Rapamycin, similar to FKS06, can promote neural regeneration in vitro. We assumed that the mechanisms of action of rapamycin and FK506 in promoting peripheral nerve regeneration were similar. This study compared the e...Rapamycin, similar to FKS06, can promote neural regeneration in vitro. We assumed that the mechanisms of action of rapamycin and FK506 in promoting peripheral nerve regeneration were similar. This study compared the effects of different concentrations of raparnycin and FK506 on Sc hwann cells and investigated effects and mechanisms of rapamycin on improving peripheral nerve regeneration. Results demonstrated that the lowest rapamycin concentration （1.53 nmol/L） more significantly promoted Schwann cell migration than the highest FK506 concentration （100μmol/L）. Rapamycin promoted the secretion of nerve growth factors and upregulated growth-associated protein 43 expression in Schwann cells, but did not significantly affect Schwann cell proliferation. Therefore, rapamycin has potential application in peripheral nerve regeneration therapy.展开更多
城市信息模型(city information model,CIM)的提出促进了GIS与建筑信息模型(building information modeling,BIM)的深度融合。本文基于工程建设项目全生命周期的数据共享需求,设计了BIM-CIM跨平台协同建模流程与数据模型;提出了面向建...城市信息模型(city information model,CIM)的提出促进了GIS与建筑信息模型(building information modeling,BIM)的深度融合。本文基于工程建设项目全生命周期的数据共享需求,设计了BIM-CIM跨平台协同建模流程与数据模型;提出了面向建筑工程建模的辅助设计及成果数据跨平台转换算法;基于BIM中台与信息本体技术实现了跨平台语义融合与属性同步。通过在深圳市全市域时空信息平台和PKPM-BIM设计平台上的应用验证,本文方法实现了BIM、CIM数据在跨平台高效融合与双向流转,有助于提升城市建设项目全生命周期管理效率。展开更多
基金supported by the Major State Basic Research Development Program of China(973 Program),No.2011CB606205the National Natural Science Foundation of China,No.51172171 and 51103112+2 种基金the Key Project of Chinese Ministry of Education,No.313041the Natural Science Foundation of Hubei Province,No.2013CFB354the Fundamental Research Funds for the Central Universities,No.WUT:2013-IV-099
文摘Rapamycin, similar to FKS06, can promote neural regeneration in vitro. We assumed that the mechanisms of action of rapamycin and FK506 in promoting peripheral nerve regeneration were similar. This study compared the effects of different concentrations of raparnycin and FK506 on Sc hwann cells and investigated effects and mechanisms of rapamycin on improving peripheral nerve regeneration. Results demonstrated that the lowest rapamycin concentration （1.53 nmol/L） more significantly promoted Schwann cell migration than the highest FK506 concentration （100μmol/L）. Rapamycin promoted the secretion of nerve growth factors and upregulated growth-associated protein 43 expression in Schwann cells, but did not significantly affect Schwann cell proliferation. Therefore, rapamycin has potential application in peripheral nerve regeneration therapy.
文摘城市信息模型(city information model,CIM)的提出促进了GIS与建筑信息模型(building information modeling,BIM)的深度融合。本文基于工程建设项目全生命周期的数据共享需求,设计了BIM-CIM跨平台协同建模流程与数据模型;提出了面向建筑工程建模的辅助设计及成果数据跨平台转换算法;基于BIM中台与信息本体技术实现了跨平台语义融合与属性同步。通过在深圳市全市域时空信息平台和PKPM-BIM设计平台上的应用验证,本文方法实现了BIM、CIM数据在跨平台高效融合与双向流转,有助于提升城市建设项目全生命周期管理效率。
