Low-level laser therapy(LLLT) may have an effect on the pain associated with orthodontic treatment. The aim of this study was to evaluate the effect of LLLT on pain and somatosensory sensitization induced by orthodont...Low-level laser therapy(LLLT) may have an effect on the pain associated with orthodontic treatment. The aim of this study was to evaluate the effect of LLLT on pain and somatosensory sensitization induced by orthodontic treatment. Forty individuals(12–33 years old; mean ± standard deviations: 20.8 ± 5.9 years) scheduled to receive orthodontic treatment were randomly divided into a laser group(LG) or a placebo group(PG)(1:1). The LG received LLLT(810-nm gallium-aluminium-arsenic diode laser in continuous mode with the power set at 400 mW, 2 J·cm–2) at 0 h, 2 h, 24 h, 4 d, and 7 d after treatment, and the PG received inactive treatment at the same time points. In both groups, the non-treated side served as a control. A numerical rating scale(NRS) of pain, pressure pain thresholds(PPTs), cold detection thresholds(CDTs), warmth detection thresholds(WDTs), cold pain thresholds(CPTs), and heat pain thresholds(HPTs) were tested on both sides at the gingiva and canine tooth and on the hand. The data were analysed by a repeated measures analysis of variance(ANOVA). The NRS pain scores were significantly lower in the LG group(P = 0.01). The CDTs,CPTs, WDTs, HPTs, and PPTs at the gingiva and the PPTs at the canine tooth were significantly less sensitive on the treatment side of the LG compared with that of the PG(P < 0.033). The parameters tested also showed significantly less sensitivity on the nontreatment side of the LG compared to that of the PG(P < 0.043). There were no differences between the groups for any quantitative sensory testing(QST) measures of the hand. The application of LLLT appears to reduce the pain and sensitivity of the tooth and gingiva associated with orthodontic treatment and may have contralateral effects within the trigeminal system but no generalized QST effects. Thus, the present study indicated a significant analgesia effect of LLLT application during orthodontic treatment.Further clinical applications are suggested.展开更多
Objective:To compare the effect of surgical intervention on functional treatment.Methods: By searching the MEDLINE(1966 to October 2011),EMBASE(1980 to October 2011),the Chinese Biomedical Database Databases(1980 to O...Objective:To compare the effect of surgical intervention on functional treatment.Methods: By searching the MEDLINE(1966 to October 2011),EMBASE(1980 to October 2011),the Chinese Biomedical Database Databases(1980 to October 2011),a total of 9 related RCT studies comparing surgical intervention with functional treatment were included in our study.RevMan software was taken to analyze the data.Results:These 9 studies Involved a total of 1 268 mostly young adults,including 580 patients with surgical treatment and 688 patients with functional treatment.The results showed the stability of ankle activity in surgical treatment group was better than that in functional treatment group,with the OR and 95%CI of 0.72(0.52-0.99).No significant difference was found in the recurrence of the surgical and functional group.However, the movement disorder in the surgical treatment suggested increased risk than that in functional group,with the OR and 95%CI of 2 39(0.98-5.85).Surgical group found more complication than the function group,such as deep vein thrombosis,deep venous thrombosis,tenderness of scar and sensory loss.Conclusions:In conclusion,our finding showed that surgical treatment could gain better efficacy than functional treatment,but may bring more complication.Therefore,further large sample size RCT is warranted.展开更多
Acupuncture at the Taichong (LR 3), Sanyinjiao (SP 6) and Ciliao (BL 32) points combined with TCM drugs for soothing the liver, replenishing the kidney, freeing the seminal passage, and eliminating the stasis showed e...Acupuncture at the Taichong (LR 3), Sanyinjiao (SP 6) and Ciliao (BL 32) points combined with TCM drugs for soothing the liver, replenishing the kidney, freeing the seminal passage, and eliminating the stasis showed effective for functional retrograde ejaculation in 25 cases. The total effective rate of 68.0% was significantly better than imipramine used in the control group (P<0.05).展开更多
