The method for rapidly, precisely and non-invasively localizing functional regions of the brain is a problem in neuromedicine research. Cortical electrostimulation is the optimal localization method during brain surge...The method for rapidly, precisely and non-invasively localizing functional regions of the brain is a problem in neuromedicine research. Cortical electrostimulation is the optimal localization method during brain surgery, with a degree of accuracy of approximately 5 mm. However, electrostimulation can damage the cerebral cortex, trigger epilepsy, and extend the operation time. Studies are required to determine whether cortical motor regions can be localized by wavelet analysis from electrocorticograms. In this study, based on wavelet analysis of electrocorticograms, a selection of algorithms for classification of the mu rhythm in the motor regions utilizing experimental data was verified. Results demonstrated that a characteristic quantity of energy ratio in the reconstructed signal was filtered in the d6 （7.81-15.62 Hz） band prior to and following motion events. A characteristic threshold was considered to be 40%. The accuracy of localization detection was 93%. The degree of accuracy was less than 5 mm. The present study avoided the problems of cerebral cortex injury and epilepsy onset, with an operation time of 60 seconds. Therefore, wavelet analysis on electrocorticogram is feasible for localizing cortical motor regions. Furthermore, this localization technique is accurate, safe and rapid.展开更多
Epilepsy is a chronic nervous disease with increasing incidence worldwide,while the accurate localization of epileptic focus and the corresponding treatment are still challenging due to the lack of effective tools to ...Epilepsy is a chronic nervous disease with increasing incidence worldwide,while the accurate localization of epileptic focus and the corresponding treatment are still challenging due to the lack of effective tools to monitor and modulate the related brain neurological activities.In this work,stretchable micro electrocorticogram(mECoG)electrodes are developed and used to investigate penicillininduced epilepsy in rats.The electrodes possess excellent stretchability,conformality,anti-interference ability and sufficient resolution to successfully monitor electroencephalogram(EEG)signals,which is superior to traditional rigid polyimide-based electrodes.Characteristic epileptic spike waves are detected and analyzed to study the epileptic focus and electrical stimulus effects during epileptic seizures.It is found that the spike waves occur first in the visual cortex which is likely to be the epileptic focus.Epileptic spike wave frequency quickly increases to 1.07 Hz where it reaches a plateau and remains stable.There is no dominant brain hemisphere that would show early warning of epileptic seizures.Electrical stimuli for various times are applied after administering penicillin.It is found that 15 min of electrical stimulus has the best restraining effect on epileptic seizures.The mECoG electrodes developed in this study show potentials for applications in stretchable biomedical devices.展开更多
High spatiotemporal resolution brain electrical signals are critical for basic neuroscience research and high-precision focus diagnostic localization,as the spatial scale of some pathologic signals is at the submillim...High spatiotemporal resolution brain electrical signals are critical for basic neuroscience research and high-precision focus diagnostic localization,as the spatial scale of some pathologic signals is at the submillimeter or micrometer level.This entails connecting hundreds or thousands of electrode wires on a limited surface.This study reported a class of flexible,ultrathin,highdensity electrocorticogram(ECoG)electrode arrays.The challenge of a large number of wiring arrangements was overcome by a laminated structure design and processing technology improvement.The flexible,ultrathin,high-density ECoG electrode array was conformably attached to the cortex for reliable,high spatial resolution electrophysiologic recordings.The minimum spacing between electrodes was 15μm,comparable to the diameter of a single neuron.Eight hundred electrodes were prepared with an electrode density of 4444 mm^(-2).In focal epilepsy surgery,the flexible,high-density,laminated ECoG electrode array with 36 electrodes was applied to collect epileptic spike waves inrabbits,improving the positioning accuracy of epilepsy lesions from the centimeter to the submillimeter level.The flexible,high-density,laminated ECoG electrode array has potential clinical applications in intractable epilepsy and other neurologic diseases requiring high-precision electroencephalogram acquisition.展开更多
文摘The method for rapidly, precisely and non-invasively localizing functional regions of the brain is a problem in neuromedicine research. Cortical electrostimulation is the optimal localization method during brain surgery, with a degree of accuracy of approximately 5 mm. However, electrostimulation can damage the cerebral cortex, trigger epilepsy, and extend the operation time. Studies are required to determine whether cortical motor regions can be localized by wavelet analysis from electrocorticograms. In this study, based on wavelet analysis of electrocorticograms, a selection of algorithms for classification of the mu rhythm in the motor regions utilizing experimental data was verified. Results demonstrated that a characteristic quantity of energy ratio in the reconstructed signal was filtered in the d6 （7.81-15.62 Hz） band prior to and following motion events. A characteristic threshold was considered to be 40%. The accuracy of localization detection was 93%. The degree of accuracy was less than 5 mm. The present study avoided the problems of cerebral cortex injury and epilepsy onset, with an operation time of 60 seconds. Therefore, wavelet analysis on electrocorticogram is feasible for localizing cortical motor regions. Furthermore, this localization technique is accurate, safe and rapid.
