Objective: To investigate the risk factors of chronic obstructive pulmonary disease(COPD) in Li and Han ethnic group in Hainan, China. Methods: All subjects were randomly selected from various regions in Hainan. Gener...Objective: To investigate the risk factors of chronic obstructive pulmonary disease(COPD) in Li and Han ethnic group in Hainan, China. Methods: All subjects were randomly selected from various regions in Hainan. General characteristics were compared between COPD cases and healthy control cases in both Li and Han ethnic groups. The odds ratio(OR), the corresponding 95% confidence interval(CI) of COPD were calculated by logistic regression.Results: A total of 277 Li COPD cases, 307 Li healthy control subjects, 290 Han COPD cases and 301 Han healthy control were included in this study. In both the Li and Han groups, the average age exceeded 65 years, and the cigarette number smoked per day and the smoking duration were correlated with risk of COPD. In the Li COPD subjects, low weight, smoking, and recurrent infection of respiratory tract were mainly risk factors; while the mainly risk factor of Han COPD subjects was family history of respiratory disease. Conclusions: The risk factors are different in COPD subjects of Han and Li nationalities in Hainan of China. The age and smoking are strongly correlated with COPD risk.展开更多
Ethnic minority areas area old revolutionary base areas,areas inhabited by ethnic minorities,remote areas,impoverished areas, and also difficult areas for construction of socialist harmonious society.Studying on facto...Ethnic minority areas area old revolutionary base areas,areas inhabited by ethnic minorities,remote areas,impoverished areas, and also difficult areas for construction of socialist harmonious society.Studying on factors influencing rural teacher flow in ethnic minority areas is of great significance to improving local teacher team structure and promoting balanced development of urban and rural education.However,it lacks empirical analysis based on field survey for the nonce.In this study,based on interview and questionnaire data of education departments and school leaders in 4 ethnic minority areas of Yunnan Province,it established binary Logistic model,analyzed factors influencing rural teacher flow in ethnic minority areas of Yunnan Province,and finally present policy recommendations.展开更多
<b>Objective:</b> To explore the pathogenesis of PTSD in the brain-derived neurotrophic factor (BDNF) gene methylation of patients with posttraumatic stress disorder (Posttraumatic Stress Disorder, PTSD) i...<b>Objective:</b> To explore the pathogenesis of PTSD in the brain-derived neurotrophic factor (BDNF) gene methylation of patients with posttraumatic stress disorder (Posttraumatic Stress Disorder, PTSD) in Hainan Province, the relationship between the influence of BDNF gene methylation and the influence of PTSD. <b>Methods:</b> A case-control study method was adopted, strictly in accordance with DSM-IV and PTSD diagnosis, and 150 Li PTSD patients matched with gender and age of 300 Han PTSD patients were selected as the research objects. The peripheral venous whole blood of the subjects was drawn, genomic DNA was extracted, modified with bisulfite, and directly sequenced to quantitatively detect the methylation status of the CpG island in the promoter region of brain-derived neurotrophic factor (BDNF). <b>Results:</b> The results showed that the methylation levels of CPGl, CPG2, CPG3, CPG4, CPG5, CPG6, CPG7, CPG9, CPGl2, CPGl3, CPGl4, CPGl5, CPGl6, CPGl7, and CPGl8 in THE BDNF promoter were significantly different between the HAN PTSD group and the Li PTSD group (<i>P</i> < 0.001). <b>Conclusion:</b> It is suggested that CPG methylation in the promoter region of BDNF gene is closely related to patients with PTSD. There is a statistical difference in the level of CpG methylation in the promoter region of BDNF gene in PTSD between Li and Han ethnic groups in Hainan Province. CpG methylation in the promoter region of BDNF gene may be used as a biomarker for the diagnosis of PTSD.展开更多
