Objective： We analyzed the proportion of cancer-caused hospitalization expenses in total hospitalization expenses from national authoritative data and explored influencing factors of the proportion so as to provide e...Objective： We analyzed the proportion of cancer-caused hospitalization expenses in total hospitalization expenses from national authoritative data and explored influencing factors of the proportion so as to provide effective data information for more rational utilization of health resources.Methods： Two-level lineal regression model was used to explore influencing factors of ratios of the cancer inpatient expenditure over the total inpatient expenditure of hospitals in China in 2015. A total of 40.76 million inpatient medical records were used to generate the outcome variables, while the explanatory variables were from hospital information database and China Health and Family Planning Statistical Yearbook and literatures.Results： Inpatient expenditure pattern for cancer（IEPC） varied largely across provinces, ranging from 3.03% to19.61%. The major sources of variability were from the differences of hospital level and number of beds. There was homogeneity within a province, while heterogeneity between the provinces. Rising one level of the hospital led to the increase of 0.475 natural logarithm units of IEPC averagely. The number of beds increasing 1,000 each made the natural logarithm of IEPC increase one unit averagely.Conclusions： Our study showed that a considerable proportion of IEPC variation could be explained by the differences of hospital level and number of beds. It implied that it is possible to estimate disease-specific ratio of inpatient expense taking into account key influencing factors in China. Furthermore, this study is an input to economic and financial analyses and provides evidence for future study on the national economic burden of cancer.展开更多
BACKGROUND As the malignant tumor,pancreatic cancer with a meager 5-years survival rate has been widely concerning.However,the molecular mechanisms that result in malignant transformation of pancreatic cells remain el...BACKGROUND As the malignant tumor,pancreatic cancer with a meager 5-years survival rate has been widely concerning.However,the molecular mechanisms that result in malignant transformation of pancreatic cells remain elusive.AIM To investigate the gene expression profiles in normal or malignant transformed pancreas development.METHODS MaSigPro and ANOVA were performed on two pancreas development datasets downloaded from the Gene Expression Omnibus database.Six pancreatic cancer datasets collected from TCGA database were used to establish differentially expressed genes related to pancreas development and pancreatic cancer.Moreover,gene clusters with highly similar interpretation patterns between pancreas development and pancreatic cancer progression were established by self-organizing map and singular value decomposition.Additionally,the hypergeometric test was performed to compare the corresponding interpretation patterns.Abnormal regions of metabolic pathway were analyzed using the Subpathway-GM method.RESULTS This study established the continuously upregulated and downregulated genes at different stages in pancreas development and progression of pancreatic cancer.Through analysis of the differentially expressed genes,we established the inverse and consistent direction development-cancer pattern associations.Based on the application of the Subpathway-GM analysis,we established 17 significant metabolic sub-pathways that were closely associated with pancreatic cancer.Of note,the most significant metabolites sub-pathway was related to glycerophospholipid metabolism.CONCLUSION The inverse and consistent direction development-cancer pattern associations were established.There was a significant correlation in the inverse patterns,but not consistent direction patterns.展开更多
In this work, optical scattering using Raman spectroscopy has been analyzed for various cancer tissues. The Raman shifts obtained at the Indiana University Bloomington (IUB) and Indiana University-Purdue University In...In this work, optical scattering using Raman spectroscopy has been analyzed for various cancer tissues. The Raman shifts obtained at the Indiana University Bloomington (IUB) and Indiana University-Purdue University Indianapolis (IUPUI) laboratories have been processed for diagnosing various types of cancer tissues. The objective of this research is to distinguish between cancerous and non-cancerous tissues. Small size tissue samples have been processed, seeking the minimum size tissue that can be diagnosed via Raman spectroscopy. The tests have been conducted on nearly 20 human tissues. A Matlab program has been written following Parzen-Window classifier to recognize the Raman shift pattern for various types of cancer tissues, including breast cancer, kidney, and Gyn-Uterus. A software visual model has been used for data processing. Unique signals for breast and kidney tumors have been obtained. The approach followed in this paper shows promise for early cancer detection in humans.展开更多
