Background: The incidence of sexually transmittedHIV infections is rapidly increasing in China, and theprevalence of AIDS-associated mycoplasmas (includingMycoplasma genitalium, Mycoplasma penetrans, Myco-plasma pirum...Background: The incidence of sexually transmittedHIV infections is rapidly increasing in China, and theprevalence of AIDS-associated mycoplasmas (includingMycoplasma genitalium, Mycoplasma penetrans, Myco-plasma pirum and Mycoplasma fermentans) infections isunknown in patients with sexually transmitted diseases.Objective: To investigate the prevalence of these 4species of AIDS-associated mycoplasmas infections inpatients with nongonococcal urethritis (NGU) andmucopurulent cervicitis (MPC).Methods: In 65 patients with NGU/MPC, detection ofM. genitalium, M. penetrans, M. pirum and M. fermentansin genital and pharyngeal specimens was performed byculture and nested polymerase chain reaction.Results: M. genitalium, M. penetrans, M. pirum and M.fermentans were identified in genital specimens from23.1% (15/65), 12.3% (8/65), 1.5% (1/65) and 0% ofpatients, respectively, and from pharyngeal samples in26.2% (17/65), 15.4% (10/65), 1.5% (1/65) and 0% ofpatients, respectively. M. genitalium was detected in bothgenital and pharyngeal samples in 10.8% (7/65) ofpatients, and M. penetrans in 4.6% (3/65) of patients. M.pirum was found in only 2 cases, and no M. fermentanswas discovered.Conclusions: This study suggests that M. genitaliumand M. penetrans infections are common in patients withNGU/MPC. M. genitalium and M. penetrans may be trans-mitted by genital-genital or oral-genital sex, and maycause urethritis and cervicitis.展开更多
Objective： To analyze the efficacy of six antibiotic methods for treating non- gonococcal urethritis /cervicitis and the factors influencing efficacy. Methods： Retrospective analysis of 878 nongonococcal urethritis ...Objective： To analyze the efficacy of six antibiotic methods for treating non- gonococcal urethritis /cervicitis and the factors influencing efficacy. Methods： Retrospective analysis of 878 nongonococcal urethritis / cervicitis cases which received regular treatment and follow-up in our institute from 1st Jan. 2001 to 31st Aug. 2003. Results： The mean cure rate of six methods for Chlamydia trachamatis （Ct） was 57.116%. There were distinct differences among these methods for Ct treatment.The mean cure rate of six methods for Ureaplasma urealyticum （Uu） was 69.556% and there was no difference among these methods for Uu treatment. Coinfection with Ct and Uu dramatically reduced the elimination rate of these two pathogens. Conclusion： The effectiveness of treatment of these antibodies for non-gonococcal urethritis / cervicitis is not currently satisfactory. Importantly, there were many antibiotic-resistant Ct and Uu strains. The factors influencing antibiotic efficacy and mechanisms need further study.展开更多
[Objectives] To observe the pharmaceutical effect of Zijin Huadu suppository on treatment of cervicitis induced by virus,bacteria and phenol in vivo and in vitro,and provide experimental basis for evaluating its thera...[Objectives] To observe the pharmaceutical effect of Zijin Huadu suppository on treatment of cervicitis induced by virus,bacteria and phenol in vivo and in vitro,and provide experimental basis for evaluating its therapeutic effects for cervicitis. [Methods]Real-time RT-PCR and CPE methods were used to observe the inhibition of Zijin Huadu suppository on virus,and turbidimetry was used to observe bacteriostatic action; HE pathological section was used to observe cervicitis of rat,and enzyme-linked immunosorbent assay was used to detect virus' s expression in cervical tissue.[Results]In cervicitis rat model infected by HPV16,Zijin Huadu suppositories at the doses of 1. 2,0. 6 and0. 3 g/( kg·d) had significant inhibitory effect on HPV16 expression in cervical tissues,and the doses of 1. 2 and 0. 6 g/( kg·d) had significantly inhibitory effect on pathological changes of cervical tissues. In cervicities rat models infected mixedly by Escherichia coli,Neisseria gonorrhoeae and Staphylococcus aureus,Zijin Huadu suppositories at the doses of 1. 2 and 0. 6 g/( kg·d) had significant inhibitory effect on pathological changes of cervical tissues. In cervicitis rat models induced by chemical substances,Zijin Huadu suppositories at the dose of1. 2 g/( kg·d) had significant inhibitory effect on vagina and cervix lesions in rats. In vitro,Zijin Huadu suppository showed obvious inhibitory effects on HSV-2,HPV16,Staphylococcus aureus,Staphylococcus albus,Staphylococcus epidermidis,group B Streptococcus,E. coli,Pseudomonas aeruginosa,Proteusbacillus vulgaris,Neisseria gonorrhoeae and Candida albicans.[Conclusions] Zijin Huadu suppository has obvious inhibitory effect in vitro on viruses and bacteria,and could obviously improve the phenol-induced cervicitis.展开更多
Chronic cervicitis is a common disease in the female reproductive system, which may be the inducing factor for carcinoma of uterine cervix. It is clinically manifested by sticky and foul leukorrhagia, contact hemo... Chronic cervicitis is a common disease in the female reproductive system, which may be the inducing factor for carcinoma of uterine cervix. It is clinically manifested by sticky and foul leukorrhagia, contact hemorrhage, pain in the lower limbs or lumbosacral region, dysmenorrhea and infertility.
