Statistical analysis of certain major diseases Jethal to the animal was carried out through on-spot investigations and consultations to related documentary materials. The resufts show that the first serious lethal fac...Statistical analysis of certain major diseases Jethal to the animal was carried out through on-spot investigations and consultations to related documentary materials. The resufts show that the first serious lethal factor is digestive system diseases. Next comes malnutrition and organic exhaustion. In order of decremental percentages, other diseases are roundworm disease, epilepsy, toxicosis, pneumonia, tumor, pericarditis, etc. In relation to 54 wild giant pandas taken for statistics, the death of malnutrition, organic exhaustion caused accounts for 42.78%. In order of reducing percentages, other diseases are roundworm disease, toxicosis. epilepsy, etc..Based on the statistics of 22 penned giant pandas, the death out of the digestive system diseases comes first,accounting for 63.64%. Other diseases nil order of decremental proportion are epilepsy, organic exhaustion, etc.,Gastroenteric hemorrhage is one of the highest mortality in digestive system diseases. the next comes orderly roundworm disease, hemorrhage, gatroenteritis and intestinal obstruction. The mortality of the sub-adults is the highest, accounting for 64.29%, or 2.6 times as that of the adults, or 7 times as that of the aged giant pandas.Some prevention measures of diseases for Giant pandas were also discussed in this paper.展开更多
Introduction: Congenital heart disease is a major cause of children’s death. In Niger, despite the frequency of these pathologies, very few studies have been carried out on associated mortality in a paediatric enviro...Introduction: Congenital heart disease is a major cause of children’s death. In Niger, despite the frequency of these pathologies, very few studies have been carried out on associated mortality in a paediatric environment. The objective of this work was to look for the risk factors of children with congenital heart disease’s death in Niamey. Patients and Method: It is about a cross-sectional study for descriptive and analytical purposes in children aged from 0 to 15 years. Carriers of congenital heart disease followed from January 2016 to July 2021 in two national hospitals in Niamey. The variable depends and the main ante was the occurrence of deaths (yes or no). The explanatory variables were related to the characteristics of the patients, the type of heart disease and management among others. Chi’s tests2 Pearson’s or Fischer’s exact test were used (P Results: During the period of the research, 514 cases of congenital heart disease were studied, including 132 deaths (25.68%). The average age of patients was 14.64 months [10 days - 15 years]. The sex ratio was 1.08. The most common reason for consultation was respiratory distress that was found in 74.90% of patients. Interventricular communication (IVC) and intear communication (CIA) were the most found type of heart disease with 36.53% and 20.44% of cases respectively. Only 9.54% of patients (n = 48) had received surgical management. The risk factors associated with mortality were pulmonary arterial hypertension (54.17%), pulmonary disease (44.55%) and the presence of anemia (63.16%) [OR > 1;p Conclusion: Congenital heart diseases remain an important cause of death among children in Niger. The pulmonary arterial hypertension and the associated comorbidities such as broncho-pulmonary diseases were the main associated factors. In the meantime, an optimal technical management of these factors will help to reduce this mortality.展开更多
AIM: To prove anthrax lethal toxin(Le Tx) blocks the mitogen activated protein kinases(MAPKs) activation by degrading the MAPK/ERK kinases(MEKs) to suppress vascular endothelial growth factor(VEGF) secretion.METHODS: ...AIM: To prove anthrax lethal toxin(Le Tx) blocks the mitogen activated protein kinases(MAPKs) activation by degrading the MAPK/ERK kinases(MEKs) to suppress vascular endothelial growth factor(VEGF) secretion.METHODS: Human adult retinal pigmented epithelium(ARPE) cells were cultured and treated with normal glucose, high glucose or high glucose with Le Tx for additional 24, 48 or 72 h for viable cell count. Total RNA from the ARPE was isolated for reverse transcription polymerase chain reaction(RT-PCR). The conditioned medium of ARPE cells treated in different group for 48 h was filtered and diluted to detect the concentration of VEGF by enzyme-linked immunosorbant assays.Evaluate the role of MEK/MAPK pathway in the secretion of VEGF by immunoblotting. RESULTS: In this study, we proved high glucose induced activation of the MAPK extracellular signal-regulated kinase(ERK1/2) and p38 in the ARPE cell line was blocked by anthrax Le Tx. Le Tx also inhibited high glucose induced ARPE cell over proliferation.CONCLUSION: Le Tx suppressed high glucose induced VEGF over secretion in the ARPE cells, mainly through a post-translational mechanism.展开更多
