Experimental therapies targeting immune and stromal cells,such as mast cells,cancer-associated fibroblasts,dendritic cells,and tumor endothelial cells,in the treatment of gastrointestinal solid tumors pose new and com...Experimental therapies targeting immune and stromal cells,such as mast cells,cancer-associated fibroblasts,dendritic cells,and tumor endothelial cells,in the treatment of gastrointestinal solid tumors pose new and complex surgical and medico-legal challenges.These innovative treatments require that informed consent not be limited to simple acceptance of the medical procedure,but instead reflect a true relational and cognitive process grounded in understanding,free choice,and the ability to revoke consent at any time.In particular,it is essential that the patient understands the experimental nature of the therapy,its development stage,potential benefits and risks,as well as the implications for their health and personal dignity.In the case of stromal cell-based treatments,which may exert complex immunomodulatory effects or activate angiogenic pathways that are not yet fully understood,patients must be made fully aware that they are participating in a non-standardized therapy whose outcomes,whether beneficial or harmful,cannot yet be predicted with certainty.This requires particularly careful medical communication,using simple yet scientifically accurate explanations delivered in appropriate language,along with a final verification of the patient’s actual understanding.展开更多
The aim of this study is to report the use of RE （remote experimentation） in an educational press. The authors developed this remote experiment with the objective to study the Hooke＇s law through the analysis of th...The aim of this study is to report the use of RE （remote experimentation） in an educational press. The authors developed this remote experiment with the objective to study the Hooke＇s law through the analysis of the coil spring. The remote experiment is available in a website, where the students can manipulate and observe the educational press and confirm Hooke＇s statements with the output information. In addition, the students will have the opportunity to read in the website about the educational press, the physical law, and the use of the press in industrial processes. This remote experimentation exerts a force in the mechanical spring creating a deformation. In the defined point, the microcomputer will collect the data from the sensors, and it will save this data in the database. After the process execution, a graph with the data will be plotted in the website. The tests confirm that the educational press has informational potential because it returned values consistent with Hooke＇s law and the experiment presented repetition in all tests realized.展开更多
背景:当前,电针治疗周围神经损伤实验研究开展迅速,涉及不同的神经与疾病种类,针对这一领域的文献计量学梳理有重要的学术价值。目的:总结电针干预周围神经损伤实验研究领域的发展历程、研究现状、热点和未来趋势。方法:在中国知网(CNKI...背景:当前,电针治疗周围神经损伤实验研究开展迅速,涉及不同的神经与疾病种类,针对这一领域的文献计量学梳理有重要的学术价值。目的:总结电针干预周围神经损伤实验研究领域的发展历程、研究现状、热点和未来趋势。方法:在中国知网(CNKI)、生物医学文献数据库(CBM)、Web of Science核心合集数据库中检索电针干预周围神经损伤的实验研究文献,检索时限为各数据库建库至2024年12月,经过筛选、去重及数据清洗后,利用Cite Space与VOSviewer软件对数据进行总结并生成可视化图谱。结果与结论:共纳入432篇文献(其中CNKI 181篇,CBM 186篇,Web of Science 65篇),发文量呈现波动性上升趋势,有一定数量的核心作者,但作者、机构分布松散,尚未形成核心作者群,中文文献有599个关键词节点,英文文献有364个关键词节点,主要病种为单神经损伤、神经病理性疼痛、糖尿病性周围神经病,研究层次逐渐深入,目前研究围绕电针适宜参数、针灸效应与分子机制展开,星形胶质细胞与小胶质细胞分别处于中、英文突现时间段内。未来应继续加大电针干预周围神经损伤实验研究力度,通过加强作者、机构交流,与材料学、高通量测序等高新技术相结合,寻找新的突破点,共同促进高质量研究文章的产出,推动该领域发展。展开更多
We emphasize the importance of studying the primate brain in cognitive neuroscience and suggest a new mind-set in primate experimentation within the boundaries of animal welfare regulations.Specifically,we list the ad...We emphasize the importance of studying the primate brain in cognitive neuroscience and suggest a new mind-set in primate experimentation within the boundaries of animal welfare regulations.Specifically,we list the advantages of investigating both genes and neural mechanisms and processes in the emergence of behavioral and cognitive functions,and propose the establishment of an open field of primate research.The latter may be conducted by implementing and harmonizing experimental practices with ethical guidelines that regulate(1)management of natural parks with free-moving populations of target nonhuman primates,(2)establishment of indoor-outdoor labs for both system genetics and neuroscience investigations,and(3)hotel space and technologies which remotely collect and dislocate information regarding primates geographically located elsewhere.展开更多