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Objective: to observe the therapeutic effect of levofloxacin combined with azithromycin in the treatment of cervicitis. Methods: in order to further analyze the clinical effect of treatment of cervicitis, 84 patients ...Objective: to observe the therapeutic effect of levofloxacin combined with azithromycin in the treatment of cervicitis. Methods: in order to further analyze the clinical effect of treatment of cervicitis, 84 patients who visited our hospital for treatment of cervicitis from April 2016 to April 2020 were selected and divided into 42 cases in the control group (single azithromycin) and 42 cases in the research group (levofloxacin combined with azithromycin). Results: after the clinical treatment of patients with cervicitis in two groups was effectively improved, the total effective rate of patients in treatment group (100%) / control group (88.1%), grade I vaginal cleanliness group (66.7%) / control group (45.2%), and incidence of adverse drug reactions group (4.7%) / control group (11.9%) were comprehensively improved. The related data of patients in two groups were statistically significant (P < 0.05). Conclusion: the conventional drug treatment for different cervicitis patients and the optimized treatment scheme of levofloxacin combined with azithromycin were comprehensively improved, so that the safety and treatment effects of the related monitoring indexes for the clinical treatment of cervicitis patients were effectively improved. The clinical application was significant.展开更多
Objective: to analyze the application effect of azithromycin combined with levofloxacin in the treatment of cervicitis. Methods: 82 patients with cervicitis in our hospital from March 2020 to December 2021 were random...Objective: to analyze the application effect of azithromycin combined with levofloxacin in the treatment of cervicitis. Methods: 82 patients with cervicitis in our hospital from March 2020 to December 2021 were randomly divided into control group (azithromycin) and observation group (azithromycin combined with levofloxacin), and the therapeutic effects were compared. Results: the total effective rate, IL-6, IL-8, improvement time of clinical symptoms, relapse rate, NKTs and VEGF levels in the observation group were better than those in the control group (P < 0.05). The incidence of adverse reactions was significantly different between the two groups (P < 0.05). Conclusion: the combination of azithromycin and levofloxacin in the treatment of cervicitis is helpful to improve the symptoms and inflammatory indexes of patients as soon as possible, and promote the improvement of treatment effect.展开更多
Objective: This article is mainly to analyze the practical effect of high-quality perioperative care for cervicitis patients undergoing cervical conization under hysteroscope. Methods: the research objects are all pat...Objective: This article is mainly to analyze the practical effect of high-quality perioperative care for cervicitis patients undergoing cervical conization under hysteroscope. Methods: the research objects are all patients in our hospital. The patients from January 2019 to January 2021 in our hospital are selected by random selection. The data period is 2 years. The above patients are all patients with cervicitis and are carefully selected. All patients are in line with the symptoms of cervicitis. Results: the data showed that the incidence of clinical complications in the high-quality care group, that is, the experimental group, was significantly lower, only 4.17%. However, for the control group patients receiving routine care, the incidence of complications was relatively high as 16.67%, and the difference was statistically significant (χ2=4.019, P<0.05). Conclusion: In patients with cervicitis undergoing cervical conization under hysteroscope, if perioperative high-quality care is adopted, the operation effect can be better to a great extent, which is more conducive to the postoperative recovery of patients and the complications will be reduced, and it is very worthy of clinical application.展开更多
Objective: to explore the clinical features of chronic cervicitis, and to analyze the related risk factors, so as to provide clinical feasibility reference. Methods: 108 patients admitted to our hospital from January ...Objective: to explore the clinical features of chronic cervicitis, and to analyze the related risk factors, so as to provide clinical feasibility reference. Methods: 108 patients admitted to our hospital from January 2018 to December 2019 were selected for clinical study. Among them, 54 patients with chronic cervicitis from January 2018 to December 2018 served as the control group. From January 2019 to December 2019, 54 healthy physical examinees served as the observation group. The general data of the two groups were analyzed retrospectively and statistically analyzed. Results: clinical studies have found that the clinical features of patients with chronic cervicitis are complex, and the main characteristic is cervical erosion, with a composition ratio of 68.52%. The risk factors for the disease include the number of abortions and living environment. Conclusion: through the analysis of the clinical features and risk factors of chronic cervicitis, it provides high medical value for the prevention of chronic cervicitis, and carries out effective solving strategies for its clinical characteristics and risk factors in order to improve the clinical symptoms and quality of life. It is worthy of extensive clinical promotion and use.展开更多
Objective: to analyze the clinical value of maternal and infant health care for cervical inflammation associated with HPV infection. Methods: a total of 100 cases of cervix cerebral inflammation were combined between ...Objective: to analyze the clinical value of maternal and infant health care for cervical inflammation associated with HPV infection. Methods: a total of 100 cases of cervix cerebral inflammation were combined between January 2019 and December 2020 at our selected institute. In the numerical table, they were randomly divided into two groups, with 50 cases in each group. A typical group of patients received a 2B gel treatment for the renorformer, on top of which a relief valve was added. Comparison of hs-CRP and TNFα between the two groups was always valid. Results: Hs-CRP, TNFα, IL-6 were lower than normal group and higher than normal group all the time, n <0.05. Conclusion: recombinant interferon A2B gel for maternal and infant health care combined treatment of cervical inflammation.展开更多
