Objective:To investigate the effects of gastrodin on neurotransmitter effect, stress response, blood vessel and nerve function in migraine patients.Methods:A total of90 patients with migraine admitted to our hospital ...Objective:To investigate the effects of gastrodin on neurotransmitter effect, stress response, blood vessel and nerve function in migraine patients.Methods:A total of90 patients with migraine admitted to our hospital from September 2016 to December 2017 were randomly divided into observation group and control group with 45 cases in each group. The control group was treated with flunarizine hydrochloride, while the observation group was treated with gastrodin based on the control group. The levels of neurotransmitter effect[including 5-serotonin (5-HT) and tumor necrosis factor alpha (TNF-alpha)], stress response[oxidized low density lipoprotein (ox-LDL) and paraoxonase-1 (PON-1)], vascular function[including nitric oxide (NO), endothelin-1 (ET-1)] and neurological function[including high brain-derived neurotrophic factor (BDNF) and calcitonin gene-related peptide (CGRP)] related indexes were observed and compared between the two groups.Results: The two groups showed significant changes in transmitter effect, stress response, blood vessel and nerve function. Before treatment, there was no significant difference in the levels between the two groups. After treatment, the levels of TNF-a, ox-LDL, NO, ET-1, BDNF and CGRP in the two groups were significantly lower than those before treatment, while the levels of 5-HT and PON-1 were significantly higher than those before treatment. And after treatment, the levels of TNF-a, ox-LDL, NO, ET-1, BDNF and CGRP in the observation group were significantly lower than those in the control group, while the levels of 5-HT and PON-1 were significantly higher than those in the control group.Conclusions:Gastrodin treatment can regulate oxidative stress level and improve vascular and neurological function in migraine patients.展开更多
BACKGROUND Conventional chemotherapy(CC)administered to patients with non-small cell lung cancer(NSCLC)often causes adverse effects,such as cardiopulmonary dysfunction and immune system imbalance.Patients may experien...BACKGROUND Conventional chemotherapy(CC)administered to patients with non-small cell lung cancer(NSCLC)often causes adverse effects,such as cardiopulmonary dysfunction and immune system imbalance.Patients may experience anxiety and depression during the perioperative period due to various factors,such as treatment costs and cancer recurrence risks,thereby compromising the overall quality of life.Consequently,we hypothesized that integrating mindfulness-based stress reduction training(MSRT)with Jinshui Liujun decoction may mitigate negative emotions and promote recovery in patients with NSCLC.AIM To explore the effects of MSRT and Jinshui Liujun decoction on the immune function and emotional state of NSCLC patients.METHODS A retrospective clinical study was conducted involving 92 patients with stage IIIb-IV NSCLC;35 patients in the control group(CG)received CC therapy(combination of pemetrexed and carboplatin),and 57 patients in the treatment group(TG)received MSRT-assisted flavored Jinshui Liujun decoction(FJLD)in addition to CC.We evaluated the survival time,Karnofsky performance status,treatment efficacy,traditional Chinese medicine syndrome score,immune function,negative emotional level,and adverse reactions of the CG and TG.RESULTS Median progression-free survival,Karnofsky performance status,and clinical efficacy of the TG were superior to those of the CG(P<0.05).Symptoms of cough,weakness,bloody sputum,shortness of breath,and chest pain significantly decreased in the TG compared to that in the CG(P<0.05).In the TG,MSRT+FJLD treatment increased the numbers of CD3^(+)and CD4^(+)immune cells,effectively reduced the number of CD8^(+)cells,and enhanced the CD4^(+)/CD8^(+)ratio,thereby restoring the immune function of patients.In the TG,the self-rating anxiety scale and self-rating depression scale scores decreased significantly.There was no statistically significant difference in the incidence of adverse reactions between the CG and TG(P>0.05).CONCLUSION MSRT+FJLD proved to be an effective treatment for patients with NSCLC.展开更多
Environmental stress is used as an indicator of the overall pressure on regional environmental systems caused by the output of various pollutants as a result of human activities. Based on the pollutant emissions and s...Environmental stress is used as an indicator of the overall pressure on regional environmental systems caused by the output of various pollutants as a result of human activities. Based on the pollutant emissions and socioeconomic databases of the counties in Beijing–Tianjin–Hebei region, this paper comprehensively calculates the environmental stress index(ESI) for the urban agglomeration using the entropy weight method(EWM) at the county scale and analyzes the spatiotemporal patterns and the differences among the four types of major functional zones(MFZ) for the period 2012–2016. In addition, the socioeconomic driving forces of environmental stress are quantitatively estimated using the geographically weighted regression(GWR) method based on the STIRPAT model framework. The results show that:(1) The level of environmental stress in the Beijing–Tianjin–Hebei region was significantly alleviated during that time period, with a decrease in ESI of 54.68% by 2016. This decrease was most significant in Beijing, Tangshan, Tianjin, Shijiazhuang, and other central urban areas, as well as the Binhai New Area. The level of environmental stress in counties decreased gradually from the central urban areas to the suburban areas, and the high-level stress counties were eliminated by 2016.