Autism and schizophrenia are of particular interest because new developments in genomic medicine address three aspects of the conditions that have been difficult, thus far, to resolve: their heterogeneity, from subcli...Autism and schizophrenia are of particular interest because new developments in genomic medicine address three aspects of the conditions that have been difficult, thus far, to resolve: their heterogeneity, from subclinical manifestations to disorders that are gravely disabling;the genetic basis for their high heritability;and the persistence of disorders in light of their high heritability but low reproductive success they convey. The origins of autism and schizophrenia, their persistence and heterogeneity can be understood by integrating information from genomic science, the social brain and the evolution of socialization, intelligence and language. Both conditions are associated with structural changes in the genome, specifically copy number variants. Such systemic mutations contribute to an unstable and mutable genome and have been especially notable during primate > hominid evolution. Along with mechanisms that affect gene expression, they contribute to a genome characterized by variability and evolvability. A dynamic and variable genome is reflected by a high degree of phenotypic variation. This, in turn, is reflected in the diversity of neurodevelopmental disorders, in particular autism and schizophrenia. Evolvability is more than a dispositional concept, it is a trait in its own right. In the special case of hominid evolution, evolvability has been both an independent and a dependent variable. Evolution of the modern human brain seems to have arisen during the cultivation of unstable regions in the genome that were conducive to a high degree of inter-individual and inter-generational variation. The consequence of even small aberrations in evolutionary processes and phenotypic variations is most likely to be manifest in the functions of the social brain: self-referential processing, perspective taking and the dual components of empathy;also language as well as intelligence itself. The trade-off is a dynamic genome that can rearrange itself in untoward ways and may be felt in one or more of the above functions. The occurrence of neurodevelopmental disorders ranging from the learning disabilities and ADD to autism and schizophrenia, are epiphenomenal to a genome that is unstable and mutable. The selective advantage of such a genome is the runaway evolution of positive prosocial and intellective traits. If there is a core to the pathology that emerges in autism and schizophrenia, it is at the genomic level, and is probably related to the unique evolvability of the human genome. Genetic transformation as an agent of evolvability is necessarily associated with untoward consequences. Just as point mutations may have deleterious effects, so do genomic transformations. The neurodevelopmental disorders, therefore, are the consequence of evolvability.展开更多
This paper, an addendum to “Dialectical Thermodynamics’ solution to the conceptual imbroglio that is the reversible path”, this journal, 10, 775-799, was written in response to the requests of several readers to pr...This paper, an addendum to “Dialectical Thermodynamics’ solution to the conceptual imbroglio that is the reversible path”, this journal, 10, 775-799, was written in response to the requests of several readers to provide further evidence of the said “imbroglio”. The evidence here presented relates to the incompatibility existing between the total-entropy and the Gibbs energy prescriptions for the reversible path. The previously published proof of the negentropic nature of the transformation of heat into work is here included to validate out conclusions about the Gibbs energy perspective.展开更多
Friendship paradox states that individuals are likely to have fewer friends than their friends do,on average.Despite of its wide existence and appealing applications in real social networks,the mathematical understand...Friendship paradox states that individuals are likely to have fewer friends than their friends do,on average.Despite of its wide existence and appealing applications in real social networks,the mathematical understanding of friendship paradox is very limited.Only few works provide theoretical evidence of single-step and multi-step friendship paradoxes,given that the neighbors of interest are onehop and multi-hop away from the target node.However,they consider non-evolving networks,as opposed to the topology of real social networks that are constantly growing over time.We are thus motivated to present a first look into friendship paradox in evolving networks,where newly added nodes preferentially attach themselves to those with higher degrees.Our analytical verification of both single-step and multistep friendship paradoxes in evolving networks,along with comparison to the non-evolving counterparts,discloses that“friendship paradox is even more paradoxical in evolving networks”,primarily from three aspects:1)we demonstrate a strengthened effect of single-step friendship paradox in evolving networks,with a larger probability(more than 0.8)of a random node’s neighbors having higher average degree than the random node itself;2)we unravel higher effectiveness of multi-step friendship paradox in seeking for influential nodes in evolving networks,as the rate of reaching the max degree node can be improved by a factor of at least Θ(t^(2/3))with t being the network size;3)we empirically verify our findings through both synthetic and real datasets,which suggest high agreements of results and consolidate the reasonability of evolving model for real social networks.展开更多
