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Prolapse Incidence in Swine Breeding Herds Is a Cause for Concern
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作者 China Supakorn Joseph D. Stock +1 位作者 Chris Hostetler Kenneth J. Stalder 《Open Journal of Veterinary Medicine》 2017年第8期85-97,共13页
Beginning in the fall of 2014 there has been a general and widespread increase in the incidence of prolapse in the U.S. swine herd. The purpose of this manuscript is to review the incidence, causative factors and trea... Beginning in the fall of 2014 there has been a general and widespread increase in the incidence of prolapse in the U.S. swine herd. The purpose of this manuscript is to review the incidence, causative factors and treatment of rectal, vaginal, uterine and preputial prolapses. Rectal and vaginal prolapses are most common in swine when compared to other prolapse types. The cause of prolapses supports a fixation mechanism failure overcome by pressure on or weakening of support tissue. The fundamental factors affecting the incidence for prolapses are many and include factors related to nutrition, physiology, hormones, genetics, environment and other disease factors such as chronic diarrhea, cough, and dystocia. Treatment of prolapsed swine includes surgical and therapeutic management that can lead to complete recovery. However, in most cases, euthanasia is the final result. Economic loss was calculated at approximately $5220 dollars/year/1000 sows. 展开更多
关键词 PROLAPSE BREEDING herds and SOW
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Gawa Dradul and His Picture Books
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作者 White Yak 《China's Tibet》 2025年第5期32-37,共6页
Born in the Lhodrag County of the Xizang Autonomous Region,Gawa Dradul enjoyed listening to folktales and operas while herding yaks on the mountains together with his aunt as a boy.
关键词 herding yaks Lhodrag County folktales OPERAS yaks Xizang Autonomous Region Gawa Dradul HERDING
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A miracle on Santa Bárbara Island
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作者 谭婷 《疯狂英语(新读写)》 2025年第8期50-51,78,共3页
Activity 1 Think about the following questions and write down your answers before reading the text.1.What are some possible ways animals can survive without access to fresh water sources?2.What other factors besides w... Activity 1 Think about the following questions and write down your answers before reading the text.1.What are some possible ways animals can survive without access to fresh water sources?2.What other factors besides water could contribute to the thriving(茁壮成长)of a herd of goats on an isolated island? 展开更多
关键词 isolated island thriving factors SURVIVAL fresh water herd goats THINK
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Sero-Prevalence of Peste des Petits Ruminants Virus Antibodies in Sudanese Sheep and Goats before and after Vaccination
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作者 Omer Algezoli Selma Kamal +8 位作者 Yazeed Raouf Alamin Mozdalifa Hiba Ali Mohamed Aljameel Salih Sir Elkhatim Sulieman Ahmed Ibtesam Fadul Elsied Tageldin Nour Mohamed Abdalla 《Journal of Biosciences and Medicines》 2025年第1期21-40,共20页
Peste des petits ruminants virus (PPRV) antibodies were studied in Sudanese sheep and goats (n = 855) before and after vaccination with a locally produced Nigeria 75/1 vaccine using a commercial competitive ELISA (cEL... Peste des petits ruminants virus (PPRV) antibodies were studied in Sudanese sheep and goats (n = 855) before and after vaccination with a locally produced Nigeria 75/1 vaccine using a commercial competitive ELISA (cELISA) kit. Animals were kept healthy under field conditions, in four states: Blue Nile (n = 250), North Kordofan (n = 189), South Darfur (n = 225) and the Northern State (n = 191). Before vaccination, the