Chiral pyridyl alcohols are a type of synthetically versatile building block for natural products,functional materials and bioactive molecules.Herein,a highly efficient Ir/f-amphox-catalyzed asymmetric hydrogenation o...Chiral pyridyl alcohols are a type of synthetically versatile building block for natural products,functional materials and bioactive molecules.Herein,a highly efficient Ir/f-amphox-catalyzed asymmetric hydrogenation of 1-(pyridin-2-yl)ketone derivatives to access chiral pyridyl alcohols was reported.The reaction proceeds smoothly under mild conditions,delivering excellent yields and enantioselectivities(up to>99%ee,turnover number(TON)up to 2000).A broad range of pyridyl alkyl and aryl ketones were successfully transformed,demonstrating the generality and synthetic utility of this methodology.展开更多
文摘Chiral pyridyl alcohols are a type of synthetically versatile building block for natural products,functional materials and bioactive molecules.Herein,a highly efficient Ir/f-amphox-catalyzed asymmetric hydrogenation of 1-(pyridin-2-yl)ketone derivatives to access chiral pyridyl alcohols was reported.The reaction proceeds smoothly under mild conditions,delivering excellent yields and enantioselectivities(up to>99%ee,turnover number(TON)up to 2000).A broad range of pyridyl alkyl and aryl ketones were successfully transformed,demonstrating the generality and synthetic utility of this methodology.