In the regulation of human nervous system, cognitive function and other genes, epigenetics changes the expression of genes after being influenced by the external environment. DNA methylation levels are also different ...In the regulation of human nervous system, cognitive function and other genes, epigenetics changes the expression of genes after being influenced by the external environment. DNA methylation levels are also different in different ethnic groups, and a large number of studies have shown that post-traumatic stress disorder (PTSD) has a certain genetic predisposition. Through the national differences of PTSD brain-derived neurotrophic factor genes, it not only provides new research directions for the pathogenesis and treatment of 5-HT-related mental diseases, but also provides information and new genetic indicators for forensic personal identification, paternity testing and assessment of mental status. A review studies on the national differences of brain-derived neurotrophic factor genes in patients with post-traumatic stress disorder.展开更多
AIM:To compare the clinical factors and tumor characteristics that predict survival in colorectal cancer(CRC)patients with different ethnicities in Xin Jiang area.METHODS:A total of 1421 histopathologically confirmed ...AIM:To compare the clinical factors and tumor characteristics that predict survival in colorectal cancer(CRC)patients with different ethnicities in Xin Jiang area.METHODS:A total of 1421 histopathologically confirmed sporadic CRC patients who were either Han/Chinese or Uyghur were identified and enrolled from a database of both diagnoses and operative procedures from Xin Jiang Tumor Hospital,which is affiliated to Xin Jiang Medical University between 2000 and 2007.Patients with family histories of CRC,hereditary nonpolyposis CRC,familial adenomatous polyposis,inflammatory bowel disease,carcinoid,squamous carcinoma or melanoma were excluded.The two ethnic groups were compared with regard to clinical features,tumor characteristics,disease stage,overall survival rate,diseasefree survival rate and cancer-specific survival rate.The factors predicting long-term survival were assessed via both univariate and multivariate analysis.RESULTS:Among the 1421 patients with CRC enrolled in this study,1210 patients were Han/Chinese(mean age,62.3±4.5 years;range,19-92 years),while 211patients were Uyghur(mean age,52.4±15.6 years;range,17-87 years).There were significant differences in proportions of gender,age,blood type,occupation and histopathological type between the Han/Chinese and Uyghur patients(P<0.05).The median overall,disease-free and cancer-specific survival time were 45,62and 65 mo for the Han/Chinese patients and 42,49 and61 mo for the Uyghur patients(P=0.000,P=0.005,P=0.007).The cumulative 5-year survival of the Uyghur patients was significantly worse than that of the Han patients(P=0.000).A multivariate analysis showed that age,ethnicity,histopathological type,differentiation,T(Infiltration depth),N(Lymph node metastasis),staging,postoperative metastasis and metastatic site(P<0.05)were found to be the prognostic factors.CONCLUSION:The Uyghur CRC patients are associated with significantly younger age,more aggressive histopathologic characteristics and have significantly worse prognosis than the Han/Chinese patients.展开更多
Objective:To investigate the prevalence and risk factors of bronchial asthma in the Li ethnic group in Hainan,China.Methods:This study employed a stratified random sample design using custom-designed questionnaires.Su...Objective:To investigate the prevalence and risk factors of bronchial asthma in the Li ethnic group in Hainan,China.Methods:This study employed a stratified random sample design using custom-designed questionnaires.Subjects with asthma-like symptoms were first identified by two rounds of surveys and then confirmed by respiratory physicians using pulmonary function test,bronchial dilation test and challenge test.Demographic data,information on family history of asthma,history of allergies,smoking habits,domestic cooking fuel and other potential risk factors were collected.Logistic regression was performed to evaluate risk factors for asthma.Results: The prevalence of asthma in the Li ethnic group was 3.38%,much higher than the national average level in China.Aging,agriculture industry(the rubber industry in particular),rural residence,family history of asthma,history of allergies,cold air,inhalation of dust and irritant gases,smoking,domestic cooking fuel and living environment were associated with increased risk of asthma.Conclusions:The high prevalence of asthma in the Li ethnic group highlights the importance of asthma prevention and treatment in this population.Risk factors indentified in this study warrant special attention.Elevating public awareness about asthma in local communities will benefit the prevention of the disease.展开更多