文摘Experimental therapies targeting immune and stromal cells,such as mast cells,cancer-associated fibroblasts,dendritic cells,and tumor endothelial cells,in the treatment of gastrointestinal solid tumors pose new and complex surgical and medico-legal challenges.These innovative treatments require that informed consent not be limited to simple acceptance of the medical procedure,but instead reflect a true relational and cognitive process grounded in understanding,free choice,and the ability to revoke consent at any time.In particular,it is essential that the patient understands the experimental nature of the therapy,its development stage,potential benefits and risks,as well as the implications for their health and personal dignity.In the case of stromal cell-based treatments,which may exert complex immunomodulatory effects or activate angiogenic pathways that are not yet fully understood,patients must be made fully aware that they are participating in a non-standardized therapy whose outcomes,whether beneficial or harmful,cannot yet be predicted with certainty.This requires particularly careful medical communication,using simple yet scientifically accurate explanations delivered in appropriate language,along with a final verification of the patient’s actual understanding.
文摘The aim of this study is to report the use of RE （remote experimentation） in an educational press. The authors developed this remote experiment with the objective to study the Hooke＇s law through the analysis of the coil spring. The remote experiment is available in a website, where the students can manipulate and observe the educational press and confirm Hooke＇s statements with the output information. In addition, the students will have the opportunity to read in the website about the educational press, the physical law, and the use of the press in industrial processes. This remote experimentation exerts a force in the mechanical spring creating a deformation. In the defined point, the microcomputer will collect the data from the sensors, and it will save this data in the database. After the process execution, a graph with the data will be plotted in the website. The tests confirm that the educational press has informational potential because it returned values consistent with Hooke＇s law and the experiment presented repetition in all tests realized.
文摘背景:当前,电针治疗周围神经损伤实验研究开展迅速,涉及不同的神经与疾病种类,针对这一领域的文献计量学梳理有重要的学术价值。目的:总结电针干预周围神经损伤实验研究领域的发展历程、研究现状、热点和未来趋势。方法:在中国知网(CNKI)、生物医学文献数据库(CBM)、Web of Science核心合集数据库中检索电针干预周围神经损伤的实验研究文献,检索时限为各数据库建库至2024年12月,经过筛选、去重及数据清洗后,利用Cite Space与VOSviewer软件对数据进行总结并生成可视化图谱。结果与结论:共纳入432篇文献(其中CNKI 181篇,CBM 186篇,Web of Science 65篇),发文量呈现波动性上升趋势,有一定数量的核心作者,但作者、机构分布松散,尚未形成核心作者群,中文文献有599个关键词节点,英文文献有364个关键词节点,主要病种为单神经损伤、神经病理性疼痛、糖尿病性周围神经病,研究层次逐渐深入,目前研究围绕电针适宜参数、针灸效应与分子机制展开,星形胶质细胞与小胶质细胞分别处于中、英文突现时间段内。未来应继续加大电针干预周围神经损伤实验研究力度,通过加强作者、机构交流,与材料学、高通量测序等高新技术相结合,寻找新的突破点,共同促进高质量研究文章的产出,推动该领域发展。
文摘We emphasize the importance of studying the primate brain in cognitive neuroscience and suggest a new mind-set in primate experimentation within the boundaries of animal welfare regulations.Specifically,we list the advantages of investigating both genes and neural mechanisms and processes in the emergence of behavioral and cognitive functions,and propose the establishment of an open field of primate research.The latter may be conducted by implementing and harmonizing experimental practices with ethical guidelines that regulate(1)management of natural parks with free-moving populations of target nonhuman primates,(2)establishment of indoor-outdoor labs for both system genetics and neuroscience investigations,and(3)hotel space and technologies which remotely collect and dislocate information regarding primates geographically located elsewhere.
