The valorization of vegetable by-products is a promising strategy to combat climate change and achieve global carbon neutrality goals.This study aimed to exploit the high-value utilization of garlic by-products and to...The valorization of vegetable by-products is a promising strategy to combat climate change and achieve global carbon neutrality goals.This study aimed to exploit the high-value utilization of garlic by-products and to investigate the antihypertensive effects and potential mechanisms of the resulting angiotensin I-converting enzyme(ACE)inhibitory peptides.After protein extraction,enzymatic hydrolysis,and activity-directed fractionation,a potent and highly stable ACE inhibitory peptide(IC_(50):31.38μmol/L)was obtained,which was identified as VWAS and acted as a competitive inhibitor.VWAS stably bound to key residues in the ACE active center mainly through hydrogen bonding interactions and effectively lowered blood pressure in spontaneously hypertensive rats via alleviating renal and cardiac injuries,improving endothelial dysfunction,and regulating the renal renin-angiotensin system,antioxidant system,and anti-inflammatory system.These findings suggested that garlic protein-derived peptide(VWAS)was a desirable candidate for antihypertensive functional foods and provided guidance for the high-value utilization of garlic by-products.展开更多
Through in-depth analysis of recent domestic research,this review elaborates on the mechanisms of garlic polysaccharides in regulating poultry gut microbiota balance,strengthening intestinal barrier function,and enhan...Through in-depth analysis of recent domestic research,this review elaborates on the mechanisms of garlic polysaccharides in regulating poultry gut microbiota balance,strengthening intestinal barrier function,and enhancing intestinal immunity.It also discusses their practical application effects in poultry farming,existing problems,and future research directions,aiming to provide comprehensive and in-depth theoretical support for promoting the widespread application of garlic polysaccharides in healthy poultry farming.展开更多
Background:Understanding the relationship between garlic and chronic diseases could help to improve prevention and reduce the burden of diseases.This study aimed to examine the association between garlic consumption a...Background:Understanding the relationship between garlic and chronic diseases could help to improve prevention and reduce the burden of diseases.This study aimed to examine the association between garlic consumption and the risk of chronic diseases.Methods:We included 26,524 participants from the Chinese Longitudinal Healthy Longevity Survey(CLHLS)with data of the frequency of garlic consumption,7658 participants from the Xinjiang multiethnic cohort(XMC)study with data of garlic intake,and 141,684 participants from the UK Biobank(UKBB)with data of the preference for garlic.The dietary pattern of garlic,including the frequency of consuming garlic,garlic intake,and garlic preference information,was collected using a food questionnaire for each cohort.Logistic regression and structural equation modeling were used to assess the effect of garlic consumption on five common chronic diseases,which comprised cancer,diabetes,hypertension,respiratory diseases,and cardiovascular disease(CVD).Results:In the CLHLS cohort,individuals who consumed garlic almost every day had a significantly lower risk of five of the most common chronic diseases(cancer:odds ratio[OR]=0.51,95%confidence interval[CI]=0.30-0.81,p=0.006;diabetes:OR=0.58,95%CI=0.43-0.76,p<0.001;hypertension:OR=0.68,95%CI=0.61-0.77,p<0.001;respiratory diseases:OR=0.77,95%CI=0.67-0.87,p<0.001;and CVD:OR=0.69,95%CI=0.59-0.80,p<0.001).Similarly,in the XMC,there was a consistent protective effect of high garlic intake on hypertension,respiratory diseases and CVD.Additionally,in the UKBB cohort,individuals who liked garlic had a decreased risk of diabetes and CVD.Notably,in three cohorts,structural equation modeling results showed that there was a significant protective total effect of garlic consumption on the five common chronic diseases.展开更多
A Se—containing polysaccharide(Se-GPS),with average molecular weight of 1.5×10~4 was isolated from Hubei Enshi garlic(Allium sativum L.)and purified by means of Sephadex G25 to G200 chromatographies.Its chemical...A Se—containing polysaccharide(Se-GPS),with average molecular weight of 1.5×10~4 was isolated from Hubei Enshi garlic(Allium sativum L.)and purified by means of Sephadex G25 to G200 chromatographies.Its chemical homogeneity and composition were studied by optical rotation,HPLC and paper chromatographical methods.The abilities of scavenging active oxygen free radicals and inhibiting the damage of erythrocyte membrane by SiO_2 were established by spin trapping ESR studies.Se-GPS was shown to inhibit human cytomegalovirus by plague reduction assays and cytopathogenic effect tests.展开更多
