目的研究1990-2021年中国归因于高体重指数(Body Mass Index,BMI)的结直肠癌疾病负担变化趋势,并对2022-2035年死亡率进行预测。方法利用2021全球疾病负担数据,分析1990-2021年中国归因于高BMI的结直肠癌死亡率和DALY(Disability-adjust...目的研究1990-2021年中国归因于高体重指数(Body Mass Index,BMI)的结直肠癌疾病负担变化趋势,并对2022-2035年死亡率进行预测。方法利用2021全球疾病负担数据,分析1990-2021年中国归因于高BMI的结直肠癌死亡率和DALY(Disability-adjusted Life Years,DALY)率及其标化率的变化趋势,计算其平均年度变化百分比(Average Annual Percent Change,AAPC)。通过年龄-时期-队列(Age-Period-Cohort,APC)模型评估归因死亡率的年龄时期队列效应,并采用贝叶斯年龄-时期-队列模型(Bayesian age-period-cohort models,BAPC)对2022-2035年中国归因于高BMI的结直肠癌死亡率进行预测。结果1990-2021年,中国高BMI所致结直肠癌的标化死亡率(Age-standardized Mortality Rate,ASMR)和标化DALY率(Age-standardized Disability-adjusted Life Years Rate,ASDR)显著上升,危险因素排名分别从第9升至第5位和第4位,AAPC值分别为2.43%(95%CI:2.29~2.57)和2.33%(95%CI:2.21~2.46),其增速超过全球及各个社会人口学指数地区。男性的疾病负担显著高于女性,死亡率的年均变化率为女性的2.37倍。此外,死亡率随年龄增长显著增加,队列效应亦表现出较高的死亡风险。预测显示,2022-2035年间,中国归因于高BMI的结直肠癌死亡率仍将继续上升,累积增幅达53.06%。结论中国归因于高BMI的结直肠癌疾病负担持续加重,男性及老年人群风险尤为显著。应通过优化公共卫生政策,包括推广健康饮食、加强体重管理、促进体力活动和完善癌症筛查策略,减少高BMI相关的结直肠癌负担。展开更多
Currently,the demand for electromagnetic wave(EMW)absorbing materials with specific functions and capable of withstanding harsh environments is becoming increasingly urgent.Multi-component interface engineering is con...Currently,the demand for electromagnetic wave(EMW)absorbing materials with specific functions and capable of withstanding harsh environments is becoming increasingly urgent.Multi-component interface engineering is considered an effective means to achieve high-efficiency EMW absorption.However,interface modulation engineering has not been fully discussed and has great potential in the field of EMW absorption.In this study,multi-component tin compound fiber composites based on carbon fiber(CF)substrate were prepared by electrospinning,hydrothermal synthesis,and high-temperature thermal reduction.By utilizing the different properties of different substances,rich heterogeneous interfaces are constructed.This effectively promotes charge transfer and enhances interfacial polarization and conduction loss.The prepared SnS/SnS_(2)/SnO_(2)/CF composites with abundant heterogeneous interfaces have and exhibit excellent EMW absorption properties at a loading of 50 wt%in epoxy resin.The minimum reflection loss(RL)is−46.74 dB and the maximum effective absorption bandwidth is 5.28 GHz.Moreover,SnS/SnS_(2)/SnO_(2)/CF epoxy composite coatings exhibited long-term corrosion resistance on Q235 steel surfaces.Therefore,this study provides an effective strategy for the design of high-efficiency EMW absorbing materials in complex and harsh environments.展开更多