Background and Aims: To evaluate the dietary habits of individuals with colorectal cancer (CRC) and healthy adults living in southern Brazil. Methods: The anthropometric assessment was carried out according to the WHO...Background and Aims: To evaluate the dietary habits of individuals with colorectal cancer (CRC) and healthy adults living in southern Brazil. Methods: The anthropometric assessment was carried out according to the WHO standard and eating habits were assessed using a questionnaire food frequency. The dietary inflammatory index (eDII) was calculated based on the frequency of consumption of anti- and pro-inflammatory foods. Results: 178 colorectal cancer cases and 178 controls were included, age over 50 years (81.7%). 38.2% of CRC individuals were smokers or former smokers and 69.1% were overweight, 15.7% had type II diabetes and 41% had hypertension. The consumption of bread and white rice (OR 1365.8;p < 0.001), meat processed up to twice a week (OR 227.35;p = 0.001) and low fruit intake (OR 40.569;p = 0.039) increased the risk for CRC development. The eDII greater than 0 and 3 increases the risk of CRC for women (OR 55.83;95% CI 6.53 - 477.16;p < 0.001) and men (OR 66.75;95% CI 19.05 - 233;p Conclusions: In the south of Brazil, the Western diet pattern was related to the diagnosis of CRC, in addition to the male gender, smoking and overweight. In an unprecedented way for the Brazilian population, we associate eDII with the risk of CRC.展开更多
Objective:This article explores the clinical effects of lung-fire-clearing,phlegm-resolving and bowels-relaxing decoction in the treatment of lung cancer of phlegm-heat pattern.Methods:A total of 6 cases of lung cance...Objective:This article explores the clinical effects of lung-fire-clearing,phlegm-resolving and bowels-relaxing decoction in the treatment of lung cancer of phlegm-heat pattern.Methods:A total of 6 cases of lung cancer patients with phlegm-heat pattern were randomly selected from Inner Mongolia Baicaotang Qin's Zhong Meng Medical Hospital from March 2018 to December 2020 to conduct the study.They were divided into the reference group and the study group by using the digital table method.The patients in the reference group were treated with conventional Western medicine whereas the patients in the study group were treated with lung-fire-clearing,phlegm-resolving,and bowels-relaxing decoction to observe the curative effect.Results:There were no significant differences in the levels of the tumor markers between the two groups before treatment(P>0.05).However,after treatment,the levels of cytokeratin 19 soluble fragments(CYFRA21-1),carbohydrate antigen 125(CA125),and carcinoembryonic antigen(CEA)in the study group were lower than those in the control group(P<0.05).The effective rate and the quality of life score of the study group were higher than those of the reference group while the incidence of adverse reactions was lower than that of the reference group,P<0.05.Conclusion:Lung-fire-clearnig,phlegm-resolving,and bowels-relaxing decoction can effectively improve the symptoms of patients with lung cancer and improve their quality of life.展开更多
In the time period 1996-2004, a case-control study on diet and cervical cancer was conducted at the National Cancer Institute in Uruguay. The study included 268 cases and 536 controls with non-neoplastic diseases. The...In the time period 1996-2004, a case-control study on diet and cervical cancer was conducted at the National Cancer Institute in Uruguay. The study included 268 cases and 536 controls with non-neoplastic diseases. The foods and beverages in the food-frequency questionnaire were included in a factor analytic model. This method retained three factors which were labeled as the drinker, red meat, and prudent patterns. The model explained 60% of the variance. Whereas the red meat and drinker patterns were directly associated with the risk of cervical cancer (OR for red meat pattern 1.79, 95% CI 1.12-2.86), on the other hand, the prudent pattern was inversely associated with cervical cancer (OR 0.60, 95% CI 0.38-0.93). To our knowledge, this study was the first one using factor analysis in order to elucidate the role of the diet in relation with cervical cancer.展开更多
