目的沙利度胺治疗炎症性肠病(inflammatory bowel disease,IBD)的临床疗效及安全性。方法 IBD患者(溃疡性结肠炎4例,克罗恩病3例)接受沙利度胺200mgd治疗,疗程24周。在治疗后2、4、8、12、24和48周时随访,计算国际IBD研究组织指数(Int...目的沙利度胺治疗炎症性肠病(inflammatory bowel disease,IBD)的临床疗效及安全性。方法 IBD患者(溃疡性结肠炎4例,克罗恩病3例)接受沙利度胺200mgd治疗,疗程24周。在治疗后2、4、8、12、24和48周时随访,计算国际IBD研究组织指数(International Organization for the Study of IBD,IOIBD)评分,并进行结肠镜、血细胞沉降率(erythrocyte sedimentation rate,ESR)、C反应蛋白(Creactive protein,CRP)的检查。同时严密监测任何不良事件。结果度胺治疗中、重度活动性IBD有效。治疗后4周内IOIBD评分下降幅度最大。所有患者炎性指标ESR、CRP水平在治疗后4周开始下降,治疗后24周所有患者镜下评分级别下调。所有患者均经历至少1个不良反应。结论沙利度胺对中、重度IBD患者具有抑制炎性反应、改善临床症状、促进肠黏膜修复及降低结肠镜下评分的作用。展开更多
目的研究安宫牛黄丸对脑缺血再灌注损伤和脑外伤大鼠的保护作用。方法成年雄性SD大鼠连续7 d灌胃给予安宫牛黄丸,灌胃第4天线栓法致脑缺血1 h再灌注72 h后检测大鼠行为学、脑梗死百分比及脑组织炎症因子肿瘤坏死因子α(TNF-α)、白介素-...目的研究安宫牛黄丸对脑缺血再灌注损伤和脑外伤大鼠的保护作用。方法成年雄性SD大鼠连续7 d灌胃给予安宫牛黄丸,灌胃第4天线栓法致脑缺血1 h再灌注72 h后检测大鼠行为学、脑梗死百分比及脑组织炎症因子肿瘤坏死因子α(TNF-α)、白介素-1β(IL-1β)和诱导型一氧化氮合酶(i NOS)mRNA的表达。此外,大鼠连续7 d灌胃给予安宫牛黄丸后,采用重物打击法诱导大鼠脑外伤模型,24 h后检测大鼠行为学改变并通过real time RT-PCR检测脑内炎症因子TNF-α、IL-1β和i NOS mRNA的表达。结果与脑缺血再灌注损伤模型组比较,安宫牛黄丸(1.5 g/kg)能够改善模型大鼠行为学改变,减少大鼠脑梗死面积,下调脑组织内TNF-α、IL-1β和i NOS mRNA的表达;与脑外伤模型组比较,安宫牛黄丸(1.5 g/kg)可以改善大鼠行为学改变,下调脑组织内TNF-α、IL-1β和i NOS mRNA的表达。结论安宫牛黄丸对大鼠脑缺血再灌注损伤和脑外伤有保护作用。展开更多
Objective: to study and analyze the actual effect of high quality nursing in clinical use of chronic bronchitis in the elderly and to analyze and discuss the use value. Methods: 120 elderly patients with chronic bronc...Objective: to study and analyze the actual effect of high quality nursing in clinical use of chronic bronchitis in the elderly and to analyze and discuss the use value. Methods: 120 elderly patients with chronic bronchitis who were admitted to our hospital from January 2020 to December 2020 were selected according to the inclusion and exclusion criteria of the study. The groups were completed according to the order of admission treatment. Among them, 60 cases received routine care as control group, while the remaining 60 cases received high quality care as the experimental group, and the nursing effects were compared. Results: the quality of life in the experimental group was significantly improved, the level of inflammatory factors was significantly reduced, the nursing satisfaction of patients was significantly improved, and the indexes were statistically significant compared with the control group (P < 0.05). Conclusion: The implementation of high quality nursing for elderly patients with chronic bronchitis can significantly improve the disease process, reduce the level of inflammatory factors, and greatly improve the quality of life of patients, improve the satisfaction of nursing services in departments, and achieve high clinical effect, which has the value of promotion and use.展开更多
文摘目的沙利度胺治疗炎症性肠病(inflammatory bowel disease,IBD)的临床疗效及安全性。方法 IBD患者(溃疡性结肠炎4例,克罗恩病3例)接受沙利度胺200mgd治疗,疗程24周。在治疗后2、4、8、12、24和48周时随访,计算国际IBD研究组织指数(International Organization for the Study of IBD,IOIBD)评分,并进行结肠镜、血细胞沉降率(erythrocyte sedimentation rate,ESR)、C反应蛋白(Creactive protein,CRP)的检查。同时严密监测任何不良事件。结果度胺治疗中、重度活动性IBD有效。治疗后4周内IOIBD评分下降幅度最大。所有患者炎性指标ESR、CRP水平在治疗后4周开始下降,治疗后24周所有患者镜下评分级别下调。所有患者均经历至少1个不良反应。结论沙利度胺对中、重度IBD患者具有抑制炎性反应、改善临床症状、促进肠黏膜修复及降低结肠镜下评分的作用。
文摘目的研究安宫牛黄丸对脑缺血再灌注损伤和脑外伤大鼠的保护作用。方法成年雄性SD大鼠连续7 d灌胃给予安宫牛黄丸,灌胃第4天线栓法致脑缺血1 h再灌注72 h后检测大鼠行为学、脑梗死百分比及脑组织炎症因子肿瘤坏死因子α(TNF-α)、白介素-1β(IL-1β)和诱导型一氧化氮合酶(i NOS)mRNA的表达。此外,大鼠连续7 d灌胃给予安宫牛黄丸后,采用重物打击法诱导大鼠脑外伤模型,24 h后检测大鼠行为学改变并通过real time RT-PCR检测脑内炎症因子TNF-α、IL-1β和i NOS mRNA的表达。结果与脑缺血再灌注损伤模型组比较,安宫牛黄丸(1.5 g/kg)能够改善模型大鼠行为学改变,减少大鼠脑梗死面积,下调脑组织内TNF-α、IL-1β和i NOS mRNA的表达;与脑外伤模型组比较,安宫牛黄丸(1.5 g/kg)可以改善大鼠行为学改变,下调脑组织内TNF-α、IL-1β和i NOS mRNA的表达。结论安宫牛黄丸对大鼠脑缺血再灌注损伤和脑外伤有保护作用。
文摘Objective: to study and analyze the actual effect of high quality nursing in clinical use of chronic bronchitis in the elderly and to analyze and discuss the use value. Methods: 120 elderly patients with chronic bronchitis who were admitted to our hospital from January 2020 to December 2020 were selected according to the inclusion and exclusion criteria of the study. The groups were completed according to the order of admission treatment. Among them, 60 cases received routine care as control group, while the remaining 60 cases received high quality care as the experimental group, and the nursing effects were compared. Results: the quality of life in the experimental group was significantly improved, the level of inflammatory factors was significantly reduced, the nursing satisfaction of patients was significantly improved, and the indexes were statistically significant compared with the control group (P < 0.05). Conclusion: The implementation of high quality nursing for elderly patients with chronic bronchitis can significantly improve the disease process, reduce the level of inflammatory factors, and greatly improve the quality of life of patients, improve the satisfaction of nursing services in departments, and achieve high clinical effect, which has the value of promotion and use.
