Objective To draw on the experience of the construction and development of drug traceability system in the USA and to provide reference for improving China’s drug traceability system.Methods Literature research and c...Objective To draw on the experience of the construction and development of drug traceability system in the USA and to provide reference for improving China’s drug traceability system.Methods Literature research and comparative study were used to sort out the background and development of drug traceability system in the USA,including drug traceability code,drug traceability model,drug traceability platform and the application of blockchain technology.On this basis,some suggestions on the construction of drug traceability system in China were put forward.Results and Conclusion The United States has a perfect system of laws and regulations on drug traceability,which encourages the construction of third-party traceability platforms to avoid the formation of monopolies.Besides,the application of blockchain technology in the construction of drug traceability system is also relatively mature.It is suggested that China strengthen the construction of drug traceability system,give play to the advantages of third-party traceability platforms,and improve the application of blockchain technology in drug traceability.展开更多
Carbonaceous aerosol,including organic carbon(OC)and elemental carbon(EC),has significant influence on human health,air quality and climate change.Accurate measurement of carbonaceous aerosol is essential to reduce th...Carbonaceous aerosol,including organic carbon(OC)and elemental carbon(EC),has significant influence on human health,air quality and climate change.Accurate measurement of carbonaceous aerosol is essential to reduce the uncertainty of radiative forcing estimation and source apportionment.The accurate separation of OC and EC is controversial due to the charring of OC.Therefore,the development of reference materials(RM)for the validation of OC/EC separation is an important basis for further study.Previous RMs were mainly based on ambient air sampling,which could not provide traceability of OC and EC concentration.To develop traceable RMs with known OC/EC contents,our study applied an improved aerosol generation and mixing technique,providing uniform deposition of particles on quartz filters.To generate OC aerosol with similar pyrolytic property of ambient aerosol,both water soluble organic carbon(WSOC)and water insoluble organic carbon(WIOC)were used,and amorphous carbon was selected for EC surrogate.The RMs were analyzed using different protocols.The homogeneity within the filter was validated,reaching below 2%.The long-term stability of RMs has been validated with RSD ranged from 1.7%–3.2%.Good correlationwas observed between nominal concentration of RMswithmeasured concentration by two protocols,while the difference of EC concentration was within 20%.The results indicated that the newly developed RMs were acceptable for the calibration of OC and EC,which could improve the accuracy of carbonaceous aerosol measurement.Moreover,the laboratory-generated EC-RMs could be suitable for the calibration of equivalent BC concentration by Aethalometers.展开更多
Prosthetic devices designed to assist individuals with damaged or missing body parts have made significant strides,particularly with advancements in machine intelligence and bioengineering.Initially focused on movemen...Prosthetic devices designed to assist individuals with damaged or missing body parts have made significant strides,particularly with advancements in machine intelligence and bioengineering.Initially focused on movement assistance,the field has shifted towards developing prosthetics that function as seamless extensions of the human body.During this progress,a key challenge remains the reduction of interface artifacts between prosthetic components and biological tissues.Soft electronics offer a promising solution due to their structural flexibility and enhanced tissue adaptability.However,achieving full integration of prosthetics with the human body requires both artificial perception and efficient transmission of physical signals.In this context,synaptic devices have garnered attention as next-generation neuromorphic computing elements because of their low power consumption,ability to enable hardware-based learning,and high compatibility with sensing units.These devices have the potential to create artificial pathways for sensory recognition and motor responses,forming a“sensory-neuromorphic system”that emulates synaptic junctions in biological neurons,thereby connecting with impaired biological tissues.Here,we discuss recent developments in prosthetic components and neuromorphic applications with a focus on sensory perception and sensorimotor actuation.Initially,we explore a prosthetic system with advanced sensory units,mechanical softness,and artificial intelligence,followed by the hardware implementation of memory devices that combine calculation and learning functions.We then highlight the importance and mechanisms of soft-form synaptic devices that are compatible with sensing units.Furthermore,we review an artificial sensory-neuromorphic perception system that replicates various biological senses and facilitates sensorimotor loops from sensory receptors,the spinal cord,and motor neurons.Finally,we propose insights into the future of closed-loop neuroprosthetics through the technical integration of soft electronics,including bio-integrated sensors and synaptic devices,into prosthetic systems.展开更多
