Bone age assessment(BAA)aims to determine whether a child’s growth and development are normal concerning their chronological age.To predict bone age more accurately based on radiographs,and for the left-hand X-ray im...Bone age assessment(BAA)aims to determine whether a child’s growth and development are normal concerning their chronological age.To predict bone age more accurately based on radiographs,and for the left-hand X-ray images of different races model can have better adaptability,we propose a neural network in parallel with the quantitative features from the left-hand bone measurements for BAA.In this study,a lightweight feature extractor(LFE)is designed to obtain the featuremaps fromradiographs,and amodule called attention erasermodule(AEM)is proposed to capture the fine-grained features.Meanwhile,the dimensional information of the metacarpal parts in the radiographs is measured to enhance the model’s generalization capability across images fromdifferent races.Ourmodel is trained and validated on the RSNA,RHPE,and digital hand atlas datasets,which include images from various racial groups.The model achieves a mean absolute error(MAE)of 4.42 months on the RSNA dataset and 15.98 months on the RHPE dataset.Compared to ResNet50,InceptionV3,and several state-of-the-art methods,our proposed method shows statistically significant improvements(p<0.05),with a reduction in MAE by 0.2±0.02 years across different racial datasets.Furthermore,t-tests on the features also confirm the statistical significance of our approach(p<0.05).展开更多
With the merits of a simple process and a short fabrication period, the capacitor structure provides a convenient way to evaluate memory characteristics of charge trap memory devices. However, the slow minority carrie...With the merits of a simple process and a short fabrication period, the capacitor structure provides a convenient way to evaluate memory characteristics of charge trap memory devices. However, the slow minority carrier generation in a capacitor often makes an underestimation of the program/erase speed. In this paper, illumination around a memory capacitor is proposed to enhance the generation of minority carriers so that an accurate measurement of the program/erase speed can be achieved. From the dependence of the inversion capacitance on frequency, a time constant is extracted to quantitatively characterize the formation of the inversion layer. Experimental results show that under a high enough illumination, this time constant is greatly reduced and the measured minority carrier-related program/erase speed is in agreement with the reported value in a transistor structure.展开更多
This paper discusses the well-known delayed choice Quantum Eraser experiment performed by Kim <em>et al.</em> in 2000 and analyzes it from a Classical Physics perspective. I have included a diagram of the ...This paper discusses the well-known delayed choice Quantum Eraser experiment performed by Kim <em>et al.</em> in 2000 and analyzes it from a Classical Physics perspective. I have included a diagram of the setup used in the experiment. I show that the result of the experiment can be explained by Classical Physics and does not require “Spooky action at a distance” due to entangled particles, as Einstein famously once put it, nor events modifying the past due to the delayed choice aspect of the experiment.展开更多
Lysine lipoylation plays vital roles in cell metabolism and redox processes.For example,removal of lipoylation will decrease pyruvate dehydrogenase activity and affect the citric acid cycle.Despite the important funct...Lysine lipoylation plays vital roles in cell metabolism and redox processes.For example,removal of lipoylation will decrease pyruvate dehydrogenase activity and affect the citric acid cycle.Despite the important functions of lysine lipoylation,the mechanisms for the addition and removal of this modification remain largely unexplored.Very few useful chemical tools are available to study the interactions of lysine lipoylation with its regulatory delipoylation proteins.For example,immunoaffinity purification-mass spectrometry is one of such tools,which highly relies on antibody efficiency and purification techniques.Single-step activity based fluorogenic probes developed by our groups and others is also an efficient method to study the deacylation activity.Affinitybased labeling probe using photo-cross-linker is a powerful platform to study the transient and dynamic interactions of peptide ligands with the interacting proteins.Herein,we have designed and synthesized a dual-function probe KTLlip for studying enzymatic delipoylation(eraser)activity and interaction of lysine lipoylation with the eraser at the same time.We show that KTLlip can be used as a useful tool to detect delipoylation as demonstrated by its ability to fluorescently label the eraser activity of recombinant Sirt2.We envision that the probe will help delineate the roles of delipoylation enzyme in biology.展开更多
