The effect of controlling strata movement in solid filling mining depends on the filling rate of the goal. However, the mechanical property of the overburden in the backfill stope and the designed size of the backfill...The effect of controlling strata movement in solid filling mining depends on the filling rate of the goal. However, the mechanical property of the overburden in the backfill stope and the designed size of the backfill mining workface should also be considered. In this study, we established a main roof strata model with loads in accordance with the theory of key strata to investigate the stability of the overburden in solid dense filling mining. We analyzed the stress distribution law of the main roof strata based on elastic thin plate theory. The results show that the position of the long side midpoint of the main roof strata failed more easily because of tensile yield, indicating that this position is the area where failure is likely to occur more easily. We also deduced the stability mechanics criterion of the main roof strata based on tensile yield criterion. The factors affecting the stability of the overburden in solid dense filling mining were also analyzed, including the thickness and elasticity modulus of the main roof strata, overlying strata loads, advanced distance and length of workface, and elastic foundation coefficient of backfill body. The research achievements can provide an important theoretical basis for determining the designed size of the solid dense filling mining workface.展开更多
This paper studies how the price movements of pork,chicken and egg respond to those of related cost factors in short terms in Chinese market.We employ a linear quantile approach not only to explore potential data hete...This paper studies how the price movements of pork,chicken and egg respond to those of related cost factors in short terms in Chinese market.We employ a linear quantile approach not only to explore potential data heteroscedasticity but also to generate confidence bands for the purpose of price stability study.We then evaluate our models by comparing the prediction intervals generated from the quantile regression models with in-sample and out-of-sample forecasts.Using monthly data from January 2000 to October 2010,we observed these findings：（i） the price changes of cost factors asymmetrically and unequally influence those of the livestock across different quantiles;（ii） the performance of our models is robust and consistent for both in-sample and out-of-sample forecasts;（iii） the confidence intervals generated from 0.05th and 0.95th quantile regression models are good methods to forecast livestock price fluctuation.展开更多
The present study established rat models of middle cerebral artery ischemia/reperfusion using the thread method. Rats performed willed-movement （climbing a ladder or wall in a box） when induced by food and water. Re...The present study established rat models of middle cerebral artery ischemia/reperfusion using the thread method. Rats performed willed-movement （climbing a ladder or wall in a box） when induced by food and water. Results revealed that Longa scores of neurological deficits significantly decreased in the willed-movement group at 15 days after reperfusion, while expression of glial fibrillary acidic protein, neurotrophic factor-3, and growth-associated protein-43 significantly increased at 7 and 15 days after reperfusion. Results suggested that willed-movement ameliorated neurological deficits by increasing expression of glial fibriliary acidic protein, neurotrophic factor-3, and growth-associated protein-43.展开更多
Constraint-induced movement therapy is an effective rehabilitative training technique used to improve the restoration of impaired upper extremity movement after stroke. However, whether constraint-induced movement the...Constraint-induced movement therapy is an effective rehabilitative training technique used to improve the restoration of impaired upper extremity movement after stroke. However, whether constraint-induced movement therapy is more effective than conventional rehabilitation in acute or sub-acute stroke remains controversial. The aim of the present study was to identify the optimal time to start constraint-induced movement therapy after ischemic stroke and to explore