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Scale-invariant 3D face recognition using computer-generated holograms and the Mellin transform
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作者 Yongwei Yao Yaping Zhang +3 位作者 Huanrong He Xianfeng David Gu Daping Chu Ting-Chung Poon 《Opto-Electronic Advances》 2025年第11期43-55,共13页
We present a novel method for scale-invariant 3D face recognition by integrating computer-generated holography with the Mellin transform.This approach leverages the scale-invariance property of the Mellin transform to... We present a novel method for scale-invariant 3D face recognition by integrating computer-generated holography with the Mellin transform.This approach leverages the scale-invariance property of the Mellin transform to address challenges related to variations in 3D facial sizes during recognition.By applying the Mellin transform to computer-generated holograms and performing correlation between them,which,to the best of our knowledge,is being done for the first time,we have developed a robust recognition framework capable of managing significant scale variations without compromising recognition accuracy.Digital holograms of 3D faces are generated from a face database,and the Mellin transform is employed to enable robust recognition across scale factors ranging from 0.4 to 2.0.Within this range,the method achieves 100%recognition accuracy,as confirmed by both simulation-based and hybrid optical/digital experimental validations.Numerical calculations demonstrate that our method significantly enhances the accuracy and reliability of 3D face recognition,as evidenced by the sharp correlation peaks and higher peak-to-noise ratio(PNR)values than that of using conventional holograms without the Mellin transform.Additionally,the hybrid optical/digital joint transform correlation hardware further validates the method's effectiveness,demonstrating its capability to accurately identify and distinguish 3D faces at various scales.This work provides a promising solution for advanced biometric systems,especially for those which require 3D scale-invariant recognition. 展开更多
关键词 3D face recognition computer-generate holography Mellin transform scale invariance BIOMETRICS
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IncepHoloRGB: multi-wavelength network model for full-color 3D computer-generated holography
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作者 Xuan Yu Zhilin Teng +6 位作者 Xuhao Fan Tianchi Liu Wenbin Chen Xinger Wang Zhe Zhao Wei Xiong Hui Gao 《Opto-Electronic Advances》 2025年第10期53-63,共11页
The popularity of deep learning has boosted computer-generated holography(CGH)as a vibrant research field,particularly physics-driven unsupervised learning.Nevertheless,present unsupervised CGH models have not yet exp... The popularity of deep learning has boosted computer-generated holography(CGH)as a vibrant research field,particularly physics-driven unsupervised learning.Nevertheless,present unsupervised CGH models have not yet explored the potential of generating full-color 3D holograms through a unified framework.In this study,we propose a lightweight multiwavelength network model capable of high-fidelity and efficient full-color hologram generation in both 2D and 3D display,called IncepHoloRGB.The high-speed