Background: The incidence of sexually transmittedHIV infections is rapidly increasing in China, and theprevalence of AIDS-associated mycoplasmas (includingMycoplasma genitalium, Mycoplasma penetrans, Myco-plasma pirum...Background: The incidence of sexually transmittedHIV infections is rapidly increasing in China, and theprevalence of AIDS-associated mycoplasmas (includingMycoplasma genitalium, Mycoplasma penetrans, Myco-plasma pirum and Mycoplasma fermentans) infections isunknown in patients with sexually transmitted diseases.Objective: To investigate the prevalence of these 4species of AIDS-associated mycoplasmas infections inpatients with nongonococcal urethritis (NGU) andmucopurulent cervicitis (MPC).Methods: In 65 patients with NGU/MPC, detection ofM. genitalium, M. penetrans, M. pirum and M. fermentansin genital and pharyngeal specimens was performed byculture and nested polymerase chain reaction.Results: M. genitalium, M. penetrans, M. pirum and M.fermentans were identified in genital specimens from23.1% (15/65), 12.3% (8/65), 1.5% (1/65) and 0% ofpatients, respectively, and from pharyngeal samples in26.2% (17/65), 15.4% (10/65), 1.5% (1/65) and 0% ofpatients, respectively. M. genitalium was detected in bothgenital and pharyngeal samples in 10.8% (7/65) ofpatients, and M. penetrans in 4.6% (3/65) of patients. M.pirum was found in only 2 cases, and no M. fermentanswas discovered.Conclusions: This study suggests that M. genitaliumand M. penetrans infections are common in patients withNGU/MPC. M. genitalium and M. penetrans may be trans-mitted by genital-genital or oral-genital sex, and maycause urethritis and cervicitis.展开更多
Objective： To analyze the efficacy of six antibiotic methods for treating non- gonococcal urethritis /cervicitis and the factors influencing efficacy. Methods： Retrospective analysis of 878 nongonococcal urethritis ...Objective： To analyze the efficacy of six antibiotic methods for treating non- gonococcal urethritis /cervicitis and the factors influencing efficacy. Methods： Retrospective analysis of 878 nongonococcal urethritis / cervicitis cases which received regular treatment and follow-up in our institute from 1st Jan. 2001 to 31st Aug. 2003. Results： The mean cure rate of six methods for Chlamydia trachamatis （Ct） was 57.116%. There were distinct differences among these methods for Ct treatment.The mean cure rate of six methods for Ureaplasma urealyticum （Uu） was 69.556% and there was no difference among these methods for Uu treatment. Coinfection with Ct and Uu dramatically reduced the elimination rate of these two pathogens. Conclusion： The effectiveness of treatment of these antibodies for non-gonococcal urethritis / cervicitis is not currently satisfactory. Importantly, there were many antibiotic-resistant Ct and Uu strains. The factors influencing antibiotic efficacy and mechanisms need further study.展开更多
[Objectives] To observe the pharmaceutical effect of Zijin Huadu suppository on treatment of cervicitis induced by virus,bacteria and phenol in vivo and in vitro,and provide experimental basis for evaluating its thera...[Objectives] To observe the pharmaceutical effect of Zijin Huadu suppository on treatment of cervicitis induced by virus,bacteria and phenol in vivo and in vitro,and provide experimental basis for evaluating its therapeutic effects for cervicitis. [Methods]Real-time RT-PCR and CPE methods were used to observe the inhibition of Zijin Huadu suppository on virus,and turbidimetry was used to observe bacteriostatic action; HE pathological section was used to observe cervicitis of rat,and enzyme-linked immunosorbent assay was used to detect virus' s expression in cervical tissue.[Results]In cervicitis rat model infected by HPV16,Zijin Huadu suppositories at the doses of 1. 2,0. 6 and0. 3 g/( kg·d) had significant inhibitory effect on HPV16 expression in cervical tissues,and the doses of 1. 2 and 0. 6 g/( kg·d) had significantly inhibitory effect on pathological changes of cervical tissues. In cervicities rat models infected mixedly by Escherichia coli,Neisseria gonorrhoeae and Staphylococcus aureus,Zijin Huadu suppositories at the doses of 1. 2 and 0. 6 g/( kg·d) had significant inhibitory effect on pathological changes of cervical tissues. In cervicitis rat models induced by chemical substances,Zijin Huadu suppositories at the dose of1. 2 g/( kg·d) had significant inhibitory effect on vagina and cervix lesions in rats. In vitro,Zijin Huadu suppository showed obvious inhibitory effects on HSV-2,HPV16,Staphylococcus aureus,Staphylococcus albus,Staphylococcus epidermidis,group B Streptococcus,E. coli,Pseudomonas aeruginosa,Proteusbacillus vulgaris,Neisseria gonorrhoeae and Candida albicans.[Conclusions] Zijin Huadu suppository has obvious inhibitory effect in vitro on viruses and bacteria,and could obviously improve the phenol-induced cervicitis.展开更多
Chronic cervicitis is a common disease in the female reproductive system, which may be the inducing factor for carcinoma of uterine cervix. It is clinically manifested by sticky and foul leukorrhagia, contact hemo... Chronic cervicitis is a common disease in the female reproductive system, which may be the inducing factor for carcinoma of uterine cervix. It is clinically manifested by sticky and foul leukorrhagia, contact hemorrhage, pain in the lower limbs or lumbosacral region, dysmenorrhea and infertility.