the mechanisms by which constraint-induced movement therapy leads to post-stroke recovery. Sixty-four adult male Sprague-Dawley rats were randomly divided into four groups: sham-surgery group, cerebral ischemia/reperfusion group, early constraint-induced movement therapy group, and late constraint-induced movement therapy group. Rat models of left middle cerebral artery occlusion were established according to the Zea Longa line embolism method. Constraint-induced movement therapy was conducted starting on day 1 or day 14 in the early constraint-induced movement therapy and late constraint-induced movement therapy groups, respectively. To explore the effect of each intervention time on neuromotor function, behavioral function was assessed using a balance beam walking test before surgery and at 8 and 21 days after surgery. The expression levels of brain-derived neurotrophic factor, nerve growth factor and Nogo receptor were evaluated using real time-polymerase chain reaction and western blot assay to assess the effect of each intervention time. The results showed that the behavioral score was significantly lower in the early constraint-induced movement therapy group than in the cerebral ischemia/reperfusion and late constraint-induced movement therapy groups at 8 days. At 21 days, the scores had significantly decreased in the early constraint-induced movement therapy and late constraint-induced movement therapy groups. At 8 days, only mild pyknosis appeared in neurons of the ischemic penumbra in the early constraint-induced movement therapy group, which was distinctly better than in the cerebral ischemia/reperfusion group. At 21 days, only a few vacuolated cells were observed and no obvious inflammatory cells were visible in late constraint-induced movement therapy group, which was much better than at 8 days. The mRNA and protein expression levels of brain-derived neurotrophic factor and nerve growth factor were significantly higher, but expression levels of Nogo receptor were significantly lower in the early constraint-induced movement therapy group compared with the cerebral ischemia/reperfusion and late constraint-induced movement therapy groups at 8 days. The changes in expression levels at 21 days were larger but similar in both the early constraint-induced movement therapy and late constraint-induced movement therapy groups. Besides, the protein nerve growth factor level was higher in the late constraint-induced movement therapy group than in the early constraint-induced movement therapy group at 21 days. These results suggest that both early(1 day) and late(14 days) constraint-induced movement therapy induces molecular plasticity and facilitates functional recovery after ischemic stroke, as illustrated by the histology. The mechanism may be associated with downregulation of Nogo receptor expression and upregulation of brain-derived neurotrophic factor and nerve growth factor expression.展开更多
The SPOT image analysis in Muzaffarabad Azad Kashmir,northwest Himalayas,Pakistan reveals that the Kashmir earthquake 2005 triggered a number of coseismic mass movements along the hanging wall block of the Muzaffaraba...The SPOT image analysis in Muzaffarabad Azad Kashmir,northwest Himalayas,Pakistan reveals that the Kashmir earthquake 2005 triggered a number of coseismic mass movements along the hanging wall block of the Muzaffarabad Fault.The Neelidandi and Langarpura rock falls have been identified as two major reactivated mass movements with an estimated volume of 3.1 × 106m3and 5.76 × 106m3,respectively.The Neelidandi and Langarpura mass movements were initiated during earthquake in the direction of northwest-southeast extension and northeastsouthwest directed thrusting,respectively.The Neelidandi rock fall occurred in sheared cherty dolomites and limestones of the Cambrian Muzaffarabad Formation,whereas the Langarpura rock fall occurred in alternating clays,shales,claystones,siltstones and sandstones of the Miocene Murree Formation.These rock units along the fault are highly fractured and jointed.The geotechnical maps and geological longitudinal profiles show the relationship between the geometrical characteristics and mechanism of these mass movements.Their characteristics were analyzed according to the role of topographic,seismic,geological and tectonic factors.The steep topography,sheared rocks,lithology,coseismic uplift and strong ground shaking of the hanging wall block along Muzaffarabad Fault facilitated the gravity collapse of these mass movements.展开更多