Almond is widely cultivated in the world thanks to the quality and healthy features of the kernel.Almond kernel is consumed fresh or employed in the food industry.Hundreds of almond cultivars were selected throughout ...Almond is widely cultivated in the world thanks to the quality and healthy features of the kernel.Almond kernel is consumed fresh or employed in the food industry.Hundreds of almond cultivars were selected throughout the long history of cultivation;in this context,an efficient method for varietal identification is essential to ensure cultivar traceability along the chain.This study surveyed the widely employed commercial kits and protocols for DNA extraction from several almond matrices including leaves,kernels(fresh and roasted)and several processed products.Commercial kits(though with minor modification)outperformed the other extraction methods for the isolation of DNA suitable for molecular analysis from all the tested matrices.In parallel,a germplasm collection composed of 140 accessions(123 Sicilian genotypes complemented with widely known national and international cultivars)was genotyped with the Axiom^(TM)60K almond SNP Array enabling the detection of 6374 unique SNPs that can be readily used for varietal traceability.A subset of unique SNPs was further validated employing a high-resolution melting(HRM)assay on a discovery panel encompassing ten of the most widely cultivated accessions.The DNA extracted from leaves and kernels of five cultivars was genotyped with eight SSRs allowing the identification of the maternal origin of each kernel.The paper integrates the survey of the widely employed protocols for DNA extraction with the high-throughput genotyping of 140 almond accessions.In this context,unique SNPs validated and optimized for an HRM assay and the availability of SSR markers demonstrated their efficacy in traceability analysis along the chain.展开更多
Rotary steering systems(RSSs)have been increasingly used to develop horizontal wells.A static push-the-bit RSS uses three hydraulic modules with varying degrees of expansion and contraction to achieve changes in the p...Rotary steering systems(RSSs)have been increasingly used to develop horizontal wells.A static push-the-bit RSS uses three hydraulic modules with varying degrees of expansion and contraction to achieve changes in the pushing force acting on the wellbore in different sizes and directions within a circular range,ultimately allowing the wellbore trajectory to be drilled in a predetermined direction.By analyzing its mathematical principles and the actual characteristics of the instrument,a vector force closed-loop control method,including steering and holding modes,was designed.The adjustment criteria for the three hydraulic modules are determined to achieve rapid adjustment of the vector force.The theoretical feasibility of the developed method was verified by comparing its results with the on-site application data of an imported rotary guidance system.展开更多
With the popularity of the Internet of Vehicles(IoV),a large amount of data is being generated every day.How to securely share data between the IoV operator and various value-added service providers becomes one of the...With the popularity of the Internet of Vehicles(IoV),a large amount of data is being generated every day.How to securely share data between the IoV operator and various value-added service providers becomes one of the critical issues.Due to its flexible and efficient fine-grained access control feature,Ciphertext-Policy Attribute-Based Encryption(CP-ABE)is suitable for data sharing in IoV.However,there are many flaws in most existing CP-ABE schemes,such as attribute privacy leakage and key misuse.This paper proposes a Traceable and Revocable CP-ABE-based Data Sharing with Partially hidden policy for IoV(TRE-DSP).A partially hidden access structure is adopted to hide sensitive user attribute values,and attribute categories are sent along with the ciphertext to effectively avoid privacy exposure.In addition,key tracking and malicious user revocation are introduced with broadcast encryption to prevent key misuse.Since the main computation task is outsourced to the cloud,the burden of the user side is relatively low.Analysis of security and performance demonstrates that TRE-DSP is more secure and practical for data sharing in IoV.展开更多
Conventional open-loop deep brain stimulation(DBS)systems with fixed parameters fail to accommodate interindividual pathological differences in Parkinson's disease(PD)management while potentially inducing adverse ...Conventional open-loop deep brain stimulation(DBS)systems with fixed parameters fail to accommodate interindividual pathological differences in Parkinson's disease(PD)management while potentially inducing adverse effects and causing excessive energy consumption.In this paper,we present an adaptive closed-loop framework integrating a Yogi-optimized proportional–integral–derivative neural network(Yogi-PIDNN)controller.The Yogi-augmented gradient adaptation mechanism accelerates the convergence of general PIDNN controllers in high-dimensional nonlinear control systems while reducing control energy usage.In addition,a system identification method establishes input–output dynamics for pre-training stimulation waveforms,bypassing real-time parameter-tuning constraints and thereby enhancing closed-loop adaptability.Finally,a theoretical analysis based on Lyapunov stability criteria establishes a sufficient condition for closed-loop stability within the identified model.Computational validations demonstrate that our approach restores thalamic relay reliability while reducing energy consumption by(81.0±0.7)%across multi-frequency tests.This study advances adaptive neuromodulation by synergizing data-driven pre-training with stability-guaranteed real-time control,offering a novel framework for energy-efficient and personalized Parkinson's therapy.展开更多
