Microplastics often co-occur with a variety of organic contaminants in aquatic environment and pose combined risks to aquatic wildlife. Here, we investigated joint effects of microsized polystyrene(mPS, 5 μm) and an ...Microplastics often co-occur with a variety of organic contaminants in aquatic environment and pose combined risks to aquatic wildlife. Here, we investigated joint effects of microsized polystyrene(mPS, 5 μm) and an organophosphate pesticide chlorpyrifos on zebrafish,using multiple endpoints at both fish individual and gut microbiota levels. It was revealed that mPS ingested by zebrafish accumulated in gut and liver, and caused oxidative stress, hyperactive swimming performance and histological damages in fish, and induced disorders and diversity alterations of the gut microbial community. More importantly, mPS exhibited considerable adsorption capacity against chlorpyrifos, and those adsorbing chlorpyrifos presented greater effects on fish individuals but no different effects on gut microbiota compared to single mPS exposure. Together with body residues of chlorpyrifos in zebrafish,it was proposed that the joint effects between mPS and chlorpyrifos were attributed to the chlorpyrifos released from mPS within zebrafish. The present results provided a comprehensive understanding of joint effects of mPS and contaminants co-occurring in the environment and emphasized the importance of considering the adsorbed chemicals in toxicological studies of microplastics.展开更多
BACKGROUND The long-term impact of vitamin D deficiency and metabolic syndrome(MetS)on cardiovascular disease(CVD)and all-cause mortality are still a matter of debate.AIM To test the hypotheses that lower serum 25 hyd...BACKGROUND The long-term impact of vitamin D deficiency and metabolic syndrome(MetS)on cardiovascular disease(CVD)and all-cause mortality are still a matter of debate.AIM To test the hypotheses that lower serum 25 hydroxyvitamin D[25(OH)D]concentrations(a marker of vitamin D level)and MetS have a long-term impact on the risk of CVD and all-cause mortality,and individuals with vitamin D deficiency can be identified by multiple factors.METHODS A sample of 9094 adults,20 to 90 years of age,who participated in the Third National Health and Nutrition Examination Survey(NHANES III,1988 to 1994)were followed through December 2015 was analyzed.The associations of serum 25(OH)D concentrations and MetS with CVD and all-cause mortality were analyzed longitudinally using Cox regression models.Classification and regression tree(CART)for machine learning was applied to classify individuals with vitamin D deficiency.RESULTS Of 9094 participants,30%had serum 25(OH)D concentrations<20 ng/mL(defined as vitamin D deficiency),39%had serum 25(OH)D concentrations between 20 to 29 ng/mL(insufficiency),and 31%had serum 25(OH)D concentrations≥30 ng/mL(sufficiency).Prevalence of MetS was 28.4%.During a mean of 18 years follow-up,vitamin D deficiency and MetS were significantly associated with increased risk of CVD and all-cause mortality.Subjects with both vitamin D deficiency and MetS had the highest risk of CVD mortality(HR=1.77,95%CI:1.22-2.58)and all-cause mortality(HR=1.62,95%CI:1.26-2.09),followed by those with both vitamin D insufficiency and MetS for CVD mortality(HR=1.59,95%CI:1.12-2.24),and all-cause mortality(HR=1.41,95%CI:1.08-1.85).Meanwhile,vitamin D sufficiency significantly decreased the risk of CVD and all-cause mortality for those who even had MetS.Among the total study sample,CART analysis suggests that being non-Hispanic Black,having lower serum folate level,and being female were the first three predictors for those with serum 25(OH)D deficiency.CONCLUSION Vitamin D deficiency and MetS were significantly associated with increased risk of CVD and allcause mortality.There was a significant joint effect of vitamin D deficiency and MetS on the risk of mortality.Findings of the CART analysis may be useful to identify individuals positioned to benefit from interventions to reduce the risk of CVD and all-cause mortality.展开更多
This work is investigating Mexidol (2-ethyl-6-methyl-3-hydroxy pyridine succinate) effect on the formation of nitric oxide (NO) in animal liver tissues, which is a regulator of many physiological processes and plays a...This work is investigating Mexidol (2-ethyl-6-methyl-3-hydroxy pyridine succinate) effect on the formation of nitric oxide (NO) in animal liver tissues, which is a regulator of many physiological processes and plays an important role in the vascular relaxation, neurotransmission and immune system functioning. Analyses performed by EPR spectroscopy revealed Hem-NO complex signals from paramagnetic centers in arbitrary units;produced nitrogen oxide amount in liver tissues was determined by method of double integration signals from nitrosyl complexes.展开更多