Objective: to explore the effectiveness of continuing nursing health education for patients with chronic cervicitis. Methods: 122 patients with cervicitis admitted to our hospital from December 2018 to December 2019 w...Objective: to explore the effectiveness of continuing nursing health education for patients with chronic cervicitis. Methods: 122 patients with cervicitis admitted to our hospital from December 2018 to December 2019 were randomly divided into observation group and control group (61 cases). The observation group provided continuous treatment. The control group received health education through routine management. Knowledge of cervicitis, duration of treatment, and satisfaction were observed and analyzed by caring for both groups of patients. Results: drug knowledge, disease knowledge, first aid knowledge, health knowledge, nursing satisfaction and shortened treatment time are all significant effects.展开更多
Objective： To observe the clinical therapeutic effect of Jieze No. 1 （洁泽Ⅰ号） on cervicitis caused by ureaplasma urealyticum and its inhibitory effect on ureaplasma urealyticum （Uu） in vitro. Methods： A total ...Objective： To observe the clinical therapeutic effect of Jieze No. 1 （洁泽Ⅰ号） on cervicitis caused by ureaplasma urealyticum and its inhibitory effect on ureaplasma urealyticum （Uu） in vitro. Methods： A total of 393 patients suffering from cervicitis induced by ureaplasma urealyticum without other complications were randomly assigned to 3 groups, the combined treatment group： 140 patients treated with Chinese herbs Jieze No.1 by vaginal lavage, 30 min each time, once a clay for 10 consecutive clays and oral administration of Azithromycin, 1.0 g once every 72 h for three times; Jieze group： 115 patients were treated with Jieze No.1 alone by vaginal lavage, 30 min each time, once a day for 10 consecutive days; and the Azithromycin group： 138 patients were treated with oral administration of Azithromycin, 1.0 g once in 72 h for three times. All the patients were treated for 1 therapeutic course and condom were used for contraception during the treatment course. The Uu patients were examined again after 21 clays of treatment. The therapeutic effect on cervicitis was observed. The experimental study of Jieze No. 1 on the Uu strain separated from the secretion of the urogenital tract was also observed. The minimum inhibitory concentration （MIC） and minimum bactericidal concentration （MBC） of the Uu were investigated. Results： The total effective rate of the combined group was 85.3%, showing a significant difference compared with the Jieze group （67.8%） and the Azithromycin group （60.3%, both P〈0.01）. There was no statistical significance between the latter two groups （P〉0.05）. The clearing rate of Uu in the combined group was 78.4%, that of the Jieze group was 60.9% and the Azithromycin group was 47.9%. The combined group also showed a significant difference in comparison with the other two groups （all P〈0.01）. Especially for the drugresistant strain, the clearing rate of Uu reached 48.1% in the combined group, 42.1% in the Jieze group, and 16.1% in the Azithromycin group, respectively. The clearing rate of Uu for the drugresistant strain in the former two groups had significant differences in comparison with the latter （P〈0.01, P〈0.05）, while there was no significant difference between the former two （P〉0.05）. The range of MIC and MBC of Jieze No. 1 to the drug-resistant strain of Uu was 15.62-250.00 mg/mL. To the non-drug-resistant MIC and MBC strain, it was 15.62-125.00 mg/mL. For the drug-resistant strain, MIC50 was ≤ 31.25 mg/mL, MBC50 was ≤ 62.50 mg/mL, MIC90 was ≤ 125.00 mg/mL and MBC90 was 250.00 mg/mL. For the non-drug-resistant strain, MICro was ≤ 31.25 mg/mL, MBC50 was ≤ 62.50 mg/mL, MIC90 was ≤ 62.50 mg/mL and MBC90 was ≤ 125.00 mg/mL. Conclusion： Jieze No.1 combined with Azithromycin can effectively treat cervicitis caused by Uu. The laboratory study confirms that Jieze No. 1 has an inhibitory effect on ureaplasma urealyticum strain. It has a remarkably effective therapeutic effects on drug-resistant strains, which is worthy of further research.展开更多
Background Cervical cancer is the only cancer that can be eliminated worldwide.Tracking the latest burden of cervical cancer is critical toward the targets set by World Health Organization(WHO)to eliminate cervical ca...Background Cervical cancer is the only cancer that can be eliminated worldwide.Tracking the latest burden of cervical cancer is critical toward the targets set by World Health Organization(WHO)to eliminate cervical cancer as a major public health problem.Methods All data were extracted from the Global Cancer Observatory(GLOBOCAN)2022.Age-standardized incidence rate(ASIR)and mortality rates(ASMR)of cervical cancer were compared and linked to Human Development Index(HDI)between populations.The estimated annual percentage changes(EAPCs)were used to characterize the temporal trend in ASIR/ASMR,and demographic estimates were projected up to 2050.Results Globally,an estimated 662,044 cases(ASIR:14.12/100,000)and 348,709 deaths(ASMR:7.08/100,000)from cervical cancer occurred in 2022,corresponding to the fourth cause of cancer morbidity and mortality in women worldwide.Specifically,42%of cases and 39%of deaths occurred in China(23%and 16%)and India(19%and 23%).Both ASIR and ASMR of cervical cancer decreased with HDI,and similar decreasing links were observed for both early-onset(0–39 years)and late-onset(≥40 years)cervical cancer.Both ASIR and ASMR of overall cervical cancer showed decreasing trends during 2003–2012(EAPC:0.04%and-1.03%);however,upward trends were observed for early-onset cervical cancer(EAPC:1.16%and 0.57%).If national rates in 2022 remain stable,the estimated cases and deaths from cervical cancer are projected to increase by 56.8%and 80.7%up to 2050.Moreover,the projected increase of early-onset cervical cancer is mainly observed in transitioning countries,while decreased burden is expected in transitioned countries.Conclusions Cervical cancer remains a common cause of cancer death in many countries,especially in transitioning countries.Unless scaling-up preventive interventions,human papillomavirus(HPV)vaccination and cervical cancer screening,as well as systematic cooperation within government,civil societies,and private enterprises,the global burden of cervical cancer would be expected to increase in the future.展开更多
