To the Editor:Multi-pathogen detection has become increasingly important,given the increasing risk of circulating contagious pathogens due to global changes characterized by urbanization and habitat fragmentation.The ...To the Editor:Multi-pathogen detection has become increasingly important,given the increasing risk of circulating contagious pathogens due to global changes characterized by urbanization and habitat fragmentation.The coronavirus disease-2019(COVID-19)pandemic disrupted the epidemiology of some respiratory pathogens,possibly due to public health and social measures,as well as changes in healthcare-seeking behaviors and interactions between viruses.Multi-respiratory pathogen surveillance could be useful for adjusting disease prevention strategies and preventing potential outbreaks of existing and emerging respiratory infectious diseases.On the other hand,symptoms and disease severity differ among respiratory pathogen infections,[1]and coinfection might be associated with increased disease severity.[2]Some respiratory pathogens such as severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),influenza viruses(IFV),respiratory syncytial virus(RSV),and Streptococcus pneumoniae(S.pneumoniae)impose a high disease burden on populations but can be prevented by vaccines.Therefore,this study aimed to determine clinical manifestations and disease severity among patients testing positive for various pathogens to offer guidance on disease diagnosis,treatment,surveillance,and immunization strategies.展开更多
Objective To investigate the epidemiological features in children after the coronavirus disease 2019(COVID-19)pandemic.Methods This study collected throat swabs and serum samples from hospitalized pediatric patients o...Objective To investigate the epidemiological features in children after the coronavirus disease 2019(COVID-19)pandemic.Methods This study collected throat swabs and serum samples from hospitalized pediatric patients of Renmin Hospital of Wuhan University,Wuhan,Hubei province,China before and after the COVID-19 pandemic.Respiratory infected pathogens[adenovirus(ADV),influenza virus A/B(Flu A/B),parainfluenza virus 1/2/3(PIV1/2/3),respiratory syncytial virus(RSV),Mycoplasma pneumoniae(MP),and Chlamydia pneumoniae(CP)]were detected.The pathogens,age,and gender were used to analyze the epidemiological features in children after the COVID-19 pandemic.Results The pathogen detection rate was significantly higher in females than in males(P<0.05),and the infection of PIV1 and MP was mainly manifested.After the COVID-19 pandemic,PIV1,PIV3,RSV,and MP had statistically different detection rates among the age groups(P<0.05),and was mainly detected in patients aged 0–6 years,0–3 years,0–3 years,and 1–6 years,respectively.When comparing before the COVID-19 pandemic,the total detection rate of common respiratory pathogens was lower(P<0.05).Except for the increase in the detection rate of PIV1 and CP,the infection rate of other pathogens had almost decreased.Conclusion The prevention and control measures for the COVID-19 pandemic effectively changed the epidemiological features of common respiratory tract infectious diseases in pediatric children.展开更多
Rex rabbit Bordetella bronchiseptica was isolated from a large rabbit field in Shandong Province. And which could be diagnosed to be Rex rabbit infectious coryza combining with the incidence,clinical symptoms,patholog...Rex rabbit Bordetella bronchiseptica was isolated from a large rabbit field in Shandong Province. And which could be diagnosed to be Rex rabbit infectious coryza combining with the incidence,clinical symptoms,pathological changes and laboratory examination. Kanamycin soluble powder was used to treat the disease according to the antibiotics usage and course,and the treatment was proved to be effective.展开更多
Infectious bursal disease(IBD)is an acute,highly contagious disease that affects chicks(Müller et al.2003).IBD mainly damages the immune organs of chicks,especially the central immune organ,causing immune suppres...Infectious bursal disease(IBD)is an acute,highly contagious disease that affects chicks(Müller et al.2003).IBD mainly damages the immune organs of chicks,especially the central immune organ,causing immune suppression in diseased chicks(Muller et al.2012).The pathogenic infectious bursal disease virus(IBDV)is a member of the Avira virus genus in the Birnaviridae family.(Harkness et al.1975;Dobos et al.1979;Müller et al.1979).IBDV is prevalent worldwide,causing serious economic losses to the global poultry industry.Currently,vaccination remains the most cost-effective way to prevent IBDV.展开更多