Congenital cataract is a common cause of childhood low vision or blindness worldwide..Early surgery should be performed in sensitive vision development period to avoid vision deprivation in cases of strabismus and nys...Congenital cataract is a common cause of childhood low vision or blindness worldwide..Early surgery should be performed in sensitive vision development period to avoid vision deprivation in cases of strabismus and nystagmus development. Postoperative recovery of visual function is of great significance for these patients and should include proper postoperative aphakia correction by the application of a contact lens and secondary implantation of an intraocular lens(IOL). Patients should receive amblyopic training after surgery to improve their postoperative visual acuity..Although recent advances in surgery techniques and materials have brought better postoperative visual acuity and less complications, a few postoperative complications can still hamper vision condition and vision development,.including posterior capsule opacification and secondary glaucoma. Surgery in early infancy are risk factors for these two complications..Life-long follow-up is essential for these patients..Further study will continue to address the surgery timing issue and methods that prevent postoperative complications.展开更多
Traumatic spinal cord injury （SCI） causes motor paralysis, sensory anesthesia and autonomic dysfunction below the le- sion site and additionally some SCI patients refer neuropathic pain together with these signs and...Traumatic spinal cord injury （SCI） causes motor paralysis, sensory anesthesia and autonomic dysfunction below the le- sion site and additionally some SCI patients refer neuropathic pain together with these signs and symptoms. Clinical and experimental studies have revealed the main pathological changes of injured spinal cord implicated in all these signs and symptoms, including neuropathic pain. After few hours of traumatic SCI, it is usual to observe broken blood brain barrier with plasma and blood cells extravasation, cell necrosis, disruption of ascending and descending spinal cord pathways and increased potassium and glutamate. Glutamate contributes to excitotoxicity of neurons whereas potassium facilitates ectopic depolarization of survival neurons and activation of resident microglia.展开更多
Recent developments in magnetic resonance(MR) functional quantitative imaging have made it a potentially powerful tool to assess treatment response in radiation therapy. With its abilities to capture functional inform...Recent developments in magnetic resonance(MR) functional quantitative imaging have made it a potentially powerful tool to assess treatment response in radiation therapy. With its abilities to capture functional information on underlying tissue characteristics, MR functional quantitative imaging can be valuable in assessing treatment response and as such to optimize therapeutic outcome. Various MR quantitative imaging techniques, including diffusion weighted imaging, diffusion tensor imaging, MR spectroscopy and dynamic contrastenhanced imaging, have been investigated and found useful for assessment of radiotherapy. However, various aspects including data reproducibility, interpretation of biomarkers, image quality and data analysis impose challenges on applications of MR functional quantitative imaging in radiotherapy assessment. All of these challenging issues shall be addressed to help us understand whether MR functional quantitative imaging is truly beneficial and contributes to future development of radiotherapy. It is evident that individualized therapy is the future direction of patient care. MR functional quantitative imaging might serves as an indispensable tool towards this promising direction.展开更多
Purpose: To research the mechanism of neurophysiological treatment of amblyopia by observing the visual cortex activation under rotating grating stimulus with functional magnetic resonance imaging (MRI), and identify ...Purpose: To research the mechanism of neurophysiological treatment of amblyopia by observing the visual cortex activation under rotating grating stimulus with functional magnetic resonance imaging (MRI), and identify the components of the activation. Methods: Nine healthy volunteers were examined using gradient-recalled echo and echo-planar imaging (GRE-EPI) pulse sequence performed at the 1.5 Tesla MRI scanner. In the block designing, rotating grating, stationary grating and luminance were plotted as task states, stationary grating, luminance and darkness as control states, respectively. The