Dear Editor,Local recurrence and cervical lymph node metastases are major causes of mortality in patients with head and neck squamous cell carcinoma(HNSCC).To date,none of the proposed strategies for predicting outcom...Dear Editor,Local recurrence and cervical lymph node metastases are major causes of mortality in patients with head and neck squamous cell carcinoma(HNSCC).To date,none of the proposed strategies for predicting outcomes in this disease have proven fully effective,and a comprehensive physical examination remains the primary method for early detection and monitoring of HNSCC.展开更多
Degenerative cervical myelopathy is a common cause of spinal cord injury,with longer symptom duration and higher myelopathy severity indicating a worse prognosis.While numerous studies have investigated serological bi...Degenerative cervical myelopathy is a common cause of spinal cord injury,with longer symptom duration and higher myelopathy severity indicating a worse prognosis.While numerous studies have investigated serological biomarkers for acute spinal cord injury,few studies have explored such biomarkers for diagnosing degenerative cervical myelopathy.This study involved 30 patients with degenerative cervical myelopathy(51.3±7.3 years old,12 women and 18 men),seven healthy controls(25.7±1.7 years old,one woman and six men),and nine patients with cervical spondylotic radiculopathy(51.9±8.6 years old,three women and six men).Analysis of blood samples from the three groups showed clear differences in transcriptomic characteristics.Enrichment analysis identified 128 differentially expressed genes that were enriched in patients with neurological disabilities.Using least absolute shrinkage and selection operator analysis,we constructed a five-gene model(TBCD,TPM2,PNKD,EIF4G2,and AP5Z1)to diagnose degenerative cervical myelopathy with an accuracy of 93.5%.One-gene models(TCAP and SDHA)identified mild and severe degenerative cervical myelopathy with accuracies of 83.3%and 76.7%,respectively.Signatures of two immune cell types(memory B cells and memory-activated CD4^(+)T cells)predicted levels of lesions in degenerative cervical myelopathy with 80%accuracy.Our results suggest that peripheral blood RNA biomarkers could be used to predict lesion severity in degenerative cervical myelopathy.展开更多
This editorial explores the potential integration of non-Western medicine into radiotherapy for cervical cancer.While radiotherapy remains a radical treatment for cervical cancer,its associated toxicity and decline in...This editorial explores the potential integration of non-Western medicine into radiotherapy for cervical cancer.While radiotherapy remains a radical treatment for cervical cancer,its associated toxicity and decline in quality of life can significantly impact patients’lives.Currently,most treatments are supportive,with no specific treatment options available in Western medicine.Non-Western medicine,often less toxic and easier to administer,has shown promising results when used alongside radiotherapy for cervical cancer.Despite these potential benefits,challenges such as limited evidence and restricted application areas persist.While non-Western medicines may offer potential improvements in chemoradiotherapy outcomes for cervical cancer,further research is necessary to substantiate these benefits.展开更多
BACKGROUND The classification of uterine sarcomas is based on distinctive morphological and immunophenotypic characteristics,increasingly supported by molecular genetic diagnostics.Data on neurotrophic tyrosine recept...BACKGROUND The classification of uterine sarcomas is based on distinctive morphological and immunophenotypic characteristics,increasingly supported by molecular genetic diagnostics.Data on neurotrophic tyrosine receptor kinase(NTRK)gene fusionpositive uterine sarcoma,potentially aggressive and morphologically similar to fibrosarcoma,are limited due to its recent recognition.Pan-TRK immunohistochemistry(IHC)analysis serves as an effective screening tool with high sensitivity and specificity for NTRK-fusion malignancies.CASE SUMMARY We report a case of a malignant mesenchymal tumor originating from the uterine cervix,which was pan-TRK IHC-positive but lacked NTRK gene fusions,accompanied by a brief literature review.A 55-year-old woman presented to the emergency department with abdominal pain and distension,exhibiting significant ascites and multiple solid pelvic masses.Pelvic examination revealed a tumor encompassing the uterine cervix,extending to the vagina and uterine corpus.A punch biopsy of the cervix indicated NTRK sarcoma with positive immunochemical pan-TRK stain.However,subsequent next generation sequencing revealed no NTRK gene fusion,leading to a diagnosis of poorly differentiated,advanced-stage sarcoma.CONCLUSION The clinical significance of NTRK gene fusion lies in potential treatment with TRK inhibitors for positive sarcomas.Identifying such rare tumors is crucial due to the potential applicability of tropomyosin receptor kinase inhibitor treatment.展开更多
BACKGROUND Cervical cancer is a formidable global health issue,particularly affecting women in lower-middle-income countries with little or no access to preventative vaccines,screening programs,and treatment modalitie...BACKGROUND Cervical cancer is a formidable global health issue,particularly affecting women in lower-middle-income countries with little or no access to preventative vaccines,screening programs,and treatment modalities.The case report presents a unique case of a large cervical cancer achieving complete response(CR)with concurrent chemoradiotherapy(CCRT),highlighting the effectiveness of this treatment approach even in advanced stages and underscoring the importance of adaptive radiotherapy(RT)in optimizing patient outcomes.CASE SUMMARY We present the case of a 53-year-old woman who presented with four years of abnormal vaginal bleeding and was found to have p16-positive,moderately differentiated cervical squamous cell carcinoma.The tumor measured 14 cm×12 cm×8 cm,the largest size reported in the literature to achieve CR with CCRT.Despite this monumental feat,the patient remained disease-free and is currently on follow-up for 2 years;however,she continued to suffer from substantial morbidity caused by a vesicovaginal fistula and hydronephrosis,underscoring the continuing impact of cervical cancer on quality of life.CONCLUSION In this case report,we highlight the effectiveness of CCRT in achieving CR,even in cases of bulky cervical cancer,with adaptive RT offering a customized strategy to improve patient outcomes.We also emphasize the necessity for multidisciplinary team discussions and highlight the need for strategies to mitigate treatment-related toxicities and long-term complications.展开更多
