Hepatitis B is a major health concern in the Asia-Pacific region, and is endemic in China, Southeast Asia, and Africa. Chronic hepatitis B virus (HBV) infection may cause hepatic cirrhosis and liver cancer. It is esti...Hepatitis B is a major health concern in the Asia-Pacific region, and is endemic in China, Southeast Asia, and Africa. Chronic hepatitis B virus (HBV) infection may cause hepatic cirrhosis and liver cancer. It is estimated that there are more than 350 million chronic HBV carriers worldwide, of whom approximately one quarter will die of chronic hepatitis B-related liver diseases. HBV is transmitted horizontally through blood and blood products or by sexual transmission, and vertically from mother to infant. Perinatal infection is the predominant mode of transmission in countries with a high prevalence of hepatitis B surface antigen (HBsAg) carriage, and perinatal transmission leads to high rates of chronic infection. Therefore, it is important to prevent the mother-to-child transmission (MTCT) of HBV. Research has shown that pregnant women with high HBV DNA levels have an increased risk of MTCT. However, most of the obstetrics guidelines do not make a distinction between pregnant women with high HBV DNA levels and those who are HBsAg positive only. This review addresses the management of pregnant women with high levels of HBV viremia, in terms of antiviral therapy, use of hepatitis B immunoglobulin (HBIG), the combined application of hepatitis B vaccine and HBIG, choice of delivery mode and feeding practices. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.展开更多
BACKGROUND Patients with thalamic infarction experience abnormal blockages of multinuc-leated vessels,affecting the body and thereby the thalamus.Most patients with thalamic infarction have an adverse prognosis,which ...BACKGROUND Patients with thalamic infarction experience abnormal blockages of multinuc-leated vessels,affecting the body and thereby the thalamus.Most patients with thalamic infarction have an adverse prognosis,which seriously affects their safety.Therefore,it is essential to analyze the independent risk factors that influence the prognosis of patients with thalamic infarction and develop corresponding preventive measures.AIM To explore the effect of non-high-density lipoprotein cholesterol(non-HDL-C)and Homocysteine(Hcy)levels in cognitive impairment in thalamic infarction.METHODS From March 2019 to March 2022,80 patients with thalamic infarction were divided into a group with cognitive impairment[Montreal Cognitive Assessment(MoCA)score<26;35 patients]and a group with normal cognitive function(MoCA score of 26-30;45 patients)according to the MoCA score.In addition,50 healthy people in the same period were selected as the control group.A correlation between the non-HDL-C and Hcy levels and the MoCA score and receiver operating characteristic curve was observed,and the serum non-HDL-C and Hcy levels were analyzed for the diagnosis of cognitive impairment in patients with thalamic infarction.According to the Modified Rankin Scale(MRS)score,80 patients with thalamic infarction were divided into a good prognosis group(MRS score≤2)and a poor prognosis group(MRS score>2).RESULTS The non-HDL-C and Hcy levels were significantly higher in the group with cognitive impairment than in the group with normal cognitive function(P<0.05).There was no significant difference in the non-HDL-C level between the control group and the group with normal cognitive function(P>0.05).The MoCA scores of the group with cognitive impairment were significantly lower than those of the group with normal cognitive function and the control group(P<0.05).There was a significant difference between the control group and the group with normal cognitive function(P<0.05).The non-HDL-C and Hcy levels were correlated with the MoCA score(P<0.05),cognitive impairment[areas under the curve(AUC)=0.709,95%confidence interval(95%CI):0.599-0.816],the non-HDL-C level,and could predict cognitive impairment in patients with thalamic infarction(AUC=0.738,95%CI:0.618-0.859).Hcy combined with non-HDL-C levels can predict cognitive impairment in patients with thalamic infarction(AUC=0.769,95%CI:0.721-0.895).RESULTS There were 50 patients in the good prognosis group and 30 patients in the poor prognosis group.Compared with the good prognosis group,in the poor prognosis group,the National Institutes of Health Stroke Scale(NIHSS)score,non-HDL-C level,Hcy level,large-area cerebral infarction,atrial fibrillation,and activated partial prothrombin time were statistically significant(P<0.05).The non-HDL-C level,the Hcy level,the NIHSS score,extensive cerebral serum,and atrial fibrillation may all be independent risk factors for poor prognosis in patients with thalamic infarction(P<0.05).CONCLUSION Non-HDL-C and Hcy levels are positively correlated with cognitive impairment in patients with thalamic infarction.Non-HDL-C and Hcy levels can be used in the diagnosis of cognitive impairment in patients with thalamic infarction,and the combined detection effect is better.The main factors affecting the prognosis of patients with thalamic infarction are the non-HDL-C level,the Hcy level,the NIHSS score,large-area cerebral infarction,and atrial fibrillation.Clinically,corresponding preventive measures can be formulated based on the above factors to prevent poor prognosis and reduce mortality.展开更多