Color is an essential component of beauty,a medium for expressing culture and attitude,and a catalyst for innovation and value creation.As Chinese styles and trends rise and return,traditional Chinese colors,regarded ...Color is an essential component of beauty,a medium for expressing culture and attitude,and a catalyst for innovation and value creation.As Chinese styles and trends rise and return,traditional Chinese colors,regarded as the most profound visual expressions of Chinese civilization,are infused with new vitality and contemporary values.These colors,imbued with philosophical concepts and poetic aesthetics,continue to evolve.展开更多
Academic journals are not only vital platforms for disseminating research findings but also key drivers of disciplinary and interdisciplinary advancement.As knowledge systems,research subjects,core questions,and appli...Academic journals are not only vital platforms for disseminating research findings but also key drivers of disciplinary and interdisciplinary advancement.As knowledge systems,research subjects,core questions,and application scenarios continuously evolve,research paradigms undergo constant innovation.Therefore,a journal’s scope must adapt to-and even lead-academic trends and demands.展开更多
The dynamic routing mechanism in evolvable networks enables adaptive reconfiguration of topol-ogical structures and transmission pathways based on real-time task requirements and data character-istics.However,the heig...The dynamic routing mechanism in evolvable networks enables adaptive reconfiguration of topol-ogical structures and transmission pathways based on real-time task requirements and data character-istics.However,the heightened architectural complexity and expanded parameter dimensionality in evolvable networks present significant implementation challenges when deployed in resource-con-strained environments.Due to the critical paths ignored,traditional pruning strategies cannot get a desired trade-off between accuracy and efficiency.For this reason,a critical path retention pruning(CPRP)method is proposed.By deeply traversing the computational graph,the dependency rela-tionship among nodes is derived.Then the nodes are grouped and sorted according to their contribu-tion value.The redundant operations are removed as much as possible while ensuring that the criti-cal path is not affected.As a result,computational efficiency is improved while a higher accuracy is maintained.On the CIFAR benchmark,the experimental results demonstrate that CPRP-induced pruning incurs accuracy degradation below 4.00%,while outperforming traditional feature-agnostic grouping methods by an average 8.98%accuracy improvement.Simultaneously,the pruned model attains a 2.41 times inference acceleration while achieving 48.92%parameter compression and 53.40%floating-point operations(FLOPs)reduction.展开更多
文摘Autism and schizophrenia are of particular interest because new developments in genomic medicine address three aspects of the conditions that have been difficult, thus far, to resolve: their heterogeneity, from subclinical manifestations to disorders that are gravely disabling;the genetic basis for their high heritability;and the persistence of disorders in light of their high heritability but low reproductive success they convey. The origins of autism and schizophrenia, their persistence and heterogeneity can be understood by integrating information from genomic science, the social brain and the evolution of socialization, intelligence and language. Both conditions are associated with structural changes in the genome, specifically copy number variants. Such systemic mutations contribute to an unstable and mutable genome and have been especially notable during primate > hominid evolution. Along with mechanisms that affect gene expression, they contribute to a genome characterized by variability and evolvability. A dynamic and variable genome is reflected by a high degree of phenotypic variation. This, in turn, is reflected in the diversity of neurodevelopmental disorders, in particular autism and schizophrenia. Evolvability is more than a dispositional concept, it is a trait in its own right. In the special case of hominid evolution, evolvability has been both an independent and a dependent variable. Evolution of the modern human brain seems to have arisen during the cultivation of unstable regions in the genome that were conducive to a high degree of inter-individual and inter-generational variation. The consequence of even small aberrations in evolutionary processes and phenotypic variations is most likely to be manifest in the functions of the social brain: self-referential processing, perspective taking and the dual components of empathy;also language as well as intelligence itself. The trade-off is a dynamic genome that can rearrange itself in untoward ways and may be felt in one or more of the above functions. The occurrence of neurodevelopmental disorders ranging from the learning disabilities and ADD to autism and schizophrenia, are epiphenomenal to a genome that is unstable and mutable. The selective advantage of such a genome is the runaway evolution of positive prosocial and intellective traits. If there is a core to the pathology that emerges in autism and schizophrenia, it is at the genomic level, and is probably related to the unique evolvability of the human genome. Genetic transformation as an agent of evolvability is necessarily associated with untoward consequences. Just as point mutations may have deleterious effects, so do genomic transformations. The neurodevelopmental disorders, therefore, are the consequence of evolvability.