This paper proposes a separated trajectory tracking controller for fishing ships at sea state level 6 to solve the trajectory tracking problem of a fishing ship in a 6-level sea state,and to adapt to different working...This paper proposes a separated trajectory tracking controller for fishing ships at sea state level 6 to solve the trajectory tracking problem of a fishing ship in a 6-level sea state,and to adapt to different working environments and safety requirements.The nonlinear feedback method is used to improve the closed-loop gain shaping algorithm.By introducing the sine function,the problem of excessive control energy of the system can be effectively solved.Moreover,an integral separation design is used to solve the influence of the integral term in conventional PID controllers on the transient performance of the system.In this paper,a common 32.98 m large fiberglass reinforced plastic(FRP)trawler is adopted for simulation research at the winds scale of Beaufort No.7.The results show that the track error is smaller than 3.5 m.The method is safe,feasible,concise and effective and has popularization value in the direction of fishing ship trajectory tracking control.This method can be used to improve the level of informatization and intelligence of fishing ships.展开更多
As the cornerstone of sterile instrument maintenance in endoscopy centers,the quality of endoscope cleaning directly impacts hospital infection control effectiveness.The traceability system for endoscopy centers utili...As the cornerstone of sterile instrument maintenance in endoscopy centers,the quality of endoscope cleaning directly impacts hospital infection control effectiveness.The traceability system for endoscopy centers utilizes digital means to document the entire cleaning process,enabling real-time monitoring and precise quality control.This paper analyzes current quality control practices in endoscope cleaning and addresses existing challenges.It explores how traceability systems standardize procedures,enhance monitoring,and improve management efficiency.The study proposes optimization strategies for traceability system implementation,clarifying its core value in endoscope cleaning quality control.These findings provide theoretical foundations and practical guidance for hospitals to refine management of endoscopy centers,ensure diagnostic safety,and reduce infection risks,ultimately advancing endoscope cleaning quality control toward standardized and informatized development.展开更多
[Objective] To establish the traceability mechanism of agricultural products safety, and the application of promote domestic based software in the supervision area of agricultural products quality and safety. [Method]...[Objective] To establish the traceability mechanism of agricultural products safety, and the application of promote domestic based software in the supervision area of agricultural products quality and safety. [Method] Through the analysis on the circulation characteristics of agricultural products, like fruits, vegetables, livestock and poultry, the agricultural products quality safety management and traceability query business component libraries were designed. Based on the run-time-supporting environment provided by domestic based software, traceability management system of agricultural products quality and safety was constructed. [Result] The traceability management system provided the information interaction and comprehensive management platform of agricultural product quality and safety based on domestic based software for the government, enterprises and consumers. [Conclusion] Through the application demonstration, the quality control and information traceability of full circulation of agricultural products was achieved effective and reliably, and the management level of agricultural products quality and safety was improved.展开更多
文摘Objective To draw on the experience of the construction and development of drug traceability system in the USA and to provide reference for improving China’s drug traceability system.Methods Literature research and comparative study were used to sort out the background and development of drug traceability system in the USA,including drug traceability code,drug traceability model,drug traceability platform and the application of blockchain technology.On this basis,some suggestions on the construction of drug traceability system in China were put forward.Results and Conclusion The United States has a perfect system of laws and regulations on drug traceability,which encourages the construction of third-party traceability platforms to avoid the formation of monopolies.Besides,the application of blockchain technology in the construction of drug traceability system is also relatively mature.It is suggested that China strengthen the construction of drug traceability system,give play to the advantages of third-party traceability platforms,and improve the application of blockchain technology in drug traceability.
