Iron deficiency anemia affects approximately 1.62 billion people worldwide,yet traditional iron supplements present bioavailability limitations and gastrointestinal side effects.This randomized,double-blind clinical t...Iron deficiency anemia affects approximately 1.62 billion people worldwide,yet traditional iron supplements present bioavailability limitations and gastrointestinal side effects.This randomized,double-blind clinical trial investigated a novel Auricularia auricula polysaccharide-iron complex(AAPIC)compared with heme iron and ferrous glycinate in 180 iron-deficient adults receiving 30 mg elemental iron daily for 12 weeks.AAPIC achieved comparable hemoglobin improvements(from 98.3±8.7 to 126.5±9.2 g/L)to heme iron(from 97.8±9.1 to 128.3±8.6 g/L)and was significantly superior to ferrous glycinate(from 98.6±8.9 to 119.7±10.3 g/L;p<0.001).Iron absorption efficiency showed AAPIC at 23.7±4.2%,heme iron at 25.1±3.8%,and ferrous glycinate at 18.4±5.1%.Toxicological assessments revealed no hepatotoxicity,nephrotoxicity,or mutagenicity.Gastrointestinal adverse events occurred in 8.3%of AAPIC recipients versus 15.0%with ferrous glycinate and 10.0%with heme iron.The polysaccharide component facilitates iron transport through enhanced intestinal uptake mechanisms.AAPIC represents a promising,well-tolerated alternative with clinical efficacy comparable to established iron formulations.展开更多
As large,room-scale environments become increasingly common,their spatial complexity increases due to variable,unstructured elements.Consequently,demand for room-scale service robots is surging,yet most technologies r...As large,room-scale environments become increasingly common,their spatial complexity increases due to variable,unstructured elements.Consequently,demand for room-scale service robots is surging,yet most technologies remain corridor-centric,and autonomous navigation in expansive rooms becomes unstable even around static obstacles.Existing approaches face several structural limitations.These include the labor-intensive requirement for large-scale object annotation and continual retraining,as well as the vulnerability of vanishing point or linebased methods when geometric cues are insufficient.In addition,the high cost of LiDAR and 3D perception errors caused by limited wall cues and dense interior clutter further limit their effectiveness.To address these challenges,we propose a zero-shot vision-based algorithm for robust 3D map reconstruction in geometry-deficient room-scale environments.The algorithm operates in three layers:Layer 1 performs dimension-wise boundary detection;Layer 2 estimates vanishing points,refines the precise perspective space,and extracts a floor mask;and Layer 3 conducts 3D spatial mapping and obstacle recognition.The proposed method was experimentally validated across various geometric-deficient room-scale environments,including lobbies,seminar rooms,conference rooms,cafeterias,and museums—demonstrating its ability to reliably reconstruct 3D maps and accurately recognize obstacles.Experimental results show that the proposed algorithm achieved an F1 score of 0.959 in precision perspective space detection and 0.965 in floor mask extraction.For obstacle recognition and classification,it obtained F1 scores of 0.980 in obstacle absent areas,0.913 in solid obstacle environments,and 0.939 in skeleton-type sparse obstacle environments,confirming its high precision and reliability in geometric-deficient room-scale environments.展开更多
This study presents a detailed investigation of the microstructure of the oxygen-deficient perovskite material Ca2FeGaO6-δ using Scanning Electron Microscopy (SEM). The material exhibits significant porosity and irre...This study presents a detailed investigation of the microstructure of the oxygen-deficient perovskite material Ca2FeGaO6-δ using Scanning Electron Microscopy (SEM). The material exhibits significant porosity and irregular grain morphology, with variations in grain size and growth. Unlike conventional perovskite structures, Ca2FeGaO6-δ shows non-uniform grain development, which can be attributed to the presence of oxygen vacancies (δ). SEM analysis reveals that the irregularities in grain size and shape, coupled with the porous nature of the material, are likely to influence its functional properties. These findings provide valuable insights into the structural features of Ca2FeGaO6-δ, offering a foundation for understanding its potential applications in catalysis, sensors, and other technologies. The study highlights the critical role of microstructural characteristics in determining the material’s performance.展开更多
AIM:To compare the Ishihara test errors scores of colour vision deficiency(CVD)subjects when wearing four different types of red-tinted contact lenses(RCL)that differ in their transmittance as determined using a spect...AIM:To compare the Ishihara test errors scores of colour vision deficiency(CVD)subjects when wearing four different types of red-tinted contact lenses(RCL)that differ in their transmittance as determined using a spectrophotometer.METHODS:Six congenital CVD subjects volunteered to participate in this study.Ishihara plates were used to determine the colour vision errors made,whereas Farnsworth-Munsell 100 Hue test was conducted to determine the total error scores(TES)and type of CVD.Four types of RCL(Types A,B,C and D)were inserted in the non-dominant eye and tested in a randomised manner by a masked operator.Errors scores in Ishihara test were determined at baseline without any contact lens and after wearing the four different RCL.The subjects were then divided into two groups based on the mean TES.RESULTS:Repeated measures ANOVA with Greenhouse-Geisser corrections showed that there was a highly significant effect of RCL type on Ishihara error score[F(2.056,10.282)=30.214,P<0.001].Error scores with RCL Type B were significantly lower than errors made when no lens was worn,and with RCL Type C and Type D(all P<0.001).Error scores with RCL Type B were also lower than those made with RCL Type A,however,they were not significantly different.For subjects with TES values less than 180,RCL type B showed the largest improvement in Ishihara error score(50%)compared to the other three RCLs.RCL type A showed the best performance in TES value of more than 180,with an improvement of 80%in Ishihara score.RCL Type A has the lowest transmittance at the confusion wavelength(450-568 nm),followed by RCL Types B,D and C.CONCLUSION:This study shows that RCL can improve Ishihara error scores.RCL with lower transmission at 450-568 nm and 90%transmittance beyond 637 nm are the most effective.Lenses which could block more light between 550-580 nm are more effective for colour defectives with more severe colour defects.展开更多
文摘Iron deficiency anemia affects approximately 1.62 billion people worldwide,yet traditional iron supplements present bioavailability limitations and gastrointestinal side effects.This randomized,double-blind clinical trial investigated a novel Auricularia auricula polysaccharide-iron complex(AAPIC)compared with heme iron and ferrous glycinate in 180 iron-deficient adults receiving 30 mg elemental iron daily for 12 weeks.AAPIC achieved comparable hemoglobin improvements(from 98.3±8.7 to 126.5±9.2 g/L)to heme iron(from 97.8±9.1 to 128.3±8.6 g/L)and was significantly superior to ferrous glycinate(from 98.6±8.9 to 119.7±10.3 g/L;p<0.001).Iron absorption efficiency showed AAPIC at 23.7±4.2%,heme iron at 25.1±3.8%,and ferrous glycinate at 18.4±5.1%.Toxicological assessments revealed no hepatotoxicity,nephrotoxicity,or mutagenicity.Gastrointestinal adverse events occurred in 8.3%of AAPIC recipients versus 15.0%with ferrous glycinate and 10.0%with heme iron.The polysaccharide component facilitates iron transport through enhanced intestinal uptake mechanisms.AAPIC represents a promising,well-tolerated alternative with clinical efficacy comparable to established iron formulations.