simultaneous generation of RGB holograms at 191 frames per second(FPS)is based on Inception sampling blocks and multi-wavelength propagation module integrated with depth-traced superimposition,achieving an average structural similarity(SSIM)of 0.88 and peak signal-to-noise ratio(PSNR)of 29.00 on the DIV2K test set in reconstruction.Full-color reconstruction of numerical simulations and optical experiments shows that IncepHoloRGB is versatile to diverse scenarios and can obtain authentic full-color holographic 3D display within a unified network model,paving the way for applications towards real-time dynamic naked-eye 3D display,virtual and augmented reality(VR/AR)systems. 展开更多
关键词 computer-generated holography deep learning physics-driven model full-color holographic 3D display
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Rural Creators:When art meets agriculture,every village becomes a canvas,turning fields,waterways and daily rural life into sources of inspiration
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作者 PENG YAO 《ChinAfrica》 2026年第2期31-31,共1页
The fertile soil of the countryside is also rich in artistic inspiration.“If farmers pick up a brush,they can become artists.If one devotes oneself wholeheartedly to something,a stroke of genius will follow,”said Mi... The fertile soil of the countryside is also rich in artistic inspiration.“If farmers pick up a brush,they can become artists.If one devotes oneself wholeheartedly to something,a stroke of genius will follow,”said Miao Huixin,a cultural envoy to Shengfeng Village in Youchegang Town,Xiuzhou District,Jiaxing City,Zhejiang Province. 展开更多
关键词 AGRICULTURE art inspiration rural life creative expression village culture
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Chain architecture-engineered artesunate nanoassemblies target LONP1 to induce oxidative damage for enhanced anti-tumor therapy
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作者 Yupeng Wang Xinxin Sun +5 位作者 Jianbin Shi Zhixiao Zhang Jin Sun Cong Luo Zhonggui He Shenwu Zhang 《Chinese Chemical Letters》 2026年第1期497-502,共6页
Despite demonstrating significant anti-tumor potential as an artemisinin derivative,artesunate faces delivery efficiency challenges due to low water solubility and insufficient targeting specificity.To improve the del... Despite demonstrating significant anti-tumor potential as an artemisinin derivative,artesunate faces delivery efficiency challenges due to low water solubility and insufficient targeting specificity.To improve the delivery efficiency,we engineered three artesunate(ART) derivatives,AC_(15)-L(linear),AC_(15)-B(branched),and AC_(15)-C(cyclic) with distinct aliphatic chain architectures.Unexpectedly,we observed that AC_(15)-C exhibited superior cytotoxicity against 4T1 breast cancer cells,and had the highest binding affinity for Lon protease 1(LONP1)(-72.6 kcal/mol).Subsequently,disulfide bond-containing lipid-PEG(DSPESS-PEG2K) modified chain architecture-engineered ART derivatives nanoassemblies(NAs) were developed to mitigate solubility-related limitations while enhancing targeting precision.Molecular docking and experimental validation demonstrated that ART derivatives inhibited LONP1 through hydrophobic interactions while preserved Fe^(2+)-mediated Fenton-like reaction activity.In