摘要
目的观察中医疗法辅助唑吡坦治疗阴虚火旺型失眠的疗效及对近期复发率的影响。方法选取2020年4月—2021年12月在佛山市中医院治未病中心就诊的100例阴虚火旺型不寐患者为对象,采用分层法随机分为两组。唑吡坦组(50例,脱落3例)给予唑吡坦治疗,中医疗法组(50例,脱落1例)在唑吡坦组基础上给予中医疗法治疗。统计两组疗效和近期复发率,检测两组睡眠进程、睡眠结构的主要参数,评估两组生命质量综合评定问卷(GQOL-74)评分、匹兹堡睡眠质量指数(Pittsburgh sleep quality index,PSQI)、中医症状评分的差异。结果中医疗法组总有效率为91.84%(45/49)高于唑吡坦组的76.60%(36/47),差异有统计学意义(P<0.05)。治疗前,两组睡眠进程、睡眠结构的主要参数比较,差异有统计学意义(P<0.05)。与本组治疗前比较,两组睡眠潜伏期(sleep latency,SL)、觉醒次数(wake times,AT)、S1%、S2%、快速眼动(REM%)治疗后下降,中医疗法组较唑吡坦组更低(P<0.05);两组总睡眠时间(total sleep time,TSA)、睡眠效率(sleep efficiency,SE)、S4%治疗后升高,中医疗法组较唑吡坦组更高(P<0.05)。治疗前,两组GQOL-74评分、中医症状评分、PSQI评分比较,差异有统计学意义(P<0.05)。与本组治疗前比较,两组PSQI评分、中医症状评分治疗后下降,中医疗法组较唑吡坦组更低(P<0.05);两组GQOL-74评分治疗后升高,中医疗法组较唑吡坦组更高(P<0.05)。停药4周,中医疗法组治愈患者复发率为20.00%(4/20)低于唑吡坦组的61.54%(8/13),差异有统计学意义(P<0.05)。结论中医疗法辅助唑吡坦治疗阴虚火旺型不寐可有效改善失眠症状,调节睡眠进程和睡眠结构,提高生活质量,减少近期复发率。
Objective To observe the effect of traditional Chinese medicine therapy assisted by zolpidem on Yin deficiency with excessive fire type of insomnia and the recent recurrence rate.Methods A total of 100 patients with Yin deficiency and excessive fire type of insomnia who were treated in the Treatment Center of Foshan Hospital of Traditional Chinese Medicine from April 2020 to December 2021 were selected as the subjects and randomly divided into two groups by stratification method.The zolpidem group(50 cases,3 cases of shedding)was given zolpidem,and the traditional Chinese medicine group(50 cases,1 case of shedding)was given traditional Chinese medicine treatment on the basis of zolpidem.The efficacy and recent recurrence rate of the two groups were analyzed,the main parameters of sleep process and sleep structure were detected,and the differences of GQOL-74 score,Pittsburgh Sleep Quality Index(PSQI)and traditional Chinese medicine symptom scores between the two groups were evaluated.Results The total effective rate of the traditional Chinese medicine group was 91.84%(45/49),higher than that of the zolpidem group(76.60%,36/47)with statistical difference(P<0.05).Before treatment,there were no significant differences in the main parameters of sleep process and sleep structure between the two groups(P<0.05).Compared with those before treatment,the levels of sleep latency(SL),wake times(AT),S1%,S2%and rapid eye movement(REM)%of the two groups decreased after treatment,and the levels of the traditional Chinese medicine group were lower than those of the zolpidem group(P<0.05).The levels of Total sleep time(TSA),sleep efficiency(SE)and S4%of the two groups were increased after treatment,and the levels of traditional Chinese medicine group were higher than those of the zolpidem group(P<0.05).Before treatment,there was no significant difference in GQOL-74 score,TCM symptom scores or PSQI score between the two groups(P<0.05).Compared with those before treatment,PSQI score and TCM symptom scores of the two groups decreased after treatment,and the scores of the traditional Chinese medicine group were lower than those of the zolpidem group(P<0.05).The score of GQOL-74 in both groups was higher after treatment,and the score in the traditional Chinese medicine group was higher than that in the zolpidem group(P<0.05).After 4 weeks of drug withdrawal,the recurrence rate of the cured patients in the traditional Chinese medicine group was 20.00%(4/20),lower than that in the zolpidem group(61.54%,8/13)with statistical difference(P<0.05).Conclusion Traditional Chinese medicine therapy assisted zolpidem in the treatment of Yin deficiency and excessive fire type of insomnia can effectively improve the symptoms of insomnia,regulate the sleep process and sleep structure,improve the quality of life and reduce the recurrence rate in the near future.
作者
李东彩
刘继洪
宋少英
杨焱
LI Dongcai;LIU Jihong;SONG Shaoying;YANG Yan(Foshan Hospital of Traditional Chinese Medicine,Foshan 528000,Guangdong,China)
出处
《辽宁中医杂志》
北大核心
2026年第2期108-111,共4页
Liaoning Journal of Traditional Chinese Medicine
基金
广东省中医药局可以项目(20211368)。
关键词
中医疗法
阴虚火旺型
失眠
睡眠进程
睡眠结构
复发
traditional Chinese medicine therapy
Yin deficiency and excessive fire type
insomnia
sleep progression
sleep structure
recurrence
