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Artificial intelligence in gastroenterology:Ethical and diagnostic challenges in clinical practice
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作者 Davide Ramoni Alessandro Scuricini +2 位作者 Federico Carbone Luca Liberale Fabrizio Montecucco 《World Journal of Gastroenterology》 2025年第10期144-150,共7页
This article discusses the manuscript recently published in the World Journal of Gastroenterology,which explores the application of deep learning models in decision-making processes via wireless capsule endoscopy.Inte... This article discusses the manuscript recently published in the World Journal of Gastroenterology,which explores the application of deep learning models in decision-making processes via wireless capsule endoscopy.Integrating artificial intelligence(AI)into gastrointestinal disease diagnosis represents a transformative step toward precision medicine,enhancing real-time accuracy in detecting multi-category lesions at earlier stages,including small bowel lesions and precancerous polyps,ultimately improving patient outcomes.However,the use of AI in clinical settings raises ethical considerations that extend beyond technological potential.Issues of patient privacy,data security,and potential diagnostic biases require careful attention.AI models must prioritize diverse and representative datasets to mitigate inequities and ensure diagnostic accuracy across populations.Furthermore,balancing AI with clinical expertise is crucial,positioning AI as a supportive tool rather than a replacement for physician judgment.Addressing these ethical challenges will support the responsible deployment of AI,through equitable contribution to patient-centered care. 展开更多
关键词 Artificial intelligence ENDOSCOPY Ethical implication Gastrointestinal disease Machine learning OMICS Precision medicine Wireless capsule endoscopy
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Hidden face of Parkinson's disease:Is it a new autoimmune disease?
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作者 Min Gi Jo Seon-Hee Kim Seung Pil Yun 《Neural Regeneration Research》 2026年第1期57-61,共5页
Parkinson's disease is a neurodegenerative disorder marked by the degeneration of dopaminergic neurons and clinical symptoms such as tremors,rigidity,and slowed movements.A key feature of Parkinson's disease i... Parkinson's disease is a neurodegenerative disorder marked by the degeneration of dopaminergic neurons and clinical symptoms such as tremors,rigidity,and slowed movements.A key feature of Parkinson's disease is the accumulation of misfoldedα-synuclein,forming insoluble Lewy bodies in the substantia nigra pars compacta,which contributes to neurodegeneration.Theseα-synuclein aggregates may act as autoantigens,leading to T-cell-mediated neuroinflammation and contributing to dopaminergic cell death.Our perspective explores the hypothesis that Parkinson's disease may have an autoimmune component,highlighting research that connects peripheral immune responses with neurodegeneration.T cells derived from Parkinson's disease patients appear to have the potential to initiate an autoimmune response againstα-synuclein and its modified peptides,possibly leading to the formation of neo-epitopes.Recent evidence associates Parkinson's disease with abnormal immune responses,as indicated by increased levels of immune cells,such as CD4^(+)and CD8^(+)T cells,observed in both patients and mouse models.The convergence of T cells filtration increasing major histocompatibility complex molecules,and the susceptibility of dopaminergic neurons supports the hypothesis that Parkinson's disease may exhibit autoimmune characteristics.Understanding the immune mechanisms involved in Parkinson's disease will be crucial for developing therapeutic strategies that target the autoimmune aspects of the disease.Novel approaches,including precision medicine based on major histocompatibility complex/human leukocyte antigen typing and early biomarker identification,could pave the way for immune-based treatments aimed at slowing or halting disease progression.This perspective explores the relationship between autoimmunity and Parkinson's disease,suggesting that further research could deepen understanding and offer new therapeutic avenues.In this paper,it is organized to provide a comprehensive perspective on the autoimmune aspects of Parkinson's disease.It investigates critical areas such as the autoimmune response observed in Parkinson's disease patients and the role of autoimmune mechanisms targetingα-synuclein in Parkinson's disease.The paper also examines the impact of CD4~+T cells,specifically Th1 and Th17,on neurons through in vitro and ex vivo studies.Additionally,it explores howα-synuclein influences glia-induced neuroinflammation in Parkinson's disease.The discussion extends to the clinical implications and therapeutic landscape,offering insights into potential treatments.Consequently,we aim to provide a comprehensive perspective on the autoimmune aspects of Parkinson's disease,incorporating both supportive and opposing views on its classification as an autoimmune disorder and exploring implications for clinical applications. 展开更多