overall sero-prevalence of PPRV antibodies was 54.6% (53.2% - 56%, 95% CI);high (64.8% - 76.4%, 95% CI) in Blue Nile State, medium (50.5% - 61.9%, 95% CI) in North Kordofan State and South Darfur State and low (28.6% - 35.2% 95%, CI) in Northern State. In high-risk areas (high sero-prevalence), Blue Nile (70.4%) and North Kordofan (57.7%), middle age groups (7 - 12 and 13 - 18 months) were identified as high-risk age. Middle age groups showed lower sero-prevalence than preceding (3 - 6 months) and subsequent (>18 months) age groups while the risk of exposure increased with age. Current and previous findings suggested a transmission pathway of PPRV involving the South Eastern border (Blue Nile) and neighbouring Central Sudan to North Kordofan. One month after vaccination 88.4% (343/388) of sero-negative animals were sero-converted suggesting the efficacy of the locally produced Nigeria 75/1 vaccine. Even if only individuals in the high-risk age group (7 - 18 months) were vaccinated, the overall population immunity (OPI) in high-risk areas (the Blue Nile and North Kordofan) would have surpassed the threshold of 70%, which is indicated for blocking PPRV transmission. However, lower vaccination coverage is expected in wider vaccination programmes. These findings primarily justified the targeting of PPR control in Sudan through the vaccination of high-risk age groups in high-risk areas. 展开更多
关键词 Peste des Petits Ruminants (PPR) Vaccination Efficacy SEROPREVALENCE Herd Immunity High-Risk Area
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Design of a silicon charge detector readout system for beam test
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作者 Xuan Liu Dong-Yu Wang +6 位作者 Wen-Xi Peng Rui Qiao Meng-Long Wu Ming Huang Ya-Qing Liu Dong-Ya Guo Ke Gong 《Nuclear Science and Techniques》 2025年第7期53-63,共11页
The high-energy cosmic radiation detector(HERD)is a planned experimental instrument at the Chinese Space Station.The silicon charge detector(SCD),a subdetector in HERD,is used to detect cosmic-ray nuclei with a high c... The high-energy cosmic radiation detector(HERD)is a planned experimental instrument at the Chinese Space Station.The silicon charge detector(SCD),a subdetector in HERD,is used to detect cosmic-ray nuclei with a high charge resolution.In this study,we present a compact readout electronic system for the SCD that is designed for the HERD heavy-ion beam test.It comprises front-end readout electronics with 200 input channels as well as data acquisition and data management electronics.The test results showed that the SCD readout system had low noise with a silicon-strip detector connected.The dynamic range could be extended from 200 to 1200 fC,and the cosmic-ray test was performed as expected. 展开更多
关键词 HERD Silicon charge detector Readout electronics
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Enhancing User Experience in AI-Powered Human-Computer Communication with Vocal Emotions Identification Using a Novel Deep Learning Method
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作者 Ahmed Alhussen Arshiya Sajid Ansari Mohammad Sajid Mohammadi 《Computers, Materials & Continua》 2025年第2期2909-2929,共21页
Voice, motion, and mimicry are naturalistic control modalities that have replaced text or display-driven control in human-computer communication (HCC). Specifically, the vocals contain a lot of knowledge, revealing de... Voice, motion, and mimicry are naturalistic control modalities that have replaced text or display-driven control in human-computer communication (HCC). Specifically, the vocals contain a lot of knowledge, revealing details about the speaker’s goals and desires, as well as their internal condition. Certain vocal characteristics reveal the speaker’s mood, intention, and motivation, while word study assists the speaker’s demand to be understood. Voice emotion