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Dark count rate and band to band tunneling optimization for single photon avalanche diode topologies 被引量:2
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作者 Taha Haddadifam Mohammad Azim Karami 《Chinese Physics B》 SCIE EI CAS CSCD 2019年第6期458-464,共7页
This paper proposes two optimal designs of single photon avalanche diodes(SPADs) minimizing dark count rate(DCR). The first structure is introduced as p^+/pwell/nwell, in which a specific shallow pwell layer is added ... This paper proposes two optimal designs of single photon avalanche diodes(SPADs) minimizing dark count rate(DCR). The first structure is introduced as p^+/pwell/nwell, in which a specific shallow pwell layer is added between p^+and nwell layers to decrease the electric field below a certain threshold. The simulation results show on average 19.7%and 8.5% reduction of p^+/nwell structure’s DCR comparing with similar previous structures in different operational excess bias and temperatures respectively. Moreover, a new structure is introduced as n+/nwell/pwell, in which a specific shallow nwell layer is added between n+and pwell layers to lower the electric field below a certain threshold. The simulation results show on average 29.2% and 5.5% decrement of p^+/nwell structure’s DCR comparing with similar previous structures in different operational excess bias and temperatures respectively. It is shown that in higher excess biases(about 6 volts), the n+/nwell/pwell structure is proper to be integrated as digital silicon photomultiplier(dSiPM) due to low DCR. On the other hand, the p^+/pwell/nwell structure is appropriate to be utilized in dSiPM in high temperatures(above 50?C) due to lower DCR value. 展开更多
关键词 SINGLE-PHOTON AVALANCHE diode digital silicon PHOTOMULTIPLIER DARK count rate
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Effect of Source to Camera Distance and Count Rate on Intrinsic Uniformity of SPECT Gamma Camera
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作者 Sabrina Sarah Mahidul Haque Prodhan +1 位作者 Kawsar Hamid Fazlul Huq 《Open Journal of Medical Imaging》 2015年第2期78-84,共7页
In this research, the excellent parameter for regular Quality Control (QC) testing of intrinsic uniformity for dual-head Single Photon Emission Computed Tomography (SPECT) gamma camera is determined. The integral and ... In this research, the excellent parameter for regular Quality Control (QC) testing of intrinsic uniformity for dual-head Single Photon Emission Computed Tomography (SPECT) gamma camera is determined. The integral and differential intrinsic uniformity tests for both Useful Field Of View (UFOV) and Centre Field Of View (CFOV) were done by insertion a point-source of 99mTc in front of the detectors with detached collimators to measure the effect of source to camera distance and a count rate on intrinsic uniformity. The result reveals that the best intrinsic uniformity image is obtained at source-to-camera distance of 3 m and a count rate between 16 and 60 M. 展开更多
关键词 Quality Control (QC) INTRINSIC UNIFORMITY Useful Field of VIEW (UFOV) Centre Field of VIEW (CFOV) SOURCE to CAMERA DISTANCE count rate
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A deep-junction single-photon detector with field polysilicon gate structure for increased photon detection efficiency and reduced dark count noise