The combined and interactive effects of the bolt-hole fit conditions and the preloads of the fasteners on the load carrying capacity of single-lap composite-to-titanium bolted joints have been investigated both experi...The combined and interactive effects of the bolt-hole fit conditions and the preloads of the fasteners on the load carrying capacity of single-lap composite-to-titanium bolted joints have been investigated both experimentally and numerically. Quasi-static tests of the hybrid joints with different fit conditions are implemented, and a three dimensional finite element progressive failure analysis model is proposed to predict the influences of the bolt-hole fit conditions and fastener＇s pre- loads on the mechanical behaviors of the joints. Based on the experimental validated simulation method, a multi-factor, mixed levels orthogonal design table and the analysis of variance method are used to arrange the simulation conditions and to further study the interactive effects of preloads and fit conditions. Through the analysis of the results, for the researched double bolt, single-lap composite-titanium joints, it is found that： the effects of both the interference fit and the preloads change from positive into negative mode with the increase of the interference fit values or preload values; appropriate bolt-hole fit conditions and preloads can improve the bolt-hole contact conditions of the loaded joints, and then retard the fiber failures around the fastener holes, and increase the load carrying capacity of the joints eventually; the interactive effect of the bolt-hole interference fit conditions and preloads cannot be ignored and the parameters need to be considered together and synthetically as the joints are being optimized.展开更多
In order to evaluate ecological risk of agrochemicals in common use, joint toxic effects of acetochlor and urea on germinating characteristics of Chinese cabbage (Brassica Pe-kinensis Rupr) seeds were investigated usi...In order to evaluate ecological risk of agrochemicals in common use, joint toxic effects of acetochlor and urea on germinating characteristics of Chinese cabbage (Brassica Pe-kinensis Rupr) seeds were investigated using the water-culture method and the soil-culture method. The results indicated(that excessive application of acetochlor and urea, when the concentrations were higher than 31.3 mg · kg-1 for acetochlor and 500 mg · kg-1 for urea, had strong inhibitory effects on the rate of seed germination, root elongation and hypocotyl length of Chinese cabbage. The inhibitory rate of the germinating characteristics of Chinese cabbage seeds was significantly increased with an increase in the concentration of acetochlor or urea. The two agrochemicals in water had a stronger toxicity than these in the soil at the same concentration. Among the three indexes, hypocotyl length was the most sensitive to the toxicity of acetochlor and urea.展开更多
In this study, the joint effects of Cd(Ⅱ), Pb(Ⅱ) and atrazine (ATR) on Solidago Canadensis L. were investigated. The results showed that soil containing Cd, Pb and ATR could inhibit root elongation of Solidago Canad...In this study, the joint effects of Cd(Ⅱ), Pb(Ⅱ) and atrazine (ATR) on Solidago Canadensis L. were investigated. The results showed that soil containing Cd, Pb and ATR could inhibit root elongation of Solidago Canadensis L., and that there was a positive linear relationship between the inhibitory rate of root elongation and the concentrations of Pb(Ⅱ). The mixture of Cd(Ⅱ) and Pb(Ⅱ)-ATR in soil showed a significant adverse effect on root and shoot biomass of Solidago Canadensis L. Acetylsalicylic acid (ASA) contents increased slightly at the lower concentrations of Cd(Ⅱ)-ATR, then decreased when Cd(Ⅱ)-ATR concentrations were higher than those of 1.0 TUmix(Cd+ATR). The toxic effect of Pb(Ⅱ)-ATR on the ASA contents of Solidago Canadensis L. was greater than that of Cd(Ⅱ)-ATR. Soluble sugar contents firstly decreased and then increased with increasing concentrations of Cd(Ⅱ)-ATR and displayed fluctuation with increasing concentrations of Pb(Ⅱ)-ATR. Total protein contents in-creased with increasing concentrations of Cd(Ⅱ) and Pb(Ⅱ)-ATR , relative to the control sample. The NP-SH con-tents showed a significant increase up to 12.2 mg/gfw of Cd(Ⅱ)-ATR, followed by a significant decline to 4.5 mg/gfw after 14 days of exposure. The effect of Pb(Ⅱ)-ATR was similar to that of Cd(Ⅱ)-ATR but the amount of NP-SH was not higher than that of Cd(Ⅱ)-ATR.展开更多
Three-dimensional thermo-electrical finite element analyses were conducted to simulate the current density and temperature distributions in solder bump joints with different pad geometries.The effects of pad thickness...Three-dimensional thermo-electrical finite element analyses were conducted to simulate the current density and temperature distributions in solder bump joints with different pad geometries.The effects of pad thickness,diameter and shape on current density and temperate distributions were investigated respectively.It was found that pads with larger thickness or/and diameter could reduce current density and temperature in solder bump significantly.Pad shapes affected the current density and temperature distributions in solder bumps.The relatively low current density and temperature didn＇t occur in the bump joint with traditional rounded pad but occurred in bump joints with octagonal and nonagonal pads respectively.Therefore,optimized pad geometry may be designed to alleviate the current crowding effect and reduce the bump temperature,and therefore delay electromigration failure and increase the mean-time-to-failure.展开更多
Based on the survey research of poverty controlling model of "Three Drives, Four Joints" in Zhen'an County, its forming motives, implementing mechanism, and constraint factors have been explored to testi...Based on the survey research of poverty controlling model of "Three Drives, Four Joints" in Zhen'an County, its forming motives, implementing mechanism, and constraint factors have been explored to testify its enlightenment and applicability, establishing a promotable, applicable, and effective poverty alleviation model. "Three Drives, Four Joints" model is linked to the poor who lacks ability of self-development. Relying on the drives from key leading companies, the capable and the rich, a community with shared interests by the poor and the subjects of the "three drives" could be formed through "Joint Production, Joint Resources, Joint Community of Stock, and Joint Operation". The linked poverty alleviation development model of "the influential and the rich bring along the poor" and "A rich household would help the others" come into being. It is found out that the model of "Three Drives, Four Joints" is in essence a poverty alleviation method focusing on the increase of the income and diversified ways of increasing the earnings. Problems of poverty alleviation carrier and joint mechanism have been solved in the poverty alleviation process. The model is innovative in activating the resource elements, helping to move the poor out of poverty. A referential, copyable, and applicable model is offered to advance the poverty alleviation in mountainous areas in China.展开更多