vitro and in vivo evaluations demonstrated that AC_(15)-C NAs outperformed free ART and other NAs,suppressing 4T1 tumor growth via dual action:LONP1-directed mitochondrial proteostasis collapse and reactive oxygen species(ROS) amplification through Fe^(2+)-ART interactions.This study elucidated a novel anti-tumor mechanism of ART through the rational design of derivatives with spatially configured aliphatic chains,and developed reductionresponsive NAs to provide an advanced delivery strategy. 展开更多
关键词 Chain architecture engineering art LONP1 NANOASSEMBLIES Cancer therapy
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Zhu Bingren:Copper Artist Extraordinaire
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作者 NILS BERGEMANN 《China Today》 2026年第2期73-75,共3页
At 82,master craftsman Zhu Bingren,China’s preeminent copper artist,continues to dynamically evolve his ancient heritage,proving that true preservation lies in innovation and bringing tradition into the contemporary ... At 82,master craftsman Zhu Bingren,China’s preeminent copper artist,continues to dynamically evolve his ancient heritage,proving that true preservation lies in innovation and bringing tradition into the contemporary world.THE copper art should not be confined to display cases,believes artist Zhu Bingren.From living rooms to fashion runways,and from the Great Wall in Beijing to the Louvre in Paris,the Chinese master craftsman brings his metal creations to life in diverse settings. 展开更多
关键词 innovation master craftsman TRADITION copper art contemporary world Zhu Bingren
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Integrating Ideological Education With Competency Cultivation:Teaching Practices for an Intercultural Communication Course Under the New Liberal Arts Background
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作者 WU Yuan 《Sino-US English Teaching》 2026年第1期10-16,共7页
This study investigates how to pedagogically integrate ideological education with competency development in the Intercultural Communication course,a challenge arising from China’s dual reform contexts of the New Libe... This study investigates how to pedagogically integrate ideological education with competency development in the Intercultural Communication course,a challenge arising from China’s dual reform contexts of the New Liberal Arts initiative and the national curriculum ideology policy.As global interactions intensify,cultivating foreign language professionals who possess both firm cultural confidence and sophisticated intercultural competence have become a critical educational imperative.This exploratory study investigates how a three-dimensional“Value-Knowledge-Competency”framework can guide the redesign of course content,task design,and assessment to achieve organic fusion.Drawing on qualitative data from a case study,it analyzes specific implementation pathways,synthesizes teacher and student feedback,and discusses the resultant challenges and broader implications for foreign language curriculum reform.The findings suggest that such an integrated approach can effectively synergize value guidance with skill cultivation,though its success hinges on overcoming issues related to pedagogical naturalness,resource allocation,and standardized evaluation. 展开更多