基金supported by the National Natural Science Foundation of China(No.22206180)the funds for establishing basic quality and technology capabilities(No.ANL2203)the special fund for basic scientific research business of central public research institutes(No.AKYZD2207-4)。
文摘Carbonaceous aerosol,including organic carbon(OC)and elemental carbon(EC),has significant influence on human health,air quality and climate change.Accurate measurement of carbonaceous aerosol is essential to reduce the uncertainty of radiative forcing estimation and source apportionment.The accurate separation of OC and EC is controversial due to the charring of OC.Therefore,the development of reference materials(RM)for the validation of OC/EC separation is an important basis for further study.Previous RMs were mainly based on ambient air sampling,which could not provide traceability of OC and EC concentration.To develop traceable RMs with known OC/EC contents,our study applied an improved aerosol generation and mixing technique,providing uniform deposition of particles on quartz filters.To generate OC aerosol with similar pyrolytic property of ambient aerosol,both water soluble organic carbon(WSOC)and water insoluble organic carbon(WIOC)were used,and amorphous carbon was selected for EC surrogate.The RMs were analyzed using different protocols.The homogeneity within the filter was validated,reaching below 2%.The long-term stability of RMs has been validated with RSD ranged from 1.7%–3.2%.Good correlationwas observed between nominal concentration of RMswithmeasured concentration by two protocols,while the difference of EC concentration was within 20%.The results indicated that the newly developed RMs were acceptable for the calibration of OC and EC,which could improve the accuracy of carbonaceous aerosol measurement.Moreover,the laboratory-generated EC-RMs could be suitable for the calibration of equivalent BC concentration by Aethalometers.
基金supported by the National Research Foundation of Korea(NRF)grant funded by the Korean government(MSIT)(No.2020R1C1C1005567)supported by the NAVER Digital Bio Innovation Research Fund,funded by NAVER Corporation(Grant No.[37-2023-0040])+3 种基金supported by Institute of Information&communications Technology Planning&Evaluation(IITP)grant funded by the Korea government(MSIT)(No.2020-0-00261,Development of low power/low delay/self-power suppliable RF simultaneous information and power transfer system and stretchable electronic epineurium for wireless nerve bypass implementation)supported by Institute for Basic Science(IBS-R015-D1,IBSR015-D2)supported by a grant of the Korea-US Collaborative Research Fund(KUCRF)funded by the Ministry of Science and ICT and Ministry of Health&Welfare,Republic of Korea(Grant Number.RS-2024-00467213)。
文摘Prosthetic devices designed to assist individuals with damaged or missing body parts have made significant strides,particularly with advancements in machine intelligence and bioengineering.Initially focused on movement assistance,the field has shifted towards developing prosthetics that function as seamless extensions of the human body.During this progress,a key challenge remains the reduction of interface artifacts between prosthetic components and biological tissues.Soft electronics offer a promising solution due to their structural flexibility and enhanced tissue adaptability.However,achieving full integration of prosthetics with the human body requires both artificial perception and efficient transmission of physical signals.In this context,synaptic devices have garnered attention as next-generation neuromorphic computing elements because of their low power consumption,ability to enable hardware-based learning,and high compatibility with sensing units.These devices have the potential to create artificial pathways for sensory recognition and motor responses,forming a“sensory-neuromorphic system”that emulates synaptic junctions in biological neurons,thereby connecting with impaired biological tissues.Here,we discuss recent developments in prosthetic components and neuromorphic applications with a focus on sensory perception and sensorimotor actuation.Initially,we explore a prosthetic system with advanced sensory units,mechanical softness,and artificial intelligence,followed by the hardware implementation of memory devices that combine calculation and learning functions.We then highlight the importance and mechanisms of soft-form synaptic devices that are compatible with sensing units.Furthermore,we review an artificial sensory-neuromorphic perception system that replicates various biological senses and facilitates sensorimotor loops from sensory receptors,the spinal cord,and motor neurons.Finally,we propose insights into the future of closed-loop neuroprosthetics through the technical integration of soft electronics,including bio-integrated sensors and synaptic devices,into prosthetic systems.