The pre-wetting of aggregate surface is a means to improve the interface performance of SBS modified asphalt and aggregate.The effect of pre-wetting technology on the interaction between SBS modified asphalt and aggre...The pre-wetting of aggregate surface is a means to improve the interface performance of SBS modified asphalt and aggregate.The effect of pre-wetting technology on the interaction between SBS modified asphalt and aggregate was analyzed by molecular dynamics simulation.The diffusion coefficient and concentration distribution of SBS modified asphalt on aggregate surface are included.The simulation results show that the diffusion coefficient of the aggregate surface of SBS modified asphalt is increased by 47.6%and 70.5%respectively after 110#asphalt and 130#asphalt are pre-wetted.The concentration distribution of SBS modified asphalt on the aggregate surface after pre-wetting is more uniform.According to the results of interface energy calculation,the interface energy of SBS modified bitumen and aggregate can be increased by about 5%after pre-wetting.According to the results of molecular dynamics simulation,the pre-wetting technology can effectively improve the interface workability of SBS modified bitumen and aggregate,so as to improve the interface performance.展开更多
目的:利用NHANES数据,探讨非高密度脂蛋白胆固醇/高密度脂蛋白胆固醇比率(NHHR)与表型年龄加速(Phenotypic Age Acceleration,PhenoAgeAccel)之间的关系,以及体质指数(Body Mass Index,BMI)在其中的中介作用。方法:选取2003年-2010年的...目的:利用NHANES数据,探讨非高密度脂蛋白胆固醇/高密度脂蛋白胆固醇比率(NHHR)与表型年龄加速(Phenotypic Age Acceleration,PhenoAgeAccel)之间的关系,以及体质指数(Body Mass Index,BMI)在其中的中介作用。方法:选取2003年-2010年的美国国家健康与营养调查(NHANES)的数据,使用加权多变量线性回归模型和亚组分析来研究NHHR与PhenoAgeAccel之间的关联。此外,利用平滑曲线拟合来识别潜在的线性关联,并探讨BMI的中介作用。结果:纳入的5032名参与者中,人群平均PhenoAgeAccel为(-3.96±6.23)岁(P<0.05)。多模型校正后,显示NHHR升高与PhenoAgeAccel呈显著正相关(P<0.001),且平滑曲线验证了两者的线性关系。分析显示,BMI在该关联中呈现49.5%的中介作用(P<0.001)。结论:本研究表明,NHHR与PhenoAgeAccel正相关,并且BMI发挥显著中介作用。研究结果提示,通过控制血脂水平可能具有抗衰老的效果,并有助于预防与衰老相关的疾病。展开更多
文摘目的研究1990-2021年中国归因于高体重指数(Body Mass Index,BMI)的结直肠癌疾病负担变化趋势,并对2022-2035年死亡率进行预测。方法利用2021全球疾病负担数据,分析1990-2021年中国归因于高BMI的结直肠癌死亡率和DALY(Disability-adjusted Life Years,DALY)率及其标化率的变化趋势,计算其平均年度变化百分比(Average Annual Percent Change,AAPC)。通过年龄-时期-队列(Age-Period-Cohort,APC)模型评估归因死亡率的年龄时期队列效应,并采用贝叶斯年龄-时期-队列模型(Bayesian age-period-cohort models,BAPC)对2022-2035年中国归因于高BMI的结直肠癌死亡率进行预测。结果1990-2021年,中国高BMI所致结直肠癌的标化死亡率(Age-standardized Mortality Rate,ASMR)和标化DALY率(Age-standardized Disability-adjusted Life Years Rate,ASDR)显著上升,危险因素排名分别从第9升至第5位和第4位,AAPC值分别为2.43%(95%CI:2.29~2.57)和2.33%(95%CI:2.21~2.46),其增速超过全球及各个社会人口学指数地区。男性的疾病负担显著高于女性,死亡率的年均变化率为女性的2.37倍。此外,死亡率随年龄增长显著增加,队列效应亦表现出较高的死亡风险。预测显示,2022-2035年间,中国归因于高BMI的结直肠癌死亡率仍将继续上升,累积增幅达53.06%。结论中国归因于高BMI的结直肠癌疾病负担持续加重,男性及老年人群风险尤为显著。应通过优化公共卫生政策,包括推广健康饮食、加强体重管理、促进体力活动和完善癌症筛查策略,减少高BMI相关的结直肠癌负担。
基金financially supported by the National Natural Science Foundation of China(No.52377026 and No.52301192)Taishan Scholars and Young Experts Program of Shandong Province(No.tsqn202103057)+4 种基金Postdoctoral Fellowship Program of CPSF under Grant Number(No.GZB20240327)Shandong Postdoctoral Science Foundation(No.SDCXZG-202400275)Qingdao Postdoctoral Application Research Project(No.QDBSH20240102023)China Postdoctoral Science Foundation(No.2024M751563)the Qingchuang Talents Induction Program of Shandong Higher Education Institution(Research and Innovation Team of Structural-Functional Polymer Composites).