In order to evaluate ecological risk of agrochemicals in agricultural environment, single and joint toxic effects of an important herbicide and a typical heavy metal on root elongation of crops were investigated. Seed...In order to evaluate ecological risk of agrochemicals in agricultural environment, single and joint toxic effects of an important herbicide and a typical heavy metal on root elongation of crops were investigated. Seeds of the three crops including wheat （Triticum aestivum）, Chinese cabbage （Brassica pekimensis） and soybean （Glycine max） as the main crops in northeast China were exposed to acetochior as a herbicide and lead （Pb） as a heavy metal using the pot-culture method, and meadow brown soil as one of the main soils distributed in northeast China was applied in the investigation. The results indicated that the interactive effects of the two pollutants on root elongation of the three crops were very complicated although they had markedly significant （P〈0.01） linear interrelationships based on the regression analyses. When the concentration of added Pb^2＋ reached 200 mg/kg, acetochlor and Pb had an antagonistic effect on the inhibition of root elongation of the three crops. However, acetochlor and Pb had significantly （P〈0.05） synergic effects on the inhibition of root elongation when concentration of added Pb^2＋ was up to 1000 mg/kg. At the low concentration of added Pb, joint toxicity of acetochlor and Pb was more dependent on the concentration of Pb. Among the three crops, wheat was the most sensitive to the toxicity of Pb and Chinese cabbage was the most sensitive to the toxicity of acetochlor.展开更多
Single and joint toxic effects of polycyclic musks including 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethylcyclopenta[g]-2- benzopyran （HHCB） and 7-acetyl-1,1,3,4,4,6-hexamethyl-1,2,3,4-tetrahydronapthalene （AHTN） a...Single and joint toxic effects of polycyclic musks including 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethylcyclopenta[g]-2- benzopyran （HHCB） and 7-acetyl-1,1,3,4,4,6-hexamethyl-1,2,3,4-tetrahydronapthalene （AHTN） and cadmium （Cd） on seed germination and seedling growth of wheat （Triticum aestivum） were investigated. The results showed that the toxicity sequence of HHCB toxic to wheat seed germination and seedling growth was similar to that of AHTN, that is, germination rate 〉 shoot elongation 〉 root elongation, while the toxicity of Cd was in the sequence of root elongation 〉 shoot elongation 〉 germination rate, according to the LC50 and EC50 values. It is suggested that polycyclic musks and Cd had different toxicological mechanisms. Root and shoot elongation of wheat might be good bioindicators for the contamination of polycyclic musks and Cd in soil. The mixture of polycyclic musks and Cd had synergistic effects on T. aestivum according to the equi-toxic mixture approach when root elongation was selected as the toxicological endpoint. Thus, the joint toxicity of HHCB and Cd was significantly higher than the single toxicity of HHCB or Cd, which was also confirmed by the EC50mix value of the mixture （EC50mix = 0.530 TUrnix）. The EC50mix value of the mixture of AHTN and Cd was 0.614 TUmix, which indicated that the mixture toxicity was strengthened when AHTN coexisted with Cd.展开更多
This paper presents an experimental study investigating factors influencing the effective width of steel reinforced concrete (SRC) column-steel beam joints of building in order to calculate its resisting moment.Five 1...This paper presents an experimental study investigating factors influencing the effective width of steel reinforced concrete (SRC) column-steel beam joints of building in order to calculate its resisting moment.Five 1/2 scaled interior SRC column-steel beam joint specimens were made with considering parameters such as beam flange width,beam depth and SRC column width.One directional increasing moment was applied to the joint by acting forces to each ends of beam and the structural behavior of joint was studied.And previous design method suggested by Deierlein was reviewed and a modified equation was proposed from the analysis of test result.Test result indicated that the equation to calculate the effective width in Deierlein’s design method didn’t consider effectively the influence caused by the variation of beam depth so that a modified equation was suggested and the validation of it was confirmed in this paper.展开更多