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作者 Zhentao Ni Dajing Bian +2 位作者 Haoxiang Jiang Xiaoming Huang Yue Xu 《Journal of Semiconductors》 2026年第1期65-71,共7页
A high-sensitivity,low-noise single photon avalanche diode(SPAD)detector was presented based on a 180 nm BCD process.The proposed device utilizes a p-implant layer/high-voltage n-well(HVNW)junction to form a deep aval... A high-sensitivity,low-noise single photon avalanche diode(SPAD)detector was presented based on a 180 nm BCD process.The proposed device utilizes a p-implant layer/high-voltage n-well(HVNW)junction to form a deep avalanche multiplication region for near-infrared(NIR)sensitivity enhancement.By optimizing the device size and electric field of the guard ring,the fill factor(FF)is significantly improved,further increasing photon detection efficiency(PDE).To solve the dark noise caused by the increasing active diameter,a field polysilicon gate structure connected to the p+anode was investigated,effectively suppressing dark count noise by 76.6%.It is experimentally shown that when the active diameter increases from 5 to 10μm,the FF is significantly improved from 20.7%to 39.1%,and thus the peak PDE also rises from 13.3%to 25.8%.At an excess bias voltage of 5 V,a NIR photon detection probability(PDP)of 6.8%at 905 nm,a dark count rate(DCR)of 2.12 cps/μm^(2),an afterpulsing probability(AP)of 1.2%,and a timing jitter of 216 ps are achieved,demonstrating excellent single photon detection performance. 展开更多
关键词 single-photon avalanche diode(SPAD) fill factor(FF) photon detection efficiency(PDE) dark count rate(DCR)
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Fiber coupled high count-rate single-photon generated from InAs quantum dots
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作者 Yao Chen Shulun Li +7 位作者 Xiangjun Shang Xiangbin Su Huiming Hao Jiaxin Shen Yu Zhang Haiqiao Ni Ying Ding Zhichuan Niu 《Journal of Semiconductors》 EI CAS CSCD 2021年第7期83-87,共5页
In this work,we achieve high count-rate single-photon output in single-mode(SM)optical fiber.Epitaxial and dilute InAs/GaAs quantum dots(QDs)are embedded in a GaAs/AlGaAs distributed Bragg reflector(DBR)with a micro-p... In this work,we achieve high count-rate single-photon output in single-mode(SM)optical fiber.Epitaxial and dilute InAs/GaAs quantum dots(QDs)are embedded in a GaAs/AlGaAs distributed Bragg reflector(DBR)with a micro-pillar cavity,so as to improve their light emission extraction in the vertical direction,thereby enhancing the optical SM fiber’s collection capabil-ity(numerical aperture:0.13).By tuning the temperature precisely to make the quantum dot exciton emission resonant to the micro-pillar cavity mode(Q~1800),we achieve a fiber-output single-photon count rate as high as 4.73×10^(6) counts per second,with the second-order auto-correlation g2(0)remaining at 0.08. 展开更多
关键词 single-photon source fiber-output high count rate
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Low-noise and high-rate front-end ASIC for APD detectors in STCF ECAL
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作者 Chao Liu Ran Zheng +4 位作者 Jia Wang Xiao-Min Wei Fei-Fei Xue Rui-Guang Zhao Yann Hu 《Nuclear Science and Techniques》 2025年第4期127-139,共13页