AIM To investigate whether minority ethnicity and the duration of education influence preoperative disability and expectations in patients undergoing total knee arthroplasty.METHODS We prospectively included 829 patie...AIM To investigate whether minority ethnicity and the duration of education influence preoperative disability and expectations in patients undergoing total knee arthroplasty.METHODS We prospectively included 829 patients undergoing primary unilateral total knee arthroplasty(TKA) from April 2013 to December 2014 at a single centre. Patients filled in pre-operative questionnaires with information regarding place of birth, duration of education, expectations for outcome of surgery and baseline characteristics. Patients were stratified based on ethnicity. Majority ethnicity was defined as born inthe study country and minority ethnicity was defined as born in any other country. Similarly, patients were stratified based on duration of education in groups defined as < 9 years, 9-12 years and > 12 years, respectively.RESULTS We found that 92.2% of patients were of majority ethnicity. We found that 24.5%, 44.8% and 30.8% of patients had an education of < 9 years, 9-12 years and > 12 years, respectively. The mean preoperative(preOP) oxford knee score(OKS) in the total population was 23.6. Patients of minority ethnicity had lower mean pre-OP OKS(18.6 vs 23.9, P < 0.001), higher pain levels(VAS 73.0 vs 58.7, P < 0.001), expected higher levels of post-OP pain(VAS 14.1 vs 6.1, P = 0.02) and of overall symptoms(VAS 16.6 vs 6.4, P = 0.006). Patients with > 12 years education had lower mean pre-OP OKS(21.5 vs 23.8 and 24.6, P < 0.001) and higher pre-OP VAS pain(65.4 vs 59.2 and 56.4, P < 0.001) compared to groups with shorter education. One year post-operative(post-OP) patients of minority ethnicity had lower mean OKS, higher pain and lower QoL. One year post-OP patients with > 12 years education reported higher pain compared to patients with shorter educations. However, the response-rate was low(44.6%), and therefore post-OP results were not considered to be significant.CONCLUSION Minority ethnicity and the duration of education influ-ence preoperative disability and expectation in patients undergoing TKA. This should be taken into account when patients are advised pre-operatively.展开更多
Decisive and correlative factors of tourism industry core competitiveness in ethnic villages were analyzed, and it was proposed that location, environment, facilities and service quality laid the foundation of tourism...Decisive and correlative factors of tourism industry core competitiveness in ethnic villages were analyzed, and it was proposed that location, environment, facilities and service quality laid the foundation of tourism industry core competitiveness, tourism attractions were the core, construction of tourism industry cluster was the direction, and tourism business management model was the guarantee.展开更多
基金financially supported by the National Natural Science Foundation of China(No.81160008 and 81660013)
文摘Objective: To investigate the risk factors of chronic obstructive pulmonary disease(COPD) in Li and Han ethnic group in Hainan, China. Methods: All subjects were randomly selected from various regions in Hainan. General characteristics were compared between COPD cases and healthy control cases in both Li and Han ethnic groups. The odds ratio(OR), the corresponding 95% confidence interval(CI) of COPD were calculated by logistic regression.Results: A total of 277 Li COPD cases, 307 Li healthy control subjects, 290 Han COPD cases and 301 Han healthy control were included in this study. In both the Li and Han groups, the average age exceeded 65 years, and the cigarette number smoked per day and the smoking duration were correlated with risk of COPD. In the Li COPD subjects, low weight, smoking, and recurrent infection of respiratory tract were mainly risk factors; while the mainly risk factor of Han COPD subjects was family history of respiratory disease. Conclusions: The risk factors are different in COPD subjects of Han and Li nationalities in Hainan of China. The age and smoking are strongly correlated with COPD risk.