tasks of stimuli included 6 steps. Imaging processing and statistical analysis were carried out off-line using statistical parametric mapping (SPM99) software in single-subject. Results: Some individual areas of visual cortex were activated by various stimuli information supplied by rotating grating. The strong activation in the middle of occipital lobe related to the stimuli of luminance, bilateral activation of Brodmann’s 19th area related to visual motion perception, and the mild activation in the middle of occipital lobe related to form perception. Conclusion: The plotting of control state is important in bock design. The effective visual information of rotating grating includes components of luminance, visual motion perception and form perception. Functional MRI has potential as a tool for studying the physiological mechanism of visual cortex.展开更多
目的研究基于近红外脑功能成像探讨针刺结合重复经颅磁刺激治疗卒中后非流利性失语的临床效应机制。方法选取2022年6月—2024年3月天津中医药大学第一附属医院收治的104例被诊断为脑卒中并伴有非流利性失语的患者作为研究对象,采取随机...目的研究基于近红外脑功能成像探讨针刺结合重复经颅磁刺激治疗卒中后非流利性失语的临床效应机制。方法选取2022年6月—2024年3月天津中医药大学第一附属医院收治的104例被诊断为脑卒中并伴有非流利性失语的患者作为研究对象,采取随机数字表法分为观察组和对照组,每组52例,所有患者均基于近红外脑功能成像技术进行探讨。对照组采用重复经颅磁刺激治疗,观察组采用针刺结合重复经颅磁刺激治疗。比较两组患者的临床效果、言语功能、声学水平以及失语症评分情况,并采取近红外脑功能成像技术检测其脑活动情况。结果观察组总有效率为98.00%(49/50),明显高于对照组的70.00%(35/50)(P<0.05)。治疗后,两组言语功能评分均高于治疗前,且观察组高于对照组(P<0.05)。治疗后,两组语言交流能力检查量表(Communicative abilities in daily living,CADL)、非语言认知评估量表(Non-linguistic cognitive assessment,NLCA)均高于治疗前,且观察组高于对照组(P<0.05)。治疗后,两组预运动皮质(Pre-motor cortex,PMC)、感觉运动皮质(Sensory motor cortex,SMC)、运动补充区(Supplementary motor area,SMA)均低于/高于治疗前,且观察组低于/高于对照组,差异有统计学意义(P<0.05)。结论卒中后非流利性失语患者采取针刺结合重复经颅磁刺激治疗,并予以近红外脑功能成像技术监测大脑后,可有效提升治疗效果,改善患者的语言功能,促进患者恢复,具有较高的临床应用价值。展开更多
经颅交流电刺激(transcranial alternating current stimulation,tACS)是一种非侵入性的电神经调控技术,它通过向头皮施加特定频率的周期性微电流,调节大脑特定脑区的神经振荡,从而改变个体的特定认知功能或改善临床症状。自2008年以来...经颅交流电刺激(transcranial alternating current stimulation,tACS)是一种非侵入性的电神经调控技术,它通过向头皮施加特定频率的周期性微电流,调节大脑特定脑区的神经振荡,从而改变个体的特定认知功能或改善临床症状。自2008年以来,心理学研究者们利用tACS揭示了大脑不同神经振荡频段与特定认知活动的因果性联系。我们首先介绍tACS技术调控神经振荡的作用机制,接着分别介绍tACS在改变单脑和双脑认知功能研究中的应用。未来研究需精确控制tACS施加电流与大脑自发脑电节律间的相位关系、考虑脑神经节律等方面的个体差异,实现精准的tACS神经调控,从而更好地揭示不同认知功能的神经电机制。同时需系统评估tACS在临床应用研究中的施治方案和疗效持续性,为临床治疗提供科学指导。展开更多
基金funded by the Priority Academic Program Development of Jiangsu Higher Education Institution(Grant No.2014-37)the Jiangsu Provincial Health and Family Planning Commission(No.H201535)Orofacial Pain and TMD Research Unit,Institute of Stomatology,Affiliated Hospital of Stomatology,Nanjing Medical University,for their support
文摘Low-level laser therapy(LLLT) may have an effect on the pain associated with orthodontic treatment. The aim of this study was to evaluate the effect of LLLT on pain and somatosensory sensitization induced by orthodontic treatment. Forty individuals(12–33 years old; mean ± standard deviations: 20.8 ± 5.9 years) scheduled to receive orthodontic treatment were randomly divided into a laser group(LG) or a placebo group(PG)(1:1). The LG received LLLT(810-nm gallium-aluminium-arsenic diode laser in continuous mode with the power set at 400 mW, 2 J·cm–2) at 0 h, 2 h, 24 h, 4 d, and 7 d after treatment, and the PG received inactive treatment at the same time points. In both groups, the non-treated side served as a control. A numerical rating scale(NRS) of pain, pressure pain thresholds(PPTs), cold detection thresholds(CDTs), warmth detection thresholds(WDTs), cold pain thresholds(CPTs), and heat pain thresholds(HPTs) were tested on both sides at the gingiva and canine tooth and on the hand. The data were analysed by a repeated measures analysis of variance(ANOVA). The NRS pain scores were significantly lower in the LG group(P = 0.01). The CDTs,CPTs, WDTs, HPTs, and PPTs at the gingiva and the PPTs at the canine tooth were significantly less sensitive on the treatment side of the LG compared with that of the PG(P < 0.033). The parameters tested also showed significantly less sensitivity on the nontreatment side of the LG compared to that of the PG(P < 0.043). There were no differences between the groups for any quantitative sensory testing(QST) measures of the hand. The application of LLLT appears to reduce the pain and sensitivity of the tooth and gingiva associated with orthodontic treatment and may have contralateral effects within the trigeminal system but no generalized QST effects. Thus, the present study indicated a significant analgesia effect of LLLT application during orthodontic treatment.Further clinical applications are suggested.