关键词 ASTROCYTE autoimmune response biomarkers clinical implication major histocompatibility complex/human leukocyte antigen MICROGLIA neurodegenerative disease NEUROINFLAMMATION Parkinson's disease T cells Α-SYNUCLEIN
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Discrete and Topological Correspondence Theory for Modal MeetImplication Logic and Modal MeetSemilattice Logic in Filter Semantics
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作者 Fei Liang Zhiguang Zhao 《逻辑学研究》 2025年第3期25-66,共42页
In the present paper,we give a systematic study of the discrete correspondence the-ory and topological correspondence theory of modal meet-implication logic and moda1 meet-semilattice logic,in the semantics provided i... In the present paper,we give a systematic study of the discrete correspondence the-ory and topological correspondence theory of modal meet-implication logic and moda1 meet-semilattice logic,in the semantics provided in[21].The special features of the present paper include the following three points:the first one is that the semantic structure used is based on a semilattice rather than an ordinary partial order,the second one is that the propositional vari-ables are interpreted as filters rather than upsets,and the nominals,which are the“first-order counterparts of propositional variables,are interpreted as principal filters rather than principal upsets;the third one is that in topological correspondence theory,the collection of admissi-ble valuations is not closed under taking disjunction,which makes the proof of the topological Ackermann 1emma different from existing settings. 展开更多
关键词 topological correspondence theory SEMILATTICE modal meet implication logic modal meet semilattice logic discrete correspondence theory semantic structure propositional variables filter semantics
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Geochemistry and Zircon U-Pb and Hf Isotopes of Early Devonian Hardawu Granites in the Eastern Segment of the Ultrahigh-Pressure Metamorphic Belt, Northern Qaidam Basin
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作者 Hua Li Ming Wang +8 位作者 Jiqing Li Haikui Tong Jiaxiang Dong Minggang Tian Xiaolin Chen Leguang Li Ting Xie Xiong Li Yuying Che 《Journal of Earth Science》 SCIE CAS CSCD 2024年第3期866-877,共12页
The Hardawu granites in the eastern segment of the ultrahigh-pressure metamorphic belt,the northern Qaidam Basin,were studied by whole-rock major and trace elements and in-situ zircon U-Pb geochronology and Hf isotope... The Hardawu granites in the eastern segment of the ultrahigh-pressure metamorphic belt,the northern Qaidam Basin,were studied by whole-rock major and trace elements and in-situ zircon U-Pb geochronology and Hf isotopes to discuss the petrogenesis and tectonic evolution.Geochronological results show that the granites have a crystallization age of 401±3 Ma,suggesting that they were formed in the Early Devonian.The granites have SiO2 contents of 75.32 wt.%-76.05 wt.%,total alkali contents of 8.23 wt.%-8.36 wt.%,and K2O/Na2O ratios of 1.62-1.91.They were rich in K2O,poor in TiO2,MnO,MgO,and P2O5,and have A/CNK values of 1.05-1.07,Rittmann indexδvalues of 2.05-2.14,and differentiation index(DI)values of 92.85-94.18.They are high potassium calc-alkaline,weakperaluminum,and highly differentiated I-type granites.The granites also show enrichment of large ion lithophile elements(LILE)such as Rb,Ba,and Th,and depletion of high field strength elements(HFSE)such as Nb,Ta,and Ti.The total REE concentrations range from 169 ppm to 232 ppm,with enrichments of light rare earth elements and negative Eu anomalies(δEu=0.39-0.55).The zirconεHf(t)values range from-0.65 to-2.29,and the two-stage model ages(tDM2)changed within a small range of 1.44 to 1.54 Ga,indicating that the magma of the Hardawu granites was originated from the partial melting of Mesoproterozoic lower crustal materials.Combined with previous studies,we suggest that the Hardawu granites were formed in the extensional tectonic setting after the collision between the Qaidam Block and the central and southern Qilian Block in the Early Devonian. 展开更多