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Objective: to observe the therapeutic effect of levofloxacin combined with azithromycin in the treatment of cervicitis. Methods: in order to further analyze the clinical effect of treatment of cervicitis, 84 patients ...Objective: to observe the therapeutic effect of levofloxacin combined with azithromycin in the treatment of cervicitis. Methods: in order to further analyze the clinical effect of treatment of cervicitis, 84 patients who visited our hospital for treatment of cervicitis from April 2016 to April 2020 were selected and divided into 42 cases in the control group (single azithromycin) and 42 cases in the research group (levofloxacin combined with azithromycin). Results: after the clinical treatment of patients with cervicitis in two groups was effectively improved, the total effective rate of patients in treatment group (100%) / control group (88.1%), grade I vaginal cleanliness group (66.7%) / control group (45.2%), and incidence of adverse drug reactions group (4.7%) / control group (11.9%) were comprehensively improved. The related data of patients in two groups were statistically significant (P < 0.05). Conclusion: the conventional drug treatment for different cervicitis patients and the optimized treatment scheme of levofloxacin combined with azithromycin were comprehensively improved, so that the safety and treatment effects of the related monitoring indexes for the clinical treatment of cervicitis patients were effectively improved. The clinical application was significant.展开更多
Objective: to analyze the application effect of azithromycin combined with levofloxacin in the treatment of cervicitis. Methods: 82 patients with cervicitis in our hospital from March 2020 to December 2021 were random...Objective: to analyze the application effect of azithromycin combined with levofloxacin in the treatment of cervicitis. Methods: 82 patients with cervicitis in our hospital from March 2020 to December 2021 were randomly divided into control group (azithromycin) and observation group (azithromycin combined with levofloxacin), and the therapeutic effects were compared. Results: the total effective rate, IL-6, IL-8, improvement time of clinical symptoms, relapse rate, NKTs and VEGF levels in the observation group were better than those in the control group (P < 0.05). The incidence of adverse reactions was significantly different between the two groups (P < 0.05). Conclusion: the combination of azithromycin and levofloxacin in the treatment of cervicitis is helpful to improve the symptoms and inflammatory indexes of patients as soon as possible, and promote the improvement of treatment effect.展开更多
Objective: This article is mainly to analyze the practical effect of high-quality perioperative care for cervicitis patients undergoing cervical conization under hysteroscope. Methods: the research objects are all pat...Objective: This article is mainly to analyze the practical effect of high-quality perioperative care for cervicitis patients undergoing cervical conization under hysteroscope. Methods: the research objects are all patients in our hospital. The patients from January 2019 to January 2021 in our hospital are selected by random selection. The data period is 2 years. The above patients are all patients with cervicitis and are carefully selected. All patients are in line with the symptoms of cervicitis. Results: the data showed that the incidence of clinical complications in the high-quality care group, that is, the experimental group, was significantly lower, only 4.17%. However, for the control group patients receiving routine care, the incidence of complications was relatively high as 16.67%, and the difference was statistically significant (χ2=4.019, P<0.05). Conclusion: In patients with cervicitis undergoing cervical conization under hysteroscope, if perioperative high-quality care is adopted, the operation effect can be better to a great extent, which is more conducive to the postoperative recovery of patients and the complications will be reduced, and it is very worthy of clinical application.展开更多
Objective: to explore the clinical features of chronic cervicitis, and to analyze the related risk factors, so as to provide clinical feasibility reference. Methods: 108 patients admitted to our hospital from January ...Objective: to explore the clinical features of chronic cervicitis, and to analyze the related risk factors, so as to provide clinical feasibility reference. Methods: 108 patients admitted to our hospital from January 2018 to December 2019 were selected for clinical study. Among them, 54 patients with chronic cervicitis from January 2018 to December 2018 served as the control group. From January 2019 to December 2019, 54 healthy physical examinees served as the observation group. The general data of the two groups were analyzed retrospectively and statistically analyzed. Results: clinical studies have found that the clinical features of patients with chronic cervicitis are complex, and the main characteristic is cervical erosion, with a composition ratio of 68.52%. The risk factors for the disease include the number of abortions and living environment. Conclusion: through the analysis of the clinical features and risk factors of chronic cervicitis, it provides high medical value for the prevention of chronic cervicitis, and carries out effective solving strategies for its clinical characteristics and risk factors in order to improve the clinical symptoms and quality of life. It is worthy of extensive clinical promotion and use.展开更多