Although many intact rock types can be very strong,a critical confining pressure can eventually be reached in triaxial testing,such that the Mohr shear strength envelope becomes horizontal.This critical state has rece...Although many intact rock types can be very strong,a critical confining pressure can eventually be reached in triaxial testing,such that the Mohr shear strength envelope becomes horizontal.This critical state has recently been better defined,and correct curvature or correct deviation from linear Mohr-Coulomb（MC） has finally been found.Standard shear testing procedures for rock joints,using multiple testing of the same sample,in case of insufficient samples,can be shown to exaggerate apparent cohesion.Even rough joints do not have any cohesion,but instead have very high friction angles at low stress,due to strong dilation.Rock masses,implying problems of large-scale interaction with engineering structures,may have both cohesive and frictional strength components.However,it is not correct to add these,following linear M-C or nonlinear Hoek-Brown（H-B） standard routines.Cohesion is broken at small strain,while friction is mobilized at larger strain and remains to the end of the shear deformation.The criterion ＇c then σn tan φ＇ should replace ＇c plus σn tan φ＇ for improved fit to reality.Transformation of principal stresses to a shear plane seems to ignore mobilized dilation,and caused great experimental difficulties until understood.There seems to be plenty of room for continued research,so that errors of judgement of the last 50 years can be corrected.展开更多
The 8-node iso-parametric thin shell element was employed in the study of stress concentrations in the welded tubular “K” joint. Element equilibrium equations were derived using isoparametric formulation based on th...The 8-node iso-parametric thin shell element was employed in the study of stress concentrations in the welded tubular “K” joint. Element equilibrium equations were derived using isoparametric formulation based on thin shell theory. After assembly, the resulting system equations were solved using existing fortran programs. Numerical experiments were conducted to isolate and locate ideal gap (positions) for the two braces of the “K” joint. The nominal stresses were calculated from which stress concentration factors were obtained. The resulting stress concentration factors were presented both as tables and as figures. A good agreement between our solutions and those for model joints in the literature is good and acceptable. It was found that the wider apart the brace spacing is, the weaker the strength of the joint. It was also found that the best location for the braces occurs when the stress level changes sign either from positive to negative or vice versa at a critical sampling point.展开更多
The synergistic effect of tetrabutylammonium canon(TBA+)or N-hexadecylpyridinium cation(HDP+)and SCN-or I-in 0. 5 mol. L-1 H2SO4 solution on the corrosion inhibition or Armco iron was investigated by potentiodynamic ...The synergistic effect of tetrabutylammonium canon(TBA+)or N-hexadecylpyridinium cation(HDP+)and SCN-or I-in 0. 5 mol. L-1 H2SO4 solution on the corrosion inhibition or Armco iron was investigated by potentiodynamic polarization and polarization resistance measurements. The results show that the synergistic effect of HDP+ containing v-electron and anion is stronger than that of TBA+ and anion.The Joint adsorption models of canon and anion at electrode-solution interface are related to the structure and property of both ions by analyzing the desorption behaviours of both ions when the electrode is polarized anodically.展开更多
Aim:?To elucidate the pattern of presentation and management of traumatic major joint dislocations as seen in Irrua Specialist Teaching Hospital. Method: A five-year retrospective review of 44 cases in 43 patients. Da...Aim:?To elucidate the pattern of presentation and management of traumatic major joint dislocations as seen in Irrua Specialist Teaching Hospital. Method: A five-year retrospective review of 44 cases in 43 patients. Data were retrieved from the Medical Records Department of the hospital. Results:?Forty-four cases of traumatic dislocations were reviewed in 43 patients. Male to female ratio was 7.6:1. Median age was 33 years. The majority of patients were in the 3rd?decade of life. Patients below 40 years accounted for 62.79% of cases. Twenty-four (55.81%) patients had hip dislocation. Knee dislocations were the least, accounting for 2.32% of cases. All cases except three resulted from road traffic accidents (RTAs). None had neurologic deficits. Nineteen (44.23%) patients had isolated injuries. 76.7% cases presented in less than 6 hours. All shoulder dislocations were anterior while all elbow dislocations were posterior. All except 3 cases were managed by closed manipulation under general anaesthesia. Two patients died from associated head injury. Fourteen patients discharged against medical advice while recuperating in the ward. Follow-up was however difficult as a significant number did not turn up. Conclusion: Hip dislocation is the commonest variety of traumatic dislocation in our setting. A majority of cases were amenable to closed manipulation and immobilization. Road traffic accidents accounted for the majority.展开更多
Objective To identify whether metabolic status mediates the associations between frailty and mortality and incident cardiovascular disease(CVD),and to assess of interactive or joint relationships between frailty and m...Objective To identify whether metabolic status mediates the associations between frailty and mortality and incident cardiovascular disease(CVD),and to assess of interactive or joint relationships between frailty and metabolic status on these outcomes.Methods In this prospective cohort study of 456,445 UK Biobank participants,frailty was assessed using five phenotype criteria.Metabolic status was scored(0–4)based on central obesity,hypertension,hyperglycemia,and dyslipidemia.Multivariable-adjusted Cox regression models were used to assess the associations between frailty and mortality and incident CVD.Results During a median follow-up of 13.8 years for mortality and 