目的探讨儿童颅脑外伤(Children with brain trauma,CBT)的病死率和死亡因素,为制定防治措施提供理论依据。方法回顾分析522例CBT的临床资料,对患者的性别、年龄、伤因、伤情、入院时生命体征、血氧饱和度、合并伤及格拉斯哥昏迷计分(Gl...目的探讨儿童颅脑外伤(Children with brain trauma,CBT)的病死率和死亡因素,为制定防治措施提供理论依据。方法回顾分析522例CBT的临床资料,对患者的性别、年龄、伤因、伤情、入院时生命体征、血氧饱和度、合并伤及格拉斯哥昏迷计分(Glasgow coma scale,GCS)等指标进行统计分析。结果Logistic回归分析发现:患者入院时脉搏、血压和血氧饱和度独立地与死亡显著相关,帽状腱膜下血肿和呼吸道误吸是重要的潜在危险因素。结论儿童对失血耐受力差,创伤后脉搏快、血压低和血氧饱和度下降是影响CBT患者死亡的主要危险因素,针对相应病因及时纠正和保持呼吸、血压平稳,有望降低病死率。展开更多
文摘Statistical analysis of certain major diseases Jethal to the animal was carried out through on-spot investigations and consultations to related documentary materials. The resufts show that the first serious lethal factor is digestive system diseases. Next comes malnutrition and organic exhaustion. In order of decremental percentages, other diseases are roundworm disease, epilepsy, toxicosis, pneumonia, tumor, pericarditis, etc. In relation to 54 wild giant pandas taken for statistics, the death of malnutrition, organic exhaustion caused accounts for 42.78%. In order of reducing percentages, other diseases are roundworm disease, toxicosis. epilepsy, etc..Based on the statistics of 22 penned giant pandas, the death out of the digestive system diseases comes first,accounting for 63.64%. Other diseases nil order of decremental proportion are epilepsy, organic exhaustion, etc.,Gastroenteric hemorrhage is one of the highest mortality in digestive system diseases. the next comes orderly roundworm disease, hemorrhage, gatroenteritis and intestinal obstruction. The mortality of the sub-adults is the highest, accounting for 64.29%, or 2.6 times as that of the adults, or 7 times as that of the aged giant pandas.Some prevention measures of diseases for Giant pandas were also discussed in this paper.
文摘Introduction: Congenital heart disease is a major cause of children’s death. In Niger, despite the frequency of these pathologies, very few studies have been carried out on associated mortality in a paediatric environment. The objective of this work was to look for the risk factors of children with congenital heart disease’s death in Niamey. Patients and Method: It is about a cross-sectional study for descriptive and analytical purposes in children aged from 0 to 15 years. Carriers of congenital heart disease followed from January 2016 to July 2021 in two national hospitals in Niamey. The variable depends and the main ante was the occurrence of deaths (yes or no). The explanatory variables were related to the characteristics of the patients, the type of heart disease and management among others. Chi’s tests2 Pearson’s or Fischer’s exact test were used (P Results: During the period of the research, 514 cases of congenital heart disease were studied, including 132 deaths (25.68%). The average age of patients was 14.64 months [10 days - 15 years]. The sex ratio was 1.08. The most common reason for consultation was respiratory distress that was found in 74.90% of patients. Interventricular communication (IVC) and intear communication (CIA) were the most found type of heart disease with 36.53% and 20.44% of cases respectively. Only 9.54% of patients (n = 48) had received surgical management. The risk factors associated with mortality were pulmonary arterial hypertension (54.17%), pulmonary disease (44.55%) and the presence of anemia (63.16%) [OR > 1;p Conclusion: Congenital heart diseases remain an important cause of death among children in Niger. The pulmonary arterial hypertension and the associated comorbidities such as broncho-pulmonary diseases were the main associated factors. In the meantime, an optimal technical management of these factors will help to reduce this mortality.
基金Supported by National Natural Science Foundation of China (No.81170855)
文摘AIM: To prove anthrax lethal toxin(Le Tx) blocks the mitogen activated protein kinases(MAPKs) activation by degrading the MAPK/ERK kinases(MEKs) to suppress vascular endothelial growth factor(VEGF) secretion.METHODS: Human adult retinal pigmented epithelium(ARPE) cells were cultured and treated with normal glucose, high glucose or high glucose with Le Tx for additional 24, 48 or 72 h for viable cell count. Total RNA from the ARPE was isolated for reverse transcription polymerase chain reaction(RT-PCR). The conditioned medium of ARPE cells treated in different group for 48 h was filtered and diluted to detect the concentration of VEGF by enzyme-linked immunosorbant assays.Evaluate the role of MEK/MAPK pathway in the secretion of VEGF by immunoblotting. RESULTS: In this study, we proved high glucose induced activation of the MAPK extracellular signal-regulated kinase(ERK1/2) and p38 in the ARPE cell line was blocked by anthrax Le Tx. Le Tx also inhibited high glucose induced ARPE cell over proliferation.CONCLUSION: Le Tx suppressed high glucose induced VEGF over secretion in the ARPE cells, mainly through a post-translational mechanism.
文摘目的探讨儿童颅脑外伤(Children with brain trauma,CBT)的病死率和死亡因素,为制定防治措施提供理论依据。方法回顾分析522例CBT的临床资料,对患者的性别、年龄、伤因、伤情、入院时生命体征、血氧饱和度、合并伤及格拉斯哥昏迷计分(Glasgow coma scale,GCS)等指标进行统计分析。结果Logistic回归分析发现:患者入院时脉搏、血压和血氧饱和度独立地与死亡显著相关,帽状腱膜下血肿和呼吸道误吸是重要的潜在危险因素。结论儿童对失血耐受力差,创伤后脉搏快、血压低和血氧饱和度下降是影响CBT患者死亡的主要危险因素,针对相应病因及时纠正和保持呼吸、血压平稳,有望降低病死率。