(2) The spatial spillover effect of environmental stress increased further at the county scale from 2012 to 2016, and spatial locking and path dependence emerged in the cities of Tangshan and Tianjin.(3) Urbanized zones(development-optimized and development-prioritized zones) were the major areas bearing environmental pollution in the Beijing–Tianjin–Hebei region in that time period. The ESI accounted for 65.98% of the whole region, where there was a need to focus on the prevention and control of environmental pollution.(4) The driving factors of environmental stress at the county scale included population size and the level of economic development. In addition, the technical capacity of environmental waste disposal, the intensity of agricultural production input, the intensity of territorial development, and the level of urbanization also had a certain degree of influence.(5) There was spatial heterogeneity in the effects of the various driving factors on the level of environmental stress. Thus, it was necessary to adopt differentiated environmental governance and reduction countermeasures in respect of emission sources, according to the intensity and spatiotemporal differences in the driving forces in order to improve the accuracy and adaptability of environmental collaborative control in the Beijing–Tianjin–Hebei region.展开更多
This article delves into the research conducted by Liu DW et al on the integration of mindfulness-based stress reduction training(MSRT)and flavored Jinshui Liujun decoction(FJLD)with conventional chemotherapy(CC)in th...This article delves into the research conducted by Liu DW et al on the integration of mindfulness-based stress reduction training(MSRT)and flavored Jinshui Liujun decoction(FJLD)with conventional chemotherapy(CC)in the treatment of non-small cell lung cancer.The study investigates the impact of this combined approach on immune function and emotional well-being of non-small cell lung cancer patients.Patients were divided into a control group(CG)receiving CC alone and a treatment group(TG)receiving MSRT+FJLD alongside CC.The primary outcomes were progression-free survival and overall survival,with secondary outcomes including Karnofsky performance status scores,clinical efficacy,immune function markers,and emotional state assessments.The findings underscore significant improvements in median progression-free survival(20.50 months in TG vs 13.10 months in CG,P<0.05),Karnofsky performance status scores(60 in TG vs 50 in CG,P<0.05),and immune cell ratios,along with reductions in negative emotions(self-rating anxiety scale and self-rating depression scale scores significantly lower in TG,P<0.05)among patients receiving MSRT+FJLD in conjunction with CC.This article highlights the potential of combining traditional Chinese medicine and modern psychological interventions to enhance the efficacy of conventional cancer treatments and improve patient outcomes.展开更多
文摘Objective:To investigate the effects of gastrodin on neurotransmitter effect, stress response, blood vessel and nerve function in migraine patients.Methods:A total of90 patients with migraine admitted to our hospital from September 2016 to December 2017 were randomly divided into observation group and control group with 45 cases in each group. The control group was treated with flunarizine hydrochloride, while the observation group was treated with gastrodin based on the control group. The levels of neurotransmitter effect[including 5-serotonin (5-HT) and tumor necrosis factor alpha (TNF-alpha)], stress response[oxidized low density lipoprotein (ox-LDL) and paraoxonase-1 (PON-1)], vascular function[including nitric oxide (NO), endothelin-1 (ET-1)] and neurological function[including high brain-derived neurotrophic factor (BDNF) and calcitonin gene-related peptide (CGRP)] related indexes were observed and compared between the two groups.Results: The two groups showed significant changes in transmitter effect, stress response, blood vessel and nerve function. Before treatment, there was no significant difference in the levels between the two groups. After treatment, the levels of TNF-a, ox-LDL, NO, ET-1, BDNF and CGRP in the two groups were significantly lower than those before treatment, while the levels of 5-HT and PON-1 were significantly higher than those before treatment. And after treatment, the levels of TNF-a, ox-LDL, NO, ET-1, BDNF and CGRP in the observation group were significantly lower than those in the control group, while the levels of 5-HT and PON-1 were significantly higher than those in the control group.Conclusions:Gastrodin treatment can regulate oxidative stress level and improve vascular and neurological function in migraine patients.
基金Supported by Zhangjiakou Science and Technology Plan Project,No.2021127HScientific Research Program Project of Hebei Provincial Administration of Traditional Chinese Medicine,No.2022146.