recognition has become an essential component of modern HCC networks. Integrating findings from the various disciplines involved in identifying vocal emotions is also challenging. Many sound analysis techniques were developed in the past. Learning about the development of artificial intelligence (AI), and especially Deep Learning (DL) technology, research incorporating real data is becoming increasingly common these days. Thus, this research presents a novel selfish herd optimization-tuned long/short-term memory (SHO-LSTM) strategy to identify vocal emotions in human communication. The RAVDESS public dataset is used to train the suggested SHO-LSTM technique. Mel-frequency cepstral coefficient (MFCC) and wiener filter (WF) techniques are used, respectively, to remove noise and extract features from the data. LSTM and SHO are applied to the extracted data to optimize the LSTM network’s parameters for effective emotion recognition. Python Software was used to execute our proposed framework. In the finding assessment phase, Numerous metrics are used to evaluate the proposed model’s detection capability, Such as F1-score (95%), precision (95%), recall (96%), and accuracy (97%). The suggested approach is tested on a Python platform, and the SHO-LSTM’s outcomes are contrasted with those of other previously conducted research. Based on comparative assessments, our suggested approach outperforms the current approaches in vocal emotion recognition. 展开更多
关键词 Human-computer communication(HCC) vocal emotions live vocal artificial intelligence(AI) deep learning(DL) selfish herd optimization-tuned long/short K term memory(SHO-LSTM)
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黄冈市某奶牛场DHI技术应用情况报告 被引量:1
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作者 李晓锋 熊海谦 +4 位作者 李文功 毛丹 熊琪 索效军 陈明新 《湖北农业科学》 北大核心 2013年第24期6092-6094,6098,共4页
通过湖北省黄冈市某奶牛场一年的DHI(Dairy herd improvement)测定结果,对生产和管理中存在的问题进行分析,以便更好地应用这一技术。结果表明,头胎牛占参测牛群的64%,产奶量及乳脂率的全年波动较大,平均SCC、产犊间隔和产奶时间分别为6... 通过湖北省黄冈市某奶牛场一年的DHI(Dairy herd improvement)测定结果,对生产和管理中存在的问题进行分析,以便更好地应用这一技术。结果表明,头胎牛占参测牛群的64%,产奶量及乳脂率的全年波动较大,平均SCC、产犊间隔和产奶时间分别为64万个、459 d和316 d,全年综合奶损失量772 t。热应激等问题是制约该奶牛场生产发展的瓶颈。 展开更多
关键词 DHI(Dairy HERD improvement) 长江中游 应用 黄冈市
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相互作用herding模型的非线性行为和动力学特性 被引量:2
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作者 董林荣 《浙江大学学报(理学版)》 CAS CSCD 北大核心 2006年第5期521-524,共4页
相互作用herding模型定性上能很好地呈现一些真实的经济规律,但定量上与真实的市场还有一定的距离,特别是收益绝对值的自关联衰退得太快.通过数值模拟研究发现该模型在它的参数取某些特定值时具有特有的非线性行为和动力学特性.此时,它... 相互作用herding模型定性上能很好地呈现一些真实的经济规律,但定量上与真实的市场还有一定的距离,特别是收益绝对值的自关联衰退得太快.通过数值模拟研究发现该模型在它的参数取某些特定值时具有特有的非线性行为和动力学特性.此时,它不仅重现该模型原有的动力学特性,并能展现出更接近真实的市场规律,其中收益绝对值表现出长程关联,呈现出幂指数分布,它的幂明显变小,落在真实的市场规律范围内. 展开更多
关键词 金融物理 相互作用herding模型 高阶 非线性行为
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基于HErD分布的信号交叉口车辆到达规律动态预测
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作者 蒋阳升 韩世凡 +1 位作者 张改 胡路 《石家庄铁道大学学报(自然科学版)》 2015年第3期105-110,共6页
为掌握信号交叉口实时优化信号控制和交通诱导所需的车流到达信号交叉口的随机时变规律,利用HErD分布具有无限逼近任意非负随机变量的特性,提出基于HErD分布的信号交叉口车辆到达时间间隔变化规律动态预测的方法,并以一个交叉口的2... 为掌握信号交叉口实时优化信号控制和交通诱导所需的车流到达信号交叉口的随机时变规律,利用HErD分布具有无限逼近任意非负随机变量的特性,提出基于HErD分布的信号交叉口车辆到达时间间隔变化规律动态预测的方法,并以一个交叉口的2个进口道进行实例验证分析。实验结果为:其中方向一的拟合度范围为86.17%~93.51%,平均拟合度高达90.32%,方向二的拟合度范围为93.24%~98.52%,平均拟合度高达96.93%,其高精度的拟合结果表明基于HErD分布的信号交叉口车辆到达规律动态预测具有科学性和实用性。 展开更多
关键词 信号交叉口 车辆到达规律 混和爱尔朗HErD分布 动态预测
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一个具有双重反馈作用的异类经纪人herding模型
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作者 董林荣 《浙江大学学报(理学版)》 CAS CSCD 北大核心 2010年第1期46-50,共5页
一个具有双重反馈作用的异类经纪人herding模型被提出.该模型认为,金融市场是由不同大小和行为倾向的经纪人集团组成.当两个不同行为倾向的经纪人集团相遇时,他们有可能发生一次交易;当两个同种行为倾向的经纪人集团相遇时,他们可能合... 一个具有双重反馈作用的异类经纪人herding模型被提出.该模型认为,金融市场是由不同大小和行为倾向的经纪人集团组成.当两个不同行为倾向的经纪人集团相遇时,他们有可能发生一次交易;当两个同种行为倾向的经纪人集团相遇时,他们可能合并成一个更大的经纪人集团.交易或合并的成功率跟市场上一次波动程度有关.当两个经纪人集团发生一次交易后,处于亏损方的经纪人集团有可能分化和翻转,分化和翻转的概率取决于经纪人集团的亏损程度和市场信念等因素.数值计算表明,该模型能较好地反映市场的经济行为和动力学特性. 展开更多