Cervical cancer,a leading malignancy globally,poses a significant threat to women's health,with an estimated 604,000 new cases and 342,000 deaths reported in 2020^([1]).As cervical cancer is closely linked to huma...Cervical cancer,a leading malignancy globally,poses a significant threat to women's health,with an estimated 604,000 new cases and 342,000 deaths reported in 2020^([1]).As cervical cancer is closely linked to human papilloma virus(HPV)infection,early detection relies on HPV screening;however,late-stage prognosis remains poor,underscoring the need for novel diagnostic and therapeutic targets^([2]).展开更多
In May 2018,the Director-General of the World Health Organization(WHO)called for global action to eliminate cervical cancer~1.This call marked the beginning of an ambitious international effort to scale up 3 key strat...In May 2018,the Director-General of the World Health Organization(WHO)called for global action to eliminate cervical cancer~1.This call marked the beginning of an ambitious international effort to scale up 3 key strategies:human papillomavirus(HPV)vaccination,cervical cancer screening,and treatment of precancerous lesions and cancer.Subsequently,the WHO and its partners developed a global strategy to accelerate the reduction of cervical cancer incidence,with an ultimate goal of achieving elimination within the next century.This Global Strategy represents a formal international commitment and is anchored in the 90-70-90 targets to be achieved by 2030.In parallel,several countries have also set national commitments,such as Sweden's pledge to achieve elimination by 2027 and Australia's target of achieving elimination by 2035.展开更多
文摘Background: The incidence of sexually transmittedHIV infections is rapidly increasing in China, and theprevalence of AIDS-associated mycoplasmas (includingMycoplasma genitalium, Mycoplasma penetrans, Myco-plasma pirum and Mycoplasma fermentans) infections isunknown in patients with sexually transmitted diseases.Objective: To investigate the prevalence of these 4species of AIDS-associated mycoplasmas infections inpatients with nongonococcal urethritis (NGU) andmucopurulent cervicitis (MPC).Methods: In 65 patients with NGU/MPC, detection ofM. genitalium, M. penetrans, M. pirum and M. fermentansin genital and pharyngeal specimens was performed byculture and nested polymerase chain reaction.Results: M. genitalium, M. penetrans, M. pirum and M.fermentans were identified in genital specimens from23.1% (15/65), 12.3% (8/65), 1.5% (1/65) and 0% ofpatients, respectively, and from pharyngeal samples in26.2% (17/65), 15.4% (10/65), 1.5% (1/65) and 0% ofpatients, respectively. M. genitalium was detected in bothgenital and pharyngeal samples in 10.8% (7/65) ofpatients, and M. penetrans in 4.6% (3/65) of patients. M.pirum was found in only 2 cases, and no M. fermentanswas discovered.Conclusions: This study suggests that M. genitaliumand M. penetrans infections are common in patients withNGU/MPC. M. genitalium and M. penetrans may be trans-mitted by genital-genital or oral-genital sex, and maycause urethritis and cervicitis.
文摘Objective： To analyze the efficacy of six antibiotic methods for treating non- gonococcal urethritis /cervicitis and the factors influencing efficacy. Methods： Retrospective analysis of 878 nongonococcal urethritis / cervicitis cases which received regular treatment and follow-up in our institute from 1st Jan. 2001 to 31st Aug. 2003. Results： The mean cure rate of six methods for Chlamydia trachamatis （Ct） was 57.116%. There were distinct differences among these methods for Ct treatment.The mean cure rate of six methods for Ureaplasma urealyticum （Uu） was 69.556% and there was no difference among these methods for Uu treatment. Coinfection with Ct and Uu dramatically reduced the elimination rate of these two pathogens. Conclusion： The effectiveness of treatment of these antibodies for non-gonococcal urethritis / cervicitis is not currently satisfactory. Importantly, there were many antibiotic-resistant Ct and Uu strains. The factors influencing antibiotic efficacy and mechanisms need further study.
基金Supported by Joint Topics of Key Disciplines,Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences(2011ZDXK-03)
文摘[Objectives] To observe the pharmaceutical effect of Zijin Huadu suppository on treatment of cervicitis induced by virus,bacteria and phenol in vivo and in vitro,and provide experimental basis for evaluating its therapeutic effects for cervicitis. [Methods]Real-time RT-PCR and CPE methods were used to observe the inhibition of Zijin Huadu suppository on virus,and turbidimetry was used to observe bacteriostatic action; HE pathological section was used to observe cervicitis of rat,and enzyme-linked immunosorbent assay was used to detect virus' s expression in cervical tissue.[Results]In cervicitis rat model infected by HPV16,Zijin Huadu suppositories at the doses of 1. 2,0. 6 and0. 3 g/( kg·d) had significant inhibitory effect on HPV16 expression in cervical tissues,and the doses of 1. 2 and 0. 6 g/( kg·d) had significantly inhibitory effect on pathological changes of cervical tissues. In cervicities rat models infected mixedly by Escherichia coli,Neisseria gonorrhoeae and Staphylococcus aureus,Zijin Huadu suppositories at the doses of 1. 2 and 0. 6 g/( kg·d) had significant inhibitory effect on pathological changes of cervical tissues. In cervicitis rat models induced by chemical substances,Zijin Huadu suppositories at the dose of1. 2 g/( kg·d) had significant inhibitory effect on vagina and cervix lesions in rats. In vitro,Zijin Huadu suppository showed obvious inhibitory effects on HSV-2,HPV16,Staphylococcus aureus,Staphylococcus albus,Staphylococcus epidermidis,group B Streptococcus,E. coli,Pseudomonas aeruginosa,Proteusbacillus vulgaris,Neisseria gonorrhoeae and Candida albicans.[Conclusions] Zijin Huadu suppository has obvious inhibitory effect in vitro on viruses and bacteria,and could obviously improve the phenol-induced cervicitis.