The erase voltage impact on the 0.18μm triple self-aligned split-gate flash endurance is studied.An optimized erase voltage is necessary in order to achieve the best endurance.A lower erase voltage can cause more cel...The erase voltage impact on the 0.18μm triple self-aligned split-gate flash endurance is studied.An optimized erase voltage is necessary in order to achieve the best endurance.A lower erase voltage can cause more cell current degradation by increasing its sensitivity to the floating gate voltage drop,which is induced by tunnel oxide charge trapping during program/erase cycling.A higher erase voltage also aggravates the endurance degradation by introducing select gate oxide charge trapping.A progressive erase voltage method is proposed and demonstrated to better balance the two degradation mechanisms and thus further improve endurance performance.展开更多
ERAS(Enhanced Recovery After Surgery)是加速术后康复或快速康复外科的缩写,是以患者为中心的新型康复理念,它通过优化外科诊疗全流程措施,减少患者生理和心理应激,助力术后快速康复。不少人秉持“术后卧床静养”“大补营养”等传统认...ERAS(Enhanced Recovery After Surgery)是加速术后康复或快速康复外科的缩写,是以患者为中心的新型康复理念,它通过优化外科诊疗全流程措施,减少患者生理和心理应激,助力术后快速康复。不少人秉持“术后卧床静养”“大补营养”等传统认知,使康复周期变长。ERAS以“减少应激、促进恢复”为要义,将术前、术中、术后的优化措施有机整合,降低手术对身体的创伤刺激,助力器官功能尽快复原。其优势众多,能大幅缩短住院时间,降低感染等并发症发生率,节省医疗费用,提升康复体验,让患者术后疼痛少、恢复快且心态积极。患者作为康复“主动者”,要与医护携手积极践行ERAS。展开更多
随着微创技术在妇科领域的广泛应用,腔镜手术已成为妇科良性肿瘤治疗的重要方式之一。然而,传统护理模式在术前准备、术中管理及术后恢复方面仍存在一定局限,难以满足患者快速康复的需求。快速康复护理路径(Enhanced Recovery After Sur...随着微创技术在妇科领域的广泛应用,腔镜手术已成为妇科良性肿瘤治疗的重要方式之一。然而,传统护理模式在术前准备、术中管理及术后恢复方面仍存在一定局限,难以满足患者快速康复的需求。快速康复护理路径(Enhanced Recovery After Surgery,ERAS)以循证医学为基础,通过对手术全过程进行科学化优化,减少机体应激反应,促进术后早期活动和功能恢复。本文以妇科良性肿瘤腔镜手术患者为研究对象,从快速康复护理路径的具体措施入手,探讨其在舒缓术后疼痛、改善肠道功能、减少并发症、缩短住院时间及提升患者身心康复方面的实际效果。研究发现,该护理路径能显著提高患者术后恢复质量,促进生活自理能力和总体满意度的提升,为妇科微创手术患者护理方案的优化提供了重要参考依据。展开更多
We found the qualitative study by Xu et al.on how patients feel about laparoscopic incisions under enhanced recovery after surgery(ERAS)protocols to be very interesting.1 Xu et al.carried out a qualitative study on pa...We found the qualitative study by Xu et al.on how patients feel about laparoscopic incisions under enhanced recovery after surgery(ERAS)protocols to be very interesting.1 Xu et al.carried out a qualitative study on patient experience with laparoscopic incisions under an ERAS protocol to highlight the problem of psychosocial and aesthetic concerns,which are often overlooked when planning surgical operations.This study,which involved semistructured interviews with sixteen people,aimed to narrow perioperative education and the decision-making process for incision site selection,thus making the processes more focused on patient priorities.The study is based on a timely but under-researched subject area;however,it is possible to outline four possible areas of improvement that would allow the study to be more transparent and,at the same time,more applicable to clinical practice.展开更多
基金supported by the grant from the National Natural Science Foundation of China(No.72071019)grant from the Natural Science Foundation of Chongqing(No.cstc2021jcyj-msxmX0185).
文摘Bone age assessment(BAA)aims to determine whether a child’s growth and development are normal concerning their chronological age.To predict bone age more accurately based on radiographs,and for the left-hand X-ray images of different races model can have better adaptability,we propose a neural network in parallel with the quantitative features from the left-hand bone measurements for BAA.In this study,a lightweight feature extractor(LFE)is designed to obtain the featuremaps fromradiographs,and amodule called attention erasermodule(AEM)is proposed to capture the fine-grained features.Meanwhile,the dimensional information of the metacarpal parts in the radiographs is measured to enhance the model’s generalization capability across images fromdifferent races.Ourmodel is trained and validated on the RSNA,RHPE,and digital hand atlas datasets,which include images from various racial groups.The model achieves a mean absolute error(MAE)of 4.42 months on the RSNA dataset and 15.98 months on the RHPE dataset.Compared to ResNet50,InceptionV3,and several state-of-the-art methods,our proposed method shows statistically significant improvements(p<0.05),with a reduction in MAE by 0.2±0.02 years across different racial datasets.Furthermore,t-tests on the features also confirm the statistical significance of our approach(p<0.05).
基金Project supported by the National Basic Research Program of China (Grant Nos. 2010CB934200 and 2011CBA00600)the National Natural Science Foundation of China (Grant Nos. 7360825403, 61176080, and 61176073)the National Science and Technology Major Project of China (Grant No. 2009ZX02023-005)
文摘With the merits of a simple process and a short fabrication period, the capacitor structure provides a convenient way to evaluate memory characteristics of charge trap memory devices. However, the slow minority carrier generation in a capacitor often makes an underestimation of the program/erase speed. In this paper, illumination around a memory capacitor is proposed to enhance the generation of minority carriers so that an accurate measurement of the program/erase speed can be achieved. From the dependence of the inversion capacitance on frequency, a time constant is extracted to quantitatively characterize the formation of the inversion layer. Experimental results show that under a high enough illumination, this time constant is greatly reduced and the measured minority carrier-related program/erase speed is in agreement with the reported value in a transistor structure.