Objective: to analyze the clinical value of maternal and infant health care for cervical inflammation associated with HPV infection. Methods: a total of 100 cases of cervix cerebral inflammation were combined between ...Objective: to analyze the clinical value of maternal and infant health care for cervical inflammation associated with HPV infection. Methods: a total of 100 cases of cervix cerebral inflammation were combined between January 2019 and December 2020 at our selected institute. In the numerical table, they were randomly divided into two groups, with 50 cases in each group. A typical group of patients received a 2B gel treatment for the renorformer, on top of which a relief valve was added. Comparison of hs-CRP and TNFα between the two groups was always valid. Results: Hs-CRP, TNFα, IL-6 were lower than normal group and higher than normal group all the time, n <0.05. Conclusion: recombinant interferon A2B gel for maternal and infant health care combined treatment of cervical inflammation.展开更多
Objective: to explore the effectiveness of continuing nursing health education for patients with chronic cervicitis. Methods: 122 patients with cervicitis admitted to our hospital from December 2018 to December 2019 w...Objective: to explore the effectiveness of continuing nursing health education for patients with chronic cervicitis. Methods: 122 patients with cervicitis admitted to our hospital from December 2018 to December 2019 were randomly divided into observation group and control group (61 cases). The observation group provided continuous treatment. The control group received health education through routine management. Knowledge of cervicitis, duration of treatment, and satisfaction were observed and analyzed by caring for both groups of patients. Results: drug knowledge, disease knowledge, first aid knowledge, health knowledge, nursing satisfaction and shortened treatment time are all significant effects.展开更多
Background:Cervicitis is a common gynecological disease,which triggers local inflammation and tissue damage by a complex mechanism,seriously affecting women’s health.Chinese medicine plays a prominent role in the tre...Background:Cervicitis is a common gynecological disease,which triggers local inflammation and tissue damage by a complex mechanism,seriously affecting women’s health.Chinese medicine plays a prominent role in the treatment of gynecological inflammation.Shuangshi Tongling Capsule(SSTL),as a traditional Chinese medicine(TCM)compound,needs to be further elucidated for the treatment of cervicitis.Methods:Cervicitis was induced with 25%phenol gel(except controls),followed by 12-day intragastric treatment.Outcomes included genital inflammation scores,uterine index,and histopathology(HE staining).Serum tumor necrosis factor-α(TNF-α),Interleukin(IL)-6,IL-8,and IL-1βwere measured via ELISA.Integrated metabolomics-transcriptomics and Western blotting identified mechanistic pathways.Results:SSTL alleviated cervicitis in rats by improving uterine histopathology,reducing external genital inflammation scores(P<0.01 vs.model),and reversing uterine hypertrophy(P<0.05).Serum pro-inflammatory cytokines(TNF-α,IL-1β,IL-6,IL-8)were suppressed(P<0.01),with concurrent weight restoration.Multi-omics analysis identified AMPK signaling as pivotal,validated by downregulation of p-NF-κB(P<0.05)and upregulation of p-AMPK/SIRT1(P<0.05)in uterine tissues,indicating SSTL mitigates inflammation through AMPK/NF-κB/SIRT1 modulation.Conclusion:This study found that SSTL ameliorates cervicitis in rats through the expression of AMPK pathway-related proteins.展开更多
Objective： To observe the clinical therapeutic effect of Jieze No. 1 （洁泽Ⅰ号） on cervicitis caused by ureaplasma urealyticum and its inhibitory effect on ureaplasma urealyticum （Uu） in vitro. Methods： A total ...Objective： To observe the clinical therapeutic effect of Jieze No. 1 （洁泽Ⅰ号） on cervicitis caused by ureaplasma urealyticum and its inhibitory effect on ureaplasma urealyticum （Uu） in vitro. Methods： A total of 393 patients suffering from cervicitis induced by ureaplasma urealyticum without other complications were randomly assigned to 3 groups, the combined treatment group： 140 patients treated with Chinese herbs Jieze No.1 by vaginal lavage, 30 min each time, once a clay for 10 consecutive clays and oral administration of Azithromycin, 1.0 g once every 72 h for three times; Jieze group： 115 patients were treated with Jieze No.1 alone by vaginal lavage, 30 min each time, once a day for 10 consecutive days; and the Azithromycin group： 138 patients were treated with oral administration of Azithromycin, 1.0 g once in 72 h for three times. All the patients were treated for 1 therapeutic course and condom were used for contraception during the treatment course. The Uu patients were examined again after 21 clays of treatment. The therapeutic effect on cervicitis was observed. The experimental study of Jieze No. 1 on the Uu strain separated from the secretion of the urogenital tract was also observed. The minimum inhibitory concentration （MIC） and minimum bactericidal concentration （MBC） of the Uu were investigated. Results： The total effective rate of the combined group was 85.3%, showing a significant difference compared with the Jieze group （67.8%） and the Azithromycin group （60.3%, both P〈0.01）. There was no statistical significance between the latter two groups （P〉0.05）. The clearing rate of Uu in the combined group was 78.4%, that of the Jieze group was 60.9% and the Azithromycin group was 47.9%. The combined group also showed a significant difference in comparison with the other two groups （all P〈0.01）. Especially for the drugresistant strain, the clearing rate of Uu reached 48.1% in the combined group, 42.1% in the Jieze group, and 16.1% in the Azithromycin group, respectively. The clearing rate of Uu for the drugresistant strain in the former two groups had significant differences in comparison with the latter （P〈0.01, P〈0.05）, while there was no significant difference between the former two （P〉0.05）. The range of MIC and MBC of Jieze No. 1 to the drug-resistant strain of Uu was 15.62-250.00 mg/mL. To the non-drug-resistant MIC and MBC strain, it was 15.62-125.00 mg/mL. For the drug-resistant strain, MIC50 was ≤ 31.25 mg/mL, MBC50 was ≤ 62.50 mg/mL, MIC90 was ≤ 125.00 mg/mL and MBC90 was 250.00 mg/mL. For the non-drug-resistant strain, MICro was ≤ 31.25 mg/mL, MBC50 was ≤ 62.50 mg/mL, MIC90 was ≤ 62.50 mg/mL and MBC90 was ≤ 125.00 mg/mL. Conclusion： Jieze No.1 combined with Azithromycin can effectively treat cervicitis caused by Uu. The laboratory study confirms that Jieze No. 1 has an inhibitory effect on ureaplasma urealyticum strain. It has a remarkably effective therapeutic effects on drug-resistant strains, which is worthy of further research.展开更多