关键词 双重反馈 异类经纪人 herding模型 分化 翻转
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信念调节着市场的演化
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作者 董林荣 《中国软科学》 CSSCI 北大核心 2010年第4期164-168,共5页
本文提出了一个带有双重反馈作用的异质herding模型,该模型假设金融市场是由不同大小和意愿的经纪人集团组成,两个不同集团发生交易或合并的成功率依赖上一次交易的市场波动程度,交易后亏损方发生翻转和分化的概率跟亏损程度有关。我们... 本文提出了一个带有双重反馈作用的异质herding模型,该模型假设金融市场是由不同大小和意愿的经纪人集团组成,两个不同集团发生交易或合并的成功率依赖上一次交易的市场波动程度,交易后亏损方发生翻转和分化的概率跟亏损程度有关。我们认为翻转和分化的概率也跟经纪人集团对市场的信念有关。为此,我们给经纪人集团一个参数k去表示他们对市场的信念程度。数值计算表明在我们的模型中动力学行为明显随k变化而变化,即信念能调节市场的演化。 展开更多
关键词 双重反馈 信念度 herding模型 分化 翻转
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Histopathological and molecular study of Neospora caninum infection in bovine aborted fetuses
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作者 Amir Kamali Hesam Adin Seifi +2 位作者 Ahmad Reza Movassaghi Gholam Reza Razmi Zahra Naseri 《Asian Pacific Journal of Tropical Biomedicine》 SCIE CAS 2014年第12期990-994,共5页
Objective:To estimate the extent to which abortion in dairy cows was associated with of Neospom caninum(N.caninum) and to determine the risk factors of neosporosis in dairy farms from 9 provinces in Iran.Methods:Polym... Objective:To estimate the extent to which abortion in dairy cows was associated with of Neospom caninum(N.caninum) and to determine the risk factors of neosporosis in dairy farms from 9 provinces in Iran.Methods:Polymerase chain reaction(PCR) test was used to detect Neospora infection in the brain of 395 bovine aborted fetuses from 9 provinces of Iran.In addition,the brains of aborted fetuses were taken for histopathological examination.To identify the risk factors associated with neosporosis,data analysis was performed by SAS.Results:N.caninum was detected in 179(45%) out of 395 fetal brain samples of bovine aborted fetuses using PCR.Among the PCR-positive brain samples,only 56 samples were suited for histopathological examination.The characteristic lesions of Neospora infection including non-suppurative encephalitis were found in 16(28%) of PCR-positive samples.The risk factors including season,parity of dam,history of bovine virus diarrhea and infectious bovine rhinotracheitis infection in herd,cow's milk production,herd size and fetal appearance did not show association with the infection.This study showed that Neospora caused abortion was significantly more in the second trimester of pregnancy than other periods.In addition,a significant association was observed between Neospora infection and stillbirth.Conclusions:The results showed N.caninum infection was detected in high percentage of aborted fetuses.In addition,at least one fourth of abortions caused by Neospora infection.These results indicate increasing number of abortions associated with the protozoa more than reported before in Iran. 展开更多
关键词 Neospora caninum Dairy herds ABORTION PCR HISTOPATHOLOGY Risk factors
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Prospective Alternatives of Antibiotics in Animal Diet
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作者 SHANAn-shan SHIBao-ming 《Journal of Northeast Agricultural University(English Edition)》 CAS 2000年第1期58-70,共13页
Antibiotics have been used in animal feeding for long history.In recent years,much attention has been received for their negative effects on animal and human being as well.Technology has been focused on alternatives o... Antibiotics have been used in animal feeding for long history.In recent years,much attention has been received for their negative effects on animal and human being as well.Technology has been focused on alternatives of antibotics,such as probiotics,oligosaccharides,acidifiers,Chinese herds,chemical drugs,and other environmental measures.Their mechanism,effects,related factors and their prospect in the future were discussed in this paper. 展开更多