As coronavirus disease 2019(COVID-19) threatens human health globally,infectious disorders have become one of the most challenging problem for the medical community.Natural products(NP) have been a prolific source of ...As coronavirus disease 2019(COVID-19) threatens human health globally,infectious disorders have become one of the most challenging problem for the medical community.Natural products(NP) have been a prolific source of antimicrobial agents with widely divergent structures and a range of vast biological activities.A dataset comprising 618 articles,including 646 NP-based compounds from 672 species of natural sources with biological activities against 21 infectious pathogens from five categories,was assembled through manual selection of published articles.These data were used to identify 268 NP-based compounds classified into ten groups,which were used for network pharmacology analysis to capture the most promising lead-compounds such as agelasine D,dicumarol,dihydroartemisinin and pyridomycin.The distribution of maximum Tanimoto scores indicated that compounds which inhibited parasites exhibited low diversity,whereas the chemistries inhibiting bacteria,fungi,and viruses showed more structural diversity.A total of 331 species of medicinal plants with compounds exhibiting antimicrobial activities were selected to classify the family sources.The family Asteraceae possesses various compounds against C.neoformans,the family Anacardiaceae has compounds against Salmonella typhi,the family Cucurbitacea against the human immunodeficiency virus(HIV),and the family Ancistrocladaceae against Plasmodium.This review summarizes currently available data on NPbased antimicrobials against refractory infections to provide information for further discovery of drugs and synthetic strategies for anti-infectious agents.展开更多
基金supported by grants from the Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(No.2022-I2M-CoV19-006)the Science & Technology Fundamental Resources Investigation Program(No.2023FY100600)+1 种基金the Investigator Initiated Study in Collaboration with Sanofi(No.FLU00152)the Chongqing Science and Technology Bureau(Nos.CSTC2021jscx-gksb-N0005 and cstc2024ycjhbgzxm0224).
文摘To the Editor:Multi-pathogen detection has become increasingly important,given the increasing risk of circulating contagious pathogens due to global changes characterized by urbanization and habitat fragmentation.The coronavirus disease-2019(COVID-19)pandemic disrupted the epidemiology of some respiratory pathogens,possibly due to public health and social measures,as well as changes in healthcare-seeking behaviors and interactions between viruses.Multi-respiratory pathogen surveillance could be useful for adjusting disease prevention strategies and preventing potential outbreaks of existing and emerging respiratory infectious diseases.On the other hand,symptoms and disease severity differ among respiratory pathogen infections,[1]and coinfection might be associated with increased disease severity.[2]Some respiratory pathogens such as severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),influenza viruses(IFV),respiratory syncytial virus(RSV),and Streptococcus pneumoniae(S.pneumoniae)impose a high disease burden on populations but can be prevented by vaccines.Therefore,this study aimed to determine clinical manifestations and disease severity among patients testing positive for various pathogens to offer guidance on disease diagnosis,treatment,surveillance,and immunization strategies.
基金supported by grants from the Fundamental Research Funds for the Central Universities(No.2042022kf1215)the Special Funds for Innovation in Scientific Research Program of Zhongshan(No.2020AG024)+4 种基金Chinese Foundation for Hepatitis Prevention and Control:TianQing Liver Disease Research Fund Subject(No.TGQB20210109)the Open Funds of Key Laboratory of Diagnosis and Treatment of Digestive System Tumors of Zhejiang Province(No.KFJJ-202005 and No.KFJJ-201907)the Open Research Program of the State Key Laboratory of Virology of China(No.2021KF002 and No.2021KF006)the Natural Science Foundation of Hubei Province(No.2020CFB619)Wuhan Municipal Health Research Foundation(No.WX21Z36).