文摘 Chronic cervicitis is a common disease in the female reproductive system, which may be the inducing factor for carcinoma of uterine cervix. It is clinically manifested by sticky and foul leukorrhagia, contact hemorrhage, pain in the lower limbs or lumbosacral region, dysmenorrhea and infertility.
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文摘Objective: to observe the therapeutic effect of levofloxacin combined with azithromycin in the treatment of cervicitis. Methods: in order to further analyze the clinical effect of treatment of cervicitis, 84 patients who visited our hospital for treatment of cervicitis from April 2016 to April 2020 were selected and divided into 42 cases in the control group (single azithromycin) and 42 cases in the research group (levofloxacin combined with azithromycin). Results: after the clinical treatment of patients with cervicitis in two groups was effectively improved, the total effective rate of patients in treatment group (100%) / control group (88.1%), grade I vaginal cleanliness group (66.7%) / control group (45.2%), and incidence of adverse drug reactions group (4.7%) / control group (11.9%) were comprehensively improved. The related data of patients in two groups were statistically significant (P < 0.05). Conclusion: the conventional drug treatment for different cervicitis patients and the optimized treatment scheme of levofloxacin combined with azithromycin were comprehensively improved, so that the safety and treatment effects of the related monitoring indexes for the clinical treatment of cervicitis patients were effectively improved. The clinical application was significant.
文摘Objective: to analyze the application effect of azithromycin combined with levofloxacin in the treatment of cervicitis. Methods: 82 patients with cervicitis in our hospital from March 2020 to December 2021 were randomly divided into control group (azithromycin) and observation group (azithromycin combined with levofloxacin), and the therapeutic effects were compared. Results: the total effective rate, IL-6, IL-8, improvement time of clinical symptoms, relapse rate, NKTs and VEGF levels in the observation group were better than those in the control group (P < 0.05). The incidence of adverse reactions was significantly different between the two groups (P < 0.05). Conclusion: the combination of azithromycin and levofloxacin in the treatment of cervicitis is helpful to improve the symptoms and inflammatory indexes of patients as soon as possible, and promote the improvement of treatment effect.
文摘Objective: This article is mainly to analyze the practical effect of high-quality perioperative care for cervicitis patients undergoing cervical conization under hysteroscope. Methods: the research objects are all patients in our hospital. The patients from January 2019 to January 2021 in our hospital are selected by random selection. The data period is 2 years. The above patients are all patients with cervicitis and are carefully selected. All patients are in line with the symptoms of cervicitis. Results: the data showed that the incidence of clinical complications in the high-quality care group, that is, the experimental group, was significantly lower, only 4.17%. However, for the control group patients receiving routine care, the incidence of complications was relatively high as 16.67%, and the difference was statistically significant (χ2=4.019, P<0.05). Conclusion: In patients with cervicitis undergoing cervical conization under hysteroscope, if perioperative high-quality care is adopted, the operation effect can be better to a great extent, which is more conducive to the postoperative recovery of patients and the complications will be reduced, and it is very worthy of clinical application.
文摘Objective: to explore the clinical features of chronic cervicitis, and to analyze the related risk factors, so as to provide clinical feasibility reference. Methods: 108 patients admitted to our hospital from January 2018 to December 2019 were selected for clinical study. Among them, 54 patients with chronic cervicitis from January 2018 to December 2018 served as the control group. From January 2019 to December 2019, 54 healthy physical examinees served as the observation group. The general data of the two groups were analyzed retrospectively and statistically analyzed. Results: clinical studies have found that the clinical features of patients with chronic cervicitis are complex, and the main characteristic is cervical erosion, with a composition ratio of 68.52%. The risk factors for the disease include the number of abortions and living environment. Conclusion: through the analysis of the clinical features and risk factors of chronic cervicitis, it provides high medical value for the prevention of chronic cervicitis, and carries out effective solving strategies for its clinical characteristics and risk factors in order to improve the clinical symptoms and quality of life. It is worthy of extensive clinical promotion and use.
文摘Objective: to analyze the clinical value of maternal and infant health care for cervical inflammation associated with HPV infection. Methods: a total of 100 cases of cervix cerebral inflammation were combined between January 2019 and December 2020 at our selected institute. In the numerical table, they were randomly divided into two groups, with 50 cases in each group. A typical group of patients received a 2B gel treatment for the renorformer, on top of which a relief valve was added. Comparison of hs-CRP and TNFα between the two groups was always valid. Results: Hs-CRP, TNFα, IL-6 were lower than normal group and higher than normal group all the time, n <0.05. Conclusion: recombinant interferon A2B gel for maternal and infant health care combined treatment of cervical inflammation.
文摘Objective: to explore the effectiveness of continuing nursing health education for patients with chronic cervicitis. Methods: 122 patients with cervicitis admitted to our hospital from December 2018 to December 2019 were randomly divided into observation group and control group (61 cases). The observation group provided continuous treatment. The control group received health education through routine management. Knowledge of cervicitis, duration of treatment, and satisfaction were observed and analyzed by caring for both groups of patients. Results: drug knowledge, disease knowledge, first aid knowledge, health knowledge, nursing satisfaction and shortened treatment time are all significant effects.