Magnetotransport experiments including tilt fields are performed on ultrahigh mobility L-shaped Hall-bar samples of GaAs/AlGaAs quantum wells. The low-temperature longitudinal resistivity （ρxx） data demonstrate tha...Magnetotransport experiments including tilt fields are performed on ultrahigh mobility L-shaped Hall-bar samples of GaAs/AlGaAs quantum wells. The low-temperature longitudinal resistivity （ρxx） data demonstrate that a striking even-odd asymmetric transport exists along the [110] direction at half filling in N ≥ 2 high Landau levels. Although the origin for the peculiar even-odd asymmetry remains unclear, we propose that the coupling strength between electrons within the same Landau level and between the neighboring two Landau levels should be considered in future studies. The tilt field data show that the in-plane field can suppress the formation of both bubble and stripe phases.展开更多
Background As shown in previous studies,high brain natriuretic peptide(BNP)is one of common abnormal laboratory test results in some critical patients infected with 2019 novel coronavirus(2019-nCoV),while the role of ...Background As shown in previous studies,high brain natriuretic peptide(BNP)is one of common abnormal laboratory test results in some critical patients infected with 2019 novel coronavirus(2019-nCoV),while the role of BNP in the prognosis of coronavirus disease 2019(COVID-19)is still unknown.This study aims to investigate the effects of the increased BNP value on the outcomes of 2019-nCoV infected patients.Methods Our study initially included patients diagnosed with COVID-19 in Guangzhou Eighth People’s Hospital from January 20 th,2020 to February 24 th.After screening out the participants based on the exclusion criteria,a total of 34 participants were finally enrolled in our research for retrospective analysis.The primary outcome was severe pneumonia defined according to the international guidelines for community-acquired pneumonia.Clinical characteristics and laboratory data were collected from their medical records.Results The best cut-off value of BNP for predicting severe pneumonia was 97.5 pg/mL with the sensitivity for 80%and the specificity for 91.7%.The median age for high BNP level group(>97.5 pg/mL)was 60.5 years(interquartile range:40-80 years).The ratio of males in those patients was 60.0%.Compared with the normal BNP level group,higher temperature(P=0.09),higher values of aspartate aminotransferase(P=0.02),troponin I(P<0.001),C-reactive protein(P<0.001)and myoglobin(P=0.001)as well as lower levels of hemoglobin(P=0.04)and platelet count(P=0.001)were observed in the high BNP group.Multivariable logistic regression demonstrated that 2019-nCoV infected patients with high BNP were more likely to develop severe pneumonia(OR:17.368,P=0.025)and be admitted to the intensive care unit(OR:27.093,P=0.048).Conclusions The increased level of BNP is associated with the undesirable condition and disease aggravation of patients with COVID-19.BNP is expected to be an independent prognostic predictor of clinical outcomes for patients with COVID-19.展开更多
The Regional Comprehensive Economic Partnership(RCEP)is a significant achievement in terms of Asia’s exploration and efforts toward regional economic integration.It integrates regional economic and trade cooperation ...The Regional Comprehensive Economic Partnership(RCEP)is a significant achievement in terms of Asia’s exploration and efforts toward regional economic integration.It integrates regional economic and trade cooperation mechanisms,demonstrates the determination and capabilities of Asian countries to promote open cooperation.展开更多
According to the field survey and ^14C dating at Luhuitou, southern Hainan Island, a subsiding area, the authors conclude the high sea level history recorded by coral reef in the Holocene. At least 4 sea level high-st...According to the field survey and ^14C dating at Luhuitou, southern Hainan Island, a subsiding area, the authors conclude the high sea level history recorded by coral reef in the Holocene. At least 4 sea level high-stands can be identified from the distribution of coral reef ages： 7300 - 6000 cal.aBP, 4800 - 4700 cal.aBP, 4300 - 4200 cal.aBP and 3100 - 2900 cal.aBP. The highest sea level occurred around 7300 - 6700 cal.aBP, and biological-morphological zones took their shape during the stage. The later coral reefs developed in ponds, depressions, and developed outwards on both sides of Luhuitou peninsula. The modern coral reefs are developing in out reef flat and reef-front slope. Moreover, the time of high sea levels in the northern South China Sea recorded by coral reefs in the Luhuitou peninsula can link up with that in other parts of South China Sea. That means the high sea levels in the South China Sea during the Holocene, which are relative to the warming climate, have the global background.展开更多
To improve the agility, dynamics, composability, reusability, and development efficiency restricted by monolithic federation object model （FOM）, a modular FOM is proposed by high level architecture （HLA） evolved p...To improve the agility, dynamics, composability, reusability, and development efficiency restricted by monolithic federation object model （FOM）, a modular FOM is proposed by high level architecture （HLA） evolved product development group. This paper reviews the state-of-the-art of HLA evolved modular FOM. In particular, related concepts, the overall impact on HLA standards, extension principles, and merging processes are discussed. Also permitted and restricted combinations, and merging rules are provided, and the influence on HLA interface specification is given. The comparison between modular FOM and base object model （BOM） is performed to illustrate the importance of their combination. The applications of modular FOM are summarized. Finally, the significance to facilitate compoable simulation both in academia and practice is presented and future directions are pointed out.展开更多