基金the PRIMA project:MEDPOMESTONE(Grant No.23A01284).
文摘Almond is widely cultivated in the world thanks to the quality and healthy features of the kernel.Almond kernel is consumed fresh or employed in the food industry.Hundreds of almond cultivars were selected throughout the long history of cultivation;in this context,an efficient method for varietal identification is essential to ensure cultivar traceability along the chain.This study surveyed the widely employed commercial kits and protocols for DNA extraction from several almond matrices including leaves,kernels(fresh and roasted)and several processed products.Commercial kits(though with minor modification)outperformed the other extraction methods for the isolation of DNA suitable for molecular analysis from all the tested matrices.In parallel,a germplasm collection composed of 140 accessions(123 Sicilian genotypes complemented with widely known national and international cultivars)was genotyped with the Axiom^(TM)60K almond SNP Array enabling the detection of 6374 unique SNPs that can be readily used for varietal traceability.A subset of unique SNPs was further validated employing a high-resolution melting(HRM)assay on a discovery panel encompassing ten of the most widely cultivated accessions.The DNA extracted from leaves and kernels of five cultivars was genotyped with eight SSRs allowing the identification of the maternal origin of each kernel.The paper integrates the survey of the widely employed protocols for DNA extraction with the high-throughput genotyping of 140 almond accessions.In this context,unique SNPs validated and optimized for an HRM assay and the availability of SSR markers demonstrated their efficacy in traceability analysis along the chain.
基金supported by the Opening Foundation of China National Logging Corporation(CNLC20229C06)the China Petroleum Technical Service Corporation's science project'Development and application of 475 rotary steering system'(2024T-001001)。
文摘Rotary steering systems(RSSs)have been increasingly used to develop horizontal wells.A static push-the-bit RSS uses three hydraulic modules with varying degrees of expansion and contraction to achieve changes in the pushing force acting on the wellbore in different sizes and directions within a circular range,ultimately allowing the wellbore trajectory to be drilled in a predetermined direction.By analyzing its mathematical principles and the actual characteristics of the instrument,a vector force closed-loop control method,including steering and holding modes,was designed.The adjustment criteria for the three hydraulic modules are determined to achieve rapid adjustment of the vector force.The theoretical feasibility of the developed method was verified by comparing its results with the on-site application data of an imported rotary guidance system.
基金supported by the National Natural Science Foundation of China(No.62272076)。
文摘With the popularity of the Internet of Vehicles(IoV),a large amount of data is being generated every day.How to securely share data between the IoV operator and various value-added service providers becomes one of the critical issues.Due to its flexible and efficient fine-grained access control feature,Ciphertext-Policy Attribute-Based Encryption(CP-ABE)is suitable for data sharing in IoV.However,there are many flaws in most existing CP-ABE schemes,such as attribute privacy leakage and key misuse.This paper proposes a Traceable and Revocable CP-ABE-based Data Sharing with Partially hidden policy for IoV(TRE-DSP).A partially hidden access structure is adopted to hide sensitive user attribute values,and attribute categories are sent along with the ciphertext to effectively avoid privacy exposure.In addition,key tracking and malicious user revocation are introduced with broadcast encryption to prevent key misuse.Since the main computation task is outsourced to the cloud,the burden of the user side is relatively low.Analysis of security and performance demonstrates that TRE-DSP is more secure and practical for data sharing in IoV.
