Background/Aim: Telogen effluvium (TE) is a scalp disorder characterized by the thinning or shedding of hair resulting from the early entry of hair in the telogen phase. Nigella sativa (NS) is a dicotyledonous belongi...Background/Aim: Telogen effluvium (TE) is a scalp disorder characterized by the thinning or shedding of hair resulting from the early entry of hair in the telogen phase. Nigella sativa (NS) is a dicotyledonous belonging to the Ranunculacae family. It has been shown that its major constituent, tymoquinon (TQ), exerts anti-oxidant and anti-inflammatory effects by inhibiting pro-inflammatory mediators, such as cyclooxygenase and prostaglandin D2. The aim of this study is to evaluate the efficacy of NS essential oil as a potential treatment for TE, a pathology characterized by a significant inflammatory component. Study Design/Methods: Twenty patients affected by TE for this double-blind, placebo controlled and randomized study were enrolled. Ten of these patients were treated with a scalp lotion containing 0.5% NS, daily for 3 months, while the other ten patients were treated with placebo daily for 3 months. Videodermatoscopic analysis (Trichoscan Dermoscope Fotofinder?) and evaluation of three independent dermatologists were performed before treatment (T0), after 3 months of treatment (T3) and at the 6 months follow-up (T6). Results: The results showed a significant improvement in 70% of patients treated with NS. Videodermatoscopic analysis showed a significant increment of hair density and hair thickness in patients treated with NS. NS was also able to reduce the inflammation observed in the majority of patients affected by TE. Conclusions: The results of this study suggest that NS can be considered potentially useful for the treatment of TE.展开更多
Introduction:Anagen effluvium (AE) is caused by impaired mitotic activity of matrix cells in the hair follicles.It presents with sudden loss of hair and myelosuppression.The diagnosis is based on the clinical history,...Introduction:Anagen effluvium (AE) is caused by impaired mitotic activity of matrix cells in the hair follicles.It presents with sudden loss of hair and myelosuppression.The diagnosis is based on the clinical history,trichoscopy,and trichogram.Case presentation:A 20-year-old woman presented with sudden loss of hair following treatment with oral azathioprine.Evaluation of the TPMT were within normal limits both in genotype and phenotype levels.Hair pull test was positive.Trichoscopy revealed yellow dots and multiple black dots,empty yellow dots,dark lines,upright regrowing hairs,and circle hairs.Azathioprine was stopped,and minoxidil 5% and oral multivitamin were started.Posttreatment trichoscopic analysis revealed terminal hairs and upright regrowing hairs.Discussion:AE is characterized by abrupt loss of anagen hairs due to impaired metabolic activity.Trichoscopy in AE shows coudability hairs,black dots,exclamation mark hairs,multiple broken shafts,and regrowing hairs.Empty yellow dots,yellow dots with black dots,pigtail hairs,and dark lines were additional features in this study.Conclusion:Trichoscopy assists in the accurate diagnosis of AE.Adverse effects of azathioprine can be observed even with normal TPMT levels.Weekly monitoring is therefore of prime importance.展开更多
Hair loss is one of the most common complaints among all patients consulting a dermatologist and is usually associated with severe psychological disturbances, distress and symptoms of depression. [1-3]. It can be temp...Hair loss is one of the most common complaints among all patients consulting a dermatologist and is usually associated with severe psychological disturbances, distress and symptoms of depression. [1-3]. It can be temporary or long lasting. Diagnosis of hair loss is based on detailed clinical history, physical exam, clinical diagnostic tests, laboratory testing, and scalp biopsy, which may be necessary to confirm some diagnoses. This article presents an overview of the most common clinical causes of hair loss and provides updated information on the current available therapeutic options for these disorders.展开更多
文摘Background/Aim: Telogen effluvium (TE) is a scalp disorder characterized by the thinning or shedding of hair resulting from the early entry of hair in the telogen phase. Nigella sativa (NS) is a dicotyledonous belonging to the Ranunculacae family. It has been shown that its major constituent, tymoquinon (TQ), exerts anti-oxidant and anti-inflammatory effects by inhibiting pro-inflammatory mediators, such as cyclooxygenase and prostaglandin D2. The aim of this study is to evaluate the efficacy of NS essential oil as a potential treatment for TE, a pathology characterized by a significant inflammatory component. Study Design/Methods: Twenty patients affected by TE for this double-blind, placebo controlled and randomized study were enrolled. Ten of these patients were treated with a scalp lotion containing 0.5% NS, daily for 3 months, while the other ten patients were treated with placebo daily for 3 months. Videodermatoscopic analysis (Trichoscan Dermoscope Fotofinder?) and evaluation of three independent dermatologists were performed before treatment (T0), after 3 months of treatment (T3) and at the 6 months follow-up (T6). Results: The results showed a significant improvement in 70% of patients treated with NS. Videodermatoscopic analysis showed a significant increment of hair density and hair thickness in patients treated with NS. NS was also able to reduce the inflammation observed in the majority of patients affected by TE. Conclusions: The results of this study suggest that NS can be considered potentially useful for the treatment of TE.
文摘Introduction:Anagen effluvium (AE) is caused by impaired mitotic activity of matrix cells in the hair follicles.It presents with sudden loss of hair and myelosuppression.The diagnosis is based on the clinical history,trichoscopy,and trichogram.Case presentation:A 20-year-old woman presented with sudden loss of hair following treatment with oral azathioprine.Evaluation of the TPMT were within normal limits both in genotype and phenotype levels.Hair pull test was positive.Trichoscopy revealed yellow dots and multiple black dots,empty yellow dots,dark lines,upright regrowing hairs,and circle hairs.Azathioprine was stopped,and minoxidil 5% and oral multivitamin were started.Posttreatment trichoscopic analysis revealed terminal hairs and upright regrowing hairs.Discussion:AE is characterized by abrupt loss of anagen hairs due to impaired metabolic activity.Trichoscopy in AE shows coudability hairs,black dots,exclamation mark hairs,multiple broken shafts,and regrowing hairs.Empty yellow dots,yellow dots with black dots,pigtail hairs,and dark lines were additional features in this study.Conclusion:Trichoscopy assists in the accurate diagnosis of AE.Adverse effects of azathioprine can be observed even with normal TPMT levels.Weekly monitoring is therefore of prime importance.
文摘Hair loss is one of the most common complaints among all patients consulting a dermatologist and is usually associated with severe psychological disturbances, distress and symptoms of depression. [1-3]. It can be temporary or long lasting. Diagnosis of hair loss is based on detailed clinical history, physical exam, clinical diagnostic tests, laboratory testing, and scalp biopsy, which may be necessary to confirm some diagnoses. This article presents an overview of the most common clinical causes of hair loss and provides updated information on the current available therapeutic options for these disorders.
