目的:利用电生理学技术探讨Long Evans大鼠视皮层眼优势柱可塑性的发育性变化。方法:取22d Long Evans大鼠7只和100d Long Evans大鼠5只,通过缝合一侧眼睑建立单眼剥夺大鼠动物模型。利用电生理学技术检测22 d正常大鼠、22 d单眼剥夺大...目的:利用电生理学技术探讨Long Evans大鼠视皮层眼优势柱可塑性的发育性变化。方法:取22d Long Evans大鼠7只和100d Long Evans大鼠5只,通过缝合一侧眼睑建立单眼剥夺大鼠动物模型。利用电生理学技术检测22 d正常大鼠、22 d单眼剥夺大鼠、100 d正常大鼠、100 d单眼剥夺大鼠眼优势柱的分布。结果:正常22 d Long Evans大鼠、正常100 d Long Evans大鼠和100 d单眼剥夺大鼠视皮层眼优势柱分布为对侧眼优势,22 d单眼剥夺大鼠视皮层眼优势柱分布为同侧眼优势。结论:正常视觉环境下发育的Long Evans大鼠,其眼优势柱的分布为对侧眼优势,幼年Long Evans大鼠视皮层具有可塑性,异常的视觉环境能影响其眼优势柱的分布;成年Long Evans大鼠视觉可塑性终止,异常的视觉环境不能再影响其眼优势柱的分布。展开更多
Although the mechanism of neurovascular coupling remains inadequately understood,physiological research has indicated that the dilation of arterioles located within the cerebral cortex column might represent the prima...Although the mechanism of neurovascular coupling remains inadequately understood,physiological research has indicated that the dilation of arterioles located within the cerebral cortex column might represent the primary mechanism of hemodynamic response during neurovascular coupling.This study examined the spatiotemporal pattern of NO diffusion induced by functional stimuli at column spatial resolution.Our modeling makes it possible to explore the responses of mediating factors to functional stimuli from a four-dimensional view,which may lead the way to decoding the mechanism of neurovascular coupling.展开更多
文摘目的:利用电生理学技术探讨Long Evans大鼠视皮层眼优势柱可塑性的发育性变化。方法:取22d Long Evans大鼠7只和100d Long Evans大鼠5只,通过缝合一侧眼睑建立单眼剥夺大鼠动物模型。利用电生理学技术检测22 d正常大鼠、22 d单眼剥夺大鼠、100 d正常大鼠、100 d单眼剥夺大鼠眼优势柱的分布。结果:正常22 d Long Evans大鼠、正常100 d Long Evans大鼠和100 d单眼剥夺大鼠视皮层眼优势柱分布为对侧眼优势,22 d单眼剥夺大鼠视皮层眼优势柱分布为同侧眼优势。结论:正常视觉环境下发育的Long Evans大鼠,其眼优势柱的分布为对侧眼优势,幼年Long Evans大鼠视皮层具有可塑性,异常的视觉环境能影响其眼优势柱的分布;成年Long Evans大鼠视觉可塑性终止,异常的视觉环境不能再影响其眼优势柱的分布。
基金supported by the National Natural Science Foundation of China (Grant No. 30770685)
文摘Although the mechanism of neurovascular coupling remains inadequately understood,physiological research has indicated that the dilation of arterioles located within the cerebral cortex column might represent the primary mechanism of hemodynamic response during neurovascular coupling.This study examined the spatiotemporal pattern of NO diffusion induced by functional stimuli at column spatial resolution.Our modeling makes it possible to explore the responses of mediating factors to functional stimuli from a four-dimensional view,which may lead the way to decoding the mechanism of neurovascular coupling.