基金the 10th Five-Year National Science and Technology Project(No.2004BA709B13-02)
文摘Objective： To observe the clinical therapeutic effect of Jieze No. 1 （洁泽Ⅰ号） on cervicitis caused by ureaplasma urealyticum and its inhibitory effect on ureaplasma urealyticum （Uu） in vitro. Methods： A total of 393 patients suffering from cervicitis induced by ureaplasma urealyticum without other complications were randomly assigned to 3 groups, the combined treatment group： 140 patients treated with Chinese herbs Jieze No.1 by vaginal lavage, 30 min each time, once a clay for 10 consecutive clays and oral administration of Azithromycin, 1.0 g once every 72 h for three times; Jieze group： 115 patients were treated with Jieze No.1 alone by vaginal lavage, 30 min each time, once a day for 10 consecutive days; and the Azithromycin group： 138 patients were treated with oral administration of Azithromycin, 1.0 g once in 72 h for three times. All the patients were treated for 1 therapeutic course and condom were used for contraception during the treatment course. The Uu patients were examined again after 21 clays of treatment. The therapeutic effect on cervicitis was observed. The experimental study of Jieze No. 1 on the Uu strain separated from the secretion of the urogenital tract was also observed. The minimum inhibitory concentration （MIC） and minimum bactericidal concentration （MBC） of the Uu were investigated. Results： The total effective rate of the combined group was 85.3%, showing a significant difference compared with the Jieze group （67.8%） and the Azithromycin group （60.3%, both P〈0.01）. There was no statistical significance between the latter two groups （P〉0.05）. The clearing rate of Uu in the combined group was 78.4%, that of the Jieze group was 60.9% and the Azithromycin group was 47.9%. The combined group also showed a significant difference in comparison with the other two groups （all P〈0.01）. Especially for the drugresistant strain, the clearing rate of Uu reached 48.1% in the combined group, 42.1% in the Jieze group, and 16.1% in the Azithromycin group, respectively. The clearing rate of Uu for the drugresistant strain in the former two groups had significant differences in comparison with the latter （P〈0.01, P〈0.05）, while there was no significant difference between the former two （P〉0.05）. The range of MIC and MBC of Jieze No. 1 to the drug-resistant strain of Uu was 15.62-250.00 mg/mL. To the non-drug-resistant MIC and MBC strain, it was 15.62-125.00 mg/mL. For the drug-resistant strain, MIC50 was ≤ 31.25 mg/mL, MBC50 was ≤ 62.50 mg/mL, MIC90 was ≤ 125.00 mg/mL and MBC90 was 250.00 mg/mL. For the non-drug-resistant strain, MICro was ≤ 31.25 mg/mL, MBC50 was ≤ 62.50 mg/mL, MIC90 was ≤ 62.50 mg/mL and MBC90 was ≤ 125.00 mg/mL. Conclusion： Jieze No.1 combined with Azithromycin can effectively treat cervicitis caused by Uu. The laboratory study confirms that Jieze No. 1 has an inhibitory effect on ureaplasma urealyticum strain. It has a remarkably effective therapeutic effects on drug-resistant strains, which is worthy of further research.
基金supported by the National Key R&D Program of China(grant number:2021YFC2500400)National Natural Science Foundation of China(grant numbers:82172894,82073028,82204121)China Postdoctoral Science Foundation(grant number:2023M742617).
文摘Background Cervical cancer is the only cancer that can be eliminated worldwide.Tracking the latest burden of cervical cancer is critical toward the targets set by World Health Organization(WHO)to eliminate cervical cancer as a major public health problem.Methods All data were extracted from the Global Cancer Observatory(GLOBOCAN)2022.Age-standardized incidence rate(ASIR)and mortality rates(ASMR)of cervical cancer were compared and linked to Human Development Index(HDI)between populations.The estimated annual percentage changes(EAPCs)were used to characterize the temporal trend in ASIR/ASMR,and demographic estimates were projected up to 2050.Results Globally,an estimated 662,044 cases(ASIR:14.12/100,000)and 348,709 deaths(ASMR:7.08/100,000)from cervical cancer occurred in 2022,corresponding to the fourth cause of cancer morbidity and mortality in women worldwide.Specifically,42%of cases and 39%of deaths occurred in China(23%and 16%)and India(19%and 23%).Both ASIR and ASMR of cervical cancer decreased with HDI,and similar decreasing links were observed for both early-onset(0–39 years)and late-onset(≥40 years)cervical cancer.Both ASIR and ASMR of overall cervical cancer showed decreasing trends during 2003–2012(EAPC:0.04%and-1.03%);however,upward trends were observed for early-onset cervical cancer(EAPC:1.16%and 0.57%).If national rates in 2022 remain stable,the estimated cases and deaths from cervical cancer are projected to increase by 56.8%and 80.7%up to 2050.Moreover,the projected increase of early-onset cervical cancer is mainly observed in transitioning countries,while decreased burden is expected in transitioned countries.Conclusions Cervical cancer remains a common cause of cancer death in many countries,especially in transitioning countries.Unless scaling-up preventive interventions,human papillomavirus(HPV)vaccination and cervical cancer screening,as well as systematic cooperation within government,civil societies,and private enterprises,the global burden of cervical cancer would be expected to increase in the future.
文摘Dear Editor,Local recurrence and cervical lymph node metastases are major causes of mortality in patients with head and neck squamous cell carcinoma(HNSCC).To date,none of the proposed strategies for predicting outcomes in this disease have proven fully effective,and a comprehensive physical examination remains the primary method for early detection and monitoring of HNSCC.