文摘Objective:To compare the effect of surgical intervention on functional treatment.Methods: By searching the MEDLINE(1966 to October 2011),EMBASE(1980 to October 2011),the Chinese Biomedical Database Databases(1980 to October 2011),a total of 9 related RCT studies comparing surgical intervention with functional treatment were included in our study.RevMan software was taken to analyze the data.Results:These 9 studies Involved a total of 1 268 mostly young adults,including 580 patients with surgical treatment and 688 patients with functional treatment.The results showed the stability of ankle activity in surgical treatment group was better than that in functional treatment group,with the OR and 95%CI of 0.72(0.52-0.99).No significant difference was found in the recurrence of the surgical and functional group.However, the movement disorder in the surgical treatment suggested increased risk than that in functional group,with the OR and 95%CI of 2 39(0.98-5.85).Surgical group found more complication than the function group,such as deep vein thrombosis,deep venous thrombosis,tenderness of scar and sensory loss.Conclusions:In conclusion,our finding showed that surgical treatment could gain better efficacy than functional treatment,but may bring more complication.Therefore,further large sample size RCT is warranted.
文摘Acupuncture at the Taichong (LR 3), Sanyinjiao (SP 6) and Ciliao (BL 32) points combined with TCM drugs for soothing the liver, replenishing the kidney, freeing the seminal passage, and eliminating the stasis showed effective for functional retrograde ejaculation in 25 cases. The total effective rate of 68.0% was significantly better than imipramine used in the control group (P<0.05).
基金National Nature Science Foundation of China(Grand Number30973276)
文摘Congenital cataract is a common cause of childhood low vision or blindness worldwide..Early surgery should be performed in sensitive vision development period to avoid vision deprivation in cases of strabismus and nystagmus development. Postoperative recovery of visual function is of great significance for these patients and should include proper postoperative aphakia correction by the application of a contact lens and secondary implantation of an intraocular lens(IOL). Patients should receive amblyopic training after surgery to improve their postoperative visual acuity..Although recent advances in surgery techniques and materials have brought better postoperative visual acuity and less complications, a few postoperative complications can still hamper vision condition and vision development,.including posterior capsule opacification and secondary glaucoma. Surgery in early infancy are risk factors for these two complications..Life-long follow-up is essential for these patients..Further study will continue to address the surgery timing issue and methods that prevent postoperative complications.
基金funded by Accions Singulars de R+D(Sing 12/17)del Vicerectorat de Recerca de la Universitat de Girona,Girona,Spain
文摘Traumatic spinal cord injury （SCI） causes motor paralysis, sensory anesthesia and autonomic dysfunction below the le- sion site and additionally some SCI patients refer neuropathic pain together with these signs and symptoms. Clinical and experimental studies have revealed the main pathological changes of injured spinal cord implicated in all these signs and symptoms, including neuropathic pain. After few hours of traumatic SCI, it is usual to observe broken blood brain barrier with plasma and blood cells extravasation, cell necrosis, disruption of ascending and descending spinal cord pathways and increased potassium and glutamate. Glutamate contributes to excitotoxicity of neurons whereas potassium facilitates ectopic depolarization of survival neurons and activation of resident microglia.