关键词 ANTIBIOTICS PROBIOTICS OLIGOSACCHARIDES acidifiers Chinese herds organic arsenic acids
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链接变量循环的Hash函数结构
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作者 任姣霞 王尚平 +1 位作者 张亚玲 韩照国 《计算机工程与应用》 CSCD 北大核心 2011年第20期53-55,61,共4页
现有的Hash函数基本上都是根据Merkle-Damg°ard结构设计的。基于Merkle-Damg°ard结构易受到长度扩展攻击、多碰撞攻击、Herding攻击等这些缺陷,设计了一种链接变量循环的Hash结构,该结构是基于宽管道Hash结构的,具有大的内部... 现有的Hash函数基本上都是根据Merkle-Damg°ard结构设计的。基于Merkle-Damg°ard结构易受到长度扩展攻击、多碰撞攻击、Herding攻击等这些缺陷,设计了一种链接变量循环的Hash结构,该结构是基于宽管道Hash结构的,具有大的内部状态,可以有效抵抗上述针对Merkle-Damg°ard结构的攻击。结构具有可分析的安全性,可以提高Hash函数的性能,尤其是基于数学困难问题的Hash算法,增加了消息块对Hash值的作用。 展开更多
关键词 HASH函数 Merkle-Damg°ard结构 链接变量 多碰撞攻击 Herding攻击
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Network correlation between investor’s herding behavior and overconfidence behavior 被引量:2
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作者 Mao Zhang Yi-Ming Wang 《Chinese Physics B》 SCIE EI CAS CSCD 2020年第4期571-581,共11页
It is generally accepted that herding behavior and overconfidence behavior are unrelated or even mutually exclusive.However,these behaviors can both lead to some similar market anomalies,such as excessive trading volu... It is generally accepted that herding behavior and overconfidence behavior are unrelated or even mutually exclusive.However,these behaviors can both lead to some similar market anomalies,such as excessive trading volume and volatility in the stock market.Due to the limitation of traditional time series analysis,we try to study whether there exists network relevance between the investor’s herding behavior and overconfidence behavior based on the complex network method.Since the investor’s herding behavior is based on market trends and overconfidence behavior is based on past performance,we convert the time series data of market trends into a market network and the time series data of the investor’s past judgments into an investor network.Then,we update these networks as new information arrives at the market and show the weighted in-degrees of the nodes in the market network and the investor network can represent the herding degree and the confidence degree of the investor,respectively.Using stock transaction data of Microsoft,US S&P 500 stock index,and China Hushen 300 stock index,we update the two networks and find that there exists a high similarity of network topological properties and a significant correlation of node parameter sequences between the market network and the investor network.Finally,we theoretically derive and conclude that the investor’s herding degree and confidence degree are highly related to each other when there is a clear market trend. 展开更多
关键词 complex NETWORK time series HERDING BEHAVIOR OVERCONFIDENCE BEHAVIOR
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Study of Digital Management System of Milking Process on Large-Sized Dairy Farm 被引量:3
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作者 XIONG Ben-hai LUO Qing-yao Lǔ Jian-qiang YANG Liang 《Agricultural Sciences in China》 CAS CSCD 2008年第8期1022-1028,共7页
This study was to supply the systemic and full milking process data to support the implementation of both dairy herd improvement (DHI) and digital feeding of dairy cattle. This study designed the relational structur... This study was to supply the systemic and full milking process data to support the implementation of both dairy herd improvement (DHI) and digital feeding of dairy cattle. This study designed the relational structured database and developed a set of digital management information system on milking process of intensive dairy farm using Visual Basic 6.0, Access databases, and Crystal report combining the milking characteristics of a grown cow, such as quality and sanitation testing indexes of raw milk. The system supplies a series of convenient, intelligent input interfaces of crude datum, and can count, analyze, and