<strong>Background:</strong><span><span><span style="font-family:""><span style="font-family:Verdana;"> In India approximately 20% of the patients with brea...<strong>Background:</strong><span><span><span style="font-family:""><span style="font-family:Verdana;"> In India approximately 20% of the patients with breast cancer are triple receptor negative. Owing to the aggressive nature and shorter disease-free survival judicious follow up and identification of failure pattern will benefit the patient. Similar studies have been conducted among non-Hispanic population and in China. This study aims to identify failure pattern in radically treated breast cancer patients who are triple receptor negative among Indian population. </span><b><span style="font-family:Verdana;">Methods</span></b><span style="font-family:Verdana;">: This prospective observational study was conducted in the Department of Radiation Oncology, a tertiary cancer centre in Kerala, India. The objective was to record the pattern of recurrence among triple negative breast cancer patients who completed their planned radical treatment. 171 patients with triple negative breast cancer were included in the study. Patients who completed the planned radical treatment were kept under regular follow up. Details of clinical examination and investigations during the follow up were recorded periodically. </span><b><span style="font-family:Verdana;">Results</span></b><span style="font-family:Verdana;">: Out of 171 patients 30 patients had </span></span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">a </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">recurrence of disease. Median age of the population was 53 years. Among the 30 patients who had </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">a </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">recurrence, 16 patients (53%) had systemic relapse and 14 patients (47%) had locoregional relapse. Lung was found to be the most common site of distant metastasis (37%). Ipsilateral chest wall was found to be the most common site of locoregional relapse (50%). 6 months disease free survival was found to be 91.8%</span></span></span><span><span><span style="font-family:""> </span></span></span><span><span><span style="font-family:""><span style="font-family:Verdana;">and 1-year disease free survival was found to be 70.2%. </span><b><span style="font-family:Verdana;">Conclusion</span></b><span style="font-family:Verdana;">: Among radically treated triple negative breast cancers relapses, systemic recurrence was more than locoregional recurrences.</span></span></span></span>展开更多
This paper aims to propose the sequential pattern discovery method of Deoxyribonucleic Acid (DNA) sequence database in order to identify cancer disease. The DNA which is composed of amino acids of gene P53 is mutated....This paper aims to propose the sequential pattern discovery method of Deoxyribonucleic Acid (DNA) sequence database in order to identify cancer disease. The DNA which is composed of amino acids of gene P53 is mutated. It effects to change of P53 formation. Sequential pattern discovery is a process of extracting data to generate knowledge about the series of events that has the sequences in a certain frequency so that it creates a pattern. PrefixSpan is to propose method to find a pattern of DNA sequence database. As a result, there are various selected patterns of DNA sequence. The pattem which has high similarity is used as biomarker to identify the breast cancer disease. The performance measure of support value average is 0.8. It means that the frequent sequence pattern is high. Another measure is confidence. All of the confidence values are 1. Then, the last performance measure is lift ratio at average more than 1. It means that the composed sequence items in the pattern has high dependency and relatedness. Futhermore, the selected patterns are applied as biomarker with accuracy as 100%.展开更多