Deep cervical lymph-venous anastomosis(LVA)is a surgical procedure initially developed to treat cervical lymphatic obstruction,such as lymphedema,a condition caused by the accumulation of lymphatic fluid due to blocke...Deep cervical lymph-venous anastomosis(LVA)is a surgical procedure initially developed to treat cervical lymphatic obstruction,such as lymphedema,a condition caused by the accumulation of lymphatic fluid due to blocked or damaged lymphatic vessels.In early 2024,Dr.Qingping Xie from Hangzhou Qiushi Hospital,China,and Dr.Wei F.Chen from the Cleveland Clinic,USA,adapted LVA for the treatment of patients with Alzheimer’s disease(AD).As a VIEWPOINT,they presented a video showcasing the post-surgery cognitive recovery of an 84-year-old AD patient(Xie et al.,2024).展开更多
Oncology Research Editorial Office Published:19 January 2026 The published article titled“miR-126-5p Restoration Promotes Cell Apoptosis in Cervical Cancer by Targeting Bcl2l2”has been retracted from Oncology Resear...Oncology Research Editorial Office Published:19 January 2026 The published article titled“miR-126-5p Restoration Promotes Cell Apoptosis in Cervical Cancer by Targeting Bcl2l2”has been retracted from Oncology Research,Vol.25,No.4,2017,pp.463-470.DOI:10.3727/096504016X14685034103879 URL:https://www.techscience.com/or/v25n4/56826.展开更多
Objective:Based on the theory of“Taiyang governs tendons”,to explore the effect of acupuncture at points of the Bladder Meridian of Foot-Taiyang on the expression of serum inflammatory factors in rabbit models of ce...Objective:Based on the theory of“Taiyang governs tendons”,to explore the effect of acupuncture at points of the Bladder Meridian of Foot-Taiyang on the expression of serum inflammatory factors in rabbit models of cervical spondylosis.Methods:Thirty New Zealand white rabbits were randomly divided into a blank group,a model group,and a treatment group,with 10 rabbits in each group.The models of cervical spondylosis in the model group and treatment group were established by long-term head-down flexion combined with cold-damp stimulation.After modeling,the treatment group received acupuncture at three points(Kunlun,Weizhong,and Feishu)on the Bladder Meridian of Foot-Taiyang,once a day for 20 minutes each time,for 14 consecutive days;the model group and blank group received no therapeutic intervention.After the intervention,cardiac blood was collected from all rabbits to detect the expression levels of serum inflammatory factors IL-6,TNF-α,and IL-1β.Meanwhile,cervical muscle tissue was collected,stained with HE,and the morphological changes of the posterior cervical muscle tissue in each group were observed under an optical microscope.Results:After modeling,the levels of inflammatory factors in the serum of rabbits in the model group and treatment group were significantly increased compared with those before modeling,with a statistically significant difference(p<0.01).After intervention,the serum inflammatory factors in the treatment group decreased significantly compared with those in the model group,and the difference was statistically significant(p<0.01).Conclusion:Acupuncture at points of the Bladder Meridian of Foot-Taiyang in rabbit models of cervical spondylosis can reduce the serum levels of inflammatory factors TNF-α,IL-1β,and IL-6.展开更多
Female reproductive tract lesions are diverse,ranging from benign inflammation to malignant tumors,all of which seriously threaten women’s health.Early accurate diagnosis is crucial for improving prognosis.As the“go...Female reproductive tract lesions are diverse,ranging from benign inflammation to malignant tumors,all of which seriously threaten women’s health.Early accurate diagnosis is crucial for improving prognosis.As the“gold standard”for diagnosis,histopathological examination is difficult to meet the needs of clinical screening and dynamic monitoring due to limitations such as invasiveness and sampling restrictions.Optical Coherence Tomography(OCT),as a non-invasive,real-time,and high-resolution imaging technology,can clearly display the microstructure of biological tissues,known as“optical biopsy”,and shows promising application prospects in the diagnosis of female reproductive tract lesions.This article systematically reviews the basic principles of OCT technology,the research progress on the correlation between OCT image features and histological features in lesions of different parts of the female reproductive tract such as the cervix and endometrium,analyzes the diagnostic efficacy,advantages and limitations of OCT technology,and prospects its future development direction,aiming to provide a reference for the clinical application of OCT technology in the diagnosis of female reproductive tract diseases.展开更多
Cervical cancer related to human papillomavirus(HPV)is a leading cause of cancer-related mortality among women worldwide.Cancer cells release fragments of their DNA,known as circulating tumor DNA(ctDNA),which can be d...Cervical cancer related to human papillomavirus(HPV)is a leading cause of cancer-related mortality among women worldwide.Cancer cells release fragments of their DNA,known as circulating tumor DNA(ctDNA),which can be detected in bodily fluids.A PubMed search using the terms“ctHPV”or“circulating tumor DNA”and“cervical cancer”,limited to the past ten years,identified 104 articles,complemented by hand-searching for literature addressing medico-legal implications.Studies were evaluated for relevance and methodological quality.Detection and characterization of circulating tumor HPV DNA(ctHPV DNA)have emerged as promising tools for assessing prognosis and disease recurrence in cervical cancer.Detection techniques include polymerase chain reaction(PCR),digital droplet PCR(ddPCR),and next-generation sequencing(NGS).This review summarizes current knowledge on ctHPV DNA in cervical cancer and explores its clinical and medico-legal implications,including management of discordant results,diagnostic errors,liability,and data protection compliance.展开更多
