A new alkaloid compound I was obtained from Solanum cathayanum, a folk medicine of Hubei Province, together with a known alkaloid, orotic acid ethyl ester. On the basis of spectroscopic data and chemical methods, I wa...A new alkaloid compound I was obtained from Solanum cathayanum, a folk medicine of Hubei Province, together with a known alkaloid, orotic acid ethyl ester. On the basis of spectroscopic data and chemical methods, I was identified as 8-hydroxy-3-methoxy- 5H-pyrido[2, 1-c]pyrazin-5-one. Compound I can inhibit the production of NO in peritoneal macrophage of mice induced with LPS. The content of NO was determined by enzyme methods. 2007 Jun Zhi Wang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.展开更多
利用溶剂提取法、正相和反相硅胶柱层析、Sephadex LH-20、RP-HPLC等色谱方法,从排风藤95%乙醇提取物中分离得到6个化合物.通过理化性质和1 H NMR、13 C NMR等光谱数据鉴定化合物的结构为β-谷甾醇(1),β-胡萝卜苷(2),N-反式-香豆酰酪胺...利用溶剂提取法、正相和反相硅胶柱层析、Sephadex LH-20、RP-HPLC等色谱方法,从排风藤95%乙醇提取物中分离得到6个化合物.通过理化性质和1 H NMR、13 C NMR等光谱数据鉴定化合物的结构为β-谷甾醇(1),β-胡萝卜苷(2),N-反式-香豆酰酪胺(3),N-反式-对羟基苯乙基阿魏酰胺(4),N-反式阿魏酰基-3-甲氧基酪胺(5),N-trans-feruloylo-ctopamine(6).其中化合物2～6为首次从该植物中分离得到.展开更多
文摘A new alkaloid compound I was obtained from Solanum cathayanum, a folk medicine of Hubei Province, together with a known alkaloid, orotic acid ethyl ester. On the basis of spectroscopic data and chemical methods, I was identified as 8-hydroxy-3-methoxy- 5H-pyrido[2, 1-c]pyrazin-5-one. Compound I can inhibit the production of NO in peritoneal macrophage of mice induced with LPS. The content of NO was determined by enzyme methods. 2007 Jun Zhi Wang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
文摘利用溶剂提取法、正相和反相硅胶柱层析、Sephadex LH-20、RP-HPLC等色谱方法,从排风藤95%乙醇提取物中分离得到6个化合物.通过理化性质和1 H NMR、13 C NMR等光谱数据鉴定化合物的结构为β-谷甾醇(1),β-胡萝卜苷(2),N-反式-香豆酰酪胺(3),N-反式-对羟基苯乙基阿魏酰胺(4),N-反式阿魏酰基-3-甲氧基酪胺(5),N-trans-feruloylo-ctopamine(6).其中化合物2～6为首次从该植物中分离得到.