Higher boll worm survival rates were detected after high temperature presented during square period in Bt cotton. The objective of this study was to investigate the effects of high temperature level on the Bt efficacy...Higher boll worm survival rates were detected after high temperature presented during square period in Bt cotton. The objective of this study was to investigate the effects of high temperature level on the Bt efficacy of two different types of Bt cotton cultivars at squaring stage. During the 2011 to 2013 cotton growth seasons, high temperature treatments ranged from 34 to 44°C in climate chambers, and field experiments under high temperature weather with various temperature levels were conducted to investigate the effects of the high temperature level on square Bt protein concentration and nitrogen metabolism. The climate chamber experiments showed that the square insecticidal protein contents reduced after 24 h elevated temperature treatments for both cultivars, whereas significant declines of the square insecticidal protein contents were detected at temperature 〉38°C, and only slightly numerical reductions were observed when temperature below 38°C. Similar high temperature responses were also observed at the two field experimental sites in 2013. Correspondingly, high temperature below 38°C seems have little effect on the square amino acid concentrations, soluble protein contents, glutamic-pyruvic transaminase（GPT） and glutamic-oxalacetic transaminase（GOT） activities as well as protease and peptidase activities; however, when the temperature was above 38°C, reduced soluble protein contents, enhanced amino acid concentrations, decreased GPT and GOT activities, bolstered protease and peptidase activities in square were detected. In general, the higher the temperature is（〉38°C）, the larger the changes for the above compound contents and key enzymes activities of the square protein cycle. The findings indicated that the unstable insect resistance of the square was related to high temperature level during square stage.展开更多
Relevant geological, geographical, archaeological data were collected to study the characteristics of middle Holocene warm period and sea level high on North China coast. Middle Holocene climate and sea level change o...Relevant geological, geographical, archaeological data were collected to study the characteristics of middle Holocene warm period and sea level high on North China coast. Middle Holocene climate and sea level change on North China coast were correlated to warm marine environment events in about 8–3 ka B.P. The sea level in about 8 ka B.P. was higher than present mean sea level, then fluctuated for 5 000 years and after that it became even in 3 ka B.P. The highest sea level occurred in about 6–5 ka B.P.; the maximum was about 2–3 m and minimum was about 1–2 m.展开更多
It is known that both excitatory and inhibitory neuronal networks can achieve robust synchronization only under certain conditions, such as long synaptic delay or low level of heterogeneity. In this work, robust synch...It is known that both excitatory and inhibitory neuronal networks can achieve robust synchronization only under certain conditions, such as long synaptic delay or low level of heterogeneity. In this work, robust synchronization can be found in an excitatory/inhibitory （E/I） neuronal network with medium synaptie delay and high level of heterogeneity, which often occurs in real neuronal networks. Two effects of post-synaptic potentials （PSP） to network synchronization are presented, and the synaptic contribution of excitatory and inhibitory neurons to robust synchronization in this E/I network is investigated. It is found that both excitatory and inhibitory neurons may contribute to robust synchronization in E/I networks, especially the excitatory PSP has a more positive effect on synchronization in E/I networks than that in excitatory networks. This may explain the strong robustness of synchronization in Eli neuronal networks.展开更多
In the modern analogue design, Transistor Level Fault Simulation (TLFS) plays the im-portant part since every fault in the whole circuit has to be simulated at that level. Unfortunately, it is a very CPU intensive tas...In the modern analogue design, Transistor Level Fault Simulation (TLFS) plays the im-portant part since every fault in the whole circuit has to be simulated at that level. Unfortunately, it is a very CPU intensive task even though it maintains the high accuracy. Therefore, High Level Fault Modeling (HLFM) and High Level Fault Simulation (HLFS) are required in order to alleviate the efforts of simulation. In this paper, different HLFM approaches are reviewed at the device level during last two decades. We clarify their domains of application and evaluate their strengths and current limitations. We also analyze causes of faults and introduce various test approaches.展开更多
This article uses the literature data method and literature review method to review and collect relevant literature,and summarizes and analyzes the representative views on domestic physical fitness research.After summ...This article uses the literature data method and literature review method to review and collect relevant literature,and summarizes and analyzes the representative views on domestic physical fitness research.After summarizing and summarizing,it is considered that:physical energy is the basic athletic ability of the human body expressed through physical qualities such as strength,speed,endurance,coordination,flexibility,and sensitivity,and is an important component of athletes'athletic ability.The level of physical fitness is closely related to the morphological characteristics of the human body and the functional characteristics of the human body.The morphological characteristics of the human body are the structural basis of its physical fitness,and the functional characteristics of the human body are its biological functional basis.As the basic ability of athletes,physical fitness is an important factor of athletes'competitive ability.Each competitive sport has its own specific physical characteristics and training rules and methods.Grasping these laws has very important guiding significance for the improvement of athletes'sports level.展开更多
