Adoptive cell therapy using chimeric antigen receptor T (CAR-T) cells, which is a promising cancer immunotherapy strategy, has been developing very rapidly in recent years. CAR-T cells are genetically modified T cells...Adoptive cell therapy using chimeric antigen receptor T (CAR-T) cells, which is a promising cancer immunotherapy strategy, has been developing very rapidly in recent years. CAR-T cells are genetically modified T cells that can specifically recognize tumor specific antigens on the surface of tumor cells, and then effectively kill tumor cells. At present, exciting results are being achieved in clinical applications of CAR-T cells for patients with hematological malignancies. The research and development of CAR-T cells for various targets and for the treatment of solid tumors have become a hot topic worldwide, so an increasing number of investigational new drug applications (INDAs) and new drug applications (NDAs) of CAR-T cell products are expected to be submitted in future. The quality control and nonclinical research of these products are of great significance in ensuring the safety and effectiveness of these products;however, they also present great challenges and difficulties. This article discusses the general principles of and key issues regarding the quality control and nonclinical research of CAR-T cell products based on their product characteristics and on relevant guidelines for gene and cell therapy products.展开更多
On the basis of reviewing the development history of drilling engineering technology over a century, this paper describes the technical and scientific background of downhole control engineering, discusses its basic is...On the basis of reviewing the development history of drilling engineering technology over a century, this paper describes the technical and scientific background of downhole control engineering, discusses its basic issues, discipline frame and main study contents, introduces the research progress of downhole control engineering in China over the past 30 years, and envisions the development direction of downhole control engineering in the future. The author proposed the study subject of well trajectory control theory and technology in 1988, and further proposed the concept of downhole control engineering in 1993. Downhole control engineering is a discipline branch, which applies the perspectives and methods of engineering control theory to solve downhole engineering control issues in oil and gas wells; meanwhile, it is an application technology field with interdisciplinarity. Downhole control engineering consists of four main aspects; primarily, investigations about dynamics of downhole system and analysis methods of control signals; secondly, designs of downhole control mechanisms and systems, research of downhole parameters collections and transmission techniques; thirdly, development of downhole control engineering products; fourthly, development of experimental methods and the laboratories. Over the past 30 years, the author and his research group have achieved a number of progress and accomplishments in the four aspects mentioned above. As a research field and a disciplinary branch of oil and gas engineering, downhole control engineering is stepping into a broader and deeper horizon.展开更多
This paper analyses the fragmenting principle of static blasting agent (SBA) and the action of its cutting fragmentation. Using SBA for sterming material proved very useful and advantageous. Here we analyse in detail ...This paper analyses the fragmenting principle of static blasting agent (SBA) and the action of its cutting fragmentation. Using SBA for sterming material proved very useful and advantageous. Here we analyse in detail the cutting action of pre- stress and stress wave in pre-stressing force blasting.展开更多
So far, most theories of economics and management are under the same premisethat the natural resources are never exhausted and regenerated repeatedly. The magic of technologybrought by industrial revolution endowed hu...So far, most theories of economics and management are under the same premisethat the natural resources are never exhausted and regenerated repeatedly. The magic of technologybrought by industrial revolution endowed human with power that they can do anything they want. Italso turns natural resources into industrial energy and enhances the development of human societyand civilization. Human uses direct comparison of input and output and the satisfaction degree ofdemands to measure the production activities, the economic benefit and management performance,regardless of the change of ecology that serves as the natural resources. However, since theecological environment has been changing worse recently and natural disaster happened frequentlyhuman's dream of conquering the nature has been broken. The nature implements reprisal against humanagain and again, and human is faced with the development limit because of the environmentalrestriction.展开更多