关键词 GRANITE Early Devonian PETROGENESIS tectonic implication Qaidam Basin GEOCHEMISTRY
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Upper and Lower Bounds of the α-Universal Triple I Method for Unified Interval Implications
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作者 Yiming Tang Jianwei Gao Yifan Huang 《Computers, Materials & Continua》 SCIE EI 2024年第4期1063-1088,共26页
Theα-universal triple I(α-UTI)method is a recognized scheme in the field of fuzzy reasoning,whichwas proposed by our research group previously.The robustness of fuzzy reasoning determines the quality of reasoning al... Theα-universal triple I(α-UTI)method is a recognized scheme in the field of fuzzy reasoning,whichwas proposed by our research group previously.The robustness of fuzzy reasoning determines the quality of reasoning algorithms to a large extent,which is quantified by calculating the disparity between the output of fuzzy reasoning with interference and the output without interference.Therefore,in this study,the interval robustness(embodied as the interval stability)of theα-UTI method is explored in the interval-valued fuzzy environment.To begin with,the stability of theα-UTI method is explored for the case of an individual rule,and the upper and lower bounds of its results are estimated,using four kinds of unified interval implications(including the R-interval implication,the S-interval implication,the QL-interval implication and the interval t-norm implication).Through analysis,it is found that theα-UTI method exhibits good interval stability for an individual rule.Moreover,the stability of theα-UTI method is revealed in the case of multiple rules,and the upper and lower bounds of its outcomes are estimated.The results show that theα-UTI method is stable for multiple rules when four kinds of unified interval implications are used,respectively.Lastly,theα-UTI reasoning chain method is presented,which contains a chain structure with multiple layers.The corresponding solutions and their interval perturbations are investigated.It is found that theα-UTI reasoning chain method is stable in the case of chain reasoning.Two application examples in affective computing are given to verify the stability of theα-UTImethod.In summary,through theoretical proof and example verification,it is found that theα-UTImethod has good interval robustness with four kinds of unified interval implications aiming at the situations of an individual rule,multi-rule and reasoning chain. 展开更多
关键词 Fuzzy reasoning the CRI method the triple I method fuzzy implication interval robustness
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Generalized Laws of Importation and Cross-Migrativity Based on(D,N)-Implications
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作者 Nana MA 《Journal of Mathematical Research with Applications》 CSCD 2024年第5期583-595,共13页
In the present article we study the generalized laws of importation and crossmigrativity based on(D,N)-implications.On the one hand,we consider the generalized law of importation I(T(x,α),y)=I(x,J(α,y)),when T is co... In the present article we study the generalized laws of importation and crossmigrativity based on(D,N)-implications.On the one hand,we consider the generalized law of importation I(T(x,α),y)=I(x,J(α,y)),when T is concretized as a fuzzy conjunction C,I and J are concretized as(D,N)-implications generated by a fuzzy disjunction D and a fuzzy negation N.On the other hand,we discuss the cross-migrativity of fuzzy disjunctions over fuzzy implications,that is,I(x,D(y,z))=D(y,I(x,z)),where I is a fuzzy implication,D is a fuzzy disjunction.In addition,we study the relationship between the(α-)cross-migrative of(I,D)and the(α-)cross-law of importation(I,ID,N,C). 展开更多
关键词 fuzzy implication generalized laws of importation cross-migrativity
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Comparison of the Development Model of DTP Pharmacy between China and the United States and Its Enlightenment
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作者 Li Yanli Huang Zhe 《Asian Journal of Social Pharmacy》 2024年第2期168-177,共10页