[Objectives] This paper aims to explore the possibility to intercrop garlic with pomegranate tree to control pomegranate wilt.[Methods] Root exudates of garlic is cultivated in 1/5 concentration of MS solution and dis...[Objectives] This paper aims to explore the possibility to intercrop garlic with pomegranate tree to control pomegranate wilt.[Methods] Root exudates of garlic is cultivated in 1/5 concentration of MS solution and distilled water is examined in lab to test their effect to growth of mycelia of pomegranate wilt pathogen（Ceratocystis fimbriata）and multiplication of Bacillus subtilis.[Results] The result shows that garlic root exudates whatever cultivated in MS solution or distilled water could not inhibit or promote mycelia growth of C.fimbriata.However,garlic root exudates cultivated in both methods effectively promote multiplication of B.subtilis.[Conclusions] It is suggested that intercropping garlic with pomegranate tree by combining application B.subtilis could be a promising way to prevent pomegranate wilt spread in practice.展开更多
[Objective] This study aimed to revealing the effects of two kinds of heavy metals including Cr6＋ and Pb2＋ on garlic germination.[Method] Root length,enzyme（SOD and CAT）activity and soluble protein content during ...[Objective] This study aimed to revealing the effects of two kinds of heavy metals including Cr6＋ and Pb2＋ on garlic germination.[Method] Root length,enzyme（SOD and CAT）activity and soluble protein content during garlic germination were determined under the stress of two kinds of heavy metals including Cr6＋ and Pb2＋.[Result] During garlic germination,there was an obvious inhibition on buds and seedlings when the concentration of heavy metals including Cr6＋ and Pb2＋ was more than 20 mg/L,while SOD and CAT had certain buffering ability to the heavy metal toxicity with low concentration.With the stress of Cr6＋ in low concentration,SOD activity increased with the increase of metal ion concentration,and then reached maximum when the treatment concentration was 50 mg/L,while CAT activity gradually increased when Cr6＋ concentration was lower than 20 mg/L.With the high concentration of Cr6＋（more than 50 mg/L）or the Pb2＋ stress,SOD and CAT activity continued to decrease with the increase of concentration of heavy metal ions.With various concentrations of heavy metal（Cr6＋ and Pb2＋）solution,soluble protein content showed the decreasing trend with time prolong,and the decreasing trend was obvious with the increase of concentration.Moreover,the tolerance of garlic on Cr6＋ toxicity was much higher than that on Pb2＋.[Conclusion] Two kinds of heavy metals including Cr6＋ and Pb2＋ have impacts on four factors mentioned above during garlic germination,and this study provides a theoretical basis for further discussion of the toxic mechanism of heavy metals on plants.展开更多
Objective To observe the effect of application of garlic paste at Shenque （神阙 CV8） on the circadian rhythm in sleep deprivation young students. Metheds Twenty healthy volunteer young male students from Southern Me...Objective To observe the effect of application of garlic paste at Shenque （神阙 CV8） on the circadian rhythm in sleep deprivation young students. Metheds Twenty healthy volunteer young male students from Southern Medical University were randomly divided into three groups： normal group （A）, sleep deprivation group （B） and treatment group （C）. Volunteers in group B and C received 48 h sleep deprivation （SD）, and in the mean time volunteers in group C were treated by garlic paste at Shenque （神阙 CV8）, while those in group A had no any treatment. The body temperature of all the volunteers was detected at 6：00 am, 12：00 am, 6：00 pm and 0：00 am, respectively, after the treatment. Results The mean body temperature values in group A and C both were highest at 6： 00 pm and lowest at 6： 00 am which had a significant difference in each group （P〈0.01）; in group B, the mean body temperature was highest at 0：00 am and lowestat 6：00 am, no significant difference was found between them （P〉0.05）. Results of cosine analysis showed that in subjects of group B the circadian rhythm of body temperature still kept going well after SD, but the peak amplitude and amplitude of vibration were higher than those of group A, and the acrophase of group B was obviously lower than that of group C and A. The 3 indexes of group C were similar to those of group A, denoting that garlic paste application of Shenque （神阙 CV8） could prevent disorders of circadian rhythm of the body temperature. Conclusion The garlic paste application at Shenque （神阙 CV8） can adjust circadian rhythm and accelerate the recovery processes of circadian rhythm in SD young students.展开更多
基金supported by the Special Fund for Leading Talent in Mount Tai Industry of Shandong Province(TSCY20200121).