关键词 New Liberal arts ideological-political education Intercultural Communication teaching practice integrated framework
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Special Artists Find their Calling in Shadow Puppetry
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作者 DENG DI 《China Today》 2026年第1期64-66,共3页
Before joining the Beijing Dragon Shadow Puppetry Art Theatre,this group of young people rarely had the chance to meet people like themselves,lacked friends,faced obstacles at work,and felt alienated from society.Now,... Before joining the Beijing Dragon Shadow Puppetry Art Theatre,this group of young people rarely had the chance to meet people like themselves,lacked friends,faced obstacles at work,and felt alienated from society.Now,they have gained appreciation,recognition,confidence,friendships,and love. 展开更多
关键词 FRIENDSHIPS Beijing Dragon Shadow Puppetry art Theatre recognition love APPRECIATION confidence young people shadow puppetry
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Lin Shuran’s Artistic Charisma
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《China Today》 2026年第3期73-73,共1页
Lin Shuran and her husband Fang Chuxiang are exceptional artists who are often mentioned together when talking about contemporary Lingnan art.Compared to her husband’s fame in the field of flower-andbird painting,Lin... Lin Shuran and her husband Fang Chuxiang are exceptional artists who are often mentioned together when talking about contemporary Lingnan art.Compared to her husband’s fame in the field of flower-andbird painting,Lin shows unique artistic sensitivity as a female inheritor of the Lingnan School and quietly preserves the cultural lineage of Lingnan painting. 展开更多
关键词 Lingnan art fang chuxiang Female Inheritor lingnan painting Cultural Lineage Flower Bird Painting lin shuran
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腮腺Warthin瘤合并HIV感染1例及文献复习
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作者 鲍刚 王静 +6 位作者 刘晓萱 周洁 卢婷 马文婷 依帕尔·买买提 魏叶叶 艾尼瓦尔·吾拉木 《传染病信息》 2026年第1期104-107,共4页
腮腺Warthin瘤多见于男性吸烟者,但合并HIV感染的病例报道较为罕见。本文报道1例新发腮腺Warthin瘤且合并HIV感染的特殊病例。该患者确诊时体内HIV病毒载量较高,免疫功能处于低下状态。在接受抗逆转录病毒治疗(antiretroviral therapy, ... 腮腺Warthin瘤多见于男性吸烟者,但合并HIV感染的病例报道较为罕见。本文报道1例新发腮腺Warthin瘤且合并HIV感染的特殊病例。该患者确诊时体内HIV病毒载量较高,免疫功能处于低下状态。在接受抗逆转录病毒治疗(antiretroviral therapy, ART)后,患者腮腺Warthin瘤体积显著减小,瘤体压迫所致的相关症状也得到明显改善。结合本病例特征及文献复习,我们推测HIV感染可能是腮腺Warthin瘤发生的一个潜在危险因素。因此,对于HIV/AIDS患者而言,积极开展ART以控制病情进展具有重要意义。为提高临床医生对腮腺Warthin瘤合并HIV/AIDS的认识,现将本病例详细报告如下。 展开更多
关键词 艾滋病 人类免疫缺陷病毒 WartHIN瘤 抗逆转录病毒治疗
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4K-DMDNet:diffraction model-driven network for 4K computer-generated holography 被引量:21
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作者 Kexuan Liu Jiachen Wu +1 位作者 Zehao He Liangcai Cao 《Opto-Electronic Advances》 SCIE EI CAS CSCD 2023年第5期17-29,共13页
Deep learning offers a novel opportunity to achieve both high-quality and high-speed computer-generated holography(CGH).Current data-driven deep learning algorithms face the challenge that the labeled training dataset... Deep learning offers a novel opportunity to achieve both high-quality and high-speed computer-generated holography(CGH).Current data-driven deep learning algorithms face the challenge that the labeled training datasets limit the training performance and generalization.The model-driven