Photoacoustic imag ing(PAI)is a nonin vasive biomedical imag ing tech no logy capable of multiscale imag ing of biological samples from orga ns dow n to cells.Multiscale PAI requires differe nt ultraso und tra nsducer...Photoacoustic imag ing(PAI)is a nonin vasive biomedical imag ing tech no logy capable of multiscale imag ing of biological samples from orga ns dow n to cells.Multiscale PAI requires differe nt ultraso und tra nsducers that are flat or focused because the current widely-used piezoelectric transducers are rigid and lack the flexibility to tune their spatial ultrasound responses.Inspired by the rapidly-developing flexible photonics,we exploited the inherent flexibility and low-loss features of optical fibers to develop a flexible fiber-laser ultrasound sensor(FUS)for multiscale PAI.By simply bending the fiber laser from straight to curved geometry,the spatial ultraso und resp onse of the FUS can be tuned for both wide-view optical-resolution photoacoustic microscopy at optical diffraction-limited depth(~1 mm)and photoacoustic computed tomography at optical dissipation-limited depth of several centimeters.A radio-frequency demodulation was employed to get the readout of the beat frequency variation of two orthogonal polarization modes in the FUS output,which ensures low-noise and stable ultrasound detection.Compared to traditional piezoelectrical transducers with fixed ultrasound responses once manufactured,the flexible FUS provides the freedom to design multiscale PAI modalities including wearable microscope,intravascular endoscopy,and portable tomography system,which is attractive to fundamental biologic-al/medical studies and clinical applications.展开更多
We demonstrate an optical frequency comb based on an erbium-doped-fiber femtosecond laser with the nonlinear polarization evolution scheme. The repetition rate of the laser is about 209 MHz. By controlling an intra-ca...We demonstrate an optical frequency comb based on an erbium-doped-fiber femtosecond laser with the nonlinear polarization evolution scheme. The repetition rate of the laser is about 209 MHz. By controlling an intra-cavity electro- optic modulator and a piezo-transducer, the repetition rate can be stabilized with a high-bandwidth servo in a frequency range of 3 kHz, enabling long-term repetition rate phase-locking. The in-loop frequency stability of repetition rate is about 1.6× 10-13 in an integration time of 1 s, limited by the measurement system; and it is inversely proportional to integration time in the short term. Furthermore, using a common path f-2f interferometer, the carrier envelope offset frequency of the comb is obtained with a signal-to-noise ratio of 40 dB in a 3-MHz resolution bandwidth. Stabilized cartier envelope offset frequency exhibits a deviation of 0.6 mHz in an integration time of 1 s.展开更多
基金This work was supported by the National Natural Science Foundation of China(61775083,61705082,61805102,and 61860206002)the Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program(2019BT02X105)Guangzhou Science and Technology Plan(201904020032).
文摘Photoacoustic imag ing(PAI)is a nonin vasive biomedical imag ing tech no logy capable of multiscale imag ing of biological samples from orga ns dow n to cells.Multiscale PAI requires differe nt ultraso und tra nsducers that are flat or focused because the current widely-used piezoelectric transducers are rigid and lack the flexibility to tune their spatial ultrasound responses.Inspired by the rapidly-developing flexible photonics,we exploited the inherent flexibility and low-loss features of optical fibers to develop a flexible fiber-laser ultrasound sensor(FUS)for multiscale PAI.By simply bending the fiber laser from straight to curved geometry,the spatial ultraso und resp onse of the FUS can be tuned for both wide-view optical-resolution photoacoustic microscopy at optical diffraction-limited depth(~1 mm)and photoacoustic computed tomography at optical dissipation-limited depth of several centimeters.A radio-frequency demodulation was employed to get the readout of the beat frequency variation of two orthogonal polarization modes in the FUS output,which ensures low-noise and stable ultrasound detection.Compared to traditional piezoelectrical transducers with fixed ultrasound responses once manufactured,the flexible FUS provides the freedom to design multiscale PAI modalities including wearable microscope,intravascular endoscopy,and portable tomography system,which is attractive to fundamental biologic-al/medical studies and clinical applications.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.91336101 and 61127901)West Light Foundation of the Chinese Academy of Sciences(Grant No.2013ZD02)
文摘We demonstrate an optical frequency comb based on an erbium-doped-fiber femtosecond laser with the nonlinear polarization evolution scheme. The repetition rate of the laser is about 209 MHz. By controlling an intra-cavity electro- optic modulator and a piezo-transducer, the repetition rate can be stabilized with a high-bandwidth servo in a frequency range of 3 kHz, enabling long-term repetition rate phase-locking. The in-loop frequency stability of repetition rate is about 1.6× 10-13 in an integration time of 1 s, limited by the measurement system; and it is inversely proportional to integration time in the short term. Furthermore, using a common path f-2f interferometer, the carrier envelope offset frequency of the comb is obtained with a signal-to-noise ratio of 40 dB in a 3-MHz resolution bandwidth. Stabilized cartier envelope offset frequency exhibits a deviation of 0.6 mHz in an integration time of 1 s.