There is an obvious gap in sprint level at home and abroad,and there are different opinions on the reasons.According to the analysis,physical energy and its distribution in each segment are the main factors restrictin...There is an obvious gap in sprint level at home and abroad,and there are different opinions on the reasons.According to the analysis,physical energy and its distribution in each segment are the main factors restricting the sprint performance in China.Different from middle and long-distance running,we must rely on accurate sectional timing technology to master the law of speed-physical energy change in the process of sprint.Each stage is an integral part of the whole dash process,and each part restricts each other.Each stage has a relative best achievement.Simply pursuing the optimal state of segment is not only not helpful to the final result,but also counterproductive.展开更多
Accurate prediction of performance decay law is an important basis for long-term planning of maintenance strategy.The statistical regression prediction model is the most widely employed method to calculate pavement pe...Accurate prediction of performance decay law is an important basis for long-term planning of maintenance strategy.The statistical regression prediction model is the most widely employed method to calculate pavement performance due to its advantages such as the small amount of calculation and good accuracy,but the traditional prediction model seems not applicable to the high maintenance level areas with excellent pavement conditions.In this paper,the service life and the cumulative number of the axle load were determined as the independent variables of prediction models of pavement performance.The pavement condition index(PCI)and rutting depth index(RDI)were selected as maintenance decision control indexes to establish the unified prediction model of PCI and RDI respectively by applying the cosine deterioration equation.Results reveal that the deterioration law of PCI presents an anti-S type or concave type and the deterioration law of RDI shows an obvious concave type.The prediction model proposed in this study added the pavement maintenance standard factor d,which brings the model parameterα(reflecting the road life)and the deterioration equations are more applicable than the traditional standard equations.It is found that the fitting effects of PCI and RDI prediction models with different traffic grades are relatively similar to the actual service state of the pavements.展开更多
Following high-level diplomacy,a recent forum has bridged China and Spanish-and Portuguese-speaking countries by injecting substance into cooperation frameworks through a new education alliance and concrete projects.
Beijing’s Demonstration of Trade in Services Outlook Weekly Issue 31,2025 To be better aligned with international rules in key industries,Beijing has accelerated efforts to foster a world-class business environment a...Beijing’s Demonstration of Trade in Services Outlook Weekly Issue 31,2025 To be better aligned with international rules in key industries,Beijing has accelerated efforts to foster a world-class business environment and promote high-level opening up.Beijing’s open economy saw its resilience and vitality steadily intensify over the past five years.The actual use of foreign investment reached US$66.2 billion,of which the proportion of the service industry accounted for over 90 percent.The scale of its trade in services remains among the top three in China,realizing an average annual growth rate of 9.4 percent since 2021.展开更多
Singapore is an important and close neighbor of China.Over a long period of time,this set of bilateral relations has stayed at the forefront of cooperation between China and ASEAN countries.Since the launch of the Suz...Singapore is an important and close neighbor of China.Over a long period of time,this set of bilateral relations has stayed at the forefront of cooperation between China and ASEAN countries.Since the launch of the Suzhou Industrial Park(SIP)and other projects,cooperation between the two countries has continuously improved in both quantity and quality.China’s high-level opening up has continuously fostered regional synergies and injected new impetus into bilateral cooperation.In recent years,China-Singapore cooperation has deepened across multiple dimensions,from high-level governmental engagement and strategic alignment to grassroots initiatives such as social partnerships and personnel exchanges.展开更多
Yuzhong District is where the city of Chongqing first originated.It opened a window to the world for the locals while serving as the city’s lounge receiving visitors from around the globe.Yuzhong is now a central hub...Yuzhong District is where the city of Chongqing first originated.It opened a window to the world for the locals while serving as the city’s lounge receiving visitors from around the globe.Yuzhong is now a central hub for implementing the China-Singapore(Chongqing)Demonstration Initiative on Strategic Connectivity,also known as China-Singapore(Chongqing)Connectivity Initiative(CCI),striving to leverage the important role of the CCI platform to promote high-level and innovation-driven opening-up from a high starting point.With focus on developing modern connectivity and the service industry,the district government has prioritized key areas such as commerce,finance,information,communications,healthcare,education.展开更多