This study presents a low-noise,high-rate front-end readout application-specific integrated circuit(ASIC)designed for the electromagnetic calorimeter(ECAL)of the Super Tau-Charm Facility(STCF).To address the high back... This study presents a low-noise,high-rate front-end readout application-specific integrated circuit(ASIC)designed for the electromagnetic calorimeter(ECAL)of the Super Tau-Charm Facility(STCF).To address the high background-count rate in the STCF ECAL,the temporal features of signals are analyzed node-by-node along the chain of the analog front-end circuit.Then,the system is optimized to mitigate the pile-up effects and elevate the count rate to megahertz levels.First,a charge-sensitive amplifier(CSA)with a fast reset path is developed,enabling quick resetting when the output reaches the maximum amplitude.This prevents the CSA from entering a pulse-dead zone owing to amplifier saturation caused by the pile-up.Second,a high-order shaper with baseline holder circuits is improved to enhance the anti-pile-up capability while maintaining an effective noise-filtering performance.Third,a high-speed peak-detection and hold circuit with an asynchronous first-input-first-output buffer function is proposed to hold and read the piled-up signals of the shaper.The ASIC is designed and manufactured using a standard commercial 1P6M 0.18μm mixed-signal CMOS process with a chip area of 2.4 mm×1.6 mm.The measurement results demonstrate a dynamic range of 4–500 fC with a nonlinearity error below 1.5%.For periodically distributed input signals,a count rate of 1.5 MHz/Ch is achieved with a peak time of 360 ns,resulting in an equivalent noise charge(ENC)of 2500 e^(-)-.The maximum count rate is 4 MHz/Ch at a peak time of 120 ns.At a peak time of 1.68μs with a 270 pF external capacitance,the minimum ENC is 1966 e^(-)-,and the noise slope is 3.08 e^(-)-∕pF.The timing resolution is better than 125 ps at an input charge of 200 fC.The power consumption is 35 mW/Ch. 展开更多
关键词 Readout electronics APD Charge measurement High count rate STCF
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Evaluation of autonomic nervous system by heart rate variability and differential count of leukocytes in athletes 被引量:2
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作者 Nobuhiro Suetake Yukiko Morita +2 位作者 Daichi Suzuki Keiko Lee Hiroyuki Kobayashi 《Health》 2010年第10期1191-1198,共8页
Top Japanese sprinters were evaluated for their physical condition, autonomic function, blood chemistry, differential leukocyte count and blood lactate level before and after short, maximal exercise to explore methods... Top Japanese sprinters were evaluated for their physical condition, autonomic function, blood chemistry, differential leukocyte count and blood lactate level before and after short, maximal exercise to explore methods of quantifying their conditioning level. Statistical analysis of data obtained before and 10 min after exercise were used to estimate the athletes’ autonomic capacity during recovery. Pre and post exercise variances in differential leukocyte count revealed strong correlations between neutrophil and sympathetic activity, and lymphocyte and parasympathetic activity. The results of the study demonstrated significant alterations in autonomic parameters and differential white blood cell count in response to maximal exercise. 展开更多