13.6 years for CVD,30,907 deaths(7,467 CVD-related)and 37,115 incident CVD cases occurred.Frailty was associated with higher risks of all-cause mortality(hazard ratio[HR],2.41;95%confidence interval[CI],2.31–2.51),CVD mortality(HR,2.64;95%CI,2.43–2.87),and incident CVD(HR,1.83;95%CI,1.75–1.91),compared with non-frail individuals.Metabolic status mediated 8.7%,16.1%,and 16.4%of these associations,respectively.Frailty and metabolic status interacted multiplicatively for all-cause mortality(P-value for interaction<0.001)and additively for CVD mortality[relative excess risk due to interaction(RERI),1.78;95%CI,0.88–2.68]and incident CVD(RERI,0.60;95%CI,0.33–0.86).Joint exposure to frailty and three to four metabolic disorders conferred 3.34-,6.32-,and 3.30-fold risks of all-cause mortality,CVD mortality,and incident CVD,respectively,compared with metabolically healthy non-frail individuals.Conclusion This study highlights the need for integrated management strategies targeting both frailty and metabolic conditions to mitigate cardiovascular and mortality risks.展开更多
基金supported by the National Natural Science Foundation of China (Nos. 21936004, 21806055)the Joint Funds of the National Natural Science Foundation of China (No. U1901220)+2 种基金the Guangdong Provincial Department of Science and Technology (No. 2019A1515011583)Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai) (No. SML2021SP208)Innovative Research Team of Department of Education of Guangdong Province (No. 2020KCXTD005)。
文摘Microplastics often co-occur with a variety of organic contaminants in aquatic environment and pose combined risks to aquatic wildlife. Here, we investigated joint effects of microsized polystyrene(mPS, 5 μm) and an organophosphate pesticide chlorpyrifos on zebrafish,using multiple endpoints at both fish individual and gut microbiota levels. It was revealed that mPS ingested by zebrafish accumulated in gut and liver, and caused oxidative stress, hyperactive swimming performance and histological damages in fish, and induced disorders and diversity alterations of the gut microbial community. More importantly, mPS exhibited considerable adsorption capacity against chlorpyrifos, and those adsorbing chlorpyrifos presented greater effects on fish individuals but no different effects on gut microbiota compared to single mPS exposure. Together with body residues of chlorpyrifos in zebrafish,it was proposed that the joint effects between mPS and chlorpyrifos were attributed to the chlorpyrifos released from mPS within zebrafish. The present results provided a comprehensive understanding of joint effects of mPS and contaminants co-occurring in the environment and emphasized the importance of considering the adsorbed chemicals in toxicological studies of microplastics.
文摘BACKGROUND The long-term impact of vitamin D deficiency and metabolic syndrome(MetS)on cardiovascular disease(CVD)and all-cause mortality are still a matter of debate.AIM To test the hypotheses that lower serum 25 hydroxyvitamin D[25(OH)D]concentrations(a marker of vitamin D level)and MetS have a long-term impact on the risk of CVD and all-cause mortality,and individuals with vitamin D deficiency can be identified by multiple factors.METHODS A sample of 9094 adults,20 to 90 years of age,who participated in the Third National Health and Nutrition Examination Survey(NHANES III,1988 to 1994)were followed through December 2015 was analyzed.The associations of serum 25(OH)D concentrations and MetS with CVD and all-cause mortality were analyzed longitudinally using Cox regression models.Classification and regression tree(CART)for machine learning was applied to classify individuals with vitamin D deficiency.RESULTS Of 9094 participants,30%had serum 25(OH)D concentrations<20 ng/mL(defined as vitamin D deficiency),39%had serum 25(OH)D concentrations between 20 to 29 ng/mL(insufficiency),and 31%had serum 25(OH)D concentrations≥30 ng/mL(sufficiency).Prevalence of MetS was 28.4%.During a mean of 18 years follow-up,vitamin D deficiency and MetS were significantly associated with increased risk of CVD and all-cause mortality.Subjects with both vitamin D deficiency and MetS had the highest risk of CVD mortality(HR=1.77,95%CI:1.22-2.58)and all-cause mortality(HR=1.62,95%CI:1.26-2.09),followed by those with both vitamin D insufficiency and MetS for CVD mortality(HR=1.59,95%CI:1.12-2.24),and all-cause mortality(HR=1.41,95%CI:1.08-1.85).Meanwhile,vitamin D sufficiency significantly decreased the risk of CVD and all-cause mortality for those who even had MetS.Among the total study sample,CART analysis suggests that being non-Hispanic Black,having lower serum folate level,and being female were the first three predictors for those with serum 25(OH)D deficiency.CONCLUSION Vitamin D deficiency and MetS were significantly associated with increased risk of CVD and allcause mortality.There was a significant joint effect of vitamin D deficiency and MetS on the risk of mortality.Findings of the CART analysis may be useful to identify individuals positioned to benefit from interventions to reduce the risk of CVD and all-cause mortality.
文摘This work is investigating Mexidol (2-ethyl-6-methyl-3-hydroxy pyridine succinate) effect on the formation of nitric oxide (NO) in animal liver tissues, which is a regulator of many physiological processes and plays an important role in the vascular relaxation, neurotransmission and immune system functioning. Analyses performed by EPR spectroscopy revealed Hem-NO complex signals from paramagnetic centers in arbitrary units;produced nitrogen oxide amount in liver tissues was determined by method of double integration signals from nitrosyl complexes.