基金Supported by Scientific Research Foundation of Yunnan Provincial Department of Education(2010Z079)
文摘Ethnic minority areas area old revolutionary base areas,areas inhabited by ethnic minorities,remote areas,impoverished areas, and also difficult areas for construction of socialist harmonious society.Studying on factors influencing rural teacher flow in ethnic minority areas is of great significance to improving local teacher team structure and promoting balanced development of urban and rural education.However,it lacks empirical analysis based on field survey for the nonce.In this study,based on interview and questionnaire data of education departments and school leaders in 4 ethnic minority areas of Yunnan Province,it established binary Logistic model,analyzed factors influencing rural teacher flow in ethnic minority areas of Yunnan Province,and finally present policy recommendations.
文摘<b>Objective:</b> To explore the pathogenesis of PTSD in the brain-derived neurotrophic factor (BDNF) gene methylation of patients with posttraumatic stress disorder (Posttraumatic Stress Disorder, PTSD) in Hainan Province, the relationship between the influence of BDNF gene methylation and the influence of PTSD. <b>Methods:</b> A case-control study method was adopted, strictly in accordance with DSM-IV and PTSD diagnosis, and 150 Li PTSD patients matched with gender and age of 300 Han PTSD patients were selected as the research objects. The peripheral venous whole blood of the subjects was drawn, genomic DNA was extracted, modified with bisulfite, and directly sequenced to quantitatively detect the methylation status of the CpG island in the promoter region of brain-derived neurotrophic factor (BDNF). <b>Results:</b> The results showed that the methylation levels of CPGl, CPG2, CPG3, CPG4, CPG5, CPG6, CPG7, CPG9, CPGl2, CPGl3, CPGl4, CPGl5, CPGl6, CPGl7, and CPGl8 in THE BDNF promoter were significantly different between the HAN PTSD group and the Li PTSD group (<i>P</i> < 0.001). <b>Conclusion:</b> It is suggested that CPG methylation in the promoter region of BDNF gene is closely related to patients with PTSD. There is a statistical difference in the level of CpG methylation in the promoter region of BDNF gene in PTSD between Li and Han ethnic groups in Hainan Province. CpG methylation in the promoter region of BDNF gene may be used as a biomarker for the diagnosis of PTSD.
文摘In the regulation of human nervous system, cognitive function and other genes, epigenetics changes the expression of genes after being influenced by the external environment. DNA methylation levels are also different in different ethnic groups, and a large number of studies have shown that post-traumatic stress disorder (PTSD) has a certain genetic predisposition. Through the national differences of PTSD brain-derived neurotrophic factor genes, it not only provides new research directions for the pathogenesis and treatment of 5-HT-related mental diseases, but also provides information and new genetic indicators for forensic personal identification, paternity testing and assessment of mental status. A review studies on the national differences of brain-derived neurotrophic factor genes in patients with post-traumatic stress disorder.
文摘AIM:To compare the clinical factors and tumor characteristics that predict survival in colorectal cancer(CRC)patients with different ethnicities in Xin Jiang area.METHODS:A total of 1421 histopathologically confirmed sporadic CRC patients who were either Han/Chinese or Uyghur were identified and enrolled from a database of both diagnoses and operative procedures from Xin Jiang Tumor Hospital,which is affiliated to Xin Jiang Medical University between 2000 and 2007.Patients with family histories of CRC,hereditary nonpolyposis CRC,familial adenomatous polyposis,inflammatory bowel disease,carcinoid,squamous carcinoma or melanoma were excluded.The two ethnic groups were compared with regard to clinical features,tumor characteristics,disease stage,overall survival rate,diseasefree survival rate and cancer-specific survival rate.The factors predicting long-term survival were assessed via both univariate and multivariate analysis.RESULTS:Among the 1421 patients with CRC enrolled in this study,1210 patients were Han/Chinese(mean age,62.3±4.5 years;range,19-92 years),while 211patients were Uyghur(mean age,52.4±15.6 years;range,17-87 years).There were significant differences in proportions of gender,age,blood type,occupation and histopathological type between the Han/Chinese and Uyghur patients(P<0.05).The median overall,disease-free and cancer-specific survival time were 45,62and 65 mo for the Han/Chinese patients and 42,49 and61 mo for the Uyghur patients(P=0.000,P=0.005,P=0.007).The cumulative 5-year survival of the Uyghur patients was significantly worse than that of the Han patients(P=0.000).A multivariate analysis showed that age,ethnicity,histopathological type,differentiation,T(Infiltration depth),N(Lymph node metastasis),staging,postoperative metastasis and metastatic site(P<0.05)were found to be the prognostic factors.CONCLUSION:The Uyghur CRC patients are associated with significantly younger age,more aggressive histopathologic characteristics and have significantly worse prognosis than the Han/Chinese patients.