过去十年中,创造性艺术疗法(CATs)的实证研究迅速增长,记录了其对广泛心理和生理(如压力、创伤、抑郁、焦虑、疼痛)的积极影响。然而,CATs如何以及为何产生积极效果,以及哪些治疗性因素导致了这些变化,目前尚不清楚。专门关注CATs中治...过去十年中,创造性艺术疗法(CATs)的实证研究迅速增长,记录了其对广泛心理和生理(如压力、创伤、抑郁、焦虑、疼痛)的积极影响。然而,CATs如何以及为何产生积极效果,以及哪些治疗性因素导致了这些变化,目前尚不清楚。专门关注CATs中治疗性因素和/或改变机制的研究才刚刚兴起。为了更深入地了解CATs如何以及为何能够产生影响,我们进行了一项范围综述(纳入研究数=67),用以指出CATs每项学科特有的治疗性因素、CATs共有的联合因素以及所有心理治疗方法中更通用的共同因素。本文对探讨CATs中治疗性因素和/或改变机制的实证性研究进行概览,并按领域分组,对治疗性因素进行详细分析,提出了一个包含19个领域的CATs治疗性因素框架,其中三个领域完全由CATs独有的因素构成:“具身化”(embodiment)、“具体化”(concretization)和“象征与隐喻”(symbolism and metaphors)。本文同时澄清了改变过程研究中使用的术语,并讨论了对未来研究、临床实践和CATs教育的启示。展开更多
基金Financial support for this work, provided by the National Natural Science Foundation of China (No.51404013)the Natural Science Foundation of Anhui Province (Nos.1508085ME77 and 1508085QE89)the Open Projects of State Key Laboratory for Geomechanics & Deep Underground Engineering at the China University of Mining and Technology (No.SKLGDUEK1212)
文摘The effect of controlling strata movement in solid filling mining depends on the filling rate of the goal. However, the mechanical property of the overburden in the backfill stope and the designed size of the backfill mining workface should also be considered. In this study, we established a main roof strata model with loads in accordance with the theory of key strata to investigate the stability of the overburden in solid dense filling mining. We analyzed the stress distribution law of the main roof strata based on elastic thin plate theory. The results show that the position of the long side midpoint of the main roof strata failed more easily because of tensile yield, indicating that this position is the area where failure is likely to occur more easily. We also deduced the stability mechanics criterion of the main roof strata based on tensile yield criterion. The factors affecting the stability of the overburden in solid dense filling mining were also analyzed, including the thickness and elasticity modulus of the main roof strata, overlying strata loads, advanced distance and length of workface, and elastic foundation coefficient of backfill body. The research achievements can provide an important theoretical basis for determining the designed size of the solid dense filling mining workface.
基金supported by the Key Project of National Key Technology R&D Program of China(2009BADA9B01)
文摘This paper studies how the price movements of pork,chicken and egg respond to those of related cost factors in short terms in Chinese market.We employ a linear quantile approach not only to explore potential data heteroscedasticity but also to generate confidence bands for the purpose of price stability study.We then evaluate our models by comparing the prediction intervals generated from the quantile regression models with in-sample and out-of-sample forecasts.Using monthly data from January 2000 to October 2010,we observed these findings：（i） the price changes of cost factors asymmetrically and unequally influence those of the livestock across different quantiles;（ii） the performance of our models is robust and consistent for both in-sample and out-of-sample forecasts;（iii） the confidence intervals generated from 0.05th and 0.95th quantile regression models are good methods to forecast livestock price fluctuation.
基金the Science and Technology Projects from Science and Technology Agency,Hunan Province,China,No. 2011FJ3206
文摘The present study established rat models of middle cerebral artery ischemia/reperfusion using the thread method. Rats performed willed-movement （climbing a ladder or wall in a box） when induced by food and water. Results revealed that Longa scores of neurological deficits significantly decreased in the willed-movement group at 15 days after reperfusion, while expression of glial fibrillary acidic protein, neurotrophic factor-3, and growth-associated protein-43 significantly increased at 7 and 15 days after reperfusion. Results suggested that willed-movement ameliorated neurological deficits by increasing expression of glial fibriliary acidic protein, neurotrophic factor-3, and growth-associated protein-43.