文摘The combined and interactive effects of the bolt-hole fit conditions and the preloads of the fasteners on the load carrying capacity of single-lap composite-to-titanium bolted joints have been investigated both experimentally and numerically. Quasi-static tests of the hybrid joints with different fit conditions are implemented, and a three dimensional finite element progressive failure analysis model is proposed to predict the influences of the bolt-hole fit conditions and fastener＇s pre- loads on the mechanical behaviors of the joints. Based on the experimental validated simulation method, a multi-factor, mixed levels orthogonal design table and the analysis of variance method are used to arrange the simulation conditions and to further study the interactive effects of preloads and fit conditions. Through the analysis of the results, for the researched double bolt, single-lap composite-titanium joints, it is found that： the effects of both the interference fit and the preloads change from positive into negative mode with the increase of the interference fit values or preload values; appropriate bolt-hole fit conditions and preloads can improve the bolt-hole contact conditions of the loaded joints, and then retard the fiber failures around the fastener holes, and increase the load carrying capacity of the joints eventually; the interactive effect of the bolt-hole interference fit conditions and preloads cannot be ignored and the parameters need to be considered together and synthetically as the joints are being optimized.
基金This work was supported by the National Natural Science Foundation of China (Grant No. 20225722) for distinguished young scholarsa component part of 973 Project (approved No.2004CB418503) supported by the Ministry of Science and Technology,People's Republic of China.
文摘In order to evaluate ecological risk of agrochemicals in common use, joint toxic effects of acetochlor and urea on germinating characteristics of Chinese cabbage (Brassica Pe-kinensis Rupr) seeds were investigated using the water-culture method and the soil-culture method. The results indicated(that excessive application of acetochlor and urea, when the concentrations were higher than 31.3 mg · kg-1 for acetochlor and 500 mg · kg-1 for urea, had strong inhibitory effects on the rate of seed germination, root elongation and hypocotyl length of Chinese cabbage. The inhibitory rate of the germinating characteristics of Chinese cabbage seeds was significantly increased with an increase in the concentration of acetochlor or urea. The two agrochemicals in water had a stronger toxicity than these in the soil at the same concentration. Among the three indexes, hypocotyl length was the most sensitive to the toxicity of acetochlor and urea.
基金supported by the Foundation of Chongqing Key Laboratory of Micro/Nano Materials Engineering and Technology (No.KFJJ1106)Foundation of Jiangsu Marine Resources Development Research Institute (No.JSIMR10E04)+1 种基金Foundation of Jiangsu university student renovation project of institution of higher education (No.1116)the National Nature Science Foundation of China (Project No.20977040)
文摘In this study, the joint effects of Cd(Ⅱ), Pb(Ⅱ) and atrazine (ATR) on Solidago Canadensis L. were investigated. The results showed that soil containing Cd, Pb and ATR could inhibit root elongation of Solidago Canadensis L., and that there was a positive linear relationship between the inhibitory rate of root elongation and the concentrations of Pb(Ⅱ). The mixture of Cd(Ⅱ) and Pb(Ⅱ)-ATR in soil showed a significant adverse effect on root and shoot biomass of Solidago Canadensis L. Acetylsalicylic acid (ASA) contents increased slightly at the lower concentrations of Cd(Ⅱ)-ATR, then decreased when Cd(Ⅱ)-ATR concentrations were higher than those of 1.0 TUmix(Cd+ATR). The toxic effect of Pb(Ⅱ)-ATR on the ASA contents of Solidago Canadensis L. was greater than that of Cd(Ⅱ)-ATR. Soluble sugar contents firstly decreased and then increased with increasing concentrations of Cd(Ⅱ)-ATR and displayed fluctuation with increasing concentrations of Pb(Ⅱ)-ATR. Total protein contents in-creased with increasing concentrations of Cd(Ⅱ) and Pb(Ⅱ)-ATR , relative to the control sample. The NP-SH con-tents showed a significant increase up to 12.2 mg/gfw of Cd(Ⅱ)-ATR, followed by a significant decline to 4.5 mg/gfw after 14 days of exposure. The effect of Pb(Ⅱ)-ATR was similar to that of Cd(Ⅱ)-ATR but the amount of NP-SH was not higher than that of Cd(Ⅱ)-ATR.
文摘Three-dimensional thermo-electrical finite element analyses were conducted to simulate the current density and temperature distributions in solder bump joints with different pad geometries.The effects of pad thickness,diameter and shape on current density and temperate distributions were investigated respectively.It was found that pads with larger thickness or/and diameter could reduce current density and temperature in solder bump significantly.Pad shapes affected the current density and temperature distributions in solder bumps.The relatively low current density and temperature didn＇t occur in the bump joint with traditional rounded pad but occurred in bump joints with octagonal and nonagonal pads respectively.Therefore,optimized pad geometry may be designed to alleviate the current crowding effect and reduce the bump temperature,and therefore delay electromigration failure and increase the mean-time-to-failure.