Background: Triple negative breast cancer (TNBC) tends to present aggressively with rapid progression and poor survival. Methods: We retrospectively reviewed patients’ files to define TNBC patients’ characteristics,...Background: Triple negative breast cancer (TNBC) tends to present aggressively with rapid progression and poor survival. Methods: We retrospectively reviewed patients’ files to define TNBC patients’ characteristics, predictive and prognostic factors, pattern of recurrence and survival. Results: 965 cases were identified. 147 patients (15.2%) were TNBC. 71.1% patients were premenopausal. T2, T3, T4 tumors represented 46.1%, 32% and 14.1%, respectively. N0, N1, N2, N3 disease represented 18.5%, 50.9%, 27.8% and 2.8%, respectively. Stages II, III & IV constituted 34.1%, 44.2% and 15.5%, respectively. 31.5% patients received neoadjuvant chemotherapy with 17.7% complete pathological response. 19.5%, 35.9%, 44.6% patients had unknown, ≤20 and >20 Ki67, respectively. Among non-metastatic patients (n = 108), 21.3% patients developed relapse with median time to relapse of 11 months. 78.3% of them had visceral (88.3% lung) metastasis, 13% bone metastasis, 21.7% brain metastasis and 13% LRR. There is significantly high risk of relapse in patients with large tumor size [T4: 66.75%, T3: 22.9%, T2: 16.7%, T1: 0% (p = 0.002)], positive LNs [N3: 100%, N2: 37.9%, N1: 15.1%, N0: 4.3% (p 0.001)] and Ki67 [>20: 31.6% versus 10.8% for Ki67 ≤ 20 (P = 0.007)]. Multivariate analysis revealed only T4 and N2-3 were significantly associated with high probability for relapse (P = 0.022 & 0.038). The 3-year DFS and OS were 73.2% and 75% respectively. For metastatic patients (n = 20), the m PFS was 7 months and m OS 1.5 years. Conclusion: Our data confirms the aggressive nature of TNBC with significant risk of relapse for patients with large tumor and positive lymph nodes. Maintenance metronomic capecitabine, neoadjuvant/adjuvant immunotherapy could be beneficial for non-metastatic patients. Lungs and brain were the most common sites of distant failure with poor survival that necessitates administration of molecular biomarkers (BRCA mutations, PD-L1 expression and microsatellite instability) for patients’ selection for novel targeted therapy.展开更多
Raman spectroscopy was used to distinguish the serums from lung cancer patients and healthy people, through spectral pretreatment method combined with pattern recognition methods including principal component analysis...Raman spectroscopy was used to distinguish the serums from lung cancer patients and healthy people, through spectral pretreatment method combined with pattern recognition methods including principal component analysis (PCA), partial least squares-discriminant analysis (PLS-DA), un-correlated linear discriminant analysis (ULDA), etc. Through the comparisons of the results, it can be found that ULDA and LDA combined with multiple scatter correction (MSC) pretreatment method successfully distinguish the patients of lung cancer and healthy people. The method has academic significance and promising clinical application value.展开更多
Introduction: Colorectal cancer (CRC) is the third most commonly diagnosed cancer and the third leading cause of cancer deaths in the United States. The goal of this study was to understand treatment patterns, biomark...Introduction: Colorectal cancer (CRC) is the third most commonly diagnosed cancer and the third leading cause of cancer deaths in the United States. The goal of this study was to understand treatment patterns, biomarker testing practices, treatment adherence, and the clinical and economic outcomes associated with chemotherapy for metastatic disease. Methods and Materials: We retrospectively examined electronic health records of patients with metastatic CRC who initiated chemotherapy between 01 January 2007 and 30 June 2011, with follow-up to 30 June 2012. Parameters analyzed included demographics and clinical characteristics, treatment patterns, clinical outcomes, and health care resource utilization. Results: In the analysis, 756 patients were included;median age was 61 years (55% male) at start of first line therapy. The most commonly used regimens in the first, second, and third line were FOLFOX + bevacizumab (46%), FOLFIRI + bevacizumab (23%), and irinotecan + cetuximab (23%) respectively. Adherence to guidelines decreased with increasing line of therapy. When assessed by treatment backbone categories in the third line, outcome measures including overall survival (OS), and time to treatment discontinuation (TTD) were not statistically different between groups. In the multivariable model, body mass index (BMI), performance status, and KRAS were significant predictors of survival. Conclusions: This study provides insight into patterns of care and outcomes of mCRC patients for the aforementioned time period. As treatment options for mCRC evolve, it is valuable to understand the continuum of care to help inform future treatment among candidates for continued therapy.展开更多