In the article"Application of Cytokines in Cervical Secretion for High-grade Squamous Intraepithelial Lesion Caused by High-risk Human Papillomavirus Infection"(Lingyun Ji,Xiao Wang,Ruixian Jiao,Ji Yang,Jiaq...In the article"Application of Cytokines in Cervical Secretion for High-grade Squamous Intraepithelial Lesion Caused by High-risk Human Papillomavirus Infection"(Lingyun Ji,Xiao Wang,Ruixian Jiao,Ji Yang,Jiaqi Han,Bowen Xu,Yang Zhou,Jing Wu,Xiaowen Pu,and Wenhong Zhang;Biomed Environ Sci,2026;39(2):215-222).展开更多
Vertebral artery dissection(VAD) is an acute vascular condition characterized by intimal tearing that leads to the formation of intramural hematomas or pseudoaneurysms.^([1,2]) The pathogenesis of VAD involves a multi...Vertebral artery dissection(VAD) is an acute vascular condition characterized by intimal tearing that leads to the formation of intramural hematomas or pseudoaneurysms.^([1,2]) The pathogenesis of VAD involves a multifactorial interplay of genetic susceptibility,structural vessel wall abnormalities,and mechanical stressors.^([3]) We present a case of VAD triggered by cervical mechanical stress,and explore the diagnostic workup and the role of multidisciplinary coordination in therapeutic decision-making.展开更多
文摘Background: The incidence of sexually transmittedHIV infections is rapidly increasing in China, and theprevalence of AIDS-associated mycoplasmas (includingMycoplasma genitalium, Mycoplasma penetrans, Myco-plasma pirum and Mycoplasma fermentans) infections isunknown in patients with sexually transmitted diseases.Objective: To investigate the prevalence of these 4species of AIDS-associated mycoplasmas infections inpatients with nongonococcal urethritis (NGU) andmucopurulent cervicitis (MPC).Methods: In 65 patients with NGU/MPC, detection ofM. genitalium, M. penetrans, M. pirum and M. fermentansin genital and pharyngeal specimens was performed byculture and nested polymerase chain reaction.Results: M. genitalium, M. penetrans, M. pirum and M.fermentans were identified in genital specimens from23.1% (15/65), 12.3% (8/65), 1.5% (1/65) and 0% ofpatients, respectively, and from pharyngeal samples in26.2% (17/65), 15.4% (10/65), 1.5% (1/65) and 0% ofpatients, respectively. M. genitalium was detected in bothgenital and pharyngeal samples in 10.8% (7/65) ofpatients, and M. penetrans in 4.6% (3/65) of patients. M.pirum was found in only 2 cases, and no M. fermentanswas discovered.Conclusions: This study suggests that M. genitaliumand M. penetrans infections are common in patients withNGU/MPC. M. genitalium and M. penetrans may be trans-mitted by genital-genital or oral-genital sex, and maycause urethritis and cervicitis.
文摘Objective： To analyze the efficacy of six antibiotic methods for treating non- gonococcal urethritis /cervicitis and the factors influencing efficacy. Methods： Retrospective analysis of 878 nongonococcal urethritis / cervicitis cases which received regular treatment and follow-up in our institute from 1st Jan. 2001 to 31st Aug. 2003. Results： The mean cure rate of six methods for Chlamydia trachamatis （Ct） was 57.116%. There were distinct differences among these methods for Ct treatment.The mean cure rate of six methods for Ureaplasma urealyticum （Uu） was 69.556% and there was no difference among these methods for Uu treatment. Coinfection with Ct and Uu dramatically reduced the elimination rate of these two pathogens. Conclusion： The effectiveness of treatment of these antibodies for non-gonococcal urethritis / cervicitis is not currently satisfactory. Importantly, there were many antibiotic-resistant Ct and Uu strains. The factors influencing antibiotic efficacy and mechanisms need further study.
基金Supported by Joint Topics of Key Disciplines,Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences(2011ZDXK-03)
文摘[Objectives] To observe the pharmaceutical effect of Zijin Huadu suppository on treatment of cervicitis induced by virus,bacteria and phenol in vivo and in vitro,and provide experimental basis for evaluating its therapeutic effects for cervicitis. [Methods]Real-time RT-PCR and CPE methods were used to observe the inhibition of Zijin Huadu suppository on virus,and turbidimetry was used to observe bacteriostatic action; HE pathological section was used to observe cervicitis of rat,and enzyme-linked immunosorbent assay was used to detect virus' s expression in cervical tissue.[Results]In cervicitis rat model infected by HPV16,Zijin Huadu suppositories at the doses of 1. 2,0. 6 and0. 3 g/( kg·d) had significant inhibitory effect on HPV16 expression in cervical tissues,and the doses of 1. 2 and 0. 6 g/( kg·d) had significantly inhibitory effect on pathological changes of cervical tissues. In cervicities rat models infected mixedly by Escherichia coli,Neisseria gonorrhoeae and Staphylococcus aureus,Zijin Huadu suppositories at the doses of 1. 2 and 0. 6 g/( kg·d) had significant inhibitory effect on pathological changes of cervical tissues. In cervicitis rat models induced by chemical substances,Zijin Huadu suppositories at the dose of1. 2 g/( kg·d) had significant inhibitory effect on vagina and cervix lesions in rats. In vitro,Zijin Huadu suppository showed obvious inhibitory effects on HSV-2,HPV16,Staphylococcus aureus,Staphylococcus albus,Staphylococcus epidermidis,group B Streptococcus,E. coli,Pseudomonas aeruginosa,Proteusbacillus vulgaris,Neisseria gonorrhoeae and Candida albicans.[Conclusions] Zijin Huadu suppository has obvious inhibitory effect in vitro on viruses and bacteria,and could obviously improve the phenol-induced cervicitis.