基金supported by Hunan Provincial Key Research and Development Program,No.2021SK2002(to BW)the Natural Science Foundation of Hunan Province of China(General Program),No.2021JJ30938(to YL)。
文摘Degenerative cervical myelopathy is a common cause of spinal cord injury,with longer symptom duration and higher myelopathy severity indicating a worse prognosis.While numerous studies have investigated serological biomarkers for acute spinal cord injury,few studies have explored such biomarkers for diagnosing degenerative cervical myelopathy.This study involved 30 patients with degenerative cervical myelopathy(51.3±7.3 years old,12 women and 18 men),seven healthy controls(25.7±1.7 years old,one woman and six men),and nine patients with cervical spondylotic radiculopathy(51.9±8.6 years old,three women and six men).Analysis of blood samples from the three groups showed clear differences in transcriptomic characteristics.Enrichment analysis identified 128 differentially expressed genes that were enriched in patients with neurological disabilities.Using least absolute shrinkage and selection operator analysis,we constructed a five-gene model(TBCD,TPM2,PNKD,EIF4G2,and AP5Z1)to diagnose degenerative cervical myelopathy with an accuracy of 93.5%.One-gene models(TCAP and SDHA)identified mild and severe degenerative cervical myelopathy with accuracies of 83.3%and 76.7%,respectively.Signatures of two immune cell types(memory B cells and memory-activated CD4^(+)T cells)predicted levels of lesions in degenerative cervical myelopathy with 80%accuracy.Our results suggest that peripheral blood RNA biomarkers could be used to predict lesion severity in degenerative cervical myelopathy.
文摘This editorial explores the potential integration of non-Western medicine into radiotherapy for cervical cancer.While radiotherapy remains a radical treatment for cervical cancer,its associated toxicity and decline in quality of life can significantly impact patients’lives.Currently,most treatments are supportive,with no specific treatment options available in Western medicine.Non-Western medicine,often less toxic and easier to administer,has shown promising results when used alongside radiotherapy for cervical cancer.Despite these potential benefits,challenges such as limited evidence and restricted application areas persist.While non-Western medicines may offer potential improvements in chemoradiotherapy outcomes for cervical cancer,further research is necessary to substantiate these benefits.
基金Supported by Grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute,funded by the Ministry of Health&Welfare,Republic of Korea,No.RS-2022-KH129889.
文摘BACKGROUND The classification of uterine sarcomas is based on distinctive morphological and immunophenotypic characteristics,increasingly supported by molecular genetic diagnostics.Data on neurotrophic tyrosine receptor kinase(NTRK)gene fusionpositive uterine sarcoma,potentially aggressive and morphologically similar to fibrosarcoma,are limited due to its recent recognition.Pan-TRK immunohistochemistry(IHC)analysis serves as an effective screening tool with high sensitivity and specificity for NTRK-fusion malignancies.CASE SUMMARY We report a case of a malignant mesenchymal tumor originating from the uterine cervix,which was pan-TRK IHC-positive but lacked NTRK gene fusions,accompanied by a brief literature review.A 55-year-old woman presented to the emergency department with abdominal pain and distension,exhibiting significant ascites and multiple solid pelvic masses.Pelvic examination revealed a tumor encompassing the uterine cervix,extending to the vagina and uterine corpus.A punch biopsy of the cervix indicated NTRK sarcoma with positive immunochemical pan-TRK stain.However,subsequent next generation sequencing revealed no NTRK gene fusion,leading to a diagnosis of poorly differentiated,advanced-stage sarcoma.CONCLUSION The clinical significance of NTRK gene fusion lies in potential treatment with TRK inhibitors for positive sarcomas.Identifying such rare tumors is crucial due to the potential applicability of tropomyosin receptor kinase inhibitor treatment.
文摘BACKGROUND Cervical cancer is a formidable global health issue,particularly affecting women in lower-middle-income countries with little or no access to preventative vaccines,screening programs,and treatment modalities.The case report presents a unique case of a large cervical cancer achieving complete response(CR)with concurrent chemoradiotherapy(CCRT),highlighting the effectiveness of this treatment approach even in advanced stages and underscoring the importance of adaptive radiotherapy(RT)in optimizing patient outcomes.CASE SUMMARY We present the case of a 53-year-old woman who presented with four years of abnormal vaginal bleeding and was found to have p16-positive,moderately differentiated cervical squamous cell carcinoma.The tumor measured 14 cm×12 cm×8 cm,the largest size reported in the literature to achieve CR with CCRT.Despite this monumental feat,the patient remained disease-free and is currently on follow-up for 2 years;however,she continued to suffer from substantial morbidity caused by a vesicovaginal fistula and hydronephrosis,underscoring the continuing impact of cervical cancer on quality of life.CONCLUSION In this case report,we highlight the effectiveness of CCRT in achieving CR,even in cases of bulky cervical cancer,with adaptive RT offering a customized strategy to improve patient outcomes.We also emphasize the necessity for multidisciplinary team discussions and highlight the need for strategies to mitigate treatment-related toxicities and long-term complications.
基金supported by a project funded by the Hebei Provincial Central Guidance Local Science and Technology Development Fund(236Z7714G)。
文摘Cervical cancer,a leading malignancy globally,poses a significant threat to women's health,with an estimated 604,000 new cases and 342,000 deaths reported in 2020^([1]).As cervical cancer is closely linked to human papilloma virus(HPV)infection,early detection relies on HPV screening;however,late-stage prognosis remains poor,underscoring the need for novel diagnostic and therapeutic targets^([2]).
基金supported by the CAMS Innovation Fund for Medical Sciences(No.2023-I2M-3-019)National Natural Science Foundation of China(No.82404366)。
文摘In May 2018,the Director-General of the World Health Organization(WHO)called for global action to eliminate cervical cancer~1.This call marked the beginning of an ambitious international effort to scale up 3 key strategies:human papillomavirus(HPV)vaccination,cervical cancer screening,and treatment of precancerous lesions and cancer.Subsequently,the WHO and its partners developed a global strategy to accelerate the reduction of cervical cancer incidence,with an ultimate goal of achieving elimination within the next century.This Global Strategy represents a formal international commitment and is anchored in the 90-70-90 targets to be achieved by 2030.In parallel,several countries have also set national commitments,such as Sweden's pledge to achieve elimination by 2027 and Australia's target of achieving elimination by 2035.