graphically show milking datum based on different types and different parities of cows or herds in a specific duration, and can dynamically produce some important derived data, such as days of grown cow, daily average of milk production of grown cow, days of cow milk production, and daily average of milking cow production; and can carry out all-pervasive data mining. With the help of system analysis and software design techniques, it is possible to realize precision farming for a dairy cattle herd based on whole digital management of milking process and realtime prediction on nutrient requirements and ration of dairy cattle, as well as dairy herd improvement. 展开更多
关键词 dairy farm dairy herd improvement (DHI) grown cow MILKING digital management
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Artificial Intelligence Based Prostate Cancer Classification Model Using Biomedical Images 被引量:2
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作者 Areej A.Malibari Reem Alshahrani +3 位作者 Fahd N.Al-Wesabi Siwar Ben Haj Hassine Mimouna Abdullah Alkhonaini Anwer Mustafa Hilal 《Computers, Materials & Continua》 SCIE EI 2022年第8期3799-3813,共15页
Medical image processing becomes a hot research topic in healthcare sector for effective decision making and diagnoses of diseases.Magnetic resonance imaging(MRI)is a widely utilized tool for the classification and de... Medical image processing becomes a hot research topic in healthcare sector for effective decision making and diagnoses of diseases.Magnetic resonance imaging(MRI)is a widely utilized tool for the classification and detection of prostate cancer.Since the manual screening process of prostate cancer is difficult,automated diagnostic methods become essential.This study develops a novel Deep Learning based Prostate Cancer Classification(DTL-PSCC)model using MRI images.The presented DTL-PSCC technique encompasses EfficientNet based feature extractor for the generation of a set of feature vectors.In addition,the fuzzy k-nearest neighbour(FKNN)model is utilized for classification process where the class labels are allotted to the input MRI images.Moreover,the membership value of the FKNN model can be optimally tuned by the use of krill herd algorithm(KHA)which results in improved classification performance.In order to demonstrate the good classification outcome of the DTL-PSCC technique,a wide range of simulations take place on benchmark MRI datasets.The extensive comparative results ensured the betterment of the DTL-PSCC technique over the recent methods with the maximum accuracy of 85.09%. 展开更多
关键词 MRI images prostate cancer deep learning medical image processing metaheuristics krill herd algorithm
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Hybrid Krill Herd Algorithm with Vortex Search for Global Numerical Optimization 被引量:2
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作者 YANG Jian WAN Zhongping PENG Zhenhua 《Wuhan University Journal of Natural Sciences》 CAS CSCD 2020年第2期109-117,共9页
In order to solve the problem that the krill herd(KH)algorithm is premature due to the decrease of population diversity,a new hybrid vortex search KH(VSKH)algorithm has been developed to deal with the global optimizat... In order to solve the problem that the krill herd(KH)algorithm is premature due to the decrease of population diversity,a new hybrid vortex search KH(VSKH)algorithm has been developed to deal with the global optimization problem.The improvement is that a new hybrid vortex search(HVS)operator is added into the updating process of the krill for the purpose of dealing with optimization problems more efficiently.Using 20 benchmark functions for comparison experiments,the results show that the VSKH algorithm has higher accuracy. 展开更多
关键词 krill herd algorithm global optimization problem hybrid vortex search operator(HVS)
