mountains,the Qinghai-Tibetan Plateau,and other high-altitude regions.Engineering activities,particularly blasting,often induce degradation of the soil microstructure,compromising its mechanical integrity and increasing the risk of slope instability and rainfall-triggered debris flows-posing serious threats to infrastructure in cold regions.Previous studies have largely treated frozen soils as homogeneous continua,thereby overlooking key micro-scale processes such as ice-soil interaction,microcrack propagation,and particle breakage.In this study,the dynamic mechanical behavior and microstructural damage mechanisms of frozen moraine soil were systematically investigated under varying temperatures(−5℃,−15℃,and−25℃)and strain rates(50 s^(-1),70 s^(-1),and 90 s^(-1)).Results reveal that both temperature and strain rate significantly influence the dynamic stress-strain response.Energy absorption exhibits a three-stage pattern of increase,stabilization,and decline.At−25℃,increased ice brittleness reduces the peak energy absorption efficiency under impact.To capture the observed nonlinear behavior,a damage-based constitutive model was developed,incorporating coupled effects of impact-induced microcracking,ice-soil interfacial debonding,and particle fracture.The stochastic evolution of interfacial debonding and grain breakage was described using a Weibull statistical framework,linking microstructural deterioration to macroscopic response.The model shows strong agreement with experimental data and accurately simulates key parameters such as peak stress and energy absorption.These findings enhance the understanding of dynamic damage mechanisms in frozen soils and offer a computational tool for the safety assessment and hazard mitigation of engineering structures in cold,high-altitude environments. 展开更多
关键词 Frozen moraine soil Damage constitutive model Impact loading Energy absorption Ice-soil interaction Cold regions engineering
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Mechanical behavior and acoustic emission characteristics of initially damaged coal under triaxial cyclic loading and unloading
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作者 Qican Ran Yunpei Liang +5 位作者 Quanle Zou Chunfeng Ye Zihan Chen Tengfei Ma Zhaopeng Wu Bichuan Zhang 《Journal of Rock Mechanics and Geotechnical Engineering》 2026年第1期230-245,共16页
During deep coal mining,an instability failure of coal usually occurs under the combined effect of initial damage and triaxial cyclic loading and unloading(TCLU).Therefore,this study investigated the impact of initial... During deep coal mining,an instability failure of coal usually occurs under the combined effect of initial damage and triaxial cyclic loading and unloading(TCLU).Therefore,this study investigated the impact of initial damage on mechanical behavior and acoustic emission(AE)characteristics of coal under TCLU.Initial damage variables(IDVs)of coal specimens were quantified using preloading,followed by TCLU experiments to assess the deformation,energy distribution,and fracture development.The results revealed that the increase in IDVs significantly reduced the structural integrity of coal specimens,increased the cumulative irreversible strain,and enhanced the dissipated energy owing to microfracture expansion.Moreover,AE monitoring showed earlier activation of fractures and a higher occurrence of large-scale rupture events of coal specimens with high IDVs,which correlated with decreasing AE b values(reflecting the different scales of fracture within specimens)and increasing S values(reflecting the AE activity within