基金supported by Kyonggi University Research Grant 2025.
文摘As large,room-scale environments become increasingly common,their spatial complexity increases due to variable,unstructured elements.Consequently,demand for room-scale service robots is surging,yet most technologies remain corridor-centric,and autonomous navigation in expansive rooms becomes unstable even around static obstacles.Existing approaches face several structural limitations.These include the labor-intensive requirement for large-scale object annotation and continual retraining,as well as the vulnerability of vanishing point or linebased methods when geometric cues are insufficient.In addition,the high cost of LiDAR and 3D perception errors caused by limited wall cues and dense interior clutter further limit their effectiveness.To address these challenges,we propose a zero-shot vision-based algorithm for robust 3D map reconstruction in geometry-deficient room-scale environments.The algorithm operates in three layers:Layer 1 performs dimension-wise boundary detection;Layer 2 estimates vanishing points,refines the precise perspective space,and extracts a floor mask;and Layer 3 conducts 3D spatial mapping and obstacle recognition.The proposed method was experimentally validated across various geometric-deficient room-scale environments,including lobbies,seminar rooms,conference rooms,cafeterias,and museums—demonstrating its ability to reliably reconstruct 3D maps and accurately recognize obstacles.Experimental results show that the proposed algorithm achieved an F1 score of 0.959 in precision perspective space detection and 0.965 in floor mask extraction.For obstacle recognition and classification,it obtained F1 scores of 0.980 in obstacle absent areas,0.913 in solid obstacle environments,and 0.939 in skeleton-type sparse obstacle environments,confirming its high precision and reliability in geometric-deficient room-scale environments.
文摘This study presents a detailed investigation of the microstructure of the oxygen-deficient perovskite material Ca2FeGaO6-δ using Scanning Electron Microscopy (SEM). The material exhibits significant porosity and irregular grain morphology, with variations in grain size and growth. Unlike conventional perovskite structures, Ca2FeGaO6-δ shows non-uniform grain development, which can be attributed to the presence of oxygen vacancies (δ). SEM analysis reveals that the irregularities in grain size and shape, coupled with the porous nature of the material, are likely to influence its functional properties. These findings provide valuable insights into the structural features of Ca2FeGaO6-δ, offering a foundation for understanding its potential applications in catalysis, sensors, and other technologies. The study highlights the critical role of microstructural characteristics in determining the material’s performance.
文摘AIM:To compare the Ishihara test errors scores of colour vision deficiency(CVD)subjects when wearing four different types of red-tinted contact lenses(RCL)that differ in their transmittance as determined using a spectrophotometer.METHODS:Six congenital CVD subjects volunteered to participate in this study.Ishihara plates were used to determine the colour vision errors made,whereas Farnsworth-Munsell 100 Hue test was conducted to determine the total error scores(TES)and type of CVD.Four types of RCL(Types A,B,C and D)were inserted in the non-dominant eye and tested in a randomised manner by a masked operator.Errors scores in Ishihara test were determined at baseline without any contact lens and after wearing the four different RCL.The subjects were then divided into two groups based on the mean TES.RESULTS:Repeated measures ANOVA with Greenhouse-Geisser corrections showed that there was a highly significant effect of RCL type on Ishihara error score[F(2.056,10.282)=30.214,P<0.001].Error scores with RCL Type B were significantly lower than errors made when no lens was worn,and with RCL Type C and Type D(all P<0.001).Error scores with RCL Type B were also lower than those made with RCL Type A,however,they were not significantly different.For subjects with TES values less than 180,RCL type B showed the largest improvement in Ishihara error score(50%)compared to the other three RCLs.RCL type A showed the best performance in TES value of more than 180,with an improvement of 80%in Ishihara score.RCL Type A has the lowest transmittance at the confusion wavelength(450-568 nm),followed by RCL Types B,D and C.CONCLUSION:This study shows that RCL can improve Ishihara error scores.RCL with lower transmission at 450-568 nm and 90%transmittance beyond 637 nm are the most effective.Lenses which could block more light between 550-580 nm are more effective for colour defectives with more severe colour defects.