Based on the research on domestic and international automatic technical development in fossil power plant,the paper analyses the recent situation of the coordinate control system between turbine and boiler of domestic...Based on the research on domestic and international automatic technical development in fossil power plant,the paper analyses the recent situation of the coordinate control system between turbine and boiler of domestic fossil Power Plant,provides the development thought of coordinate control system between turbine and boiler,and describes the application prospect in control system of fossil power plant combining with the application experience.展开更多
目的可视化分析葛根质量控制研究文献,总结该领域研究现状及研究热点,为后续研究提供参考。方法检索中国知识资源总库(CNKI)、中国学术期刊数据库(万方数据)、中文科技期刊数据库(VIP)和Web of Science(WOS)1993年1月1日-2023年7月29日...目的可视化分析葛根质量控制研究文献,总结该领域研究现状及研究热点,为后续研究提供参考。方法检索中国知识资源总库(CNKI)、中国学术期刊数据库(万方数据)、中文科技期刊数据库(VIP)和Web of Science(WOS)1993年1月1日-2023年7月29日收录的葛根质量控制研究文献,利用Citespace6.2.R4软件可视化分析作者、发文机构、关键词。结果纳入中文文献1188篇,英文文献550篇。中、英文文献发文总体呈上升趋势。中文文献作者以王钰乐、何艳发文量较高(5篇),英文文献发文量最高的作者为Putalun Waraporn(13篇),研究机构以北京中医药大学为主。高频关键词为“葛根素”“质量控制”“含量测定”“葛根”“指纹图谱”,中文文献关键词聚为13类,英文文献关键词聚为11类,分别探测到20个突现关键词。结论当前研究围绕葛根化学成分、指纹图谱、提取与制备工艺、药理作用展开,葛根质量控制多采用多成分定性定量研究。经典名方质量控制研究、中药整体性研究、药理作用相关性研究及作用机制研究将成为该领域研究趋势。展开更多
Tobacco black shank is one of the devastating diseases of tobacco. In recent years, this disease widely occurred in most tobacco-growing areas, which caused disastrous losses and has severely threatened the sustainabl...Tobacco black shank is one of the devastating diseases of tobacco. In recent years, this disease widely occurred in most tobacco-growing areas, which caused disastrous losses and has severely threatened the sustainable development of flue-cured tobacco. In order to lay a theoretical foundation for the better control of tobacco black shank, the occurrence characteristics and integrated control strategis of this disease were systematically discussed according to the aspects of agricultural control, chemical control, biological control, etc.展开更多
A unit pump test bench is developed on an in-line pump test platform. The bench is composed of pump adapting assembly, fuel supply subsystem, lubricating subsystem and a control unit. A crank angle domain injection co...A unit pump test bench is developed on an in-line pump test platform. The bench is composed of pump adapting assembly, fuel supply subsystem, lubricating subsystem and a control unit. A crank angle domain injection control method is given out and the control accuracy can be 0.1° crank degree. The bench can test both mechanical unit pump and electronic unit pump. A test model-PLD12 electronic unit pump is tested. Full pump delivery map and some influence factors test is done. Experimental results show that the injection quantity is linear with the delivery angle. The quantity change rate is 15% when fuel temperature increases 30 ℃. The delivery quantity per cycle increases 30 mg at 28 V drive voltage. The average delivery difference for two same type pumps is 5 %. Test results show that the bench can be used for unit pump verification.展开更多
The macroeconomic control of interest rate is studied using the elastic theory and correlation analysis and the concrete influence of interest rate on the consumption, savings and investment in China are investigated....The macroeconomic control of interest rate is studied using the elastic theory and correlation analysis and the concrete influence of interest rate on the consumption, savings and investment in China are investigated. It is pointed out that although the interest rate mechanisms in China has gone through several adjustments and reforms, the results are not yet fully up to expectations. The interest rate does not adjust the national economic structure, and direct the trend of funds, nor regulate the general social supply and demand and balance the price and currency in circulation, to achieve a rational distribution of social resources. The interest rate policy of Central Bank does not have much actual influence on the economic departments, and this influence was continuously weakened in recent years. Countermeasures are suggested for improving the macro control of interest rate.展开更多
Based on the programming method, an electromechanical coupling adaptive statically indeterminate truss structure is controlled for increasing its load capacity. Several main parameters during the process of design of ...Based on the programming method, an electromechanical coupling adaptive statically indeterminate truss structure is controlled for increasing its load capacity. Several main parameters during the process of design of the adaptive structure are selected for a study of its characteristic during the control stage. The curves of each parameter for the effect of control results are plotted and corresponding conclusions are drawn. Thus, the theoretical basis is presented for optimal design, manufacture and control of the adaptive structure.展开更多
