Two new complexes[Mn(DHTA)(PLQ)]_(n)(1)and{[Co_(2)(DHTA)(phen)_(2)(H_(2)O)_(6)]·DHTA}_(n)(2)(H_(2)DHTA=2,5-dihydroxy-1,4-benzenedicarboxylic acid,PLQ=1,10-phenanthroline-5,6-quinone,phen=1,10-phenanthroline)have ...Two new complexes[Mn(DHTA)(PLQ)]_(n)(1)and{[Co_(2)(DHTA)(phen)_(2)(H_(2)O)_(6)]·DHTA}_(n)(2)(H_(2)DHTA=2,5-dihydroxy-1,4-benzenedicarboxylic acid,PLQ=1,10-phenanthroline-5,6-quinone,phen=1,10-phenanthroline)have been hydrothermally synthesized and structurally characterized by elemental analysis,IR spectrum,fluorescence spectrum,single-crystal and power X-ray diffraction.Complex 1 exhibits a two-dimensional(2 D)network,which was stabilized through O–H···O hydrogen bonding interactions.Complex 2 shows a zero-dimensional structure,which was further extended into a three-dimensional supramolecular structure through O–H···O hydrogen bonds andπ-πinteractions.展开更多
The formaidehyde-free finishing agent 4,5-di-hydroxy-1,3-dimethy1-2-imidazolidinone(DMeDHEU)was prepared by the reaction of 1,3-dimethylurea and glyoxal.The reaction rate and equilib-rium conversion in relation to pH ...The formaidehyde-free finishing agent 4,5-di-hydroxy-1,3-dimethy1-2-imidazolidinone(DMeDHEU)was prepared by the reaction of 1,3-dimethylurea and glyoxal.The reaction rate and equilib-rium conversion in relation to pH value,molar ratio,temperature and catalyst were studied.The conversionto DMeDHEU,catalyzed with citric acid/anhydrousNaAc,reached 95% in 6 hours at 40℃, pH 5.5 andmolar ratio 1.2.展开更多
目的探索酮还原酶家族1成员C3(aldo-keto reductase family 1 member C3,AKR1C3)对乳腺癌恶性细胞生物学行为的干预作用及对程序性细胞死亡蛋白/程序性死亡-配体1(programmed cell death protein1/programmed death-ligand1,PD-1/PD-L)...目的探索酮还原酶家族1成员C3(aldo-keto reductase family 1 member C3,AKR1C3)对乳腺癌恶性细胞生物学行为的干预作用及对程序性细胞死亡蛋白/程序性死亡-配体1(programmed cell death protein1/programmed death-ligand1,PD-1/PD-L)通路的影响。方法把MCF-7人乳腺癌细胞中NC组和AKR1C3组分别转染空质粒和AKR1C3质粒,采用MTT法检测转染后24 h、48 h、72 h细胞活力;采用流式细胞技术测定各组细胞的存活率以及早期、晚期凋亡比例;通过Transwell实验对各组细胞的迁移和侵袭能力进行检测;通过Western blot检测各组细胞PD-1、PD-L1、蛋白激酶B(protein kinase b,AKT)蛋白表达水平。使用C57BL/6小鼠构建荷瘤模型,将采用人乳腺癌MCF-7细胞转染NC质粒和AKR1C3质粒进行细胞荷瘤,每3 d测量瘤体积,持续21 d,绘制两组小鼠肿瘤生长曲线,并于实验终点测量肿瘤质量。结果相较于NC组,AKR1C3组细胞活力降低(P<0.05),并且具有时间依赖效应(P<0.05),迁移和侵袭能力降低(P<0.05),早期凋亡和晚期凋亡比例升高(P<0.05),PD-1、PD-L1、AKT蛋白表达水平降低(P<0.05)。动物实验表明,AKR1C3组小鼠肿瘤体积降低,肿瘤质量下降(P<0.05)。结论AKR1C3可以抑制人乳腺癌细胞恶性生物学行为,抑制PD-1/PDL1信号通路蛋白表达。展开更多
基金supported by the Science and Technology development plan of Jilin Province(2015052006JH)
文摘Two new complexes[Mn(DHTA)(PLQ)]_(n)(1)and{[Co_(2)(DHTA)(phen)_(2)(H_(2)O)_(6)]·DHTA}_(n)(2)(H_(2)DHTA=2,5-dihydroxy-1,4-benzenedicarboxylic acid,PLQ=1,10-phenanthroline-5,6-quinone,phen=1,10-phenanthroline)have been hydrothermally synthesized and structurally characterized by elemental analysis,IR spectrum,fluorescence spectrum,single-crystal and power X-ray diffraction.Complex 1 exhibits a two-dimensional(2 D)network,which was stabilized through O–H···O hydrogen bonding interactions.Complex 2 shows a zero-dimensional structure,which was further extended into a three-dimensional supramolecular structure through O–H···O hydrogen bonds andπ-πinteractions.
文摘The formaidehyde-free finishing agent 4,5-di-hydroxy-1,3-dimethy1-2-imidazolidinone(DMeDHEU)was prepared by the reaction of 1,3-dimethylurea and glyoxal.The reaction rate and equilib-rium conversion in relation to pH value,molar ratio,temperature and catalyst were studied.The conversionto DMeDHEU,catalyzed with citric acid/anhydrousNaAc,reached 95% in 6 hours at 40℃, pH 5.5 andmolar ratio 1.2.
