Zeolitic imidazolate frameworks(ZIFs)as smart drug delivery systems with microenvironment-triggered release have attracted much attention for tumor therapy.However,the exploration of ZIFs in biomedicine still encounte...Zeolitic imidazolate frameworks(ZIFs)as smart drug delivery systems with microenvironment-triggered release have attracted much attention for tumor therapy.However,the exploration of ZIFs in biomedicine still encounters many issues,such as inconvenient surface modification,fast drug release during blood circulation,undesired damage to major organs,and severe in vivo toxicity.To address the above issues,we developed an Mn-ZIF-90 nanosystem functionalized with an originally designed active-targeting and pH-responsive magnetic resonance imaging(MRI)Y1 receptor ligand[Asn28,Pro30,Trp32]-NPY(25-36)for imaging-guided tumor therapy.After Y1 receptor ligand modification,the Mn-ZIF-90 nanosystem exhibited high drug loading,better blood circulation stability,and dual breast cancer cell membrane and mitochondria targetability,further favoring specific microenvironment-triggered tumor therapy.Meanwhile,this nanosystem showed promising T1-weighted magnetic resonance imaging contrast in vivo in the tumor sites.Especially,this nanosystem with fast clean-up had almost no obvious toxicity and no damage occurred to the major organs in mice.Therefore,this nanosystem shows potential for use in imaging-guided tumor therapy.展开更多
通过耦合计算流体力学(computational fluid dynamics,CFD)与离散单元法(discrete element method,DEM),对球柱状颗粒在90°弯管中的气力输送过程进行了数值模拟研究。重点分析了入口气体速度、颗粒质量流量、颗粒长径比和管道直径...通过耦合计算流体力学(computational fluid dynamics,CFD)与离散单元法(discrete element method,DEM),对球柱状颗粒在90°弯管中的气力输送过程进行了数值模拟研究。重点分析了入口气体速度、颗粒质量流量、颗粒长径比和管道直径等参数对管道压降、出口处平均颗粒速度、平均颗粒碰撞次数和碰撞强度等指标的影响规律。结果显示,不同参数组合对系统的输送性能有较大影响,系列定量结果加深了对球柱状颗粒在90°弯管中气力输送特性的认识,并对提高其气力输送效率有指导意义。展开更多
基金financially supported by Natural Science Foundation of China(No.81871411)National Key R&D Program of China(2018YFC0910601)+1 种基金Youth Innovation Promotion Association Foundation of CAS(2017340)The Science&Technology Bureau of Ningbo City(2015B11002).
文摘Zeolitic imidazolate frameworks(ZIFs)as smart drug delivery systems with microenvironment-triggered release have attracted much attention for tumor therapy.However,the exploration of ZIFs in biomedicine still encounters many issues,such as inconvenient surface modification,fast drug release during blood circulation,undesired damage to major organs,and severe in vivo toxicity.To address the above issues,we developed an Mn-ZIF-90 nanosystem functionalized with an originally designed active-targeting and pH-responsive magnetic resonance imaging(MRI)Y1 receptor ligand[Asn28,Pro30,Trp32]-NPY(25-36)for imaging-guided tumor therapy.After Y1 receptor ligand modification,the Mn-ZIF-90 nanosystem exhibited high drug loading,better blood circulation stability,and dual breast cancer cell membrane and mitochondria targetability,further favoring specific microenvironment-triggered tumor therapy.Meanwhile,this nanosystem showed promising T1-weighted magnetic resonance imaging contrast in vivo in the tumor sites.Especially,this nanosystem with fast clean-up had almost no obvious toxicity and no damage occurred to the major organs in mice.Therefore,this nanosystem shows potential for use in imaging-guided tumor therapy.
文摘通过耦合计算流体力学(computational fluid dynamics,CFD)与离散单元法(discrete element method,DEM),对球柱状颗粒在90°弯管中的气力输送过程进行了数值模拟研究。重点分析了入口气体速度、颗粒质量流量、颗粒长径比和管道直径等参数对管道压降、出口处平均颗粒速度、平均颗粒碰撞次数和碰撞强度等指标的影响规律。结果显示,不同参数组合对系统的输送性能有较大影响,系列定量结果加深了对球柱状颗粒在90°弯管中气力输送特性的认识,并对提高其气力输送效率有指导意义。
