Pulmonary fibrosis, a progressive chronic disease with a high mortality rate, has limited treatment options. Currently, lung transplantation remains the only effective treatment. Here we report that a small RNA, HJT-s...Pulmonary fibrosis, a progressive chronic disease with a high mortality rate, has limited treatment options. Currently, lung transplantation remains the only effective treatment. Here we report that a small RNA, HJT-sRNA-m7, from a Chinese herbal medicine Hong Jing Tian(HJT, RHODIOHAE CRENULATAE RADIX ET RHIZOMA, Rhodiola crenulata) can effectively reduce the expressions of fibrotic hallmark genes and proteins both in alveolar in vitro and in mouse lung tissues in vivo. We also discovered over one hundred oil-soluble chemicals from HJT decoctions, most of which are found in lipid extracts from other Chinese herbals decoctions, including Pu Gong Ying(PGY, TARAXACI HERBA, Taraxacum mongolicum), Chuan Xin Lian(CXL, changed to "ANDROGRAPHIS HERBA, Andrographis paniculata"), and Jin Yin Hua(JYH, lonicera japonica or Honeysuckle). We identified the active component in these decoctions as two forms of phosphocholines, PC(18:0/18:2) and PC(16:0/18:2). These PCs potentially could form liposomes with small RNAs to enter human alveolar and gastric cells. Our experimental results suggest an unprecendent lipid complex route through which botanic small RNA can enter human bodies.Our results provide an innovative treatment strategy for oral delivery of siRNAs as therapeutic medication.展开更多
In this study,the power generation difference between the east-west and the north-south orientation of the vertically installed heterojunction solar cell(HJT)modules was deeply discussed.East-west oriented HJT module ...In this study,the power generation difference between the east-west and the north-south orientation of the vertically installed heterojunction solar cell(HJT)modules was deeply discussed.East-west oriented HJT module has 30%higher power generation,especially in desert photovoltaic(PV)with a bimodal distribution.While the south-north one has a single peak,the same as normal PV modules.Vertical power generation technology of HJT also has less land occupation,which is of great significance for optimizing the design of photovoltaic systems.展开更多
基金supported by the Ministry of Science and Technology of China (2015CB553406)the National Natural Science Foundation of China (81230002, 81490531)the Ministry of Education (IRT1121, B08007)
文摘Pulmonary fibrosis, a progressive chronic disease with a high mortality rate, has limited treatment options. Currently, lung transplantation remains the only effective treatment. Here we report that a small RNA, HJT-sRNA-m7, from a Chinese herbal medicine Hong Jing Tian(HJT, RHODIOHAE CRENULATAE RADIX ET RHIZOMA, Rhodiola crenulata) can effectively reduce the expressions of fibrotic hallmark genes and proteins both in alveolar in vitro and in mouse lung tissues in vivo. We also discovered over one hundred oil-soluble chemicals from HJT decoctions, most of which are found in lipid extracts from other Chinese herbals decoctions, including Pu Gong Ying(PGY, TARAXACI HERBA, Taraxacum mongolicum), Chuan Xin Lian(CXL, changed to "ANDROGRAPHIS HERBA, Andrographis paniculata"), and Jin Yin Hua(JYH, lonicera japonica or Honeysuckle). We identified the active component in these decoctions as two forms of phosphocholines, PC(18:0/18:2) and PC(16:0/18:2). These PCs potentially could form liposomes with small RNAs to enter human alveolar and gastric cells. Our experimental results suggest an unprecendent lipid complex route through which botanic small RNA can enter human bodies.Our results provide an innovative treatment strategy for oral delivery of siRNAs as therapeutic medication.
文摘In this study,the power generation difference between the east-west and the north-south orientation of the vertically installed heterojunction solar cell(HJT)modules was deeply discussed.East-west oriented HJT module has 30%higher power generation,especially in desert photovoltaic(PV)with a bimodal distribution.While the south-north one has a single peak,the same as normal PV modules.Vertical power generation technology of HJT also has less land occupation,which is of great significance for optimizing the design of photovoltaic systems.
