Consider SE(3)as a submanifold of the Euclidean space E12.At first,the intrinsic and extrinsic geometries of SE(3)are studied.Then the Frenet typed equations for curves in SE(3)are derived.The relationship between the...Consider SE(3)as a submanifold of the Euclidean space E12.At first,the intrinsic and extrinsic geometries of SE(3)are studied.Then the Frenet typed equations for curves in SE(3)are derived.The relationship between the k-th order covariant curvatures of a curve in SE(3)and the parametric equation of its pre-image in se(3)is established.Finally,some kinds of curves in SE(3)with vanish 5-th order covariant curvature are constructed.The behaviours of these curves are exhibited.展开更多
应用传统的压缩感知理论对天线阵列信号的波达方向(Direction-of-arrival,DOA)进行估计,存在基的失配问题。基于交替方向乘子法(Alternative Direction Method of Multiplier,ADMM)的无网格压缩感知(Grid-less Compressive Sensing)技...应用传统的压缩感知理论对天线阵列信号的波达方向(Direction-of-arrival,DOA)进行估计,存在基的失配问题。基于交替方向乘子法(Alternative Direction Method of Multiplier,ADMM)的无网格压缩感知(Grid-less Compressive Sensing)技术能够解决该问题,但仍存在收敛速度慢的缺陷。针对该缺陷,提出带自适应惩罚项的ADMM(ADMM with adaptive penalty,AP-ADMM)算法,即根据输入信号的噪声功率,自适应地选择惩罚项的初始值;同时在算法迭代求解的过程中,自适应地对目标函数的惩罚项进行调整。与传统算法相比,在保证收敛精度和DOA的恢复成功概率的条件下,带自适应惩罚项的ADMM算法收敛速率明显加快。仿真结果验证了新算法的有效性。展开更多
[目的]本文旨在研究Th表位肽和聚肌胞苷酸[Poly(I:C)]2种免疫增强剂对猪O型口蹄疫合成肽抗原细胞免疫和体液免疫的增强作用。[方法]将上述2种免疫增强剂分别与O型口蹄疫病毒(FMDV)合成肽抗原混合乳化,分组免疫Balb/c小鼠,分别在免疫后7...[目的]本文旨在研究Th表位肽和聚肌胞苷酸[Poly(I:C)]2种免疫增强剂对猪O型口蹄疫合成肽抗原细胞免疫和体液免疫的增强作用。[方法]将上述2种免疫增强剂分别与O型口蹄疫病毒(FMDV)合成肽抗原混合乳化,分组免疫Balb/c小鼠,分别在免疫后7、14、21和28 d检测小鼠血清中的VP1抗体、IL-4和IFN-γ水平,以及脾脏中T淋巴细胞转化率及脾脏组织形态变化。[结果]免疫后14 d Th表位肽疫苗组和Poly(I:C)疫苗组血清VP1抗体水平显著高于普通疫苗组(P<0.05),免疫后28 d Th表位肽疫苗组显著高于Poly(I:C)疫苗组和普通疫苗组(P<0.05)。细胞因子检测结果显示:免疫后14、21 d Th表位肽与Poly(I:C)疫苗组IL-4含量显著高于普通疫苗组(P<0.05),免疫后14 d Th表位肽疫苗组IFN-γ含量明显高于其他组(P<0.05),免疫后21 d Th表位肽与Poly(I:C)疫苗组IFN-γ含量显著高于普通疫苗组(P<0.05)。Th表位肽与Poly(I:C)均可使试验小鼠脾脏白髓区增大,着色加深,动脉周围淋巴鞘胀大,Poly(I:C)疫苗组淋巴细胞增殖系数显著高于其他各试验组(P<0.05)。[结论]Th表位肽和Poly(I:C)对猪O型口蹄疫合成肽抗原均有显著免疫增强作用,而Th表位肽可延长体液免疫持续时间。展开更多
EPSAH is an exopolysaccharide from Aphanothece halophytica GR02. The present study was designed to evaluate its toxicity and adjuvant potential in the specific cellular and humoral immune responses in ovalbumin(OVA) i...EPSAH is an exopolysaccharide from Aphanothece halophytica GR02. The present study was designed to evaluate its toxicity and adjuvant potential in the specific cellular and humoral immune responses in ovalbumin(OVA) in mice. EPSAH did not cause any mortality and side effects when the mice were administered subcutaneously twice at the dose of 50 mg×kg^(–1). Hemolytic activity in vitro indicated that EPSAH was non-hemolytic. Splenocyte proliferation in vitro was assayed with different concentrations of EPSAH. The mice were immunized subcutaneously with OVA 0.1 mg alone or with OVA 0.1 mg dissolved in saline containing Alum(0.2 mg) or EPSAH(0.2, 0.4, or 0.8 mg) on Day 1 and 15. Two weeks later, splenocyte proliferation, natural killer(NK) cell activity, production of cytokines IL-2 from splenocytes, and serum OVA-specific antibody titers were measured. Phagocytic activity, production of pro-inflammatory cytokines IL-1 and IL-12 in mice peritoneal macrophages were also determined. EPSAH showed a dose-dependent stimulating effect on mitogen-induced proliferation. The Con A-, LPS-, and OVA-induced splenocyte proliferation and the serum OVA-specific IgG, IgG1, and IgG2 a antibody titers in the immunized mice were significantly enhanced. EPSAH also significantly promoted the production of Th1 cytokine IL-2. Besides, EPSAH remarkably increased the killing activities of NK cells from splenocytes in the immunized mice. In addition, EPSAH enhanced phagocytic activity and the generation of pro-inflammatory cytokines IL-1 and IL-12 in macrophages. These results indicated that EPSAH had a strong potential to increase both cellular and humoral immune responses, particularly promoting the development of Th1 polarization.展开更多
基金Supported by the National Natural Science Foundation of China(Grant No.61473059)。
文摘Consider SE(3)as a submanifold of the Euclidean space E12.At first,the intrinsic and extrinsic geometries of SE(3)are studied.Then the Frenet typed equations for curves in SE(3)are derived.The relationship between the k-th order covariant curvatures of a curve in SE(3)and the parametric equation of its pre-image in se(3)is established.Finally,some kinds of curves in SE(3)with vanish 5-th order covariant curvature are constructed.The behaviours of these curves are exhibited.