[Objective] The aim was to study the rear-end real-time data quality control method of regional automatic weather station. [Method] The basic content and steps of rear-end real-time data quality control of regional au...[Objective] The aim was to study the rear-end real-time data quality control method of regional automatic weather station. [Method] The basic content and steps of rear-end real-time data quality control of regional automatic weather station were introduced. Each element was treated with systematic quality control procedure. The existence of rear-end real time data of regional meteorological station in Guangxi was expounded. Combining with relevant elements and linear changes, improvement based on traditional quality control method was made. By dint of evaluation and relevant check of element, the quality of temperature and pressure was controlled. [Result] The method was optimized based on traditional quality control method, and it narrowed the effectiveness of real-time data quality control. The quality check of hourly precipitation applied relevant check of hourly minimum temperature, vertical consistency check of radar data, which can effectively improve the accuracy and credibility of hourly precipitation quality control. [Conclusion] The method was on trial for one year in the quality control of real-time data in the regional automatic meteorological station in Guangxi and had gained good outcome.展开更多
文摘Adoptive cell therapy using chimeric antigen receptor T (CAR-T) cells, which is a promising cancer immunotherapy strategy, has been developing very rapidly in recent years. CAR-T cells are genetically modified T cells that can specifically recognize tumor specific antigens on the surface of tumor cells, and then effectively kill tumor cells. At present, exciting results are being achieved in clinical applications of CAR-T cells for patients with hematological malignancies. The research and development of CAR-T cells for various targets and for the treatment of solid tumors have become a hot topic worldwide, so an increasing number of investigational new drug applications (INDAs) and new drug applications (NDAs) of CAR-T cell products are expected to be submitted in future. The quality control and nonclinical research of these products are of great significance in ensuring the safety and effectiveness of these products;however, they also present great challenges and difficulties. This article discusses the general principles of and key issues regarding the quality control and nonclinical research of CAR-T cell products based on their product characteristics and on relevant guidelines for gene and cell therapy products.
文摘On the basis of reviewing the development history of drilling engineering technology over a century, this paper describes the technical and scientific background of downhole control engineering, discusses its basic issues, discipline frame and main study contents, introduces the research progress of downhole control engineering in China over the past 30 years, and envisions the development direction of downhole control engineering in the future. The author proposed the study subject of well trajectory control theory and technology in 1988, and further proposed the concept of downhole control engineering in 1993. Downhole control engineering is a discipline branch, which applies the perspectives and methods of engineering control theory to solve downhole engineering control issues in oil and gas wells; meanwhile, it is an application technology field with interdisciplinarity. Downhole control engineering consists of four main aspects; primarily, investigations about dynamics of downhole system and analysis methods of control signals; secondly, designs of downhole control mechanisms and systems, research of downhole parameters collections and transmission techniques; thirdly, development of downhole control engineering products; fourthly, development of experimental methods and the laboratories. Over the past 30 years, the author and his research group have achieved a number of progress and accomplishments in the four aspects mentioned above. As a research field and a disciplinary branch of oil and gas engineering, downhole control engineering is stepping into a broader and deeper horizon.
文摘This paper analyses the fragmenting principle of static blasting agent (SBA) and the action of its cutting fragmentation. Using SBA for sterming material proved very useful and advantageous. Here we analyse in detail the cutting action of pre- stress and stress wave in pre-stressing force blasting.
文摘So far, most theories of economics and management are under the same premisethat the natural resources are never exhausted and regenerated repeatedly. The magic of technologybrought by industrial revolution endowed human with power that they can do anything they want. Italso turns natural resources into industrial energy and enhances the development of human societyand civilization. Human uses direct comparison of input and output and the satisfaction degree ofdemands to measure the production activities, the economic benefit and management performance,regardless of the change of ecology that serves as the natural resources. However, since theecological environment has been changing worse recently and natural disaster happened frequentlyhuman's dream of conquering the nature has been broken. The nature implements reprisal against humanagain and again, and human is faced with the development limit because of the environmentalrestriction.
文摘Based on the research on domestic and international automatic technical development in fossil power plant,the paper analyses the recent situation of the coordinate control system between turbine and boiler of domestic fossil Power Plant,provides the development thought of coordinate control system between turbine and boiler,and describes the application prospect in control system of fossil power plant combining with the application experience.