基金supported by National Natural Science Funds for Distinguished Young Scholar (Grant No. 71503202)the Fundamental Research Funds for the Central Universities (Grant No. 2017RWYB14)
文摘Based on the survey research of poverty controlling model of "Three Drives, Four Joints" in Zhen'an County, its forming motives, implementing mechanism, and constraint factors have been explored to testify its enlightenment and applicability, establishing a promotable, applicable, and effective poverty alleviation model. "Three Drives, Four Joints" model is linked to the poor who lacks ability of self-development. Relying on the drives from key leading companies, the capable and the rich, a community with shared interests by the poor and the subjects of the "three drives" could be formed through "Joint Production, Joint Resources, Joint Community of Stock, and Joint Operation". The linked poverty alleviation development model of "the influential and the rich bring along the poor" and "A rich household would help the others" come into being. It is found out that the model of "Three Drives, Four Joints" is in essence a poverty alleviation method focusing on the increase of the income and diversified ways of increasing the earnings. Problems of poverty alleviation carrier and joint mechanism have been solved in the poverty alleviation process. The model is innovative in activating the resource elements, helping to move the poor out of poverty. A referential, copyable, and applicable model is offered to advance the poverty alleviation in mountainous areas in China.
基金Project supported by the National Science Fund for Distinguished Young Scholar of China(No.20225722)the National Natural Science Founda-tion of China(No.20337010)the National Basic Research Program (973)of China(No.2004CB418503).
文摘In order to evaluate ecological risk of agrochemicals in agricultural environment, single and joint toxic effects of an important herbicide and a typical heavy metal on root elongation of crops were investigated. Seeds of the three crops including wheat （Triticum aestivum）, Chinese cabbage （Brassica pekimensis） and soybean （Glycine max） as the main crops in northeast China were exposed to acetochior as a herbicide and lead （Pb） as a heavy metal using the pot-culture method, and meadow brown soil as one of the main soils distributed in northeast China was applied in the investigation. The results indicated that the interactive effects of the two pollutants on root elongation of the three crops were very complicated although they had markedly significant （P〈0.01） linear interrelationships based on the regression analyses. When the concentration of added Pb^2＋ reached 200 mg/kg, acetochlor and Pb had an antagonistic effect on the inhibition of root elongation of the three crops. However, acetochlor and Pb had significantly （P〈0.05） synergic effects on the inhibition of root elongation when concentration of added Pb^2＋ was up to 1000 mg/kg. At the low concentration of added Pb, joint toxicity of acetochlor and Pb was more dependent on the concentration of Pb. Among the three crops, wheat was the most sensitive to the toxicity of Pb and Chinese cabbage was the most sensitive to the toxicity of acetochlor.
基金supported by the National Natural Science Foundation of China(No. 20777040)the Ministry of Education of China(No. 707011)
文摘Single and joint toxic effects of polycyclic musks including 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethylcyclopenta[g]-2- benzopyran （HHCB） and 7-acetyl-1,1,3,4,4,6-hexamethyl-1,2,3,4-tetrahydronapthalene （AHTN） and cadmium （Cd） on seed germination and seedling growth of wheat （Triticum aestivum） were investigated. The results showed that the toxicity sequence of HHCB toxic to wheat seed germination and seedling growth was similar to that of AHTN, that is, germination rate 〉 shoot elongation 〉 root elongation, while the toxicity of Cd was in the sequence of root elongation 〉 shoot elongation 〉 germination rate, according to the LC50 and EC50 values. It is suggested that polycyclic musks and Cd had different toxicological mechanisms. Root and shoot elongation of wheat might be good bioindicators for the contamination of polycyclic musks and Cd in soil. The mixture of polycyclic musks and Cd had synergistic effects on T. aestivum according to the equi-toxic mixture approach when root elongation was selected as the toxicological endpoint. Thus, the joint toxicity of HHCB and Cd was significantly higher than the single toxicity of HHCB or Cd, which was also confirmed by the EC50mix value of the mixture （EC50mix = 0.530 TUrnix）. The EC50mix value of the mixture of AHTN and Cd was 0.614 TUmix, which indicated that the mixture toxicity was strengthened when AHTN coexisted with Cd.
基金supported by a grant from the Academic Research Program of Chungju National University in 2011
文摘This paper presents an experimental study investigating factors influencing the effective width of steel reinforced concrete (SRC) column-steel beam joints of building in order to calculate its resisting moment.Five 1/2 scaled interior SRC column-steel beam joint specimens were made with considering parameters such as beam flange width,beam depth and SRC column width.One directional increasing moment was applied to the joint by acting forces to each ends of beam and the structural behavior of joint was studied.And previous design method suggested by Deierlein was reviewed and a modified equation was proposed from the analysis of test result.Test result indicated that the equation to calculate the effective width in Deierlein’s design method didn’t consider effectively the influence caused by the variation of beam depth so that a modified equation was suggested and the validation of it was confirmed in this paper.