Background: The purpose of this study was to evaluate the use of 18FDG-PET/CT in staging procedure, the pattern of failure and survival in patients with small-cell lung cancer limited disease (LD-SCLC) undergoing chem...Background: The purpose of this study was to evaluate the use of 18FDG-PET/CT in staging procedure, the pattern of failure and survival in patients with small-cell lung cancer limited disease (LD-SCLC) undergoing chemo-radiotherapy. Methods: A total of 79 LD-SCLC patients were treated with a combination of chemotherapy and chest radiotherapy. Radiotherapy of the tumour and the pathological lymph nodes was performed either as 45 Gy twice-daily or 46 - 50 Gy once-daily. 18Fluro-2-deoxy-D-glucose (18FDG)-PET/CT was performed in 35 patients as part of the staging procedure. Results: With a median follow-up time of 17 months 6% developed isolated loco-regional failures while 57% developed distant metastases. No isolated regional failures were seen. Median overall survival was 22 months. Patients staged with a 18FDG-PET/CT had a significantly lower incidence of distant failures and a significantly improved overall survival compared with patients only staged with a CT scan (p = 0.03) (median overall survival of 34 versus 17 months, respectively). Conclusion: The pattern of failure showed a high risk of distant metastases but a low incidence of isolated loco-regional failures. Patients staged with an 18FDG-PET/CT had a significantly lower incidence of distant failures and better overall survival, indicating that 18FDG-PET could be beneficial in patients with LD-SCLC before deciding on treatment regimen.展开更多
目的基于《苗族抗肿瘤药物集》药物,挖掘探索苗族医学干预癌性疼痛的用药规律。方法选取《苗族抗肿瘤药物集》药物,拟定关键词对中国知网、维普数据库、万方数据库、中国生物医学文献数据库、Pubmed、Embase、Web of Science、Cochrane ...目的基于《苗族抗肿瘤药物集》药物,挖掘探索苗族医学干预癌性疼痛的用药规律。方法选取《苗族抗肿瘤药物集》药物,拟定关键词对中国知网、维普数据库、万方数据库、中国生物医学文献数据库、Pubmed、Embase、Web of Science、Cochrane library依次进行检索,纳入明确具有镇痛、止痛的药物并建立数据库进行分析。结果133味苗族抗肿瘤药物筛选后共纳入83味药物,科属分布中菊科频数最多,占9.64%;来源属性以土性药为主,占77.11%;走关以中、里关居多,共占85.63%;九架均有涉及,位居前三的为身架、肚架、肺架;药性以冷药最多,占74.70%;药味以苦、辣、甜为主,共占72.26%;归经主要集中在热经、冷经上,共占89.25%;功效以治毒药、补体药为主,共占69.88%;毒性以无毒药物居多,高达63味。结论苗族医学干预癌性疼痛以土性冷药为主,多归热经,多走中、里关,多入身架、肚架、肺架,用药虽以治毒为主,但无毒药物居多。展开更多
目的系统整理并归纳总结乳腺癌的中医证候分布及临床组方用药论治规律,为临床应用中医药治疗乳腺癌提供选方用药思路借鉴。方法检索建库至2024年6月30日中国知网(CNKI)、万方医学网(WANFANG MED ONLINE)、维普网(VIP)、中国生物医学服...目的系统整理并归纳总结乳腺癌的中医证候分布及临床组方用药论治规律,为临床应用中医药治疗乳腺癌提供选方用药思路借鉴。方法检索建库至2024年6月30日中国知网(CNKI)、万方医学网(WANFANG MED ONLINE)、维普网(VIP)、中国生物医学服务系统(SinoMed)文献数据库有关中医诊治乳腺癌的文献资料,建立数据库,通过Excel、SPSS Statistics、SPSS Modeler软件对证型、症状、方剂、药物进行频数统计、系统聚类和Apriori关联规则分析。结果共筛选得到文献164篇,中医证型36个,其中气血两虚、肝郁脾虚、肝郁气滞、气阴两虚、肝肾阴虚、瘀毒互结为常见证型;包含方剂257首,其中成方47首,以逍遥散、八珍汤、六君子汤为主;涉及中药281味,高频中药有白术、茯苓、甘草、黄芪、当归、柴胡、白芍、陈皮、白花蛇舌草等,功效以补虚药、清热药、活血化瘀药、理气药为主,主归肝、脾、肾经;45味高频中药系统聚类分析得到4个聚类方;关联规则分析得到20个药物组合。结论乳腺癌患者以气血两虚、肝郁脾虚、肝郁气滞证为主,在遣方用药上以益气健脾、滋阴养血为基本治法,同时辅以行气活血、清热解毒散结等药物辨证论治。展开更多
基金supported by National Natural Science Foundation of China (No. 71403189)
文摘Objective： We analyzed the proportion of cancer-caused hospitalization expenses in total hospitalization expenses from national authoritative data and explored influencing factors of the proportion so as to provide effective data information for more rational utilization of health resources.Methods： Two-level lineal regression model was used to explore influencing factors of ratios of the cancer inpatient expenditure over the total inpatient expenditure of hospitals in China in 2015. A total of 40.76 million inpatient medical records were used to generate the outcome variables, while the explanatory variables were from hospital information database and China Health and Family Planning Statistical Yearbook and literatures.Results： Inpatient expenditure pattern for cancer（IEPC） varied largely across provinces, ranging from 3.03% to19.61%. The major sources of variability were from the differences of hospital level and number of beds. There was homogeneity within a province, while heterogeneity between the provinces. Rising one level of the hospital led to the increase of 0.475 natural logarithm units of IEPC averagely. The number of beds increasing 1,000 each made the natural logarithm of IEPC increase one unit averagely.Conclusions： Our study showed that a considerable proportion of IEPC variation could be explained by the differences of hospital level and number of beds. It implied that it is possible to estimate disease-specific ratio of inpatient expense taking into account key influencing factors in China. Furthermore, this study is an input to economic and financial analyses and provides evidence for future study on the national economic burden of cancer.