文摘目的可视化分析葛根质量控制研究文献,总结该领域研究现状及研究热点,为后续研究提供参考。方法检索中国知识资源总库(CNKI)、中国学术期刊数据库(万方数据)、中文科技期刊数据库(VIP)和Web of Science(WOS)1993年1月1日-2023年7月29日收录的葛根质量控制研究文献,利用Citespace6.2.R4软件可视化分析作者、发文机构、关键词。结果纳入中文文献1188篇,英文文献550篇。中、英文文献发文总体呈上升趋势。中文文献作者以王钰乐、何艳发文量较高(5篇),英文文献发文量最高的作者为Putalun Waraporn(13篇),研究机构以北京中医药大学为主。高频关键词为“葛根素”“质量控制”“含量测定”“葛根”“指纹图谱”,中文文献关键词聚为13类,英文文献关键词聚为11类,分别探测到20个突现关键词。结论当前研究围绕葛根化学成分、指纹图谱、提取与制备工艺、药理作用展开,葛根质量控制多采用多成分定性定量研究。经典名方质量控制研究、中药整体性研究、药理作用相关性研究及作用机制研究将成为该领域研究趋势。
基金Supported by Project of Yunnan Tobacco Company of Science and Technology(2014YN20)
文摘Tobacco black shank is one of the devastating diseases of tobacco. In recent years, this disease widely occurred in most tobacco-growing areas, which caused disastrous losses and has severely threatened the sustainable development of flue-cured tobacco. In order to lay a theoretical foundation for the better control of tobacco black shank, the occurrence characteristics and integrated control strategis of this disease were systematically discussed according to the aspects of agricultural control, chemical control, biological control, etc.
基金the Ministerial Level Advanced Research Foundation (404050301 .4)
文摘A unit pump test bench is developed on an in-line pump test platform. The bench is composed of pump adapting assembly, fuel supply subsystem, lubricating subsystem and a control unit. A crank angle domain injection control method is given out and the control accuracy can be 0.1° crank degree. The bench can test both mechanical unit pump and electronic unit pump. A test model-PLD12 electronic unit pump is tested. Full pump delivery map and some influence factors test is done. Experimental results show that the injection quantity is linear with the delivery angle. The quantity change rate is 15% when fuel temperature increases 30 ℃. The delivery quantity per cycle increases 30 mg at 28 V drive voltage. The average delivery difference for two same type pumps is 5 %. Test results show that the bench can be used for unit pump verification.
文摘The macroeconomic control of interest rate is studied using the elastic theory and correlation analysis and the concrete influence of interest rate on the consumption, savings and investment in China are investigated. It is pointed out that although the interest rate mechanisms in China has gone through several adjustments and reforms, the results are not yet fully up to expectations. The interest rate does not adjust the national economic structure, and direct the trend of funds, nor regulate the general social supply and demand and balance the price and currency in circulation, to achieve a rational distribution of social resources. The interest rate policy of Central Bank does not have much actual influence on the economic departments, and this influence was continuously weakened in recent years. Countermeasures are suggested for improving the macro control of interest rate.
基金the National Natural Science Foundation of China(10072005)Beijing Educational Committee(99LG-11)Beijing Natural Science(3002002)Foundation
文摘Based on the programming method, an electromechanical coupling adaptive statically indeterminate truss structure is controlled for increasing its load capacity. Several main parameters during the process of design of the adaptive structure are selected for a study of its characteristic during the control stage. The curves of each parameter for the effect of control results are plotted and corresponding conclusions are drawn. Thus, the theoretical basis is presented for optimal design, manufacture and control of the adaptive structure.
文摘[Objective] The aim was to study the rear-end real-time data quality control method of regional automatic weather station. [Method] The basic content and steps of rear-end real-time data quality control of regional automatic weather station were introduced. Each element was treated with systematic quality control procedure. The existence of rear-end real time data of regional meteorological station in Guangxi was expounded. Combining with relevant elements and linear changes, improvement based on traditional quality control method was made. By dint of evaluation and relevant check of element, the quality of temperature and pressure was controlled. [Result] The method was optimized based on traditional quality control method, and it narrowed the effectiveness of real-time data quality control. The quality check of hourly precipitation applied relevant check of hourly minimum temperature, vertical consistency check of radar data, which can effectively improve the accuracy and credibility of hourly precipitation quality control. [Conclusion] The method was on trial for one year in the quality control of real-time data in the regional automatic meteorological station in Guangxi and had gained good outcome.