文摘Although many intact rock types can be very strong,a critical confining pressure can eventually be reached in triaxial testing,such that the Mohr shear strength envelope becomes horizontal.This critical state has recently been better defined,and correct curvature or correct deviation from linear Mohr-Coulomb（MC） has finally been found.Standard shear testing procedures for rock joints,using multiple testing of the same sample,in case of insufficient samples,can be shown to exaggerate apparent cohesion.Even rough joints do not have any cohesion,but instead have very high friction angles at low stress,due to strong dilation.Rock masses,implying problems of large-scale interaction with engineering structures,may have both cohesive and frictional strength components.However,it is not correct to add these,following linear M-C or nonlinear Hoek-Brown（H-B） standard routines.Cohesion is broken at small strain,while friction is mobilized at larger strain and remains to the end of the shear deformation.The criterion ＇c then σn tan φ＇ should replace ＇c plus σn tan φ＇ for improved fit to reality.Transformation of principal stresses to a shear plane seems to ignore mobilized dilation,and caused great experimental difficulties until understood.There seems to be plenty of room for continued research,so that errors of judgement of the last 50 years can be corrected.
文摘The 8-node iso-parametric thin shell element was employed in the study of stress concentrations in the welded tubular “K” joint. Element equilibrium equations were derived using isoparametric formulation based on thin shell theory. After assembly, the resulting system equations were solved using existing fortran programs. Numerical experiments were conducted to isolate and locate ideal gap (positions) for the two braces of the “K” joint. The nominal stresses were calculated from which stress concentration factors were obtained. The resulting stress concentration factors were presented both as tables and as figures. A good agreement between our solutions and those for model joints in the literature is good and acceptable. It was found that the wider apart the brace spacing is, the weaker the strength of the joint. It was also found that the best location for the braces occurs when the stress level changes sign either from positive to negative or vice versa at a critical sampling point.
文摘The synergistic effect of tetrabutylammonium canon(TBA+)or N-hexadecylpyridinium cation(HDP+)and SCN-or I-in 0. 5 mol. L-1 H2SO4 solution on the corrosion inhibition or Armco iron was investigated by potentiodynamic polarization and polarization resistance measurements. The results show that the synergistic effect of HDP+ containing v-electron and anion is stronger than that of TBA+ and anion.The Joint adsorption models of canon and anion at electrode-solution interface are related to the structure and property of both ions by analyzing the desorption behaviours of both ions when the electrode is polarized anodically.
文摘Aim:?To elucidate the pattern of presentation and management of traumatic major joint dislocations as seen in Irrua Specialist Teaching Hospital. Method: A five-year retrospective review of 44 cases in 43 patients. Data were retrieved from the Medical Records Department of the hospital. Results:?Forty-four cases of traumatic dislocations were reviewed in 43 patients. Male to female ratio was 7.6:1. Median age was 33 years. The majority of patients were in the 3rd?decade of life. Patients below 40 years accounted for 62.79% of cases. Twenty-four (55.81%) patients had hip dislocation. Knee dislocations were the least, accounting for 2.32% of cases. All cases except three resulted from road traffic accidents (RTAs). None had neurologic deficits. Nineteen (44.23%) patients had isolated injuries. 76.7% cases presented in less than 6 hours. All shoulder dislocations were anterior while all elbow dislocations were posterior. All except 3 cases were managed by closed manipulation under general anaesthesia. Two patients died from associated head injury. Fourteen patients discharged against medical advice while recuperating in the ward. Follow-up was however difficult as a significant number did not turn up. Conclusion: Hip dislocation is the commonest variety of traumatic dislocation in our setting. A majority of cases were amenable to closed manipulation and immobilization. Road traffic accidents accounted for the majority.
基金supported by grants from the National Natural Science Foundation of China(82192902 and 82325043)the National Key R&D Program of China(2023YFC3606300)supported by grants from the National Natural Science Foundation of China(82273623 and 82073554).
文摘Objective To identify whether metabolic status mediates the associations between frailty and mortality and incident cardiovascular disease(CVD),and to assess of interactive or joint relationships between frailty and metabolic status on these outcomes.Methods In this prospective cohort study of 456,445 UK Biobank participants,frailty was assessed using five phenotype criteria.Metabolic status was scored(0–4)based on central obesity,hypertension,hyperglycemia,and dyslipidemia.Multivariable-adjusted Cox regression models were used to assess the associations between frailty and mortality and incident CVD.Results During a median follow-up of 13.8 years for mortality and 13.6 years for CVD,30,907 deaths(7,467 CVD-related)and 37,115 incident CVD cases occurred.Frailty was associated with higher risks of all-cause mortality(hazard ratio[HR],2.41;95%confidence interval[CI],2.31–2.51),CVD mortality(HR,2.64;95%CI,2.43–2.87),and incident CVD(HR,1.83;95%CI,1.75–1.91),compared with non-frail individuals.Metabolic status mediated 8.7%,16.1%,and 16.4%of these associations,respectively.Frailty and metabolic status interacted multiplicatively for all-cause mortality(P-value for interaction<0.001)and additively for CVD mortality[relative excess risk due to interaction(RERI),1.78;95%CI,0.88–2.68]and incident CVD(RERI,0.60;95%CI,0.33–0.86).Joint exposure to frailty and three to four metabolic disorders conferred 3.34-,6.32-,and 3.30-fold risks of all-cause mortality,CVD mortality,and incident CVD,respectively,compared with metabolically healthy non-frail individuals.Conclusion This study highlights the need for integrated management strategies targeting both frailty and metabolic conditions to mitigate cardiovascular and mortality risks.