关键词 HEART rate VARIABILITY CONDITIONING DIFFERENTIAL count of Leukocytes
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An active base designed in high-counting-rate applications for Hamamatsu R1924A photomultiplier tube
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作者 Pei-Pei Ren Wei-Ping Lin +10 位作者 Roy Wada Xing-Quan Liu Mei-Rong Huang Guo-Yu Tian Fei Luo Qi Sun Zhi-Qiang Chen Guo-Qing Xiao Rui Han Fu-Dong Shi Bo-Xing Gou 《Nuclear Science and Techniques》 SCIE CAS CSCD 2017年第10期59-63,共5页
Hamamatsu R1924A is one of the most widely used photomultiplier tubes(PMTs) in nuclear physics.Since the active base suitable for R1924A is still not available in market, an active base is designed for Hamamatsu R1924... Hamamatsu R1924A is one of the most widely used photomultiplier tubes(PMTs) in nuclear physics.Since the active base suitable for R1924A is still not available in market, an active base is designed for Hamamatsu R1924A PMT, and the test results at high counting rates are presented. The active bases with two different sets of resistor chains were tested and compared by a frequency-controlled green straw hat LED light. A stable signal output up to 100 kHz is achieved using frequency-controlled LED pulsed light. The temperature of bases, which reflects the power consumption and is crucial for applications in vacuum, is also monitored with the same LED pulsed light. The temperature of the active base with smaller resistances reaches about twice of that of the active base with larger resistances in the resistor chain. For the applications in vacuum, the active base with resistance between the two sets of resistor chains may be preferable. 展开更多
关键词 光电倍增管 高计数率 应用 设计 活性基团 LED灯 频率控制
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不同制备条件对去白细胞悬浮红细胞质量的影响
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作者 张雪松 柴婷婷 +4 位作者 葛乃嘉 刘微 刘祥君 巩春玲 李建民 《中国实用医药》 2026年第5期20-26,共7页
目的研究不同垂直高度差过滤血液、血液表面温度、离心力、离心时间、储存介质等条件对制备去白细胞悬浮红细胞质量的影响。方法采用随机抽样法选取480袋400 ml全血作为研究对象,分别用于白细胞去除、离心以及分离。去除白细胞环节选取6... 目的研究不同垂直高度差过滤血液、血液表面温度、离心力、离心时间、储存介质等条件对制备去白细胞悬浮红细胞质量的影响。方法采用随机抽样法选取480袋400 ml全血作为研究对象,分别用于白细胞去除、离心以及分离。去除白细胞环节选取60袋当天采集且血液温度为18℃的全血,血液过滤垂直高度差分别为1.2 m组、1.5 m组、1.8 m组,每组20袋;另选取60袋当天采集的全血,根据血液表面温度分为高温组(>20℃)、中温组(15~20℃)、低温组(<15℃),每组20袋;在相同垂直高度差下进行去白细胞过滤,对比三组的过滤时间并采用流式法检测白细胞残留量。离心环节选取320袋当天采集并过滤的去白细胞全血按照16种不同离心条件进行离心,对比制备后去白细胞悬浮红细胞容量、血红蛋白含量以及溶血率。分离环节选取40袋当天采集并过滤的去白细胞全血于当天完成分离制备,保存去白细胞全血样本与去白细胞悬浮红细胞样本,分别于0、5、7、14、28 d检测储存于血浆和红细胞添加液中红细胞内三磷酸腺苷(ATP)含量以及上清液中2,3-二磷酸甘油酸(2,3-DPG)释放含量,对比同源红细胞储存在血浆与红细胞添加液中对ATP与2,3-DPG释放含量的影响。结果①不同垂直高度差条件下,血液表面温度为18℃的全血,去除白细胞后1.2 m组白细胞残留量(2.29±1.34)×10^(6)/L显著低于1.5 m组的(3.74±1.66)×10^(6)/L和1.8 m组的(4.45±2.26)×10^(6)/L,差异有统计学意义(P<0.05);三组在过滤时间上差异无统计学意义(P>0.05)。不同滤前血液表面温度条件下,低温组的白细胞残留量(1.50±1.23)×10^(6)/L低于中温组的(2.14±0.54)×10^(6)/L和高温组的(2.71±1.95)×10^(6)/L,差异有统计学意义(P<0.05);三组在过滤时间上差异无统计学意义(P>0.05)。②不同离心力和离心时间条件下:随着离心力的增大与离心时间的延长,去白细胞悬浮红细胞容量、血红蛋白含量差异无统计学意义(P>0.05)。随着离心力的增大与离心时间的延长,溶血率呈上升趋势,差异有统计学意义(P<0.05);且离心力对溶血率的影响较离心时间更大。③不同储存介质条件下,红细胞内ATP含量0 d时接近相同,3 d时差异初显,随着储存时间的延长ATP含量差异逐渐增大,28 d储存于血浆中红细胞内ATP含量减少约48%。而储存于红细胞添加液中红细胞内ATP含量仅减少20%,减少速度明显少于全血样本;2,3-DPG释放含量储存于红细胞添加液中在0~7 d时趋于稳定,7 d后2,3-DPG释放含量开始增加;而储存于血浆中在3 d时2,3-DPG释放含量较0 d增加明显,随着储存时间的延长红细胞释放到上清液中2,3-DPG含量逐渐增多。储存在红细胞添加液内的2,3-DPG释放含量明显少于全血。结论垂直高度差和血液表面温度均对白细胞残留量有显著影响,建议将垂直高度差控制在1.2 m,并将滤前血液表面温度控制在20℃以下。随着离心时间与离心力的增加,去白细胞悬浮红细胞溶血率明显增加。相较于离心时间,离心力对溶血率的影响更加明显。制备过程中,可根据制备需要选择更佳的离心方式,离心力大、离心时间短可以节省制备时间,而离心力小、离心时间长对于红细胞“更温和”,可根据制备需要选择适合的离心参数。研究表明在制备红细胞制剂时,当离心力为5000 g,则离心时间不宜超过7 min。如4000 g/15 min、4500 g/12 min、4500 g/15 min、5000 g/7 min等更为适合。红细胞储存在不同介质中会影响红细胞内ATP与红细胞释放到储存介质的2,3-DPG释放含量,3d时二者差异初显,3 d后差异开始明显,建议在3 d内完成去白细胞全血的分离并制备成去白细胞悬浮红细胞。 展开更多
