Bone age assessment(BAA)aims to determine whether a child’s growth and development are normal concerning their chronological age.To predict bone age more accurately based on radiographs,and for the left-hand X-ray im...Bone age assessment(BAA)aims to determine whether a child’s growth and development are normal concerning their chronological age.To predict bone age more accurately based on radiographs,and for the left-hand X-ray images of different races model can have better adaptability,we propose a neural network in parallel with the quantitative features from the left-hand bone measurements for BAA.In this study,a lightweight feature extractor(LFE)is designed to obtain the featuremaps fromradiographs,and amodule called attention erasermodule(AEM)is proposed to capture the fine-grained features.Meanwhile,the dimensional information of the metacarpal parts in the radiographs is measured to enhance the model’s generalization capability across images fromdifferent races.Ourmodel is trained and validated on the RSNA,RHPE,and digital hand atlas datasets,which include images from various racial groups.The model achieves a mean absolute error(MAE)of 4.42 months on the RSNA dataset and 15.98 months on the RHPE dataset.Compared to ResNet50,InceptionV3,and several state-of-the-art methods,our proposed method shows statistically significant improvements(p<0.05),with a reduction in MAE by 0.2±0.02 years across different racial datasets.Furthermore,t-tests on the features also confirm the statistical significance of our approach(p<0.05).展开更多
This paper discusses the well-known delayed choice Quantum Eraser experiment performed by Kim <em>et al.</em> in 2000 and analyzes it from a Classical Physics perspective. I have included a diagram of the ...This paper discusses the well-known delayed choice Quantum Eraser experiment performed by Kim <em>et al.</em> in 2000 and analyzes it from a Classical Physics perspective. I have included a diagram of the setup used in the experiment. I show that the result of the experiment can be explained by Classical Physics and does not require “Spooky action at a distance” due to entangled particles, as Einstein famously once put it, nor events modifying the past due to the delayed choice aspect of the experiment.展开更多
目的探讨跟骨骨折术后患者应用基于加速康复外科理念(Enhanced recovery after surgery,ERAS)的多维度护理,对其足踝功能康复训练耐受情况的影响。方法对2022年6月-2024年5月,收治的121例跟骨骨折患者,按简单随机抽样法分为对照组(n=60...目的探讨跟骨骨折术后患者应用基于加速康复外科理念(Enhanced recovery after surgery,ERAS)的多维度护理,对其足踝功能康复训练耐受情况的影响。方法对2022年6月-2024年5月,收治的121例跟骨骨折患者,按简单随机抽样法分为对照组(n=60)、观察组(n=61),两组均行外科手术后分别予以常规护理、常规护理+基于ERAS理念的多维度护理,对比两组遵医行为、足踝功能。结果观察组遵医行为率高于对照组(96.72%>81.67%)(χ2=7.149,P=0.008);护理后观察组踝关节功能评分(American Orthopaedic Foot and Ankle Society,AOFAS)(85.29±5.45)分均高于对照组(80.41±4.27)分(P<0.05)。结论应用基于ERAS理念的多维度护理,可有效提高跟骨骨折术后患者遵医行为,改善足踝功能,可行性良好。展开更多
目的:探究基于快速康复外科理念(enhanced recovery after surgery,ERAS)的童趣化护理在学龄前期儿童肱骨髁上骨折中的应用效果。方法:选取2021年7月-2023年3月苏州大学附属儿童医院收治的326例学龄前期肱骨髁上骨折住院患儿为研究对象...目的:探究基于快速康复外科理念(enhanced recovery after surgery,ERAS)的童趣化护理在学龄前期儿童肱骨髁上骨折中的应用效果。方法:选取2021年7月-2023年3月苏州大学附属儿童医院收治的326例学龄前期肱骨髁上骨折住院患儿为研究对象,按照随机数字表法将患儿分为对照组和ERAS组各163例。对照组采取围术期常规护理,ERAS组在对照组的基础上采取基于ERAS理念的童趣化护理干预,比较两组患儿配合度、疼痛程度、功能锻炼依从性、末梢血运障碍发生率及护理满意度。结果:ERAS组患儿配合度明显优于对照组,差异有统计学意义(P<0.001);ERAS组功能锻炼依从性明显优于对照组,差异有统计学意义(P<0.001);ERAS组肢体末梢循环障碍率低于对照组意义(P<0.05);ERAS组护理满意度优于对照组,差异有统计学意义(P<0.05)。结论:学龄前期肱骨髁上骨折患儿围术期运用基于ERAS理念的童趣化护理可促进术后尽快恢复,减轻疼痛反应,缩短住院时间,提高护理满意度。展开更多