文摘Objective To investigate the epidemiological features in children after the coronavirus disease 2019(COVID-19)pandemic.Methods This study collected throat swabs and serum samples from hospitalized pediatric patients of Renmin Hospital of Wuhan University,Wuhan,Hubei province,China before and after the COVID-19 pandemic.Respiratory infected pathogens[adenovirus(ADV),influenza virus A/B(Flu A/B),parainfluenza virus 1/2/3(PIV1/2/3),respiratory syncytial virus(RSV),Mycoplasma pneumoniae(MP),and Chlamydia pneumoniae(CP)]were detected.The pathogens,age,and gender were used to analyze the epidemiological features in children after the COVID-19 pandemic.Results The pathogen detection rate was significantly higher in females than in males(P<0.05),and the infection of PIV1 and MP was mainly manifested.After the COVID-19 pandemic,PIV1,PIV3,RSV,and MP had statistically different detection rates among the age groups(P<0.05),and was mainly detected in patients aged 0–6 years,0–3 years,0–3 years,and 1–6 years,respectively.When comparing before the COVID-19 pandemic,the total detection rate of common respiratory pathogens was lower(P<0.05).Except for the increase in the detection rate of PIV1 and CP,the infection rate of other pathogens had almost decreased.Conclusion The prevention and control measures for the COVID-19 pandemic effectively changed the epidemiological features of common respiratory tract infectious diseases in pediatric children.
基金Supported by Shandong Province Natural Science Foundation(ZR2014CQ012)Natural Science Foundation of China(31402243)
文摘Rex rabbit Bordetella bronchiseptica was isolated from a large rabbit field in Shandong Province. And which could be diagnosed to be Rex rabbit infectious coryza combining with the incidence,clinical symptoms,pathological changes and laboratory examination. Kanamycin soluble powder was used to treat the disease according to the antibiotics usage and course,and the treatment was proved to be effective.
基金supported by grants from the National Key R&D Program of China(2022YFD1801000)the Natural Science Foundation of Shanghai,China(24ZR1479200)。
文摘Infectious bursal disease(IBD)is an acute,highly contagious disease that affects chicks(Müller et al.2003).IBD mainly damages the immune organs of chicks,especially the central immune organ,causing immune suppression in diseased chicks(Muller et al.2012).The pathogenic infectious bursal disease virus(IBDV)is a member of the Avira virus genus in the Birnaviridae family.(Harkness et al.1975;Dobos et al.1979;Müller et al.1979).IBDV is prevalent worldwide,causing serious economic losses to the global poultry industry.Currently,vaccination remains the most cost-effective way to prevent IBDV.
基金supported by the Scientific and Technological Innovation Project of China Academy of Chinese Medical Sciences (CI2021A04013)the Fundamental Research Funds for the Central Public Welfare Research Institutes (L2021029)。
文摘As coronavirus disease 2019(COVID-19) threatens human health globally,infectious disorders have become one of the most challenging problem for the medical community.Natural products(NP) have been a prolific source of antimicrobial agents with widely divergent structures and a range of vast biological activities.A dataset comprising 618 articles,including 646 NP-based compounds from 672 species of natural sources with biological activities against 21 infectious pathogens from five categories,was assembled through manual selection of published articles.These data were used to identify 268 NP-based compounds classified into ten groups,which were used for network pharmacology analysis to capture the most promising lead-compounds such as agelasine D,dicumarol,dihydroartemisinin and pyridomycin.The distribution of maximum Tanimoto scores indicated that compounds which inhibited parasites exhibited low diversity,whereas the chemistries inhibiting bacteria,fungi,and viruses showed more structural diversity.A total of 331 species of medicinal plants with compounds exhibiting antimicrobial activities were selected to classify the family sources.The family Asteraceae possesses various compounds against C.neoformans,the family Anacardiaceae has compounds against Salmonella typhi,the family Cucurbitacea against the human immunodeficiency virus(HIV),and the family Ancistrocladaceae against Plasmodium.This review summarizes currently available data on NPbased antimicrobials against refractory infections to provide information for further discovery of drugs and synthetic strategies for anti-infectious agents.