文摘This paper discusses the well-known delayed choice Quantum Eraser experiment performed by Kim <em>et al.</em> in 2000 and analyzes it from a Classical Physics perspective. I have included a diagram of the setup used in the experiment. I show that the result of the experiment can be explained by Classical Physics and does not require “Spooky action at a distance” due to entangled particles, as Einstein famously once put it, nor events modifying the past due to the delayed choice aspect of the experiment.
基金supported by the Science Technology and Innovation Committee of Shenzhen Municipality(Grant Nos.JCYJ20180507181654823 and JCYJ20170413141047772)the National Natural Science Foundation of China(Grant No.21778044).
文摘Lysine lipoylation plays vital roles in cell metabolism and redox processes.For example,removal of lipoylation will decrease pyruvate dehydrogenase activity and affect the citric acid cycle.Despite the important functions of lysine lipoylation,the mechanisms for the addition and removal of this modification remain largely unexplored.Very few useful chemical tools are available to study the interactions of lysine lipoylation with its regulatory delipoylation proteins.For example,immunoaffinity purification-mass spectrometry is one of such tools,which highly relies on antibody efficiency and purification techniques.Single-step activity based fluorogenic probes developed by our groups and others is also an efficient method to study the deacylation activity.Affinitybased labeling probe using photo-cross-linker is a powerful platform to study the transient and dynamic interactions of peptide ligands with the interacting proteins.Herein,we have designed and synthesized a dual-function probe KTLlip for studying enzymatic delipoylation(eraser)activity and interaction of lysine lipoylation with the eraser at the same time.We show that KTLlip can be used as a useful tool to detect delipoylation as demonstrated by its ability to fluorescently label the eraser activity of recombinant Sirt2.We envision that the probe will help delineate the roles of delipoylation enzyme in biology.
文摘The erase voltage impact on the 0.18μm triple self-aligned split-gate flash endurance is studied.An optimized erase voltage is necessary in order to achieve the best endurance.A lower erase voltage can cause more cell current degradation by increasing its sensitivity to the floating gate voltage drop,which is induced by tunnel oxide charge trapping during program/erase cycling.A higher erase voltage also aggravates the endurance degradation by introducing select gate oxide charge trapping.A progressive erase voltage method is proposed and demonstrated to better balance the two degradation mechanisms and thus further improve endurance performance.
文摘ERAS(Enhanced Recovery After Surgery)是加速术后康复或快速康复外科的缩写,是以患者为中心的新型康复理念,它通过优化外科诊疗全流程措施,减少患者生理和心理应激,助力术后快速康复。不少人秉持“术后卧床静养”“大补营养”等传统认知,使康复周期变长。ERAS以“减少应激、促进恢复”为要义,将术前、术中、术后的优化措施有机整合,降低手术对身体的创伤刺激,助力器官功能尽快复原。其优势众多,能大幅缩短住院时间,降低感染等并发症发生率,节省医疗费用,提升康复体验,让患者术后疼痛少、恢复快且心态积极。患者作为康复“主动者”,要与医护携手积极践行ERAS。
文摘随着微创技术在妇科领域的广泛应用,腔镜手术已成为妇科良性肿瘤治疗的重要方式之一。然而,传统护理模式在术前准备、术中管理及术后恢复方面仍存在一定局限,难以满足患者快速康复的需求。快速康复护理路径(Enhanced Recovery After Surgery,ERAS)以循证医学为基础,通过对手术全过程进行科学化优化,减少机体应激反应,促进术后早期活动和功能恢复。本文以妇科良性肿瘤腔镜手术患者为研究对象,从快速康复护理路径的具体措施入手,探讨其在舒缓术后疼痛、改善肠道功能、减少并发症、缩短住院时间及提升患者身心康复方面的实际效果。研究发现,该护理路径能显著提高患者术后恢复质量,促进生活自理能力和总体满意度的提升,为妇科微创手术患者护理方案的优化提供了重要参考依据。
文摘We found the qualitative study by Xu et al.on how patients feel about laparoscopic incisions under enhanced recovery after surgery(ERAS)protocols to be very interesting.1 Xu et al.carried out a qualitative study on patient experience with laparoscopic incisions under an ERAS protocol to highlight the problem of psychosocial and aesthetic concerns,which are often overlooked when planning surgical operations.This study,which involved semistructured interviews with sixteen people,aimed to narrow perioperative education and the decision-making process for incision site selection,thus making the processes more focused on patient priorities.The study is based on a timely but under-researched subject area;however,it is possible to outline four possible areas of improvement that would allow the study to be more transparent and,at the same time,more applicable to clinical practice.