关键词 白细胞残留量 溶血率 离心力 离心时间 三磷酸腺苷 2 3-二磷酸甘油酸
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源量程中子测量系统堆积脉冲甄别的数字化处理研究
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作者 朱朝阳 唐鹏 +2 位作者 李立涛 王振涛 邢桂来 《核电子学与探测技术》 北大核心 2026年第2期158-164,共7页
源量程中子测量是反应堆三段式中子测量方式之一,该方法以涂硼正比管作为中子探测器,在对高中子注量率测量时输出脉冲信号会产生堆积效应,造成甄别漏记,导致计数率准确性降低。本文基于数字信号处理技术在核测领域的应用,针对涂硼正比... 源量程中子测量是反应堆三段式中子测量方式之一,该方法以涂硼正比管作为中子探测器,在对高中子注量率测量时输出脉冲信号会产生堆积效应,造成甄别漏记,导致计数率准确性降低。本文基于数字信号处理技术在核测领域的应用,针对涂硼正比管的脉冲波形提出一种脉冲信号数字处理方法,实现对含噪声的堆积脉冲信号分离识别与计数。该脉冲信号数字处理过程由低通滤波、极零相消成形、平滑化差分三级级联构成,可对前置放大器输出信号经模数转换后的脉冲完成数字处理。采用FPGA实现该数字处理并开展功能测试。结果表明,经数字处理后的脉冲分辨时间从970 ns降至385 ns,缩减幅度达60%,显著提高涂硼计数管计数率上限。本文设计的数字处理方法有利于提升源量程中子注量率测量范围,配合FPGA能便捷调节参数以匹配探测器脉冲信号,可调性与普适性强,适用于反应堆源量程中子测量系统的数字化改进。 展开更多
关键词 脉冲信号处理 数字化处理 脉冲堆积 计数率
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Tests on Application of Soil Magnetic and Integrated Gamma Ray TLD and TC Methods to the Exploration of Sandstone-Type Uranium Deposits 被引量:1
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作者 ZOU Ligui ZHANG Jiyun +1 位作者 YAN Jun GUAN Shaobin 《Acta Geologica Sinica(English Edition)》 SCIE CAS CSCD 2000年第2期418-424,共7页
This paper introduces the test results of the soil magnetic survey and the integrated gamma-ray TLD and TC methods for sandstone-type uranium exploration and describes the prospecting mechanism. The tests have proved ... This paper introduces the test results of the soil magnetic survey and the integrated gamma-ray TLD and TC methods for sandstone-type uranium exploration and describes the prospecting mechanism. The tests have proved that these approaches have yielded good results on classifying the sedimentary facies, defining the redox transitional zones and reflecting deep mineralization information. They may probably become new methods on searching for sandstone-type uranium deposits. 展开更多
关键词 soil magnetism gamma-ray thermoluminescence dosimetry total count rate of gamma ray sandstone-type uranium deposit
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牛冷冻精液稀释液的消毒法研究
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作者 杨利锋 《现代畜牧兽医》 2026年第1期21-24,共4页
试验旨在探究牛冻精生产中含卵黄冻精稀释液的微生物控制方法,以及冻精稀释液消毒对冻精性能的影响。试验以冻精稀释液中菌落数以及冷冻精液冻前、冻后的精子活力及冻后的精子畸形率为核心指标,设置巴氏消毒处理组与未处理组冻精稀释液... 试验旨在探究牛冻精生产中含卵黄冻精稀释液的微生物控制方法,以及冻精稀释液消毒对冻精性能的影响。试验以冻精稀释液中菌落数以及冷冻精液冻前、冻后的精子活力及冻后的精子畸形率为核心指标,设置巴氏消毒处理组与未处理组冻精稀释液进行对比分析。结果显示:未经消毒的含卵黄冻精稀释液菌落数均大于1 000 CFU/剂,而经巴氏消毒后的冻精稀释液中菌落数均为0,消毒效果极其显著;巴氏消毒处理冻精稀释液对冷冻精液冻前、冻后的精子活力及冻后精子畸形率均无明显影响。研究表明,巴氏消毒法可在牛冻精稀释液处理中推广应用。 展开更多
关键词 牛冷冻精液 巴氏消毒 冻精稀释液 菌落数 精子活力 精子畸形率
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An Interconnection between Elevated SCC Levels in Milk around the First Artificial Insemination and Pregnancy Rate in Dairy Cows
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作者 Găvan Constantin 《Open Journal of Animal Sciences》 2023年第4期529-538,共10页