specimens).Additionally,computed tomography analysis revealed intensified fracture networks and increasing three-dimensional fractal dimensions of coal specimens with higher IDVs.Finally,the coupling effect of TCLU and initial damage on the weakening mechanism of coal was investigated.Initial damage significantly reduced the structural integrity of coal by increasing the number of weak planes within coal specimens,contributing to the earlier activation and rapid expansion of fractures at low stress levels under TCLU and eventually accelerating the weakening process of coal.This study provides a scientific basis and theoretical support for the prevention and control of dynamic disasters in deep coal mining. 展开更多
关键词 Triaxial cyclic loading Initially damaged coal Linear energy storage(LES) Acoustic emission(AE) Computed tomography(CT)
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Pyrazino[2,3-f][1,10]phenanthroline Derivatives as Photoredox Catalysts for Photoinduced Organocatalyzed Atom Transfer Radical Polymerization(O-ATRP)at ppm-Level Loading
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作者 Wen-Zhe Xu Wan-Chao Hu +1 位作者 Bei Liu Chang-Li Lü 《Chinese Journal of Polymer Science》 2026年第3期664-674,I0009,共12页
Organocatalyzed atom transfer radical polymerization(O-ATRP)is a pivotal technique for the synthesis of polymers with well-defined structures that are devoid of metallic residues.A major challenge in this area is the ... Organocatalyzed atom transfer radical polymerization(O-ATRP)is a pivotal technique for the synthesis of polymers with well-defined structures that are devoid of metallic residues.A major challenge in this area is the reduction of catalyst loading while maintaining precise control over polymer architecture and properties.Herein,we systematically evaluate the efficacy of six pyrazino[2,3-f][1,10]phenanthroline(pyzPhen)-based photoredox catalysts in photoinduced O-ATRP.Experimental results indicate that the introduction of various substituents markedly influences the photophysical properties and redox behavior of the catalysts,thereby resulting in differing catalytic efficiencies in the O-ATRP of methyl methacrylate(MMA).Following additional optimization,two highly efficient O-ATRP photocatalysts capable of exhibiting thermally activated delayed fluorescence(TADF)were successfully identified.Under visible light irradiation,TADF catalysts effectively mediated the controlled polymerization of MMA at a low loading level of 50 ppm,particularly when used in conjunction with the initiator DBMM.The catalytic systems demonstrate excellent temporal control,broad monomer applicability,and favorable compatibility with various initiators and solvent systems.This work offers new insights into the development of efficient,low-catalyst-loading,metal-free ATRP systems. 展开更多
关键词 Organocatalyzedatom transfer radical polymerization(O-ATRP) Photoredox catalysts Pyrazino[2 3-f][1 10]phenanthroline derivatives Thermally activated delayed fluorescence(TADF) Low catalyst loading
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SIL-TAL1^(+)儿童急性T淋巴细胞白血病的临床分析
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作者 薛玉娟 王毓 +3 位作者 张乐萍 陆爱东 贾月萍 曾慧敏 《中国实验血液学杂志》 北大核心 2025年第5期1262-1268,共7页
目的:探究SIL-TAL1融合基因阳性的儿童急性T淋巴细胞白血病(SIL-TAL1^(+)T-ALL)的临床和预后特征。方法:回顾性分析2010年1月至2018年12月我院儿科收治的110例初诊T-ALL患儿的临床资料,比较SIL-TAL1^(+)组和SIL-TAL1-组的临床特征、治... 目的:探究SIL-TAL1融合基因阳性的儿童急性T淋巴细胞白血病(SIL-TAL1^(+)T-ALL)的临床和预后特征。方法:回顾性分析2010年1月至2018年12月我院儿科收治的110例初诊T-ALL患儿的临床资料,比较SIL-TAL1^(+)组和SIL-TAL1-组的临床特征、治疗反应和预后情况。结果:110例T-ALL患儿中,SIL-TAL1^(+)组有25例(22.7%),SIL-TAL1-组有85例(77.3%)。SIL-TAL1^(+)组的初诊白细胞计数明显高于SIL-TAL1-组(P<0.05),两组间的其他临床特征及治疗反应均无明显差异。SIL-TAL1^(+)组和SIL-TAL1-组的5年总生存(OS)率分别为80.0%和75.5%,5年无病生存(DFS)率分别为76.0%和72.9%,两组间OS率及DFS率比较差异均无统计学意义(P>0.05)。在初诊年龄<10岁的患儿中,SIL-TAL1^(+)组与SIL-TAL1-组的5年OS率分别为100%与75.1%,两组间的差异具有统计学意义(P<0.05)。结论:儿童SIL-TAL1^(+)T-ALL初诊时白细胞水平更高,临床疗效与SIL-TAL1-无显著差异。但在初诊年龄<10岁的T-ALL患儿中,SIL-TAL1^(+)组的长期生存率明显更优。 展开更多