文摘Recent developments in magnetic resonance(MR) functional quantitative imaging have made it a potentially powerful tool to assess treatment response in radiation therapy. With its abilities to capture functional information on underlying tissue characteristics, MR functional quantitative imaging can be valuable in assessing treatment response and as such to optimize therapeutic outcome. Various MR quantitative imaging techniques, including diffusion weighted imaging, diffusion tensor imaging, MR spectroscopy and dynamic contrastenhanced imaging, have been investigated and found useful for assessment of radiotherapy. However, various aspects including data reproducibility, interpretation of biomarkers, image quality and data analysis impose challenges on applications of MR functional quantitative imaging in radiotherapy assessment. All of these challenging issues shall be addressed to help us understand whether MR functional quantitative imaging is truly beneficial and contributes to future development of radiotherapy. It is evident that individualized therapy is the future direction of patient care. MR functional quantitative imaging might serves as an indispensable tool towards this promising direction.
基金supported by Nanjing Jinling Hospital ( 2004082) Basic application grant supported by The Department ofEducation of Jiangsu Province
文摘Purpose: To research the mechanism of neurophysiological treatment of amblyopia by observing the visual cortex activation under rotating grating stimulus with functional magnetic resonance imaging (MRI), and identify the components of the activation. Methods: Nine healthy volunteers were examined using gradient-recalled echo and echo-planar imaging (GRE-EPI) pulse sequence performed at the 1.5 Tesla MRI scanner. In the block designing, rotating grating, stationary grating and luminance were plotted as task states, stationary grating, luminance and darkness as control states, respectively. The tasks of stimuli included 6 steps. Imaging processing and statistical analysis were carried out off-line using statistical parametric mapping (SPM99) software in single-subject. Results: Some individual areas of visual cortex were activated by various stimuli information supplied by rotating grating. The strong activation in the middle of occipital lobe related to the stimuli of luminance, bilateral activation of Brodmann’s 19th area related to visual motion perception, and the mild activation in the middle of occipital lobe related to form perception. Conclusion: The plotting of control state is important in bock design. The effective visual information of rotating grating includes components of luminance, visual motion perception and form perception. Functional MRI has potential as a tool for studying the physiological mechanism of visual cortex.
文摘目的研究基于近红外脑功能成像探讨针刺结合重复经颅磁刺激治疗卒中后非流利性失语的临床效应机制。方法选取2022年6月—2024年3月天津中医药大学第一附属医院收治的104例被诊断为脑卒中并伴有非流利性失语的患者作为研究对象,采取随机数字表法分为观察组和对照组,每组52例,所有患者均基于近红外脑功能成像技术进行探讨。对照组采用重复经颅磁刺激治疗,观察组采用针刺结合重复经颅磁刺激治疗。比较两组患者的临床效果、言语功能、声学水平以及失语症评分情况,并采取近红外脑功能成像技术检测其脑活动情况。结果观察组总有效率为98.00%(49/50),明显高于对照组的70.00%(35/50)(P<0.05)。治疗后,两组言语功能评分均高于治疗前,且观察组高于对照组(P<0.05)。治疗后,两组语言交流能力检查量表(Communicative abilities in daily living,CADL)、非语言认知评估量表(Non-linguistic cognitive assessment,NLCA)均高于治疗前,且观察组高于对照组(P<0.05)。治疗后,两组预运动皮质(Pre-motor cortex,PMC)、感觉运动皮质(Sensory motor cortex,SMC)、运动补充区(Supplementary motor area,SMA)均低于/高于治疗前,且观察组低于/高于对照组,差异有统计学意义(P<0.05)。结论卒中后非流利性失语患者采取针刺结合重复经颅磁刺激治疗,并予以近红外脑功能成像技术监测大脑后,可有效提升治疗效果,改善患者的语言功能,促进患者恢复,具有较高的临床应用价值。
文摘经颅交流电刺激(transcranial alternating current stimulation,tACS)是一种非侵入性的电神经调控技术,它通过向头皮施加特定频率的周期性微电流,调节大脑特定脑区的神经振荡,从而改变个体的特定认知功能或改善临床症状。自2008年以来,心理学研究者们利用tACS揭示了大脑不同神经振荡频段与特定认知活动的因果性联系。我们首先介绍tACS技术调控神经振荡的作用机制,接着分别介绍tACS在改变单脑和双脑认知功能研究中的应用。未来研究需精确控制tACS施加电流与大脑自发脑电节律间的相位关系、考虑脑神经节律等方面的个体差异,实现精准的tACS神经调控,从而更好地揭示不同认知功能的神经电机制。同时需系统评估tACS在临床应用研究中的施治方案和疗效持续性,为临床治疗提供科学指导。