Objective To systematically analyze the development status of DTP pharmacy in the United States and China,and to find out the problems in China’s DTP pharmacy and put forward some countermeasures and suggestions.Meth... Objective To systematically analyze the development status of DTP pharmacy in the United States and China,and to find out the problems in China’s DTP pharmacy and put forward some countermeasures and suggestions.Methods Relevant literature was searched and reviewed to study the history,market scale and development trend of DTP pharmacy in the United States and China.Then,the problems in China’s DTP pharmacy were found out.Results and Conclusion DTP pharmacy model in the U.S.has taken shape and is maturing.The high degree of industry concentration is an important feature of the U.S.pharmacy.In contrast,China’s DTP pharmacy started late,and the industry pattern has not yet been finalized.There are still some problems in the DTP pharmacy certification and quality management.It is recommended to promote the rapid development of DTP pharmacies in China by encouraging the outflow of prescription drugs,establishing a third-party pharmacy accreditation organization and strengthening the team of licensed pharmacists and other personnel. 展开更多
关键词 DTP pharmacy specialty pharmacy development model policy implication
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Application of anterior scleral thickness measurement in different ocular conditions using anterior segment optical coherence tomography:a systemic review
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作者 Lihui Meng Qianyi Yu +1 位作者 Jingyuan Yang Youxin Chen 《Eye Science》 2024年第4期319-335,共17页
Purpose:To conduct a review to systematically evaluate the use of anterior segment optical coherence tomography(AS-OCT)in measuring anterior scleral thickness across diverse ocular conditions and its clinical implicat... Purpose:To conduct a review to systematically evaluate the use of anterior segment optical coherence tomography(AS-OCT)in measuring anterior scleral thickness across diverse ocular conditions and its clinical implications.Methods:Literature search was conducted across electronic databases,including PubMed,Scopus,and Embase,to identify relevant studies.The risk of bias was assessed,and the main characteristics of each studies were analyzed.We calculated the overall mean anterior scleral thickness using the data which have measurement at the same locations.Results:A total of 32 studies were included that utilized AS-OCT to measure anterior scleral thickness in both healthy subjects and individuals with ocular disorders such as myopia,keratoconus,scleritis,and others.The review found that anterior scleral thickness is significantly influenced by age,diurnal variation,and specific ocular conditions.For example,myopic eyes may exhibit thinner sclera,particularly along certain meridians,while conditions like scleritis showed increased scleral thickness due to inflammation.However,some studies have inconsistent results.Additionally,AS-OCT proved effective in detecting subtle variations in anterior scleral thickness,which could be linked to the progression of ocular diseases.Conclusions:Anterior scleral thickness varies considerably depending on age,time of day,and ocular health,making it a valuable parameter in the assessment of eye conditions.AS-OCT's ability to measure these variations non-invasively broadens its application in both clinical practice and research,offering new insights into the biomechanical properties of the sclera and their implications for ocular diseases. 展开更多
关键词 anterior scleral thickness anterior segment optical coherence tomography ocular disorder clinical implication
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Three Dimensions of Cultivating New Generations: Value Implication, Scientific Connotation, and Cultivation Path
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作者 Yihan Zhang Yuhang Fang 《Journal of Contemporary Educational Research》 2024年第6期255-260,共6页
The new generation of the times is the latest requirement for young people in the new era,and it is the latest training goal for young people put forward by the Party and the country in the face of the second centenni... The new generation of the times is the latest requirement for young people in the new era,and it is the latest training goal for young people put forward by the Party and the country in the face of the second centennial goal.At the 19th National Congress,it was put forward by the country that the concept of“new generation of the times”for the first time,indicating the training direction and theoretical guidance for the new generation of the times.The new age requires young people to have firm ideals and beliefs,excellent skills,and a great spirit of responsibility.The proposition of cultivating a new generation of the times is a deep exploration and summary of Marx’s theory of“all-round human development,”Lenin’s youth view and the education view of excellent traditional Chinese culture,and the proposition needs to strengthen the leadership of the Party,give play to the leading role of socialist core values,and the youth themselves should actively act to realize the transformation of theoretical and practical results. 展开更多