关键词 急性T淋巴细胞白血病 儿童 sil-TAL1融合基因 预后
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益气补肺汤加减联合西药治疗肺结核气阴两虚证疗效观察及对TNFSF14、sIL-2R水平的影响
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作者 唐苗苗 曹培谦 王志刚 《新中医》 2025年第22期28-33,共6页
目的:观察益气补肺汤加减联合西药治疗肺结核(PTB)气阴两虚证的疗效以及对血清肿瘤坏死因子配体超家族成员14(TNFSF14)、可溶性白细胞介素-2受体(sIL-2R)水平的影响。方法:纳入2021年9月—2024年9月在郑州市第六人民医院治疗的120例PTB... 目的:观察益气补肺汤加减联合西药治疗肺结核(PTB)气阴两虚证的疗效以及对血清肿瘤坏死因子配体超家族成员14(TNFSF14)、可溶性白细胞介素-2受体(sIL-2R)水平的影响。方法:纳入2021年9月—2024年9月在郑州市第六人民医院治疗的120例PTB气阴两虚证患者,采用随机数字表法分入对照组与联合组,每组60例。对照组予抗结核西药治疗,联合组在对照组基础上使用益气补肺汤加减治疗。2组均连续治疗6个月。比较2组临床疗效、中医证候疗效、气阴两虚证评分、不良反应发生率以及血清TNFSF14、sIL-2R水平。结果:治疗6个月后,联合组临床疗效总有效率93.33%(56/60)、中医证候疗效总有效率95.00%(57/60),均高于对照组78.33%(47/60)、73.33%(44/60),差异均有统计学意义(P<0.05)。治疗3个月、6个月后,2组气阴两虚证评分均较治疗前下降,联合组气阴两虚证评分均低于同期对照组,差异均有统计学意义(P<0.05)。治疗6个月后,2组血清TNFSF14、sIL-2R水平均较治疗前下降,联合组血清TNFSF14、sIL-2R水平均低于对照组,差异均有统计学意义(P<0.05)。治疗期间,联合组不良反应发生率10.00%(6/60),对照组不良反应发生率15.00%(9/60),2组比较,差异无统计学意义(P>0.05)。结论:在抗结核西药基础上联合益气补肺汤加减治疗PTB气阴两虚证疗效确切,可有效缓解临床症状,有助于痰菌转阴、肺结核病灶吸收,以及下调血清TNFSF14、sIL-2R水平。 展开更多
关键词 肺结核 气阴两虚证 益气补肺汤 肿瘤坏死因子配体超家族成员14 可溶性白细胞介素-2受体
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Tensile Strength Characteristics of GFRP Bars in Concrete Beams with Work Cracks under Sustained Loading and Severe Environments 被引量:4
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作者 何雄君 YANG Jingnan Charles E Bakis 《Journal of Wuhan University of Technology(Materials Science)》 SCIE EI CAS 2013年第5期934-937,共4页
To investigate the effect of different environmental conditions of GFRP bars in concrete beams with work cracks subjected to sustained loads, the beams were exposed in indoor, freeze/thaw cycles and immersed in alkali... To investigate the effect of different environmental conditions of GFRP bars in concrete beams with work cracks subjected to sustained loads, the beams were exposed in indoor, freeze/thaw cycles and immersed in alkaline solution at elevated temperature. The bars were carefully extracted from the beams and tested in order to evaluate residual tensile properties. The results show that the tensile strength decreased significantly in the highly aggressive conditions but not in the natural conditions. The effect of GFRP bars casting in concrete beams demonstrated approximately 2.5% decrease of tensile strength caused by pore water environment in concrete beams on basis of those of the original bars. The effect of sustained loading plus work cracks demonstrated about 10.5% tensile strength decrease on basis of those of the bars only casted in concrete beams. The effect of environments under sustained loading plus work cracks demonstrated about 17% tensile strength decrease caused by a saturated solution of Ca(OH)2 and 60-2 ℃ tap water (pH=12-13) and about 8% tensile strength decrease caused by freezing and thawing cycle (F/T), both on basis of those of the bars of the indoor beams only under sustained loading plus work cracks. The results demonstrate the effects of the tensile strengths under different environmental conditions of GFRP bars in concrete beams with work cracks subjected to sustained loads. 展开更多
关键词 GFRP bars concrete beams working cracks sustained loading and severe environments tensile strength
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