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Herding behavior in Ramadan and financial crises: the case of the Pakistani stock market 被引量:2
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作者 Imran Yousaf Shoaib Ali Syed Zulfiqar Ali Shah 《Financial Innovation》 2018年第1期242-255,共14页
This study examines herding behavior in the Pakistani Stock Market under different market conditions,focusing on the Ramadan effect and Crisis period by using data from 2004 to 2014.Two regression models of Christie a... This study examines herding behavior in the Pakistani Stock Market under different market conditions,focusing on the Ramadan effect and Crisis period by using data from 2004 to 2014.Two regression models of Christie and Huang(Financ Analysts J 51:31-37,1995)and Chang et al.,(J Bank Finance 24:1651-1679,2000)are used for herding estimations.Results based on daily stock data reveal that there is an absence of herding behavior during rising(up)and falling(down)market as well as during high and low volatility in market.While herding behavior is detected during low trading volume days.Yearly analysis shows that herding existed during 2005,2006 and 2007,while it is not evident during rest of the period.However,herding behavior is not detected during Ramadan.Furthermore,during financial crisis of 2007-08,Pakistani Stock Market exhibits herding behavior due to higher uncertainty and information asymmetry. 展开更多
关键词 Herding behavior Financial crisis Ramadan effect Stock markets
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Viral evolution and transmission effectiveness 被引量:2
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作者 Patsarin Rodpothong Prasert Auewarakul 《World Journal of Virology》 2012年第5期131-134,共4页
Different viruses transmit among hosts with different degrees of efficiency. A basic reproductive number(R0) indicates an average number of cases getting infected from a single infected case. R0 can vary widely from a... Different viruses transmit among hosts with different degrees of efficiency. A basic reproductive number(R0) indicates an average number of cases getting infected from a single infected case. R0 can vary widely from a little over 1 to more than 10. Low R0 is usually found among rapidly evolving viruses that are often under a strong positive selection pressure, while high R0 is often found among viruses that are highly stable. The reason for the difference between antigenically diverse viruses with low R0, such as influenza A virus, and antigenically stable viruses with high R0, such as measles virus, is not clear and has been a subject of great interest. Optimization of transmissibility fitness considering intra-host dynamics and inter-host transmissibility was shown to result in strategies for tradeoff between transmissibility and diversity. The nature of transmission, targeting either a na?ve children population or an adult population with partial immunity, has been proposed as a contributing factor for the difference in the strategies used by the two groups of viruses. The R0 determines the levels of threshold heard immunity. Lower R0 requires lowerherd immunity to terminate an outbreak. Therefore, it can be assumed that the outbreak saturation can be reached more readily when the R0 is low. In addition, one may assume that when the outbreak saturation is reached, herd immunity may provide a strong positive selection pressure that could possibly result in an occurrence of escape mutants. Studies of these hypotheses will give us an important insight into viral evolution. This review discusses the above hypotheses as well as some possible mechanistic explanation for the difference in transmission efficiency of 展开更多
关键词 Basic REPRODUCTIVE number Transmission VIRAL infection Antigenic diversity HERD IMMUNITY Selective pressure INFLUENZA MEASLES
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