关键词 New generation of the times Value implication Scientific connotation Cultivation path
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常规关系在借代翻译研究中的应用——含意理论在翻译技巧中的应用之二 被引量:2
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作者 徐莉娜 《上海翻译》 CSSCI 北大核心 1999年第4期28-31,共4页
This paper approaches interpretation of metonymies in translation from the angle of implicationalization,in the process of which stereotypical relations play an important role.It discusses semantic motivation and form... This paper approaches interpretation of metonymies in translation from the angle of implicationalization,in the process of which stereotypical relations play an important role.It discusses semantic motivation and formulation of a metonymy and concerns itself with the contextual elements which bring the relevant association into prominence and with the mapping relations with the community as well.It suggests that to come at the right semantic orientation of the original,the translator should be alert to the ways the author sees the world and the principles by which the SL community establishes relations between one thing and another. [ 展开更多
关键词 METONYMY implicationalization stereotypical RELATIONS semantic orientation This paper approaches interpretation of metonymies in translation from the angle of implicationalization in the process of WHICH stereotypical RELATIONS PLAY an impo
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栾川上房沟钼矿床流体包裹体特征及其地质意义 被引量:21
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作者 杨艳 张静 +1 位作者 杨永飞 石英霞 《岩石学报》 SCIE EI CAS CSCD 北大核心 2009年第10期2563-2574,共12页
上房沟钼矿床位于栾川断裂带北侧的华北克拉通南缘,矿体赋存于晚元古代栾川群碎屑岩-碳酸盐建造中。钼成矿经历了早、中、晚3个阶段:早阶段为钾长石-石英-辉钼矿-黄铁矿组合,中阶段为石英-辉钼矿-多金属硫化物组合,晚阶段以方解石-石英... 上房沟钼矿床位于栾川断裂带北侧的华北克拉通南缘,矿体赋存于晚元古代栾川群碎屑岩-碳酸盐建造中。钼成矿经历了早、中、晚3个阶段:早阶段为钾长石-石英-辉钼矿-黄铁矿组合,中阶段为石英-辉钼矿-多金属硫化物组合,晚阶段以方解石-石英-萤石脉为特征。流体包裹体可划分为富/含CO_2型、含子矿物型和NaCl-H_2O型3类。早、中成矿阶段发育较多CO_2-H_2O型和含子晶型包裹体,晚阶段为NaCl-H_2O型包裹体。早阶段流体具有高温(320℃~500℃)、高盐度(31.75~66.75wt%NaCl eqv.)、富CO_2的特点,显示浆控高温热液矿床的特征;中阶段流体具有中温(190℃~400℃)、中等盐度(2.07~12.85 wt%NaCl eqv.,个别超过30 wt%NaCl eqv.)、富/含CO_2特点;晚阶段为中低温(160℃~260℃)、低盐度(~4.8 wt%NaCl eqv.)、贫CO_2的NaCl-H_2O体系。早、中阶段流体沸腾作用强烈,造成CO_2不断逸失、流体氧化性降低、成矿物质大量沉淀,是成矿的重要机制。 展开更多
关键词 栾川断裂带 钼矿床 流体包裹体 特征 地质意义 Mo deposit geological implication fluid inclusions NaCl 成矿物质 华北克拉通南缘 早阶段 盐度 石英 辉钼矿 高温热液矿床 多金属硫化物 组合 晚元古代 特点
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Implicative and Fuzzy Implicative Ideals of Lattice Implication Algebras 被引量:11
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作者 赵光峰 徐扬 宋振明 《Chinese Quarterly Journal of Mathematics》 CSCD 2001年第4期104-110,共7页
In this paper, we defined the concept of implicative and fuzzy implicative ideals of lattice implication algebras, and discussed the properties of them. And then, we pointed out the relations between implicative ideal... In this paper, we defined the concept of implicative and fuzzy implicative ideals of lattice implication algebras, and discussed the properties of them. And then, we pointed out the relations between implicative ideal and LI _ideal, implicative iedal and implicative filter, implicative ideal and fuzzy implicative ideal, fuzzy implicative ideal and fuzzy implicative filter, and fuzzy implicative ideal and fuzzy LI _ideal. 展开更多
关键词 lattice implication algebra fuzzy LI _ideal fuzzy filter implicative ideal fuzzy implicative ideal
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The Logical Properties of Filters of Lattice Implication Algebra 被引量:3
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作者 王伟 徐扬 宋振明 《Chinese Quarterly Journal of Mathematics》 CSCD 2001年第3期8-13,共6页
In this paper, we discuss some propertie s of lattice implication algebra and difine the transitivity of implication in a set, we show the transitivity of implication and the substitution Theorem hold i n filters. S... In this paper, we discuss some propertie s of lattice implication algebra and difine the transitivity of implication in a set, we show the transitivity of implication and the substitution Theorem hold i n filters. So every filter of lattice implication algebra satisfies the Syllogis m and substitution Theorem of propositional logic. 展开更多
关键词 lattice implication algebra FILTER TRANSITIVITY
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基于蕴涵算子族L-λ-R_0的反向三I约束算法
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作者 王庆平 张兴芳 《计算机科学与探索》 CSCD 2007年第3期340-346,共7页
提出基于蕴涵算子族L-λ-R0的模糊推理的思想,这将有助于提高推理结果的可靠性。针对蕴涵算子族L-λ-R0给出了模糊推理的FMP模型及FMT模型的反向三I约束算法。
关键词 蕴涵 算子族 反向三 约束算法 IMPLICATION OPERATOR 模糊推理 模型 可靠性 思想
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中西语言学视域的“义生文外”概念解读
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作者 王晓军 《求索》 CSSCI 2014年第5期123-127,共5页