文摘This paper, an addendum to “Dialectical Thermodynamics’ solution to the conceptual imbroglio that is the reversible path”, this journal, 10, 775-799, was written in response to the requests of several readers to provide further evidence of the said “imbroglio”. The evidence here presented relates to the incompatibility existing between the total-entropy and the Gibbs energy prescriptions for the reversible path. The previously published proof of the negentropic nature of the transformation of heat into work is here included to validate out conclusions about the Gibbs energy perspective.
基金supported by NSF China(No.61960206002,62020106005,42050105,62061146002)Shanghai Pilot Program for Basic Research–Shanghai Jiao Tong University.
文摘Friendship paradox states that individuals are likely to have fewer friends than their friends do,on average.Despite of its wide existence and appealing applications in real social networks,the mathematical understanding of friendship paradox is very limited.Only few works provide theoretical evidence of single-step and multi-step friendship paradoxes,given that the neighbors of interest are onehop and multi-hop away from the target node.However,they consider non-evolving networks,as opposed to the topology of real social networks that are constantly growing over time.We are thus motivated to present a first look into friendship paradox in evolving networks,where newly added nodes preferentially attach themselves to those with higher degrees.Our analytical verification of both single-step and multistep friendship paradoxes in evolving networks,along with comparison to the non-evolving counterparts,discloses that“friendship paradox is even more paradoxical in evolving networks”,primarily from three aspects:1)we demonstrate a strengthened effect of single-step friendship paradox in evolving networks,with a larger probability(more than 0.8)of a random node’s neighbors having higher average degree than the random node itself;2)we unravel higher effectiveness of multi-step friendship paradox in seeking for influential nodes in evolving networks,as the rate of reaching the max degree node can be improved by a factor of at least Θ(t^(2/3))with t being the network size;3)we empirically verify our findings through both synthetic and real datasets,which suggest high agreements of results and consolidate the reasonability of evolving model for real social networks.
文摘Color is an essential component of beauty,a medium for expressing culture and attitude,and a catalyst for innovation and value creation.As Chinese styles and trends rise and return,traditional Chinese colors,regarded as the most profound visual expressions of Chinese civilization,are infused with new vitality and contemporary values.These colors,imbued with philosophical concepts and poetic aesthetics,continue to evolve.
文摘Academic journals are not only vital platforms for disseminating research findings but also key drivers of disciplinary and interdisciplinary advancement.As knowledge systems,research subjects,core questions,and application scenarios continuously evolve,research paradigms undergo constant innovation.Therefore,a journal’s scope must adapt to-and even lead-academic trends and demands.
基金Supported by the National Key Research and Development Program of China(No.2022ZD0119003)and the National Natural Science Founda-tion of China(No.61834005).
文摘The dynamic routing mechanism in evolvable networks enables adaptive reconfiguration of topol-ogical structures and transmission pathways based on real-time task requirements and data character-istics.However,the heightened architectural complexity and expanded parameter dimensionality in evolvable networks present significant implementation challenges when deployed in resource-con-strained environments.Due to the critical paths ignored,traditional pruning strategies cannot get a desired trade-off between accuracy and efficiency.For this reason,a critical path retention pruning(CPRP)method is proposed.By deeply traversing the computational graph,the dependency rela-tionship among nodes is derived.Then the nodes are grouped and sorted according to their contribu-tion value.The redundant operations are removed as much as possible while ensuring that the criti-cal path is not affected.As a result,computational efficiency is improved while a higher accuracy is maintained.On the CIFAR benchmark,the experimental results demonstrate that CPRP-induced pruning incurs accuracy degradation below 4.00%,while outperforming traditional feature-agnostic grouping methods by an average 8.98%accuracy improvement.Simultaneously,the pruned model attains a 2.41 times inference acceleration while achieving 48.92%parameter compression and 53.40%floating-point operations(FLOPs)reduction.