Lysine lipoylation plays vital roles in cell metabolism and redox processes.For example,removal of lipoylation will decrease pyruvate dehydrogenase activity and affect the citric acid cycle.Despite the important funct...Lysine lipoylation plays vital roles in cell metabolism and redox processes.For example,removal of lipoylation will decrease pyruvate dehydrogenase activity and affect the citric acid cycle.Despite the important functions of lysine lipoylation,the mechanisms for the addition and removal of this modification remain largely unexplored.Very few useful chemical tools are available to study the interactions of lysine lipoylation with its regulatory delipoylation proteins.For example,immunoaffinity purification-mass spectrometry is one of such tools,which highly relies on antibody efficiency and purification techniques.Single-step activity based fluorogenic probes developed by our groups and others is also an efficient method to study the deacylation activity.Affinitybased labeling probe using photo-cross-linker is a powerful platform to study the transient and dynamic interactions of peptide ligands with the interacting proteins.Herein,we have designed and synthesized a dual-function probe KTLlip for studying enzymatic delipoylation(eraser)activity and interaction of lysine lipoylation with the eraser at the same time.We show that KTLlip can be used as a useful tool to detect delipoylation as demonstrated by its ability to fluorescently label the eraser activity of recombinant Sirt2.We envision that the probe will help delineate the roles of delipoylation enzyme in biology.展开更多
肝癌是我国常见的恶性肿瘤之一。肝切除术是肝癌的标准根治性治疗方法,研究表明将快速康复外科(enhanced recovery after surgery,ERAS)应用在肝胆手术中是安全且有效的。本文基于ERAS理念在肝切除术的术前、术中、术后护理现状及相关...肝癌是我国常见的恶性肿瘤之一。肝切除术是肝癌的标准根治性治疗方法,研究表明将快速康复外科(enhanced recovery after surgery,ERAS)应用在肝胆手术中是安全且有效的。本文基于ERAS理念在肝切除术的术前、术中、术后护理现状及相关研究进展进行综述,以期为肝切除术的患者护理提供参考。展开更多
基金supported by the grant from the National Natural Science Foundation of China(No.72071019)grant from the Natural Science Foundation of Chongqing(No.cstc2021jcyj-msxmX0185).
文摘Bone age assessment(BAA)aims to determine whether a child’s growth and development are normal concerning their chronological age.To predict bone age more accurately based on radiographs,and for the left-hand X-ray images of different races model can have better adaptability,we propose a neural network in parallel with the quantitative features from the left-hand bone measurements for BAA.In this study,a lightweight feature extractor(LFE)is designed to obtain the featuremaps fromradiographs,and amodule called attention erasermodule(AEM)is proposed to capture the fine-grained features.Meanwhile,the dimensional information of the metacarpal parts in the radiographs is measured to enhance the model’s generalization capability across images fromdifferent races.Ourmodel is trained and validated on the RSNA,RHPE,and digital hand atlas datasets,which include images from various racial groups.The model achieves a mean absolute error(MAE)of 4.42 months on the RSNA dataset and 15.98 months on the RHPE dataset.Compared to ResNet50,InceptionV3,and several state-of-the-art methods,our proposed method shows statistically significant improvements(p<0.05),with a reduction in MAE by 0.2±0.02 years across different racial datasets.Furthermore,t-tests on the features also confirm the statistical significance of our approach(p<0.05).