THIS year marks the 20th anniversary of the vision“lucid waters and lush mountains are invaluable assets,”which reveals the intrinsic link between economic development and ecological protection.As the birthplace of ...THIS year marks the 20th anniversary of the vision“lucid waters and lush mountains are invaluable assets,”which reveals the intrinsic link between economic development and ecological protection.As the birthplace of this idea,representatives of Huzhou City in east China’s Zhejiang Province were invited to the 2025 United Nations High-Level Political Forum on Sustainable Development in New York on July 14.At the forum,Executive Vice Mayor Wang Zongming delivered a speech titled“Beautiful China,Dynamic Huzhou,”sharing the city’s sustainable development practices and stories in four aspects:ecology,industry,culture,and urban–rural integration.展开更多
文摘Hepatitis B is a major health concern in the Asia-Pacific region, and is endemic in China, Southeast Asia, and Africa. Chronic hepatitis B virus (HBV) infection may cause hepatic cirrhosis and liver cancer. It is estimated that there are more than 350 million chronic HBV carriers worldwide, of whom approximately one quarter will die of chronic hepatitis B-related liver diseases. HBV is transmitted horizontally through blood and blood products or by sexual transmission, and vertically from mother to infant. Perinatal infection is the predominant mode of transmission in countries with a high prevalence of hepatitis B surface antigen (HBsAg) carriage, and perinatal transmission leads to high rates of chronic infection. Therefore, it is important to prevent the mother-to-child transmission (MTCT) of HBV. Research has shown that pregnant women with high HBV DNA levels have an increased risk of MTCT. However, most of the obstetrics guidelines do not make a distinction between pregnant women with high HBV DNA levels and those who are HBsAg positive only. This review addresses the management of pregnant women with high levels of HBV viremia, in terms of antiviral therapy, use of hepatitis B immunoglobulin (HBIG), the combined application of hepatitis B vaccine and HBIG, choice of delivery mode and feeding practices. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.
基金The study was reviewed and approved by the Institutional Review Board of Chaohu Hospital Affiliated to AnhuiMedical University,Approval No.KYXM-202208-011.
文摘BACKGROUND Patients with thalamic infarction experience abnormal blockages of multinuc-leated vessels,affecting the body and thereby the thalamus.Most patients with thalamic infarction have an adverse prognosis,which seriously affects their safety.Therefore,it is essential to analyze the independent risk factors that influence the prognosis of patients with thalamic infarction and develop corresponding preventive measures.AIM To explore the effect of non-high-density lipoprotein cholesterol(non-HDL-C)and Homocysteine(Hcy)levels in cognitive impairment in thalamic infarction.METHODS From March 2019 to March 2022,80 patients with thalamic infarction were divided into a group with cognitive impairment[Montreal Cognitive Assessment(MoCA)score<26;35 patients]and a group with normal cognitive function(MoCA score of 26-30;45 patients)according to the MoCA score.In addition,50 healthy people in the same period were selected as the control group.A correlation between the non-HDL-C and Hcy levels and the MoCA score and receiver operating characteristic curve was observed,and the serum non-HDL-C and Hcy levels were analyzed for the diagnosis of cognitive impairment in patients with thalamic infarction.According to the Modified Rankin Scale(MRS)score,80 patients with thalamic infarction were divided into a good prognosis group(MRS score≤2)and a poor prognosis group(MRS score>2).RESULTS The non-HDL-C and Hcy levels were significantly higher in the group with cognitive impairment than in the group with normal cognitive function(P<0.05).There was no significant difference in the non-HDL-C level between the control group and the group with normal cognitive function(P>0.05).The MoCA scores of the group with cognitive impairment were significantly lower than those of the group with normal cognitive function and the control group(P<0.05).There was a significant difference between the control group and the group with normal cognitive function(P<0.05).The non-HDL-C and Hcy levels were correlated with the MoCA score(P<0.05),cognitive impairment[areas under the curve(AUC)=0.709,95%confidence interval(95%CI):0.599-0.816],the non-HDL-C level,and could predict cognitive impairment in patients with thalamic infarction(AUC=0.738,95%CI:0.618-0.859).Hcy combined with non-HDL-C levels can predict cognitive impairment in patients with thalamic infarction(AUC=0.769,95%CI:0.721-0.895).RESULTS There were 50 patients in the good prognosis group and 30 patients in the poor prognosis group.Compared with the good prognosis group,in the poor prognosis group,the National Institutes of Health Stroke Scale(NIHSS)score,non-HDL-C level,Hcy level,large-area cerebral infarction,atrial fibrillation,and activated partial prothrombin time were statistically significant(P<0.05).The non-HDL-C level,the Hcy level,the NIHSS score,extensive cerebral serum,and atrial fibrillation may all be independent risk factors for poor prognosis in patients with thalamic infarction(P<0.05).CONCLUSION Non-HDL-C and Hcy levels are positively correlated with cognitive impairment in patients with thalamic infarction.Non-HDL-C and Hcy levels can be used in the diagnosis of cognitive impairment in patients with thalamic infarction,and the combined detection effect is better.The main factors affecting the prognosis of patients with thalamic infarction are the non-HDL-C level,the Hcy level,the NIHSS score,large-area cerebral infarction,and atrial fibrillation.Clinically,corresponding preventive measures can be formulated based on the above factors to prevent poor prognosis and reduce mortality.