deep learning introduces the diffraction model into the neural network.It eliminates the need for the labeled training dataset and has been extensively applied to hologram generation.However,the existing model-driven deep learning algorithms face the problem of insufficient constraints.In this study,we propose a model-driven neural network capable of high-fidelity 4K computer-generated hologram generation,called 4K Diffraction Model-driven Network(4K-DMDNet).The constraint of the reconstructed images in the frequency domain is strengthened.And a network structure that combines the residual method and sub-pixel convolution method is built,which effectively enhances the fitting ability of the network for inverse problems.The generalization of the 4K-DMDNet is demonstrated with binary,grayscale and 3D images.High-quality full-color optical reconstructions of the 4K holograms have been achieved at the wavelengths of 450 nm,520 nm,and 638 nm. 展开更多
关键词 computer-generated holography deep learning model-driven neural network sub-pixel convolution OVERSAMPLING
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身体与身份:美国Art to wear艺术的女性主义叙事
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作者 许大鹏 王月彤 《美与时代(美学)(下)》 2025年第2期96-99,共4页
本文探讨Art to Wear即“可以穿的艺术”,其中大部分作品为服装,少量作品是帽子和首饰。通过分析Art to Wear代表艺术家,解读Art to Wear艺术作品,从而探讨美国20世纪60年代到80年代女性艺术家群体如何以艺术为媒介对自身经历进行叙述... 本文探讨Art to Wear即“可以穿的艺术”,其中大部分作品为服装,少量作品是帽子和首饰。通过分析Art to Wear代表艺术家,解读Art to Wear艺术作品,从而探讨美国20世纪60年代到80年代女性艺术家群体如何以艺术为媒介对自身经历进行叙述性表现。60年代末70年代初处于美国女性主义的第二次浪潮,众多美国名校的年轻白人女大学生,不断为女性的参政、就业、医疗、最低工资等争取更多的权利,而到了80年代遭到美国保守主义的强烈打击,追求自由平等的女性主义运动跌入低谷。第二次女性主义运动的跌宕正是Art to Wear艺术运动的发展时期,艺术学院在读青年女生们发起Art to Wear艺术运动,她们在保守主义与激进主义的影响下寻求精神、生活的平衡,极力反叛女性束身塑形来博得男性视觉愉悦、通过同性的嫉妒来肯定自身价值。她们对家庭、事业、社会地位开始深思,通过作品叙述对社会性别与身份认定的迷茫,表达保守与激进思想的内心纠结。 展开更多
关键词 身体 身份 女性 art to Wear艺术 美国
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人工智能辅助下的Art Deco风格家具创新设计研究 被引量:1
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作者 谭雄 吴佳莉 +1 位作者 宋杰 郭琼 《包装工程》 北大核心 2025年第16期320-331,共12页
目的旨在通过人工智能算法辅助提取Art Deco风格中的设计因子,以提高提取的效率和准确性,并通过生成式人工智能技术完成设计创意方案,为现代家具设计提供创新性思路和方法。方法通过人工智能技术Canny边缘检测算法和T2I-Adapter算法来... 目的旨在通过人工智能算法辅助提取Art Deco风格中的设计因子,以提高提取的效率和准确性,并通过生成式人工智能技术完成设计创意方案,为现代家具设计提供创新性思路和方法。方法通过人工智能技术Canny边缘检测算法和T2I-Adapter算法来快速且精准地提取Art Deco风格在各类设计案例中的造型、色彩因子特征,整理提炼出造型、色彩、材质和文化内涵的提示词,形成Art Deco风格数据库。利用Midjourney和Stable Diffusion人工智能生成图像技术完成家具创新设计实践,探索多样化设计方案的高效实现。结论利用人工智能算法能够快速且精准地提取出Art Deco风格的设计因子,结合AIGC技术设计出更多有创意的家具方案,拓展了人工智能的应用领域,为现代家具设计技术创新研究提供参考。 展开更多
关键词 家具设计 art Deco风格 生成式人工智能 因子提取
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ART智能干选系统在大平矿选煤厂的应用研究 被引量:1
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作者 刘凤军 杨睿 +1 位作者 安国斌 王慎军 《煤炭加工与综合利用》 2025年第8期40-42,48,共4页
铁法煤业集团大平煤矿选煤厂为改善手选工作条件,提高生产效率,采用ART智能干选机对原手选系统进行了改造,阐述了项目实施背景、智能干选机工作原理、选煤工艺改造方案、设备选型、分选精度验收以及所带来的显著经济效益;通过对该项目... 铁法煤业集团大平煤矿选煤厂为改善手选工作条件,提高生产效率,采用ART智能干选机对原手选系统进行了改造,阐述了项目实施背景、智能干选机工作原理、选煤工艺改造方案、设备选型、分选精度验收以及所带来的显著经济效益;通过对该项目全方位剖析,展现ART智能干选技术在煤炭分选领域的优势与实践成果,为煤炭行业选煤工艺升级提供有益参考。 展开更多
关键词 选煤厂 art智能干选机 分选精度 矸中带煤率
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Grid-based computer-generated holograms synthesizing for holographic three-dimensional display
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作者 陈国华 张爱军 《Journal of Beijing Institute of Technology》 EI CAS 2011年第3期415-420,共6页