"义生文外"概念的内涵是隐秀论,属于汉语语言学"言外之意"的范畴,与"言内之意"相对应。研究发现,不仅中西语言学不同语境下,汉语"言外之意"与英语"implicature"、"implication&... "义生文外"概念的内涵是隐秀论,属于汉语语言学"言外之意"的范畴,与"言内之意"相对应。研究发现,不仅中西语言学不同语境下,汉语"言外之意"与英语"implicature"、"implication"不能划等号,即便同处汉语语言学语境下,"义生文外"与"言外之意"也不能划等号。 展开更多
关键词 “义生文外” “言外之意” “implicature” “implication”
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Cultural Implication of Plants in Classical Chinese Gardens
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作者 汤振兴 王延方 《Journal of Landscape Research》 2009年第7期49-53,共5页
Besides the ornamental and landscape composition functions,plants in classical Chinese gardens also play another significant role,i.e.cultural function.The cultural psychology of taking garden plants as emotional vect... Besides the ornamental and landscape composition functions,plants in classical Chinese gardens also play another significant role,i.e.cultural function.The cultural psychology of taking garden plants as emotional vectors and a living history as well as that of garden plant furnishing were elaborated in this study,and the cultural implication of plants was studied to make the cultural connotation of classical Chinese gardens be understood fully. 展开更多
关键词 CLASSICAL gardens PLANTS CULTURAL IMPLICATION
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INFLUENCE FACTOR ANALYSIS OF CHINESE STUDENTS' LERANING STYLES
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作者 周平 《广西大学学报(哲学社会科学版)》 2009年第S1期125-127,共3页
Learning style,aiming at language learner,is a hot issue of second language acquisition.The article first reviews the various definitions of learning style.From the perspective of cognition,three influence factors of ... Learning style,aiming at language learner,is a hot issue of second language acquisition.The article first reviews the various definitions of learning style.From the perspective of cognition,three influence factors of Chinese students' learning styles are analyzed.Suggestions are proposed for teachers to help students develop learning styles. 展开更多
关键词 learning STYLE definition INFLUENCE FACTOR teaching IMPLICATION
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From Concrete Object "Tress" of English Poems to Abstract Image in Chinese Counterparts
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作者 刘桂兰 《Sino-US English Teaching》 2007年第1期62-65,共4页
Image is an important and creative way to express poets" feelings in both Chinese and English poetry. There are concrete representations and abstract concept in image. They are two key notions in Poetics and Aestheti... Image is an important and creative way to express poets" feelings in both Chinese and English poetry. There are concrete representations and abstract concept in image. They are two key notions in Poetics and Aesthetics. This paper is to show the different versions of "tress" in poems and to explore the exact nature of concepts of sensitive affection in English and Chinese, so as to appreciate the artistic beauty of images. 展开更多
关键词 POETRY image concrete object abstract concept IMPLICATION
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Language Awareness and Second Language Learning:A Critical Review
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作者 何周春 龚彦知 《海外英语》 2011年第14期59-62,68,共5页
Beginning with the history,definition and levels of Language Awareness,this paper reviewed and analyzed two views:1) Language awareness is one necessary condition in language learning,or 2) Language learning can be ac... Beginning with the history,definition and levels of Language Awareness,this paper reviewed and analyzed two views:1) Language awareness is one necessary condition in language learning,or 2) Language learning can be achieved without Language Awareness.It pointed out the problems existing in these studies:1) Limitations in sample choice,concerning the adult beginning learners instead of the learners in different learning stages;2) Limitations in methodology,preferring cross-sectional researches to longitudinal case studies;and 3) Limitations in material choice,focusing on "word" level rather than other levels or aspects of language learning.This paper argued that language awareness is dynamic in the whole process of language learning. 展开更多
关键词 LANGUAGE AWARENESS SECOND LANGUAGE learning LIMITATION IMPLICATION
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非英语专业《大学英语自学教程》(上册)辅导(5)
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作者 朱传枝 《语言教育》 2002年第12期29-30,共2页
一、根据给出的汉语词义和规定的词性写出相应的英语单词,每条短线上写一个字母。该词的首字母已给出。
关键词 英语专业 汉语词义 MOTIVE implication intend technological intention EXPLAIN CHANCE BECOMING
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