基金Supported by the National Basic Research Program of China under Grant Nos 2014CB920904 and 2013CB921702the National Natural Science Foundation of China under Grant Nos 11174340,11174357,91221203 and 91421303+2 种基金the Strategic Priority Research Program B of the Chinese Academy of Sciences under Grant No XDB07010100the Gordon and Betty Moore Foundation through the EPiQS initiative under Grant No GBMF4420the National Science Foundation of MRSEC under Grant No DMR-1420541
文摘Magnetotransport experiments including tilt fields are performed on ultrahigh mobility L-shaped Hall-bar samples of GaAs/AlGaAs quantum wells. The low-temperature longitudinal resistivity （ρxx） data demonstrate that a striking even-odd asymmetric transport exists along the [110] direction at half filling in N ≥ 2 high Landau levels. Although the origin for the peculiar even-odd asymmetry remains unclear, we propose that the coupling strength between electrons within the same Landau level and between the neighboring two Landau levels should be considered in future studies. The tilt field data show that the in-plane field can suppress the formation of both bubble and stripe phases.
文摘Background As shown in previous studies,high brain natriuretic peptide(BNP)is one of common abnormal laboratory test results in some critical patients infected with 2019 novel coronavirus(2019-nCoV),while the role of BNP in the prognosis of coronavirus disease 2019(COVID-19)is still unknown.This study aims to investigate the effects of the increased BNP value on the outcomes of 2019-nCoV infected patients.Methods Our study initially included patients diagnosed with COVID-19 in Guangzhou Eighth People’s Hospital from January 20 th,2020 to February 24 th.After screening out the participants based on the exclusion criteria,a total of 34 participants were finally enrolled in our research for retrospective analysis.The primary outcome was severe pneumonia defined according to the international guidelines for community-acquired pneumonia.Clinical characteristics and laboratory data were collected from their medical records.Results The best cut-off value of BNP for predicting severe pneumonia was 97.5 pg/mL with the sensitivity for 80%and the specificity for 91.7%.The median age for high BNP level group(>97.5 pg/mL)was 60.5 years(interquartile range:40-80 years).The ratio of males in those patients was 60.0%.Compared with the normal BNP level group,higher temperature(P=0.09),higher values of aspartate aminotransferase(P=0.02),troponin I(P<0.001),C-reactive protein(P<0.001)and myoglobin(P=0.001)as well as lower levels of hemoglobin(P=0.04)and platelet count(P=0.001)were observed in the high BNP group.Multivariable logistic regression demonstrated that 2019-nCoV infected patients with high BNP were more likely to develop severe pneumonia(OR:17.368,P=0.025)and be admitted to the intensive care unit(OR:27.093,P=0.048).Conclusions The increased level of BNP is associated with the undesirable condition and disease aggravation of patients with COVID-19.BNP is expected to be an independent prognostic predictor of clinical outcomes for patients with COVID-19.
文摘The Regional Comprehensive Economic Partnership(RCEP)is a significant achievement in terms of Asia’s exploration and efforts toward regional economic integration.It integrates regional economic and trade cooperation mechanisms,demonstrates the determination and capabilities of Asian countries to promote open cooperation.
基金We gratefully acknowledge the financial supports from the National Natural Science Foundation of China(Grant No.49976015).
文摘According to the field survey and ^14C dating at Luhuitou, southern Hainan Island, a subsiding area, the authors conclude the high sea level history recorded by coral reef in the Holocene. At least 4 sea level high-stands can be identified from the distribution of coral reef ages： 7300 - 6000 cal.aBP, 4800 - 4700 cal.aBP, 4300 - 4200 cal.aBP and 3100 - 2900 cal.aBP. The highest sea level occurred around 7300 - 6700 cal.aBP, and biological-morphological zones took their shape during the stage. The later coral reefs developed in ponds, depressions, and developed outwards on both sides of Luhuitou peninsula. The modern coral reefs are developing in out reef flat and reef-front slope. Moreover, the time of high sea levels in the northern South China Sea recorded by coral reefs in the Luhuitou peninsula can link up with that in other parts of South China Sea. That means the high sea levels in the South China Sea during the Holocene, which are relative to the warming climate, have the global background.
基金supported by the National Natural Science Foundation of China(6067406960574056).
