In this paper we present two strategies of AUV (Autonomous Underwater Vehicle) region detection and an approach to decompose the detection region according to the direction of the ocean current. In the task of local d...In this paper we present two strategies of AUV (Autonomous Underwater Vehicle) region detection and an approach to decompose the detection region according to the direction of the ocean current. In the task of local detection and identification, the algorithm against the ocean current was proposed. In the tasks of closing obstacle, going back or moving, the fuzzy logic theory was used to solve the effect of ocean current. In one of our strategies the concept of weighted journey based on the angle between heading and ocean current is suggested and the TSP's exact optimal result is utilized to solve the global path planning. Simulations demonstrate the feasibility of this approach.展开更多
Mitotane,an orphan drug with narrow therapeutic window and significant interindividual variability for treating adrenocortical carcinoma,requires therapeutic drug monitoring[1].Current detection methods fail to accura...Mitotane,an orphan drug with narrow therapeutic window and significant interindividual variability for treating adrenocortical carcinoma,requires therapeutic drug monitoring[1].Current detection methods fail to accurately measure plasma drug concentrations after a high-fat meal,and the reasons behind the significant pharmacokinetic variability among individuals remain unclear,complicating individualized treatment[2,3].During our therapeutic drug monitoring process,we found that hyperlipidemic patients are more likely to reach the target drug concentration and experience concurrent neurotoxicity.展开更多
The effect from the interaction of the alternating current(AC)magnetic field with kilogram-level test mass(TM)limits the detectivity of the TianQin space-based gravitational wave detection.The quantifed effect require...The effect from the interaction of the alternating current(AC)magnetic field with kilogram-level test mass(TM)limits the detectivity of the TianQin space-based gravitational wave detection.The quantifed effect requires the determination of the AC magnetic susceptibilityχ(f)of the TM.A torque method is proposed to measure theχ(f)of kg-level samples at the mHz band with a precision of 1×10^(-7).Combined with our previous work[Phys.Rev.Appl.18044010(2022)],the general frequency-dependent susceptibility of the alloy cube with side length L and electrical conductivityσis determined asχ(f)=χ0+(0.24±0.01)σμ0L^(2)f from 0.1 mHz to 1 Hz.The determination is helpful for the preliminary estimation of the in-band eddy current efect in the TianQin noise budget.The technique can be adopted to accurately measureχ(f)of the actual TM in other precision experiments,where the magnetic noise is a signifcant detection limit.展开更多
基金Supported by the Research Fund for the Doctoral Program of Higher Education from the Ministry of Education
文摘In this paper we present two strategies of AUV (Autonomous Underwater Vehicle) region detection and an approach to decompose the detection region according to the direction of the ocean current. In the task of local detection and identification, the algorithm against the ocean current was proposed. In the tasks of closing obstacle, going back or moving, the fuzzy logic theory was used to solve the effect of ocean current. In one of our strategies the concept of weighted journey based on the angle between heading and ocean current is suggested and the TSP's exact optimal result is utilized to solve the global path planning. Simulations demonstrate the feasibility of this approach.
基金supported by 1·3·5 Project for Disciplines of ExcellenceeClinical Research Fund,West China Hospital,Sichuan University,China(Grant No.:23HXFH027)Foundation of Development and Related Diseases of Women and Children Key Laboratory of Sichuan Province,China(Grant No.:FYYFEJB2024002)The Key Research and Development Program of Sichuan Province,China(Grant No.:2024YFFK0334).
文摘Mitotane,an orphan drug with narrow therapeutic window and significant interindividual variability for treating adrenocortical carcinoma,requires therapeutic drug monitoring[1].Current detection methods fail to accurately measure plasma drug concentrations after a high-fat meal,and the reasons behind the significant pharmacokinetic variability among individuals remain unclear,complicating individualized treatment[2,3].During our therapeutic drug monitoring process,we found that hyperlipidemic patients are more likely to reach the target drug concentration and experience concurrent neurotoxicity.
基金supported by the National Key R&D Program of China(Grant No.2020YFC2200500)the Key Laboratory of Tian Qin Project(Sun Yat-sen University),Ministry of Education+1 种基金the National Natural Science Foundation of China(Grant Nos.12075325,12005308,and 11605065)the Doctoral Research Foundation Project of Hubei University of Arts and Science(Grant No.kyqdf2059017)。
文摘The effect from the interaction of the alternating current(AC)magnetic field with kilogram-level test mass(TM)limits the detectivity of the TianQin space-based gravitational wave detection.The quantifed effect requires the determination of the AC magnetic susceptibilityχ(f)of the TM.A torque method is proposed to measure theχ(f)of kg-level samples at the mHz band with a precision of 1×10^(-7).Combined with our previous work[Phys.Rev.Appl.18044010(2022)],the general frequency-dependent susceptibility of the alloy cube with side length L and electrical conductivityσis determined asχ(f)=χ0+(0.24±0.01)σμ0L^(2)f from 0.1 mHz to 1 Hz.The determination is helpful for the preliminary estimation of the in-band eddy current efect in the TianQin noise budget.The technique can be adopted to accurately measureχ(f)of the actual TM in other precision experiments,where the magnetic noise is a signifcant detection limit.