文摘The valorization of vegetable by-products is a promising strategy to combat climate change and achieve global carbon neutrality goals.This study aimed to exploit the high-value utilization of garlic by-products and to investigate the antihypertensive effects and potential mechanisms of the resulting angiotensin I-converting enzyme(ACE)inhibitory peptides.After protein extraction,enzymatic hydrolysis,and activity-directed fractionation,a potent and highly stable ACE inhibitory peptide(IC_(50):31.38μmol/L)was obtained,which was identified as VWAS and acted as a competitive inhibitor.VWAS stably bound to key residues in the ACE active center mainly through hydrogen bonding interactions and effectively lowered blood pressure in spontaneously hypertensive rats via alleviating renal and cardiac injuries,improving endothelial dysfunction,and regulating the renal renin-angiotensin system,antioxidant system,and anti-inflammatory system.These findings suggested that garlic protein-derived peptide(VWAS)was a desirable candidate for antihypertensive functional foods and provided guidance for the high-value utilization of garlic by-products.
文摘Through in-depth analysis of recent domestic research,this review elaborates on the mechanisms of garlic polysaccharides in regulating poultry gut microbiota balance,strengthening intestinal barrier function,and enhancing intestinal immunity.It also discusses their practical application effects in poultry farming,existing problems,and future research directions,aiming to provide comprehensive and in-depth theoretical support for promoting the widespread application of garlic polysaccharides in healthy poultry farming.
基金supported by Natural Science Foundation of Jiangsu Province(BK20230003)Science and Technology Department of Xinjiang Uyghur Autonomous Region(2022TSYCTD0013)the National Natural Science Foundation of China(82173601).
文摘Background:Understanding the relationship between garlic and chronic diseases could help to improve prevention and reduce the burden of diseases.This study aimed to examine the association between garlic consumption and the risk of chronic diseases.Methods:We included 26,524 participants from the Chinese Longitudinal Healthy Longevity Survey(CLHLS)with data of the frequency of garlic consumption,7658 participants from the Xinjiang multiethnic cohort(XMC)study with data of garlic intake,and 141,684 participants from the UK Biobank(UKBB)with data of the preference for garlic.The dietary pattern of garlic,including the frequency of consuming garlic,garlic intake,and garlic preference information,was collected using a food questionnaire for each cohort.Logistic regression and structural equation modeling were used to assess the effect of garlic consumption on five common chronic diseases,which comprised cancer,diabetes,hypertension,respiratory diseases,and cardiovascular disease(CVD).Results:In the CLHLS cohort,individuals who consumed garlic almost every day had a significantly lower risk of five of the most common chronic diseases(cancer:odds ratio[OR]=0.51,95%confidence interval[CI]=0.30-0.81,p=0.006;diabetes:OR=0.58,95%CI=0.43-0.76,p<0.001;hypertension:OR=0.68,95%CI=0.61-0.77,p<0.001;respiratory diseases:OR=0.77,95%CI=0.67-0.87,p<0.001;and CVD:OR=0.69,95%CI=0.59-0.80,p<0.001).Similarly,in the XMC,there was a consistent protective effect of high garlic intake on hypertension,respiratory diseases and CVD.Additionally,in the UKBB cohort,individuals who liked garlic had a decreased risk of diabetes and CVD.Notably,in three cohorts,structural equation modeling results showed that there was a significant protective total effect of garlic consumption on the five common chronic diseases.
文摘A Se—containing polysaccharide(Se-GPS),with average molecular weight of 1.5×10~4 was isolated from Hubei Enshi garlic(Allium sativum L.)and purified by means of Sephadex G25 to G200 chromatographies.Its chemical homogeneity and composition were studied by optical rotation,HPLC and paper chromatographical methods.The abilities of scavenging active oxygen free radicals and inhibiting the damage of erythrocyte membrane by SiO_2 were established by spin trapping ESR studies.Se-GPS was shown to inhibit human cytomegalovirus by plague reduction assays and cytopathogenic effect tests.