文摘To improve the agility, dynamics, composability, reusability, and development efficiency restricted by monolithic federation object model （FOM）, a modular FOM is proposed by high level architecture （HLA） evolved product development group. This paper reviews the state-of-the-art of HLA evolved modular FOM. In particular, related concepts, the overall impact on HLA standards, extension principles, and merging processes are discussed. Also permitted and restricted combinations, and merging rules are provided, and the influence on HLA interface specification is given. The comparison between modular FOM and base object model （BOM） is performed to illustrate the importance of their combination. The applications of modular FOM are summarized. Finally, the significance to facilitate compoable simulation both in academia and practice is presented and future directions are pointed out.
基金supported by the National Natural Science Foundation of China (31171479, 31301263 and 31471435)the Doctoral Advisor Foundation of Ministry of Education of China (20113250110001)+1 种基金the Priority Academic Program Development of Jiangsu Higher Education Institutions, China (PAPD)the Three New Technology Foundation of Agriculture in Jiangsu Province, China (SXGC(2014)317)
文摘Higher boll worm survival rates were detected after high temperature presented during square period in Bt cotton. The objective of this study was to investigate the effects of high temperature level on the Bt efficacy of two different types of Bt cotton cultivars at squaring stage. During the 2011 to 2013 cotton growth seasons, high temperature treatments ranged from 34 to 44°C in climate chambers, and field experiments under high temperature weather with various temperature levels were conducted to investigate the effects of the high temperature level on square Bt protein concentration and nitrogen metabolism. The climate chamber experiments showed that the square insecticidal protein contents reduced after 24 h elevated temperature treatments for both cultivars, whereas significant declines of the square insecticidal protein contents were detected at temperature 〉38°C, and only slightly numerical reductions were observed when temperature below 38°C. Similar high temperature responses were also observed at the two field experimental sites in 2013. Correspondingly, high temperature below 38°C seems have little effect on the square amino acid concentrations, soluble protein contents, glutamic-pyruvic transaminase（GPT） and glutamic-oxalacetic transaminase（GOT） activities as well as protease and peptidase activities; however, when the temperature was above 38°C, reduced soluble protein contents, enhanced amino acid concentrations, decreased GPT and GOT activities, bolstered protease and peptidase activities in square were detected. In general, the higher the temperature is（〉38°C）, the larger the changes for the above compound contents and key enzymes activities of the square protein cycle. The findings indicated that the unstable insect resistance of the square was related to high temperature level during square stage.
文摘Relevant geological, geographical, archaeological data were collected to study the characteristics of middle Holocene warm period and sea level high on North China coast. Middle Holocene climate and sea level change on North China coast were correlated to warm marine environment events in about 8–3 ka B.P. The sea level in about 8 ka B.P. was higher than present mean sea level, then fluctuated for 5 000 years and after that it became even in 3 ka B.P. The highest sea level occurred in about 6–5 ka B.P.; the maximum was about 2–3 m and minimum was about 1–2 m.
基金Supported by the National Natural Science Foundation of China under Grant Nos 11102038,11472061,70971021,71371046and 61203325the Shanghai Natural Science Foundation under Grant No 13ZR1400200+1 种基金the Undergraduate Education Key Reform Project of Shanghai Universities under Grant No X12071306the Fundamental Research Funds for the Central Universities at Donghua University under Grant Nos 14D110402,2232013D3-39 and 14D110417
文摘It is known that both excitatory and inhibitory neuronal networks can achieve robust synchronization only under certain conditions, such as long synaptic delay or low level of heterogeneity. In this work, robust synchronization can be found in an excitatory/inhibitory （E/I） neuronal network with medium synaptie delay and high level of heterogeneity, which often occurs in real neuronal networks. Two effects of post-synaptic potentials （PSP） to network synchronization are presented, and the synaptic contribution of excitatory and inhibitory neurons to robust synchronization in this E/I network is investigated. It is found that both excitatory and inhibitory neurons may contribute to robust synchronization in E/I networks, especially the excitatory PSP has a more positive effect on synchronization in E/I networks than that in excitatory networks. This may explain the strong robustness of synchronization in Eli neuronal networks.
基金Supported by the Fundamental Research Grand Scheme(Ref: frgs 2/2010/TK/UTP/0318, Ministry of High Education (MOHE)MalaysiaShort Tem Internal Research Fund (STIRF No. 20/10.11)) provided by Research Enterprise Office, Universiti Teknologi Petronas, Malaysia in 2010-2012
文摘In the modern analogue design, Transistor Level Fault Simulation (TLFS) plays the im-portant part since every fault in the whole circuit has to be simulated at that level. Unfortunately, it is a very CPU intensive task even though it maintains the high accuracy. Therefore, High Level Fault Modeling (HLFM) and High Level Fault Simulation (HLFS) are required in order to alleviate the efforts of simulation. In this paper, different HLFM approaches are reviewed at the device level during last two decades. We clarify their domains of application and evaluate their strengths and current limitations. We also analyze causes of faults and introduce various test approaches.