To reduce the computing time of composite computer-generated holograms (CGHs) gen- eration based upon the angular projection algorithm for holographic three-dimensional (3D) display, a grid-based holographic displ... To reduce the computing time of composite computer-generated holograms (CGHs) gen- eration based upon the angular projection algorithm for holographic three-dimensional (3D) display, a grid-based holographic display ( GHD ) scheme was designed. The grid computing technology was applied to numerically process the different angular projections of an object in distributed-parallel manner to create the corresponding CGHs. The whole treatment of a projection was regarded as a job executed on the grid node machine. The number of jobs which were submitted to grid nodes, therefore, was equal to that of the projections of the object. A Condor-based grid testbed was constructed to verify the feasibility of the GHD scheme, and a graphical user interface (GUI) program and several service modules were developed for it. A 3D terrain model as an example was processed on the testbed. The result showed that the scheme was feasible and able to improve the execution elficiency greatly. 展开更多
关键词 computer-generated hologram (CGH) GRID three-dimensional (3D) display
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基于ART-2人工神经网络算法的煤矿应急管理能力综合评价模型研究
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作者 张玉华 丁立培 王宇 《中国矿业》 北大核心 2025年第8期145-151,共7页
在评价煤矿应急管理能力时,为指标分配权重的过程易产生数据缺失值,导致指标计算精度较差,影响了评价结果的准确性。为此,构建基于ART-2人工神经网络算法的煤矿应急管理能力综合评价模型,以提升评价的客观性与准确性。首先,依据煤矿应... 在评价煤矿应急管理能力时,为指标分配权重的过程易产生数据缺失值,导致指标计算精度较差,影响了评价结果的准确性。为此,构建基于ART-2人工神经网络算法的煤矿应急管理能力综合评价模型,以提升评价的客观性与准确性。首先,依据煤矿应急管理体系结构,对打分数值进行规范化处理,将其转化为类别样本矢量集,为后续利用ART-2人工神经网络算法进行指标筛选提供标准化的数据输入。其次,运用ART-2人工神经网络算法对煤矿管理能力指标进行筛选。再次,组合网络层级中的元素,构建评价指标间相互影响的未加权矩阵。该矩阵全面反映了各评价指标之间的关联关系,为后续的权重分配提供依据。在目标层神经元节点处设置警戒数值,通过ART-2人工神经网络对未加权矩阵进行训练和优化。在此过程中,算法能够自动调整和修正指标权重,降低权重分配的主观性和模糊性。最后,根据修正后的权值,重新对各层神经元节点处的指标评分进行计算,得出最终的评价结果。研究结论表明,基于ART-2人工神经网络算法的煤矿应急管理能力评价模型,在解决传统评价方法中权重分配主观性强、数据易缺失等问题上具有显著优势,能够为煤矿应急管理决策提供更科学、合理的依据,有助于煤矿企业更好地评估和提升应急管理能力,从而保障煤矿的安全生产。 展开更多
关键词 art-2人工神经网络 煤矿应急管理能力 类别样本矢量集 网络层级 警戒数值
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ART-EGCG序贯给药静电纺丝纤维的制备及协同抗肝癌效果研究
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作者 陈彦昊 彭艳 +4 位作者 刘惠军 王胜男 杨艳玲 代方银 李智 《材料导报》 北大核心 2025年第20期257-262,共6页
为抑制手术后肝癌复发,常通过局部给药的方式抑制癌细胞生长及肿瘤形成。基于青蒿素(ART)和表没食子儿茶素没食子酸酯(EGCG)两种药物的抗癌机制,研究二者对肝癌细胞的协同抑制作用。结果表明,序贯给药的最优顺序为ART-EGCG,最优给药时间... 为抑制手术后肝癌复发,常通过局部给药的方式抑制癌细胞生长及肿瘤形成。基于青蒿素(ART)和表没食子儿茶素没食子酸酯(EGCG)两种药物的抗癌机制,研究二者对肝癌细胞的协同抑制作用。结果表明,序贯给药的最优顺序为ART-EGCG,最优给药时间为15 h+9 h,最优ART、EGCG给药比例为1∶1,最优给药浓度均为25μg/mL,此时二者具有很好的协同抑制肝癌细胞作用。基于二者协同抑制作用的给药方式,采用同轴静电纺丝技术,以15%(质量分数)PLGA和ART混合作为皮层纺丝液,10%(质量分数)PEG和EGCG混合作为芯层纺丝液,设计并制备出具有皮芯结构的载药静电纺丝纤维膜,其可以有效调控ART和EGCG的序贯释放,协同抑制肝癌细胞的生长及增殖,在24 h时,该载药静电纺丝膜对HepG2细胞的抑制率为(38.66±4.12)%。 展开更多
关键词 同轴静电纺丝 序贯给药 青蒿素(art) 表没食子儿茶素没食子酸酯(EGCG) 抗癌药物
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Application of Modern Art in Urban Landscape Design 被引量:1
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作者 ZHUANG Zi-yi ABUDUGENI Abuduxukuer TANG Xian-gong 《Agricultural Science & Technology》 2025年第1期55-59,共5页