The aim of this study was to evaluate the impact of the somatic cell count (SCC) levels measured at 28-test-day intervals or pregnancy rate at the first artificial insemination of Holstein Friesian cows. All necessary... The aim of this study was to evaluate the impact of the somatic cell count (SCC) levels measured at 28-test-day intervals or pregnancy rate at the first artificial insemination of Holstein Friesian cows. All necessary information was taken from test day and farm records. Levels of SCC in milk, 30 days before, and 30 days after the first artificial insemination (FAI) date were divided into 4 categories and their interconnection with pregnancy rate (PR) at FAI was evaluated by applying logistic models. A SCC threshold of 150.000 cells/ml of milk was used to differentiate uninfected udders and infected udders of Holstein Friesian cows. A level of SCC > 150.000 cells/ml in milk, and a level of SCC < 150.000 cells/ml before and after FAI respectively were considered udders with new infections. A level of SCC > 150.000 cells/ml in milk before FAI as well as after FAI, was considered chronically infected udders or subclinical intramammary infections (IMI). Data from 792 FAIs from farm and test day records over a 4-year period (2019-2022) were evaluated. The outcome of this study revealed that the risk for low PR at the first AI was increased in cows with infected udders (OR = 1.33, CI 0.99 - 1.78), compared with uninfected udders. Increased levels of SCC after FAI had a negative effect on PR, while before FAI was not affected. To achieve a good PR, mastitis control measures must be fully adopted to a large extent around the first AI. 展开更多
关键词 Somatic Cell count FERTILITY Pregnant rate Test-Day-Milk Data
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基于FPGA的实时核信号堆积分离算法实现及验证
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作者 唐超 周文雄 +5 位作者 童腾 张传文 李道武 黄润之 潘良明 魏龙 《核技术》 北大核心 2025年第8期52-62,共11页
在核探测中,随着实验研究的深入,探测器信号的计数率越来越高。然而,高计数率下的核信号堆积问题会影响后续数据分析的效率和精度,因此需要对堆积信号进行处理。目前常用的解决方法是采用堆积识别判弃,但此方法会造成计数的丢失,在一些... 在核探测中,随着实验研究的深入,探测器信号的计数率越来越高。然而,高计数率下的核信号堆积问题会影响后续数据分析的效率和精度,因此需要对堆积信号进行处理。目前常用的解决方法是采用堆积识别判弃,但此方法会造成计数的丢失,在一些定时分析等应用中存在局限性。本文提出一种基于现场可编程逻辑门阵列(Field Programmable Gate Array,FPGA)的实时堆积分离算法,通过对原始信号进行快/慢成形处理,快成形采用三角成形方法,用于获取核信号的到达时间,以确定是否发生堆积;慢成形采用梯形成形方法,用于提取核信号的能量信息,同时借助梯形信号对称上升/下降沿特征,根据叠加原理和堆积发生时间点分离堆积信号,提升系统计数性能,其算法简单且计算量小,利于在FPGA内中实现。在仿真测试实验中,所提算法在保证分离准确度前提下计数率有效提高4%~26.5%,在放射源实验中,所提算法在所测试计数率范围内,计数率有效提高6.8%~13.5%,为高计数率环境下堆积信号处理提供了新的分离方法。 展开更多
关键词 核信号堆积 高计数率 梯形成形 堆积分离 FPGA
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Drone-based superconducting nanowire single-photon detection system with a detection efficiency of more than 90% 被引量:2
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作者 Ruoyan Ma Zhimin Guo +11 位作者 Dai Chen Xiaojun Dai You Xiao Chengjun Zhang Jiamin Xiong Jia Huang Xingyu Zhang Xiaoyu Liu Liangliang Rong Hao Li Xiaofu Zhang Lixing You 《Advanced Photonics Nexus》 2025年第2期25-30,共6页
Conventional superconducting nanowire single-photon detectors(SNSPDs)have been typically limited in their applications due to their size,weight,and power consumption,which confine their use to laboratory settings.Howe... Conventional superconducting nanowire single-photon detectors(SNSPDs)have been typically limited in their applications due to their size,weight,and power consumption,which confine their use to laboratory settings.However,with the rapid development of remote imaging,sensing technologies,and long-range quantum communication with fewer topographical