文摘BACKGROUND Conventional chemotherapy(CC)administered to patients with non-small cell lung cancer(NSCLC)often causes adverse effects,such as cardiopulmonary dysfunction and immune system imbalance.Patients may experience anxiety and depression during the perioperative period due to various factors,such as treatment costs and cancer recurrence risks,thereby compromising the overall quality of life.Consequently,we hypothesized that integrating mindfulness-based stress reduction training(MSRT)with Jinshui Liujun decoction may mitigate negative emotions and promote recovery in patients with NSCLC.AIM To explore the effects of MSRT and Jinshui Liujun decoction on the immune function and emotional state of NSCLC patients.METHODS A retrospective clinical study was conducted involving 92 patients with stage IIIb-IV NSCLC;35 patients in the control group(CG)received CC therapy(combination of pemetrexed and carboplatin),and 57 patients in the treatment group(TG)received MSRT-assisted flavored Jinshui Liujun decoction(FJLD)in addition to CC.We evaluated the survival time,Karnofsky performance status,treatment efficacy,traditional Chinese medicine syndrome score,immune function,negative emotional level,and adverse reactions of the CG and TG.RESULTS Median progression-free survival,Karnofsky performance status,and clinical efficacy of the TG were superior to those of the CG(P<0.05).Symptoms of cough,weakness,bloody sputum,shortness of breath,and chest pain significantly decreased in the TG compared to that in the CG(P<0.05).In the TG,MSRT+FJLD treatment increased the numbers of CD3^(+)and CD4^(+)immune cells,effectively reduced the number of CD8^(+)cells,and enhanced the CD4^(+)/CD8^(+)ratio,thereby restoring the immune function of patients.In the TG,the self-rating anxiety scale and self-rating depression scale scores decreased significantly.There was no statistically significant difference in the incidence of adverse reactions between the CG and TG(P>0.05).CONCLUSION MSRT+FJLD proved to be an effective treatment for patients with NSCLC.
基金National Natural Science Foundation of China,No.41971164, No.42071148Strategic Priority Research Program of the Chinese Academy of Sciences,Grant No.XDA23020101。
文摘Environmental stress is used as an indicator of the overall pressure on regional environmental systems caused by the output of various pollutants as a result of human activities. Based on the pollutant emissions and socioeconomic databases of the counties in Beijing–Tianjin–Hebei region, this paper comprehensively calculates the environmental stress index(ESI) for the urban agglomeration using the entropy weight method(EWM) at the county scale and analyzes the spatiotemporal patterns and the differences among the four types of major functional zones(MFZ) for the period 2012–2016. In addition, the socioeconomic driving forces of environmental stress are quantitatively estimated using the geographically weighted regression(GWR) method based on the STIRPAT model framework. The results show that:(1) The level of environmental stress in the Beijing–Tianjin–Hebei region was significantly alleviated during that time period, with a decrease in ESI of 54.68% by 2016. This decrease was most significant in Beijing, Tangshan, Tianjin, Shijiazhuang, and other central urban areas, as well as the Binhai New Area. The level of environmental stress in counties decreased gradually from the central urban areas to the suburban areas, and the high-level stress counties were eliminated by 2016.(2) The spatial spillover effect of environmental stress increased further at the county scale from 2012 to 2016, and spatial locking and path dependence emerged in the cities of Tangshan and Tianjin.(3) Urbanized zones(development-optimized and development-prioritized zones) were the major areas bearing environmental pollution in the Beijing–Tianjin–Hebei region in that time period. The ESI accounted for 65.98% of the whole region, where there was a need to focus on the prevention and control of environmental pollution.(4) The driving factors of environmental stress at the county scale included population size and the level of economic development. In addition, the technical capacity of environmental waste disposal, the intensity of agricultural production input, the intensity of territorial development, and the level of urbanization also had a certain degree of influence.(5) There was spatial heterogeneity in the effects of the various driving factors on the level of environmental stress. Thus, it was necessary to adopt differentiated environmental governance and reduction countermeasures in respect of emission sources, according to the intensity and spatiotemporal differences in the driving forces in order to improve the accuracy and adaptability of environmental collaborative control in the Beijing–Tianjin–Hebei region.
基金Supported by the Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education,No.RS-2023-00237287。
文摘This article delves into the research conducted by Liu DW et al on the integration of mindfulness-based stress reduction training(MSRT)and flavored Jinshui Liujun decoction(FJLD)with conventional chemotherapy(CC)in the treatment of non-small cell lung cancer.The study investigates the impact of this combined approach on immune function and emotional well-being of non-small cell lung cancer patients.Patients were divided into a control group(CG)receiving CC alone and a treatment group(TG)receiving MSRT+FJLD alongside CC.The primary outcomes were progression-free survival and overall survival,with secondary outcomes including Karnofsky performance status scores,clinical efficacy,immune function markers,and emotional state assessments.The findings underscore significant improvements in median progression-free survival(20.50 months in TG vs 13.10 months in CG,P<0.05),Karnofsky performance status scores(60 in TG vs 50 in CG,P<0.05),and immune cell ratios,along with reductions in negative emotions(self-rating anxiety scale and self-rating depression scale scores significantly lower in TG,P<0.05)among patients receiving MSRT+FJLD in conjunction with CC.This article highlights the potential of combining traditional Chinese medicine and modern psychological interventions to enhance the efficacy of conventional cancer treatments and improve patient outcomes.