With the progress of urbanization,urban landscape design has garnered increasing attention.Urban landscape design can not only reflect the construction level of a city but also has the functions of beautifying the urb... With the progress of urbanization,urban landscape design has garnered increasing attention.Urban landscape design can not only reflect the construction level of a city but also has the functions of beautifying the urban environment and enhancing the city image.Modern art enriches the expression forms of urban landscape design,and its integration with urban landscape design can greatly improve the urban landscape.This article elaborated on the connotations of modern art and urban landscape design and analyzed the application of modern art in urban landscape design.The application of modern art can help to achieve the goal of urban landscape design to the maximum extent. 展开更多
关键词 Modern art Urban landscape DESIGN
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民国时期水明昌海派西式家具Art Deco设计风格研究
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作者 沈修远 门德来 杨颖 《南京艺术学院学报(美术与设计)》 北大核心 2025年第5期52-60,I0001,共10页
民国时期,为迎合上海人摩登化的文化生活偏好,本土海派西式家具厂商流行设计Art Deco风格家具。以水明昌木器公司Art Deco风格海派西式家具为研究对象,从历史资料、相关图纸及实物等方面,对其家具的工艺、技术及设计特征进行研究;在社... 民国时期,为迎合上海人摩登化的文化生活偏好,本土海派西式家具厂商流行设计Art Deco风格家具。以水明昌木器公司Art Deco风格海派西式家具为研究对象,从历史资料、相关图纸及实物等方面,对其家具的工艺、技术及设计特征进行研究;在社会变迁维度空间中阐述中国Art Deco风格设计形成的原因,解读20世纪30年代海派设计风尚。 展开更多
关键词 民国时期 水明昌 海派西式家具 art Deco设计风格
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肠道菌群及其代谢物和ART妊娠结局的相关性研究
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作者 任士威 郭焕 《医学诊断》 2025年第4期403-410,共8页
这篇论文综述了辅助生殖技术(ART)的进展及其对妊娠结果和胎儿发育的影响。文中强调不孕症的日益普遍,各种ART技术的发展及其对胚胎和胎儿健康潜在的影响。文章还探讨了母体肠道菌群及其代谢物对胚胎发育和妊娠结果的作用,指出ART可能... 这篇论文综述了辅助生殖技术(ART)的进展及其对妊娠结果和胎儿发育的影响。文中强调不孕症的日益普遍,各种ART技术的发展及其对胚胎和胎儿健康潜在的影响。文章还探讨了母体肠道菌群及其代谢物对胚胎发育和妊娠结果的作用,指出ART可能导致母体肠道菌群及其代谢产物的变化,从而影响胎盘功能和胚胎发育能力。进一步研究了ART与母体肠道菌群及其代谢物通过调控机制影响胎盘功能及胚胎发育能力之间关系的重要性,以及这些关系对妊娠结局和胎儿发育的影响,对于进一步提高辅助生殖技术的成功率和胎儿健康具有重要的意义。 展开更多
关键词 辅助生殖技术(art) 肠道菌群 妊娠结局
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2022年合肥市艾滋病ART失败人群HIV基因型耐药特征分析
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作者 韦德琴 朱琳 +4 位作者 何柳 田登菊 郑君 赵明伍 万永虎 《热带医学杂志》 2025年第9期1175-1179,I0001,共6页
目的 了解合肥市艾滋病抗逆转录病毒治疗(ART)失败人群人类免疫缺陷病毒(HIV)基因型耐药特征,为艾滋病的防治提供依据。方法 2022年1-12月在合肥市14个区县医疗单位门诊及住院期间接受ART并且失败的艾滋病患者(治疗24周以上)608人,检测... 目的 了解合肥市艾滋病抗逆转录病毒治疗(ART)失败人群人类免疫缺陷病毒(HIV)基因型耐药特征,为艾滋病的防治提供依据。方法 2022年1-12月在合肥市14个区县医疗单位门诊及住院期间接受ART并且失败的艾滋病患者(治疗24周以上)608人,检测患者外周血中的病毒载量,收集≥1 000 CPs/mL的血浆标本,提取血浆RNA,通过巢式PCR方法扩增HIV-1 pol区蛋白酶和反转录酶区的基因序列,测序后通过斯坦福大学HIV-1耐药性分析数据库序列比对分析统计HIV的型别和耐药突变情况。结果 共计扩增出抗病毒治疗失败患者HIV pol区基因序列608例,C、BC、CRF01_AE、CRF07_BC、CRF08_BC亚型HIV基因型耐药率分别为65.00%(13/20)、43.42%(99/228)、40.00%(74/185)、32.76%(38/116)、28.21%(11/39),不同亚型HIV基因型耐药突变率差异有统计学意义(χ^(2)=20.824,P=0.001)。合肥市东北部、东南部、西南部、西北部等地区HIV基因型耐药突变率分别为31.76%(27/85)、59.38%(19/32)、36.76%(100/272)、47.49%(104/219),不同地区HIV基因型耐药突变率差异有统计学意义(χ^(2)=13.277,P=0.004)。合肥市艾滋病ART失败人群对核苷类逆转录酶抑制剂(NRTIs)、非核苷类逆转录酶抑制剂(NNRTIs)和蛋白酶抑制剂(PIs)三大类药物的耐药突变率分别为12.01%(73/608)、37.34%(227/608)和3.45%(21/608)。耐药程度分类中,高度耐药突变率最高的是恩曲他滨和拉米夫定,均为95.59%(65/68),其次是奈韦拉平为80.79%(164/203)和依非韦仑为72.64%(146/201)。氨基酸位点突变率最高为K103 18.75%(114/608),其次是M184位点和V179位点,突变率分别为10.69%(65/608)和8.88%(54/608)。结论 合肥市艾滋病ART失败人群总体耐药发生率高,不同型别和不同地区耐药突变率有差异,个别治疗药物高度耐药突变率严重,应加强监测和及时调整治疗方案,保障艾滋病患者的疗效,从而有效防治艾滋病。 展开更多
关键词 艾滋病 抗逆转录病毒治疗 基因 耐药
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