constraints,the demand for high-efficiency single-photon detectors integrated with avionic platforms is rapidly growing.We herein designed and manufactured the first drone-based SNSPD system with a system detection efficiency(SDE)as high as 91.8%.This drone-based system incorporates high-performance NbTiN SNSPDs,a self-developed miniature liquid helium dewar,and custom-built integrated electrical setups,making it capable of being launched in complex topographical conditions.Such a drone-based SNSPD system may open the use of SNSPDs for applications that demand high SDE in complex environments. 展开更多
关键词 superconducting nanowire single-photon detector drone-based single-photon detection system high system detection efficiency dark count rate
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高压纹波对光电倍增管计数率的影响及补偿方法
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作者 王小鹏 李家隆 许金玉 《光学精密工程》 北大核心 2025年第16期2531-2542,共12页
在化工产品生产过程,利用放射源射线穿透管道测量溶液密度时,光电倍增管输出计数率易受高压纹波噪声的影响,发生明显衰减,导致密度测量精度下降。为降低纹波噪声对计数率的影响,需要补偿因纹波而衰减的计数率。首先,根据在不同高压纹波... 在化工产品生产过程,利用放射源射线穿透管道测量溶液密度时,光电倍增管输出计数率易受高压纹波噪声的影响,发生明显衰减,导致密度测量精度下降。为降低纹波噪声对计数率的影响,需要补偿因纹波而衰减的计数率。首先,根据在不同高压纹波条件下所收集得到的计数率实验数据,建立了计数率与高压纹波之间的数学模型。然后,通过分析数学模型得知,降低高压纹波幅值和频率能够减少高压纹波对计数率的影响。最后,采用自适应卡尔曼滤波算法对高压纹波进行抑制,通过调整过程噪声和测量噪声因子,实现对计数率的自适应补偿。实验采用40%的酒精溶液进行测试,对补偿前后的计数率及溶液密度测量结果进行对比分析。实验结果表明,相比较补偿前,补偿后所测得的脉冲计数损失率降低至3.54%~5.46%,溶液密度与真实值之间最大偏差为0.019 g/cm^(3),密度检测精度提高了1.51%。 展开更多
关键词 光电倍增管 纹波噪声 计数率 卡尔曼滤波 自适应补偿
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婴儿川崎病冠状动脉病变的临床特点及危险因素分析 被引量:1
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作者 刘威 张兰 《分子诊断与治疗杂志》 2025年第1期38-40,45,共4页
目的探讨婴儿川崎病冠状动脉病变的临床特点及危险因素。方法选择2018年1月至2023年1月中国科学技术大学附属第一医院(安徽省立医院)收治的婴儿川崎病患者150例,根据患者是否合并冠状动脉病变分为病例组37例、对照组113例,比较两组临床... 目的探讨婴儿川崎病冠状动脉病变的临床特点及危险因素。方法选择2018年1月至2023年1月中国科学技术大学附属第一医院(安徽省立医院)收治的婴儿川崎病患者150例,根据患者是否合并冠状动脉病变分为病例组37例、对照组113例,比较两组临床资料,采用多因素Logistic分析婴儿川崎病冠状动脉病变的危险因素,分析血清红细胞沉降率(ESR)、血小板计数(PLT)对婴儿川崎病冠状动脉病变的诊断效能。结果两组年龄、WBC、PDW、RBC、HGB、MPV、NLR、PCT及CK⁃MB比较差异无统计学意义(P>0.05);两组性别、CRP、ALB、RDW、ESR及PLT比较差异有统计学意义(P<0.05);多因素Logistic回归分析显示,性别男、CRP升高、ALB降低、RDW升高、ESR升高及PLT升高均是导致婴儿川崎病冠状动脉病变的危险因素(P<0.05);ROC结果显示,血清ESR预测婴儿川崎病冠状动脉病变的AUC为0.872,灵敏度为0.867,特异度为0.882,PLT预测婴儿川崎病冠状动脉病变AUC为0.892,灵敏度为0.887,特异度为0.893。结论婴儿川崎病冠状动脉病变患者的临床特点及危险因素较多,检测血清ESR、PLT有较高的预测价值,临床上应予以密切关注以降低冠状动脉病变的发生率。 展开更多
关键词 婴儿 川崎病 冠状动脉病变 红细胞沉降率 血小板计数
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A high-sensitivity deep-junction single-photon detector for near-infrared imaging
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作者 Yuanhao Bi Dajing Bian +1 位作者 Ming Li Yue Xu 《Chinese Physics B》 2025年第6期604-608,共5页
A near-infrared(NIR) enhanced silicon single-photon avalanche diode(SPAD) detector is proposed using 0.18 μm bipolar-CMOS-DMOS technology. It is based on a deep multiplication region, formed by a junction between the... A near-infrared(NIR) enhanced silicon single-photon avalanche diode(SPAD) detector is proposed using 0.18 μm bipolar-CMOS-DMOS technology. It is based on a deep multiplication region, formed by a junction between the highvoltage P-well(HVPW) and high-voltage buried N+ layer, to enhance the NIR photon detection probability(PDP). Thanks to the lightly doped P-type epitaxial layer, the electric field in the guard ring is reduced and premature breakdown is prevented. In particular, an extra