基金Supported by National"973" Project(2011CB100400)~~
文摘[Objectives] This paper aims to explore the possibility to intercrop garlic with pomegranate tree to control pomegranate wilt.[Methods] Root exudates of garlic is cultivated in 1/5 concentration of MS solution and distilled water is examined in lab to test their effect to growth of mycelia of pomegranate wilt pathogen（Ceratocystis fimbriata）and multiplication of Bacillus subtilis.[Results] The result shows that garlic root exudates whatever cultivated in MS solution or distilled water could not inhibit or promote mycelia growth of C.fimbriata.However,garlic root exudates cultivated in both methods effectively promote multiplication of B.subtilis.[Conclusions] It is suggested that intercropping garlic with pomegranate tree by combining application B.subtilis could be a promising way to prevent pomegranate wilt spread in practice.
基金Supported by Key Project of Haixi Construction Served by Universities in Fujian(A101)Subject(Biology)Determined and Constructed by Master Degree-conferring Units+1 种基金A-class Scientific and Technological Project of Education Department in Fujian(JA09213)Scientific and Technological Project of Quanzhou(2010N28)~~
文摘[Objective] This study aimed to revealing the effects of two kinds of heavy metals including Cr6＋ and Pb2＋ on garlic germination.[Method] Root length,enzyme（SOD and CAT）activity and soluble protein content during garlic germination were determined under the stress of two kinds of heavy metals including Cr6＋ and Pb2＋.[Result] During garlic germination,there was an obvious inhibition on buds and seedlings when the concentration of heavy metals including Cr6＋ and Pb2＋ was more than 20 mg/L,while SOD and CAT had certain buffering ability to the heavy metal toxicity with low concentration.With the stress of Cr6＋ in low concentration,SOD activity increased with the increase of metal ion concentration,and then reached maximum when the treatment concentration was 50 mg/L,while CAT activity gradually increased when Cr6＋ concentration was lower than 20 mg/L.With the high concentration of Cr6＋（more than 50 mg/L）or the Pb2＋ stress,SOD and CAT activity continued to decrease with the increase of concentration of heavy metal ions.With various concentrations of heavy metal（Cr6＋ and Pb2＋）solution,soluble protein content showed the decreasing trend with time prolong,and the decreasing trend was obvious with the increase of concentration.Moreover,the tolerance of garlic on Cr6＋ toxicity was much higher than that on Pb2＋.[Conclusion] Two kinds of heavy metals including Cr6＋ and Pb2＋ have impacts on four factors mentioned above during garlic germination,and this study provides a theoretical basis for further discussion of the toxic mechanism of heavy metals on plants.
文摘Objective To observe the effect of application of garlic paste at Shenque （神阙 CV8） on the circadian rhythm in sleep deprivation young students. Metheds Twenty healthy volunteer young male students from Southern Medical University were randomly divided into three groups： normal group （A）, sleep deprivation group （B） and treatment group （C）. Volunteers in group B and C received 48 h sleep deprivation （SD）, and in the mean time volunteers in group C were treated by garlic paste at Shenque （神阙 CV8）, while those in group A had no any treatment. The body temperature of all the volunteers was detected at 6：00 am, 12：00 am, 6：00 pm and 0：00 am, respectively, after the treatment. Results The mean body temperature values in group A and C both were highest at 6： 00 pm and lowest at 6： 00 am which had a significant difference in each group （P〈0.01）; in group B, the mean body temperature was highest at 0：00 am and lowestat 6：00 am, no significant difference was found between them （P〉0.05）. Results of cosine analysis showed that in subjects of group B the circadian rhythm of body temperature still kept going well after SD, but the peak amplitude and amplitude of vibration were higher than those of group A, and the acrophase of group B was obviously lower than that of group C and A. The 3 indexes of group C were similar to those of group A, denoting that garlic paste application of Shenque （神阙 CV8） could prevent disorders of circadian rhythm of the body temperature. Conclusion The garlic paste application at Shenque （神阙 CV8） can adjust circadian rhythm and accelerate the recovery processes of circadian rhythm in SD young students.