基金supported by the Natural Science Foundation of Shandong Province of China,No.2014ZRB14502(to XHL)
文摘Constraint-induced movement therapy is an effective rehabilitative training technique used to improve the restoration of impaired upper extremity movement after stroke. However, whether constraint-induced movement therapy is more effective than conventional rehabilitation in acute or sub-acute stroke remains controversial. The aim of the present study was to identify the optimal time to start constraint-induced movement therapy after ischemic stroke and to explore the mechanisms by which constraint-induced movement therapy leads to post-stroke recovery. Sixty-four adult male Sprague-Dawley rats were randomly divided into four groups: sham-surgery group, cerebral ischemia/reperfusion group, early constraint-induced movement therapy group, and late constraint-induced movement therapy group. Rat models of left middle cerebral artery occlusion were established according to the Zea Longa line embolism method. Constraint-induced movement therapy was conducted starting on day 1 or day 14 in the early constraint-induced movement therapy and late constraint-induced movement therapy groups, respectively. To explore the effect of each intervention time on neuromotor function, behavioral function was assessed using a balance beam walking test before surgery and at 8 and 21 days after surgery. The expression levels of brain-derived neurotrophic factor, nerve growth factor and Nogo receptor were evaluated using real time-polymerase chain reaction and western blot assay to assess the effect of each intervention time. The results showed that the behavioral score was significantly lower in the early constraint-induced movement therapy group than in the cerebral ischemia/reperfusion and late constraint-induced movement therapy groups at 8 days. At 21 days, the scores had significantly decreased in the early constraint-induced movement therapy and late constraint-induced movement therapy groups. At 8 days, only mild pyknosis appeared in neurons of the ischemic penumbra in the early constraint-induced movement therapy group, which was distinctly better than in the cerebral ischemia/reperfusion group. At 21 days, only a few vacuolated cells were observed and no obvious inflammatory cells were visible in late constraint-induced movement therapy group, which was much better than at 8 days. The mRNA and protein expression levels of brain-derived neurotrophic factor and nerve growth factor were significantly higher, but expression levels of Nogo receptor were significantly lower in the early constraint-induced movement therapy group compared with the cerebral ischemia/reperfusion and late constraint-induced movement therapy groups at 8 days. The changes in expression levels at 21 days were larger but similar in both the early constraint-induced movement therapy and late constraint-induced movement therapy groups. Besides, the protein nerve growth factor level was higher in the late constraint-induced movement therapy group than in the early constraint-induced movement therapy group at 21 days. These results suggest that both early(1 day) and late(14 days) constraint-induced movement therapy induces molecular plasticity and facilitates functional recovery after ischemic stroke, as illustrated by the histology. The mechanism may be associated with downregulation of Nogo receptor expression and upregulation of brain-derived neurotrophic factor and nerve growth factor expression.
基金the University of Azad Jammu and Kashmir Muzaffarabad,for funding the research under Faculty Development Programme
文摘The SPOT image analysis in Muzaffarabad Azad Kashmir,northwest Himalayas,Pakistan reveals that the Kashmir earthquake 2005 triggered a number of coseismic mass movements along the hanging wall block of the Muzaffarabad Fault.The Neelidandi and Langarpura rock falls have been identified as two major reactivated mass movements with an estimated volume of 3.1 × 106m3and 5.76 × 106m3,respectively.The Neelidandi and Langarpura mass movements were initiated during earthquake in the direction of northwest-southeast extension and northeastsouthwest directed thrusting,respectively.The Neelidandi rock fall occurred in sheared cherty dolomites and limestones of the Cambrian Muzaffarabad Formation,whereas the Langarpura rock fall occurred in alternating clays,shales,claystones,siltstones and sandstones of the Miocene Murree Formation.These rock units along the fault are highly fractured and jointed.The geotechnical maps and geological longitudinal profiles show the relationship between the geometrical characteristics and mechanism of these mass movements.Their characteristics were analyzed according to the role of topographic,seismic,geological and tectonic factors.The steep topography,sheared rocks,lithology,coseismic uplift and strong ground shaking of the hanging wall block along Muzaffarabad Fault facilitated the gravity collapse of these mass movements.
文摘过去十年中,创造性艺术疗法(CATs)的实证研究迅速增长,记录了其对广泛心理和生理(如压力、创伤、抑郁、焦虑、疼痛)的积极影响。然而,CATs如何以及为何产生积极效果,以及哪些治疗性因素导致了这些变化,目前尚不清楚。专门关注CATs中治疗性因素和/或改变机制的研究才刚刚兴起。为了更深入地了解CATs如何以及为何能够产生影响,我们进行了一项范围综述(纳入研究数=67),用以指出CATs每项学科特有的治疗性因素、CATs共有的联合因素以及所有心理治疗方法中更通用的共同因素。本文对探讨CATs中治疗性因素和/或改变机制的实证性研究进行概览,并按领域分组,对治疗性因素进行详细分析,提出了一个包含19个领域的CATs治疗性因素框架,其中三个领域完全由CATs独有的因素构成:“具身化”(embodiment)、“具体化”(concretization)和“象征与隐喻”(symbolism and metaphors)。本文同时澄清了改变过程研究中使用的术语,并讨论了对未来研究、临床实践和CATs教育的启示。