文摘Currently,the demand for electromagnetic wave(EMW)absorbing materials with specific functions and capable of withstanding harsh environments is becoming increasingly urgent.Multi-component interface engineering is considered an effective means to achieve high-efficiency EMW absorption.However,interface modulation engineering has not been fully discussed and has great potential in the field of EMW absorption.In this study,multi-component tin compound fiber composites based on carbon fiber(CF)substrate were prepared by electrospinning,hydrothermal synthesis,and high-temperature thermal reduction.By utilizing the different properties of different substances,rich heterogeneous interfaces are constructed.This effectively promotes charge transfer and enhances interfacial polarization and conduction loss.The prepared SnS/SnS_(2)/SnO_(2)/CF composites with abundant heterogeneous interfaces have and exhibit excellent EMW absorption properties at a loading of 50 wt%in epoxy resin.The minimum reflection loss(RL)is−46.74 dB and the maximum effective absorption bandwidth is 5.28 GHz.Moreover,SnS/SnS_(2)/SnO_(2)/CF epoxy composite coatings exhibited long-term corrosion resistance on Q235 steel surfaces.Therefore,this study provides an effective strategy for the design of high-efficiency EMW absorbing materials in complex and harsh environments.
基金Funded by the Research Funds of China University of Mining and Technology(No.102523215)。
文摘The pre-wetting of aggregate surface is a means to improve the interface performance of SBS modified asphalt and aggregate.The effect of pre-wetting technology on the interaction between SBS modified asphalt and aggregate was analyzed by molecular dynamics simulation.The diffusion coefficient and concentration distribution of SBS modified asphalt on aggregate surface are included.The simulation results show that the diffusion coefficient of the aggregate surface of SBS modified asphalt is increased by 47.6%and 70.5%respectively after 110#asphalt and 130#asphalt are pre-wetted.The concentration distribution of SBS modified asphalt on the aggregate surface after pre-wetting is more uniform.According to the results of interface energy calculation,the interface energy of SBS modified bitumen and aggregate can be increased by about 5%after pre-wetting.According to the results of molecular dynamics simulation,the pre-wetting technology can effectively improve the interface workability of SBS modified bitumen and aggregate,so as to improve the interface performance.
文摘目的:利用NHANES数据,探讨非高密度脂蛋白胆固醇/高密度脂蛋白胆固醇比率(NHHR)与表型年龄加速(Phenotypic Age Acceleration,PhenoAgeAccel)之间的关系,以及体质指数(Body Mass Index,BMI)在其中的中介作用。方法:选取2003年-2010年的美国国家健康与营养调查(NHANES)的数据,使用加权多变量线性回归模型和亚组分析来研究NHHR与PhenoAgeAccel之间的关联。此外,利用平滑曲线拟合来识别潜在的线性关联,并探讨BMI的中介作用。结果:纳入的5032名参与者中,人群平均PhenoAgeAccel为(-3.96±6.23)岁(P<0.05)。多模型校正后,显示NHHR升高与PhenoAgeAccel呈显著正相关(P<0.001),且平滑曲线验证了两者的线性关系。分析显示,BMI在该关联中呈现49.5%的中介作用(P<0.001)。结论:本研究表明,NHHR与PhenoAgeAccel正相关,并且BMI发挥显著中介作用。研究结果提示,通过控制血脂水平可能具有抗衰老的效果,并有助于预防与衰老相关的疾病。