P-type implantation layer(PIL) is added to the HVPW to reduce the breakdown voltage and enhance the device's sensitivity. Further research on the impact of different PIL sizes on the device performance is carried out. It is experimentally shown that at an excess bias voltage of 5 V, the optimized SPAD achieves a dark count rate of 0.64 cps/μm^(2), peak PDP of 54.8% at 555 nm and PDP of 10.53% at 905 nm. The full width at half-maximum of the timing jitter is 285 ps, and the afterpulsing probability is lower than 1.17%. This novel device provides a practical, low-cost solution for high-performance NIR time-of-flight detectors and 3D imaging sensors. 展开更多
关键词 single-photon avalanche diode(SPAD) near-infrared(NIR)enhancement photon detection probability(PDP) dark count rate(DCR) time-of-flight(ToF)
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WBC、PLT、Hb、ESR及血浆FIB水平与川崎病患儿冠状动脉损伤的相关性分析
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作者 黄梅英 汪世平 金花 《反射疗法与康复医学》 2025年第4期155-157,165,共4页
目的探讨白细胞计数(WBC)、血小板计数(PLT)、血红蛋白(Hb)、红细胞沉降率(ESR)、血浆纤维蛋白原(FIB)水平与川崎病患儿冠状动脉损伤(CAL)的相关性。方法回顾性分析2022年1月—2023年12月深圳市龙岗区人民医院收治的60例川崎病患儿的临... 目的探讨白细胞计数(WBC)、血小板计数(PLT)、血红蛋白(Hb)、红细胞沉降率(ESR)、血浆纤维蛋白原(FIB)水平与川崎病患儿冠状动脉损伤(CAL)的相关性。方法回顾性分析2022年1月—2023年12月深圳市龙岗区人民医院收治的60例川崎病患儿的临床资料,依据川崎病患儿是否发生CAL将其分为CAL组(n=22)和非CAL组(n=38)。两组患儿均检测WBC、PLT、Hb、ESR及血浆FIB水平,绘制ROC曲线分析各指标及联合检测川崎病患儿CAL的诊断价值。结果CAL组WBC、PLT、ESR及血浆FIB水平均高于非CAL组,Hb水平低于非CAL组,组间差异有统计学意义(P<0.05)。绘制ROC曲线显示,WBC、PLT、Hb、ESR、血浆FIB及联合检测川崎病患儿CAL的曲线下面积分别为0.826、0.772、0.649、0.801、0.827、0.946,具有较高的诊断价值。结论WBC、PLT、Hb、ESR及血浆FIB水平对川崎病患儿CAL具有一定的诊断价值,联合检测有助于临床早期识别CAL,并以此采取针对性治疗。 展开更多
关键词 川崎病 冠状动脉损伤 白细胞计数 血小板计数 红细胞沉降率
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血流感染新生儿PCT、NLR、SAA和PLR水平及其早期诊断价值 被引量:1
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作者 谢维维 罗菁 +1 位作者 应燕芬 王丽珍 《中华医院感染学杂志》 北大核心 2025年第12期1841-1845,共5页
目的探讨血流感染新生儿血清降钙素原(PCT)、血小板计数与淋巴细胞计数比率(PLR)、中性粒细胞与淋巴细胞比值(NLR)、白细胞计数(WBC)和血清淀粉样蛋白A(SAA)水平,及其对新生儿血流感染早期诊断的价值。方法选择2021年1月-2024年1月浙江... 目的探讨血流感染新生儿血清降钙素原(PCT)、血小板计数与淋巴细胞计数比率(PLR)、中性粒细胞与淋巴细胞比值(NLR)、白细胞计数(WBC)和血清淀粉样蛋白A(SAA)水平,及其对新生儿血流感染早期诊断的价值。方法选择2021年1月-2024年1月浙江省台州医院血培养检测呈阳性的100例新生儿血流感染患者。根据病原菌类型,分为革兰阴性菌组74例、革兰阳性菌组19例和真菌组7例,并选择同期血培养测试结果呈阴性的100例新生儿作为对照组。通过比较不同病原菌感染下新生儿血液中的PCT、PLR、NLR、WBC和SAA的水平,使用受试者工作特征(ROC)曲线评估各指标在新生儿血流感染诊断中的诊断价值。结果100例血培养阳性新生儿中感染革兰阴性菌74株,感染革兰阳性菌19株,感染真菌7株。革兰阳性组、革兰阴性组、真菌组PCT、PLR、NLR、WBC和SAA水平均高于对照组(P<0.05)。ROC曲线结果显示,PCT、PLR、NLR、WBC和SAA五者联合对革兰阴性菌血流感染和革兰阳性菌血流感染的诊断效能均高于单独指标(P<0.05),曲线下面积(AUC)分别为0.982和0.969。结论PCT、PLR、NLR、WBC和SAA可作为新生儿血流感染早期诊断的有效生物标志物,有助于快速准确地识别感染类型。 展开更多
关键词 病原菌 血流感染 血清降钙素原 血小板计数与淋巴细胞计数比率 中性粒细胞与淋巴细胞比值 白细胞计数 血清淀粉样蛋白A
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单光子激光探测中大气传输及背景辐射的影响 被引量:1
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作者 缪瑞晴 王励横 +4 位作者 徐广平 韩隆 许连望 赵宇昊 丁浩宇 《激光与红外》 北大核心 2025年第4期554-561,共8页
单光子激光测距技术由于具有高探测灵敏度而被广泛应用于各种测距场景。为探究单光子探测体制下,大气传输和背景辐射参数对1064nm波段背景噪声的影响,本文使用两种大气辐射传输仿真工具MODTRAN和CART对水平路径下不同探测条件中的大气... 单光子激光测距技术由于具有高探测灵敏度而被广泛应用于各种测距场景。为探究单光子探测体制下,大气传输和背景辐射参数对1064nm波段背景噪声的影响,本文使用两种大气辐射传输仿真工具MODTRAN和CART对水平路径下不同探测条件中的大气透过率和太阳辐射参数进行计算和对比,进一步仿真分析其对背景噪声计数率的影响。研究发现,白天测距时,越接近正午时刻,背景噪声越小,越有利于探测;当探测高度高于3km时可以基本摆脱地表能见度对背景噪声的影响,且探测高度越高,背景噪声越小;且在探测高度高,探测距离近的应用场景中,不可忽略目标背景辐射。本文可以为全天候不同探测条件下的单光子激光机载远程测距系统设计提供背景噪声水平的参考。 展开更多
关键词 单光子激光测距 大气透过率 太阳辐射 背景噪声计数率 MODTRAN CART
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