基金supported by the National Natural Science Foundation of China(Grant Nos.12372064 and 12172291)the Youth and Middle-Aged Science and Technology Development Program of Shanghai Institute of Technology(Grant No.ZQ2024-10)。
文摘Conventional open-loop deep brain stimulation(DBS)systems with fixed parameters fail to accommodate interindividual pathological differences in Parkinson's disease(PD)management while potentially inducing adverse effects and causing excessive energy consumption.In this paper,we present an adaptive closed-loop framework integrating a Yogi-optimized proportional–integral–derivative neural network(Yogi-PIDNN)controller.The Yogi-augmented gradient adaptation mechanism accelerates the convergence of general PIDNN controllers in high-dimensional nonlinear control systems while reducing control energy usage.In addition,a system identification method establishes input–output dynamics for pre-training stimulation waveforms,bypassing real-time parameter-tuning constraints and thereby enhancing closed-loop adaptability.Finally,a theoretical analysis based on Lyapunov stability criteria establishes a sufficient condition for closed-loop stability within the identified model.Computational validations demonstrate that our approach restores thalamic relay reliability while reducing energy consumption by(81.0±0.7)%across multi-frequency tests.This study advances adaptive neuromodulation by synergizing data-driven pre-training with stability-guaranteed real-time control,offering a novel framework for energy-efficient and personalized Parkinson's therapy.
基金supported by Liaoning Provincial Department of Education 2023 Basic Research Projects for Universities and Colleges(Grant No.JYTQN2023131)Liaoning Provincial Science and Technology Program:Cooperative Control and Recognition of Unmanned Vessels for Fishing Vessel Operation Scenarios(Grant No.600024003)Liaoning Provincial Department of Education Scientific Research Funding Project(Grant No.LJKZ0726).
文摘This paper proposes a separated trajectory tracking controller for fishing ships at sea state level 6 to solve the trajectory tracking problem of a fishing ship in a 6-level sea state,and to adapt to different working environments and safety requirements.The nonlinear feedback method is used to improve the closed-loop gain shaping algorithm.By introducing the sine function,the problem of excessive control energy of the system can be effectively solved.Moreover,an integral separation design is used to solve the influence of the integral term in conventional PID controllers on the transient performance of the system.In this paper,a common 32.98 m large fiberglass reinforced plastic(FRP)trawler is adopted for simulation research at the winds scale of Beaufort No.7.The results show that the track error is smaller than 3.5 m.The method is safe,feasible,concise and effective and has popularization value in the direction of fishing ship trajectory tracking control.This method can be used to improve the level of informatization and intelligence of fishing ships.
文摘As the cornerstone of sterile instrument maintenance in endoscopy centers,the quality of endoscope cleaning directly impacts hospital infection control effectiveness.The traceability system for endoscopy centers utilizes digital means to document the entire cleaning process,enabling real-time monitoring and precise quality control.This paper analyzes current quality control practices in endoscope cleaning and addresses existing challenges.It explores how traceability systems standardize procedures,enhance monitoring,and improve management efficiency.The study proposes optimization strategies for traceability system implementation,clarifying its core value in endoscope cleaning quality control.These findings provide theoretical foundations and practical guidance for hospitals to refine management of endoscopy centers,ensure diagnostic safety,and reduce infection risks,ultimately advancing endoscope cleaning quality control toward standardized and informatized development.
基金Supported by Common Chips and Basic Software Products(2010ZX01045-001-004-3)~~
文摘[Objective] To establish the traceability mechanism of agricultural products safety, and the application of promote domestic based software in the supervision area of agricultural products quality and safety. [Method] Through the analysis on the circulation characteristics of agricultural products, like fruits, vegetables, livestock and poultry, the agricultural products quality safety management and traceability query business component libraries were designed. Based on the run-time-supporting environment provided by domestic based software, traceability management system of agricultural products quality and safety was constructed. [Result] The traceability management system provided the information interaction and comprehensive management platform of agricultural product quality and safety based on domestic based software for the government, enterprises and consumers. [Conclusion] Through the application demonstration, the quality control and information traceability of full circulation of agricultural products was achieved effective and reliably, and the management level of agricultural products quality and safety was improved.