文摘This paper discusses the well-known delayed choice Quantum Eraser experiment performed by Kim <em>et al.</em> in 2000 and analyzes it from a Classical Physics perspective. I have included a diagram of the setup used in the experiment. I show that the result of the experiment can be explained by Classical Physics and does not require “Spooky action at a distance” due to entangled particles, as Einstein famously once put it, nor events modifying the past due to the delayed choice aspect of the experiment.
文摘目的探讨跟骨骨折术后患者应用基于加速康复外科理念(Enhanced recovery after surgery,ERAS)的多维度护理,对其足踝功能康复训练耐受情况的影响。方法对2022年6月-2024年5月,收治的121例跟骨骨折患者,按简单随机抽样法分为对照组(n=60)、观察组(n=61),两组均行外科手术后分别予以常规护理、常规护理+基于ERAS理念的多维度护理,对比两组遵医行为、足踝功能。结果观察组遵医行为率高于对照组(96.72%>81.67%)(χ2=7.149,P=0.008);护理后观察组踝关节功能评分(American Orthopaedic Foot and Ankle Society,AOFAS)(85.29±5.45)分均高于对照组(80.41±4.27)分(P<0.05)。结论应用基于ERAS理念的多维度护理,可有效提高跟骨骨折术后患者遵医行为,改善足踝功能,可行性良好。
文摘目的:探究基于快速康复外科理念(enhanced recovery after surgery,ERAS)的童趣化护理在学龄前期儿童肱骨髁上骨折中的应用效果。方法:选取2021年7月-2023年3月苏州大学附属儿童医院收治的326例学龄前期肱骨髁上骨折住院患儿为研究对象,按照随机数字表法将患儿分为对照组和ERAS组各163例。对照组采取围术期常规护理,ERAS组在对照组的基础上采取基于ERAS理念的童趣化护理干预,比较两组患儿配合度、疼痛程度、功能锻炼依从性、末梢血运障碍发生率及护理满意度。结果:ERAS组患儿配合度明显优于对照组,差异有统计学意义(P<0.001);ERAS组功能锻炼依从性明显优于对照组,差异有统计学意义(P<0.001);ERAS组肢体末梢循环障碍率低于对照组意义(P<0.05);ERAS组护理满意度优于对照组,差异有统计学意义(P<0.05)。结论:学龄前期肱骨髁上骨折患儿围术期运用基于ERAS理念的童趣化护理可促进术后尽快恢复,减轻疼痛反应,缩短住院时间,提高护理满意度。
基金supported by the Science Technology and Innovation Committee of Shenzhen Municipality(Grant Nos.JCYJ20180507181654823 and JCYJ20170413141047772)the National Natural Science Foundation of China(Grant No.21778044).
文摘Lysine lipoylation plays vital roles in cell metabolism and redox processes.For example,removal of lipoylation will decrease pyruvate dehydrogenase activity and affect the citric acid cycle.Despite the important functions of lysine lipoylation,the mechanisms for the addition and removal of this modification remain largely unexplored.Very few useful chemical tools are available to study the interactions of lysine lipoylation with its regulatory delipoylation proteins.For example,immunoaffinity purification-mass spectrometry is one of such tools,which highly relies on antibody efficiency and purification techniques.Single-step activity based fluorogenic probes developed by our groups and others is also an efficient method to study the deacylation activity.Affinitybased labeling probe using photo-cross-linker is a powerful platform to study the transient and dynamic interactions of peptide ligands with the interacting proteins.Herein,we have designed and synthesized a dual-function probe KTLlip for studying enzymatic delipoylation(eraser)activity and interaction of lysine lipoylation with the eraser at the same time.We show that KTLlip can be used as a useful tool to detect delipoylation as demonstrated by its ability to fluorescently label the eraser activity of recombinant Sirt2.We envision that the probe will help delineate the roles of delipoylation enzyme in biology.
文摘肝癌是我国常见的恶性肿瘤之一。肝切除术是肝癌的标准根治性治疗方法,研究表明将快速康复外科(enhanced recovery after surgery,ERAS)应用在肝胆手术中是安全且有效的。本文基于ERAS理念在肝切除术的术前、术中、术后护理现状及相关研究进展进行综述,以期为肝切除术的患者护理提供参考。