基金financially supported by the National Key Scientific Research Instrument Development Project(81927804)the Major Scientific and Technological Innovation Projects of Shandong Province(2019JZZY011112)+1 种基金the Clinical Research Project of Shandong University(2020SDUCRCB004)the National Nature Science Foundation of China(81960419 and 81760416)。
文摘Epilepsy is a chronic nervous disease with increasing incidence worldwide,while the accurate localization of epileptic focus and the corresponding treatment are still challenging due to the lack of effective tools to monitor and modulate the related brain neurological activities.In this work,stretchable micro electrocorticogram(mECoG)electrodes are developed and used to investigate penicillininduced epilepsy in rats.The electrodes possess excellent stretchability,conformality,anti-interference ability and sufficient resolution to successfully monitor electroencephalogram(EEG)signals,which is superior to traditional rigid polyimide-based electrodes.Characteristic epileptic spike waves are detected and analyzed to study the epileptic focus and electrical stimulus effects during epileptic seizures.It is found that the spike waves occur first in the visual cortex which is likely to be the epileptic focus.Epileptic spike wave frequency quickly increases to 1.07 Hz where it reaches a plateau and remains stable.There is no dominant brain hemisphere that would show early warning of epileptic seizures.Electrical stimuli for various times are applied after administering penicillin.It is found that 15 min of electrical stimulus has the best restraining effect on epileptic seizures.The mECoG electrodes developed in this study show potentials for applications in stretchable biomedical devices.
基金support of the National Natural Science Foundation of China(Nos.U20A6001,12002190,11972207,and 11921002)the Fundamental Research Funds for the Central Universities,China(No.SWUKQ22029)the Chongqing Natural Science Foundation of China(No.CSTB2022NSCQ-MSX1635).
文摘High spatiotemporal resolution brain electrical signals are critical for basic neuroscience research and high-precision focus diagnostic localization,as the spatial scale of some pathologic signals is at the submillimeter or micrometer level.This entails connecting hundreds or thousands of electrode wires on a limited surface.This study reported a class of flexible,ultrathin,highdensity electrocorticogram(ECoG)electrode arrays.The challenge of a large number of wiring arrangements was overcome by a laminated structure design and processing technology improvement.The flexible,ultrathin,high-density ECoG electrode array was conformably attached to the cortex for reliable,high spatial resolution electrophysiologic recordings.The minimum spacing between electrodes was 15μm,comparable to the diameter of a single neuron.Eight hundred electrodes were prepared with an electrode density of 4444 mm^(-2).In focal epilepsy surgery,the flexible,high-density,laminated ECoG electrode array with 36 electrodes was applied to collect epileptic spike waves inrabbits,improving the positioning accuracy of epilepsy lesions from the centimeter to the submillimeter level.The flexible,high-density,laminated ECoG electrode array has potential clinical applications in intractable epilepsy and other neurologic diseases requiring high-precision electroencephalogram acquisition.