基金supported by Hainan Natural Science Fund (2002-203-30222)
文摘Objective:To investigate the prevalence and risk factors of bronchial asthma in the Li ethnic group in Hainan,China.Methods:This study employed a stratified random sample design using custom-designed questionnaires.Subjects with asthma-like symptoms were first identified by two rounds of surveys and then confirmed by respiratory physicians using pulmonary function test,bronchial dilation test and challenge test.Demographic data,information on family history of asthma,history of allergies,smoking habits,domestic cooking fuel and other potential risk factors were collected.Logistic regression was performed to evaluate risk factors for asthma.Results: The prevalence of asthma in the Li ethnic group was 3.38%,much higher than the national average level in China.Aging,agriculture industry(the rubber industry in particular),rural residence,family history of asthma,history of allergies,cold air,inhalation of dust and irritant gases,smoking,domestic cooking fuel and living environment were associated with increased risk of asthma.Conclusions:The high prevalence of asthma in the Li ethnic group highlights the importance of asthma prevention and treatment in this population.Risk factors indentified in this study warrant special attention.Elevating public awareness about asthma in local communities will benefit the prevention of the disease.
基金Supported by the Danish Rheumatism Association,No.R111-A2587
文摘AIM To investigate whether minority ethnicity and the duration of education influence preoperative disability and expectations in patients undergoing total knee arthroplasty.METHODS We prospectively included 829 patients undergoing primary unilateral total knee arthroplasty(TKA) from April 2013 to December 2014 at a single centre. Patients filled in pre-operative questionnaires with information regarding place of birth, duration of education, expectations for outcome of surgery and baseline characteristics. Patients were stratified based on ethnicity. Majority ethnicity was defined as born inthe study country and minority ethnicity was defined as born in any other country. Similarly, patients were stratified based on duration of education in groups defined as < 9 years, 9-12 years and > 12 years, respectively.RESULTS We found that 92.2% of patients were of majority ethnicity. We found that 24.5%, 44.8% and 30.8% of patients had an education of < 9 years, 9-12 years and > 12 years, respectively. The mean preoperative(preOP) oxford knee score(OKS) in the total population was 23.6. Patients of minority ethnicity had lower mean pre-OP OKS(18.6 vs 23.9, P < 0.001), higher pain levels(VAS 73.0 vs 58.7, P < 0.001), expected higher levels of post-OP pain(VAS 14.1 vs 6.1, P = 0.02) and of overall symptoms(VAS 16.6 vs 6.4, P = 0.006). Patients with > 12 years education had lower mean pre-OP OKS(21.5 vs 23.8 and 24.6, P < 0.001) and higher pre-OP VAS pain(65.4 vs 59.2 and 56.4, P < 0.001) compared to groups with shorter education. One year post-operative(post-OP) patients of minority ethnicity had lower mean OKS, higher pain and lower QoL. One year post-OP patients with > 12 years education reported higher pain compared to patients with shorter educations. However, the response-rate was low(44.6%), and therefore post-OP results were not considered to be significant.CONCLUSION Minority ethnicity and the duration of education influ-ence preoperative disability and expectation in patients undergoing TKA. This should be taken into account when patients are advised pre-operatively.
文摘Decisive and correlative factors of tourism industry core competitiveness in ethnic villages were analyzed, and it was proposed that location, environment, facilities and service quality laid the foundation of tourism industry core competitiveness, tourism attractions were the core, construction of tourism industry cluster was the direction, and tourism business management model was the guarantee.