文摘This article uses the literature data method and literature review method to review and collect relevant literature,and summarizes and analyzes the representative views on domestic physical fitness research.After summarizing and summarizing,it is considered that:physical energy is the basic athletic ability of the human body expressed through physical qualities such as strength,speed,endurance,coordination,flexibility,and sensitivity,and is an important component of athletes'athletic ability.The level of physical fitness is closely related to the morphological characteristics of the human body and the functional characteristics of the human body.The morphological characteristics of the human body are the structural basis of its physical fitness,and the functional characteristics of the human body are its biological functional basis.As the basic ability of athletes,physical fitness is an important factor of athletes'competitive ability.Each competitive sport has its own specific physical characteristics and training rules and methods.Grasping these laws has very important guiding significance for the improvement of athletes'sports level.
文摘There is an obvious gap in sprint level at home and abroad,and there are different opinions on the reasons.According to the analysis,physical energy and its distribution in each segment are the main factors restricting the sprint performance in China.Different from middle and long-distance running,we must rely on accurate sectional timing technology to master the law of speed-physical energy change in the process of sprint.Each stage is an integral part of the whole dash process,and each part restricts each other.Each stage has a relative best achievement.Simply pursuing the optimal state of segment is not only not helpful to the final result,but also counterproductive.
基金the National Key Research and Development Program of China with Grant No.2018YFB1600100the National Natural Science Foundation of China with Grant No.51978219 and No.51878228.
文摘Accurate prediction of performance decay law is an important basis for long-term planning of maintenance strategy.The statistical regression prediction model is the most widely employed method to calculate pavement performance due to its advantages such as the small amount of calculation and good accuracy,but the traditional prediction model seems not applicable to the high maintenance level areas with excellent pavement conditions.In this paper,the service life and the cumulative number of the axle load were determined as the independent variables of prediction models of pavement performance.The pavement condition index(PCI)and rutting depth index(RDI)were selected as maintenance decision control indexes to establish the unified prediction model of PCI and RDI respectively by applying the cosine deterioration equation.Results reveal that the deterioration law of PCI presents an anti-S type or concave type and the deterioration law of RDI shows an obvious concave type.The prediction model proposed in this study added the pavement maintenance standard factor d,which brings the model parameterα(reflecting the road life)and the deterioration equations are more applicable than the traditional standard equations.It is found that the fitting effects of PCI and RDI prediction models with different traffic grades are relatively similar to the actual service state of the pavements.
文摘Following high-level diplomacy,a recent forum has bridged China and Spanish-and Portuguese-speaking countries by injecting substance into cooperation frameworks through a new education alliance and concrete projects.
文摘Beijing’s Demonstration of Trade in Services Outlook Weekly Issue 31,2025 To be better aligned with international rules in key industries,Beijing has accelerated efforts to foster a world-class business environment and promote high-level opening up.Beijing’s open economy saw its resilience and vitality steadily intensify over the past five years.The actual use of foreign investment reached US$66.2 billion,of which the proportion of the service industry accounted for over 90 percent.The scale of its trade in services remains among the top three in China,realizing an average annual growth rate of 9.4 percent since 2021.
文摘Singapore is an important and close neighbor of China.Over a long period of time,this set of bilateral relations has stayed at the forefront of cooperation between China and ASEAN countries.Since the launch of the Suzhou Industrial Park(SIP)and other projects,cooperation between the two countries has continuously improved in both quantity and quality.China’s high-level opening up has continuously fostered regional synergies and injected new impetus into bilateral cooperation.In recent years,China-Singapore cooperation has deepened across multiple dimensions,from high-level governmental engagement and strategic alignment to grassroots initiatives such as social partnerships and personnel exchanges.
文摘Yuzhong District is where the city of Chongqing first originated.It opened a window to the world for the locals while serving as the city’s lounge receiving visitors from around the globe.Yuzhong is now a central hub for implementing the China-Singapore(Chongqing)Demonstration Initiative on Strategic Connectivity,also known as China-Singapore(Chongqing)Connectivity Initiative(CCI),striving to leverage the important role of the CCI platform to promote high-level and innovation-driven opening-up from a high starting point.With focus on developing modern connectivity and the service industry,the district government has prioritized key areas such as commerce,finance,information,communications,healthcare,education.
文摘THIS year marks the 20th anniversary of the vision“lucid waters and lush mountains are invaluable assets,”which reveals the intrinsic link between economic development and ecological protection.As the birthplace of this idea,representatives of Huzhou City in east China’s Zhejiang Province were invited to the 2025 United Nations High-Level Political Forum on Sustainable Development in New York on July 14.At the forum,Executive Vice Mayor Wang Zongming delivered a speech titled“Beautiful China,Dynamic Huzhou,”sharing the city’s sustainable development practices and stories in four aspects:ecology,industry,culture,and urban–rural integration.