文摘 Chronic cervicitis is a common disease in the female reproductive system, which may be the inducing factor for carcinoma of uterine cervix. It is clinically manifested by sticky and foul leukorrhagia, contact hemorrhage, pain in the lower limbs or lumbosacral region, dysmenorrhea and infertility.
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文摘Objective: to observe the therapeutic effect of levofloxacin combined with azithromycin in the treatment of cervicitis. Methods: in order to further analyze the clinical effect of treatment of cervicitis, 84 patients who visited our hospital for treatment of cervicitis from April 2016 to April 2020 were selected and divided into 42 cases in the control group (single azithromycin) and 42 cases in the research group (levofloxacin combined with azithromycin). Results: after the clinical treatment of patients with cervicitis in two groups was effectively improved, the total effective rate of patients in treatment group (100%) / control group (88.1%), grade I vaginal cleanliness group (66.7%) / control group (45.2%), and incidence of adverse drug reactions group (4.7%) / control group (11.9%) were comprehensively improved. The related data of patients in two groups were statistically significant (P < 0.05). Conclusion: the conventional drug treatment for different cervicitis patients and the optimized treatment scheme of levofloxacin combined with azithromycin were comprehensively improved, so that the safety and treatment effects of the related monitoring indexes for the clinical treatment of cervicitis patients were effectively improved. The clinical application was significant.
文摘Objective: to analyze the application effect of azithromycin combined with levofloxacin in the treatment of cervicitis. Methods: 82 patients with cervicitis in our hospital from March 2020 to December 2021 were randomly divided into control group (azithromycin) and observation group (azithromycin combined with levofloxacin), and the therapeutic effects were compared. Results: the total effective rate, IL-6, IL-8, improvement time of clinical symptoms, relapse rate, NKTs and VEGF levels in the observation group were better than those in the control group (P < 0.05). The incidence of adverse reactions was significantly different between the two groups (P < 0.05). Conclusion: the combination of azithromycin and levofloxacin in the treatment of cervicitis is helpful to improve the symptoms and inflammatory indexes of patients as soon as possible, and promote the improvement of treatment effect.
文摘Objective: This article is mainly to analyze the practical effect of high-quality perioperative care for cervicitis patients undergoing cervical conization under hysteroscope. Methods: the research objects are all patients in our hospital. The patients from January 2019 to January 2021 in our hospital are selected by random selection. The data period is 2 years. The above patients are all patients with cervicitis and are carefully selected. All patients are in line with the symptoms of cervicitis. Results: the data showed that the incidence of clinical complications in the high-quality care group, that is, the experimental group, was significantly lower, only 4.17%. However, for the control group patients receiving routine care, the incidence of complications was relatively high as 16.67%, and the difference was statistically significant (χ2=4.019, P<0.05). Conclusion: In patients with cervicitis undergoing cervical conization under hysteroscope, if perioperative high-quality care is adopted, the operation effect can be better to a great extent, which is more conducive to the postoperative recovery of patients and the complications will be reduced, and it is very worthy of clinical application.
文摘Objective: to explore the clinical features of chronic cervicitis, and to analyze the related risk factors, so as to provide clinical feasibility reference. Methods: 108 patients admitted to our hospital from January 2018 to December 2019 were selected for clinical study. Among them, 54 patients with chronic cervicitis from January 2018 to December 2018 served as the control group. From January 2019 to December 2019, 54 healthy physical examinees served as the observation group. The general data of the two groups were analyzed retrospectively and statistically analyzed. Results: clinical studies have found that the clinical features of patients with chronic cervicitis are complex, and the main characteristic is cervical erosion, with a composition ratio of 68.52%. The risk factors for the disease include the number of abortions and living environment. Conclusion: through the analysis of the clinical features and risk factors of chronic cervicitis, it provides high medical value for the prevention of chronic cervicitis, and carries out effective solving strategies for its clinical characteristics and risk factors in order to improve the clinical symptoms and quality of life. It is worthy of extensive clinical promotion and use.
文摘Objective: to analyze the clinical value of maternal and infant health care for cervical inflammation associated with HPV infection. Methods: a total of 100 cases of cervix cerebral inflammation were combined between January 2019 and December 2020 at our selected institute. In the numerical table, they were randomly divided into two groups, with 50 cases in each group. A typical group of patients received a 2B gel treatment for the renorformer, on top of which a relief valve was added. Comparison of hs-CRP and TNFα between the two groups was always valid. Results: Hs-CRP, TNFα, IL-6 were lower than normal group and higher than normal group all the time, n <0.05. Conclusion: recombinant interferon A2B gel for maternal and infant health care combined treatment of cervical inflammation.
文摘Objective: to explore the effectiveness of continuing nursing health education for patients with chronic cervicitis. Methods: 122 patients with cervicitis admitted to our hospital from December 2018 to December 2019 were randomly divided into observation group and control group (61 cases). The observation group provided continuous treatment. The control group received health education through routine management. Knowledge of cervicitis, duration of treatment, and satisfaction were observed and analyzed by caring for both groups of patients. Results: drug knowledge, disease knowledge, first aid knowledge, health knowledge, nursing satisfaction and shortened treatment time are all significant effects.