文摘应用传统的压缩感知理论对天线阵列信号的波达方向(Direction-of-arrival,DOA)进行估计,存在基的失配问题。基于交替方向乘子法(Alternative Direction Method of Multiplier,ADMM)的无网格压缩感知(Grid-less Compressive Sensing)技术能够解决该问题,但仍存在收敛速度慢的缺陷。针对该缺陷,提出带自适应惩罚项的ADMM(ADMM with adaptive penalty,AP-ADMM)算法,即根据输入信号的噪声功率,自适应地选择惩罚项的初始值;同时在算法迭代求解的过程中,自适应地对目标函数的惩罚项进行调整。与传统算法相比,在保证收敛精度和DOA的恢复成功概率的条件下,带自适应惩罚项的ADMM算法收敛速率明显加快。仿真结果验证了新算法的有效性。
文摘[目的]本文旨在研究Th表位肽和聚肌胞苷酸[Poly(I:C)]2种免疫增强剂对猪O型口蹄疫合成肽抗原细胞免疫和体液免疫的增强作用。[方法]将上述2种免疫增强剂分别与O型口蹄疫病毒(FMDV)合成肽抗原混合乳化,分组免疫Balb/c小鼠,分别在免疫后7、14、21和28 d检测小鼠血清中的VP1抗体、IL-4和IFN-γ水平,以及脾脏中T淋巴细胞转化率及脾脏组织形态变化。[结果]免疫后14 d Th表位肽疫苗组和Poly(I:C)疫苗组血清VP1抗体水平显著高于普通疫苗组(P<0.05),免疫后28 d Th表位肽疫苗组显著高于Poly(I:C)疫苗组和普通疫苗组(P<0.05)。细胞因子检测结果显示:免疫后14、21 d Th表位肽与Poly(I:C)疫苗组IL-4含量显著高于普通疫苗组(P<0.05),免疫后14 d Th表位肽疫苗组IFN-γ含量明显高于其他组(P<0.05),免疫后21 d Th表位肽与Poly(I:C)疫苗组IFN-γ含量显著高于普通疫苗组(P<0.05)。Th表位肽与Poly(I:C)均可使试验小鼠脾脏白髓区增大,着色加深,动脉周围淋巴鞘胀大,Poly(I:C)疫苗组淋巴细胞增殖系数显著高于其他各试验组(P<0.05)。[结论]Th表位肽和Poly(I:C)对猪O型口蹄疫合成肽抗原均有显著免疫增强作用,而Th表位肽可延长体液免疫持续时间。
基金supported by College Students Innovation Project for the R&D of Novel Drugs(J1030830)Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)
文摘EPSAH is an exopolysaccharide from Aphanothece halophytica GR02. The present study was designed to evaluate its toxicity and adjuvant potential in the specific cellular and humoral immune responses in ovalbumin(OVA) in mice. EPSAH did not cause any mortality and side effects when the mice were administered subcutaneously twice at the dose of 50 mg×kg^(–1). Hemolytic activity in vitro indicated that EPSAH was non-hemolytic. Splenocyte proliferation in vitro was assayed with different concentrations of EPSAH. The mice were immunized subcutaneously with OVA 0.1 mg alone or with OVA 0.1 mg dissolved in saline containing Alum(0.2 mg) or EPSAH(0.2, 0.4, or 0.8 mg) on Day 1 and 15. Two weeks later, splenocyte proliferation, natural killer(NK) cell activity, production of cytokines IL-2 from splenocytes, and serum OVA-specific antibody titers were measured. Phagocytic activity, production of pro-inflammatory cytokines IL-1 and IL-12 in mice peritoneal macrophages were also determined. EPSAH showed a dose-dependent stimulating effect on mitogen-induced proliferation. The Con A-, LPS-, and OVA-induced splenocyte proliferation and the serum OVA-specific IgG, IgG1, and IgG2 a antibody titers in the immunized mice were significantly enhanced. EPSAH also significantly promoted the production of Th1 cytokine IL-2. Besides, EPSAH remarkably increased the killing activities of NK cells from splenocytes in the immunized mice. In addition, EPSAH enhanced phagocytic activity and the generation of pro-inflammatory cytokines IL-1 and IL-12 in macrophages. These results indicated that EPSAH had a strong potential to increase both cellular and humoral immune responses, particularly promoting the development of Th1 polarization.