基金supported by Science and Technology Innovative Talent Program of Shaanxi University of Chinese Medicine(No.2024-CXTD-03)Key Research&Development Program of Shaanxi Provincial Department of Science and Technology(No.2024CY-JJQ-36,2024CY-JJQ-78)+4 种基金Shaanxi Provincial Administration of Traditional Chinese Medicine Research and Innovation Team Project(No.TZKN-CXTD-03)Youth Innovation Team of Aromatic Chinese Medicine Industrialization Key Technology(No.2022-95)Scientific Research Project of Shaanxi Administration of Traditional Chinese Medicine(ZYJXG-L23002)the Science and Technology Innovative Team Project of Shaanxi Administration of Traditional Chinese Medicine(No.2025-CXTD-02)The cartoon elements in the mechanism diagram are from https://www.figdraw.com.Shaanxi Provincial Science and Technology Department’s“two chains”integrated enterprise(institute)joint project(2023-LL-QY-39).
文摘Background:Cervicitis is a common gynecological disease,which triggers local inflammation and tissue damage by a complex mechanism,seriously affecting women’s health.Chinese medicine plays a prominent role in the treatment of gynecological inflammation.Shuangshi Tongling Capsule(SSTL),as a traditional Chinese medicine(TCM)compound,needs to be further elucidated for the treatment of cervicitis.Methods:Cervicitis was induced with 25%phenol gel(except controls),followed by 12-day intragastric treatment.Outcomes included genital inflammation scores,uterine index,and histopathology(HE staining).Serum tumor necrosis factor-α(TNF-α),Interleukin(IL)-6,IL-8,and IL-1βwere measured via ELISA.Integrated metabolomics-transcriptomics and Western blotting identified mechanistic pathways.Results:SSTL alleviated cervicitis in rats by improving uterine histopathology,reducing external genital inflammation scores(P<0.01 vs.model),and reversing uterine hypertrophy(P<0.05).Serum pro-inflammatory cytokines(TNF-α,IL-1β,IL-6,IL-8)were suppressed(P<0.01),with concurrent weight restoration.Multi-omics analysis identified AMPK signaling as pivotal,validated by downregulation of p-NF-κB(P<0.05)and upregulation of p-AMPK/SIRT1(P<0.05)in uterine tissues,indicating SSTL mitigates inflammation through AMPK/NF-κB/SIRT1 modulation.Conclusion:This study found that SSTL ameliorates cervicitis in rats through the expression of AMPK pathway-related proteins.
基金the 10th Five-Year National Science and Technology Project(No.2004BA709B13-02)
文摘Objective： To observe the clinical therapeutic effect of Jieze No. 1 （洁泽Ⅰ号） on cervicitis caused by ureaplasma urealyticum and its inhibitory effect on ureaplasma urealyticum （Uu） in vitro. Methods： A total of 393 patients suffering from cervicitis induced by ureaplasma urealyticum without other complications were randomly assigned to 3 groups, the combined treatment group： 140 patients treated with Chinese herbs Jieze No.1 by vaginal lavage, 30 min each time, once a clay for 10 consecutive clays and oral administration of Azithromycin, 1.0 g once every 72 h for three times; Jieze group： 115 patients were treated with Jieze No.1 alone by vaginal lavage, 30 min each time, once a day for 10 consecutive days; and the Azithromycin group： 138 patients were treated with oral administration of Azithromycin, 1.0 g once in 72 h for three times. All the patients were treated for 1 therapeutic course and condom were used for contraception during the treatment course. The Uu patients were examined again after 21 clays of treatment. The therapeutic effect on cervicitis was observed. The experimental study of Jieze No. 1 on the Uu strain separated from the secretion of the urogenital tract was also observed. The minimum inhibitory concentration （MIC） and minimum bactericidal concentration （MBC） of the Uu were investigated. Results： The total effective rate of the combined group was 85.3%, showing a significant difference compared with the Jieze group （67.8%） and the Azithromycin group （60.3%, both P〈0.01）. There was no statistical significance between the latter two groups （P〉0.05）. The clearing rate of Uu in the combined group was 78.4%, that of the Jieze group was 60.9% and the Azithromycin group was 47.9%. The combined group also showed a significant difference in comparison with the other two groups （all P〈0.01）. Especially for the drugresistant strain, the clearing rate of Uu reached 48.1% in the combined group, 42.1% in the Jieze group, and 16.1% in the Azithromycin group, respectively. The clearing rate of Uu for the drugresistant strain in the former two groups had significant differences in comparison with the latter （P〈0.01, P〈0.05）, while there was no significant difference between the former two （P〉0.05）. The range of MIC and MBC of Jieze No. 1 to the drug-resistant strain of Uu was 15.62-250.00 mg/mL. To the non-drug-resistant MIC and MBC strain, it was 15.62-125.00 mg/mL. For the drug-resistant strain, MIC50 was ≤ 31.25 mg/mL, MBC50 was ≤ 62.50 mg/mL, MIC90 was ≤ 125.00 mg/mL and MBC90 was 250.00 mg/mL. For the non-drug-resistant strain, MICro was ≤ 31.25 mg/mL, MBC50 was ≤ 62.50 mg/mL, MIC90 was ≤ 62.50 mg/mL and MBC90 was ≤ 125.00 mg/mL. Conclusion： Jieze No.1 combined with Azithromycin can effectively treat cervicitis caused by Uu. The laboratory study confirms that Jieze No. 1 has an inhibitory effect on ureaplasma urealyticum strain. It has a remarkably effective therapeutic effects on drug-resistant strains, which is worthy of further research.
基金supported by AG057842 from the National Institutes of Health,TRIBA/Physiology Faculty Startup Fund from Augusta University (to FF)the National Natural Science Foundation of China (82173384)(to MG)
文摘Deep cervical lymph-venous anastomosis(LVA)is a surgical procedure initially developed to treat cervical lymphatic obstruction,such as lymphedema,a condition caused by the accumulation of lymphatic fluid due to blocked or damaged lymphatic vessels.In early 2024,Dr.Qingping Xie from Hangzhou Qiushi Hospital,China,and Dr.Wei F.Chen from the Cleveland Clinic,USA,adapted LVA for the treatment of patients with Alzheimer’s disease(AD).As a VIEWPOINT,they presented a video showcasing the post-surgery cognitive recovery of an 84-year-old AD patient(Xie et al.,2024).
文摘Oncology Research Editorial Office Published:19 January 2026 The published article titled“miR-126-5p Restoration Promotes Cell Apoptosis in Cervical Cancer by Targeting Bcl2l2”has been retracted from Oncology Research,Vol.25,No.4,2017,pp.463-470.DOI:10.3727/096504016X14685034103879 URL:https://www.techscience.com/or/v25n4/56826.
基金Yunnan Provincial High-Level Traditional Chinese Medicine Talent Training ProjectYunnan Provincial Department of Science and Technology Traditional Chinese Medicine Basic Research Joint Special Project(Project No.:202101AZ070001-138)。
文摘Objective:Based on the theory of“Taiyang governs tendons”,to explore the effect of acupuncture at points of the Bladder Meridian of Foot-Taiyang on the expression of serum inflammatory factors in rabbit models of cervical spondylosis.Methods:Thirty New Zealand white rabbits were randomly divided into a blank group,a model group,and a treatment group,with 10 rabbits in each group.The models of cervical spondylosis in the model group and treatment group were established by long-term head-down flexion combined with cold-damp stimulation.After modeling,the treatment group received acupuncture at three points(Kunlun,Weizhong,and Feishu)on the Bladder Meridian of Foot-Taiyang,once a day for 20 minutes each time,for 14 consecutive days;the model group and blank group received no therapeutic intervention.After the intervention,cardiac blood was collected from all rabbits to detect the expression levels of serum inflammatory factors IL-6,TNF-α,and IL-1β.Meanwhile,cervical muscle tissue was collected,stained with HE,and the morphological changes of the posterior cervical muscle tissue in each group were observed under an optical microscope.Results:After modeling,the levels of inflammatory factors in the serum of rabbits in the model group and treatment group were significantly increased compared with those before modeling,with a statistically significant difference(p<0.01).After intervention,the serum inflammatory factors in the treatment group decreased significantly compared with those in the model group,and the difference was statistically significant(p<0.01).Conclusion:Acupuncture at points of the Bladder Meridian of Foot-Taiyang in rabbit models of cervical spondylosis can reduce the serum levels of inflammatory factors TNF-α,IL-1β,and IL-6.
基金2022 University-Level Scientific Research Project(Project No.:KJ2022-19)Innovation Project for Undergraduate Students in 2025(Project No.:bkcx2025035)。
文摘Female reproductive tract lesions are diverse,ranging from benign inflammation to malignant tumors,all of which seriously threaten women’s health.Early accurate diagnosis is crucial for improving prognosis.As the“gold standard”for diagnosis,histopathological examination is difficult to meet the needs of clinical screening and dynamic monitoring due to limitations such as invasiveness and sampling restrictions.Optical Coherence Tomography(OCT),as a non-invasive,real-time,and high-resolution imaging technology,can clearly display the microstructure of biological tissues,known as“optical biopsy”,and shows promising application prospects in the diagnosis of female reproductive tract lesions.This article systematically reviews the basic principles of OCT technology,the research progress on the correlation between OCT image features and histological features in lesions of different parts of the female reproductive tract such as the cervix and endometrium,analyzes the diagnostic efficacy,advantages and limitations of OCT technology,and prospects its future development direction,aiming to provide a reference for the clinical application of OCT technology in the diagnosis of female reproductive tract diseases.
文摘Cervical cancer related to human papillomavirus(HPV)is a leading cause of cancer-related mortality among women worldwide.Cancer cells release fragments of their DNA,known as circulating tumor DNA(ctDNA),which can be detected in bodily fluids.A PubMed search using the terms“ctHPV”or“circulating tumor DNA”and“cervical cancer”,limited to the past ten years,identified 104 articles,complemented by hand-searching for literature addressing medico-legal implications.Studies were evaluated for relevance and methodological quality.Detection and characterization of circulating tumor HPV DNA(ctHPV DNA)have emerged as promising tools for assessing prognosis and disease recurrence in cervical cancer.Detection techniques include polymerase chain reaction(PCR),digital droplet PCR(ddPCR),and next-generation sequencing(NGS).This review summarizes current knowledge on ctHPV DNA in cervical cancer and explores its clinical and medico-legal implications,including management of discordant results,diagnostic errors,liability,and data protection compliance.
文摘In the article"Application of Cytokines in Cervical Secretion for High-grade Squamous Intraepithelial Lesion Caused by High-risk Human Papillomavirus Infection"(Lingyun Ji,Xiao Wang,Ruixian Jiao,Ji Yang,Jiaqi Han,Bowen Xu,Yang Zhou,Jing Wu,Xiaowen Pu,and Wenhong Zhang;Biomed Environ Sci,2026;39(2):215-222).
文摘Vertebral artery dissection(VAD) is an acute vascular condition characterized by intimal tearing that leads to the formation of intramural hematomas or pseudoaneurysms.^([1,2]) The pathogenesis of VAD involves a multifactorial interplay of genetic susceptibility,structural vessel wall abnormalities,and mechanical stressors.^([3]) We present a case of VAD triggered by cervical mechanical stress,and explore the diagnostic workup and the role of multidisciplinary coordination in therapeutic decision-making.