文摘BACKGROUND As the malignant tumor,pancreatic cancer with a meager 5-years survival rate has been widely concerning.However,the molecular mechanisms that result in malignant transformation of pancreatic cells remain elusive.AIM To investigate the gene expression profiles in normal or malignant transformed pancreas development.METHODS MaSigPro and ANOVA were performed on two pancreas development datasets downloaded from the Gene Expression Omnibus database.Six pancreatic cancer datasets collected from TCGA database were used to establish differentially expressed genes related to pancreas development and pancreatic cancer.Moreover,gene clusters with highly similar interpretation patterns between pancreas development and pancreatic cancer progression were established by self-organizing map and singular value decomposition.Additionally,the hypergeometric test was performed to compare the corresponding interpretation patterns.Abnormal regions of metabolic pathway were analyzed using the Subpathway-GM method.RESULTS This study established the continuously upregulated and downregulated genes at different stages in pancreas development and progression of pancreatic cancer.Through analysis of the differentially expressed genes,we established the inverse and consistent direction development-cancer pattern associations.Based on the application of the Subpathway-GM analysis,we established 17 significant metabolic sub-pathways that were closely associated with pancreatic cancer.Of note,the most significant metabolites sub-pathway was related to glycerophospholipid metabolism.CONCLUSION The inverse and consistent direction development-cancer pattern associations were established.There was a significant correlation in the inverse patterns,but not consistent direction patterns.
文摘In this work, optical scattering using Raman spectroscopy has been analyzed for various cancer tissues. The Raman shifts obtained at the Indiana University Bloomington (IUB) and Indiana University-Purdue University Indianapolis (IUPUI) laboratories have been processed for diagnosing various types of cancer tissues. The objective of this research is to distinguish between cancerous and non-cancerous tissues. Small size tissue samples have been processed, seeking the minimum size tissue that can be diagnosed via Raman spectroscopy. The tests have been conducted on nearly 20 human tissues. A Matlab program has been written following Parzen-Window classifier to recognize the Raman shift pattern for various types of cancer tissues, including breast cancer, kidney, and Gyn-Uterus. A software visual model has been used for data processing. Unique signals for breast and kidney tumors have been obtained. The approach followed in this paper shows promise for early cancer detection in humans.
文摘Background and Aims: To evaluate the dietary habits of individuals with colorectal cancer (CRC) and healthy adults living in southern Brazil. Methods: The anthropometric assessment was carried out according to the WHO standard and eating habits were assessed using a questionnaire food frequency. The dietary inflammatory index (eDII) was calculated based on the frequency of consumption of anti- and pro-inflammatory foods. Results: 178 colorectal cancer cases and 178 controls were included, age over 50 years (81.7%). 38.2% of CRC individuals were smokers or former smokers and 69.1% were overweight, 15.7% had type II diabetes and 41% had hypertension. The consumption of bread and white rice (OR 1365.8;p < 0.001), meat processed up to twice a week (OR 227.35;p = 0.001) and low fruit intake (OR 40.569;p = 0.039) increased the risk for CRC development. The eDII greater than 0 and 3 increases the risk of CRC for women (OR 55.83;95% CI 6.53 - 477.16;p < 0.001) and men (OR 66.75;95% CI 19.05 - 233;p Conclusions: In the south of Brazil, the Western diet pattern was related to the diagnosis of CRC, in addition to the male gender, smoking and overweight. In an unprecedented way for the Brazilian population, we associate eDII with the risk of CRC.
文摘Objective:This article explores the clinical effects of lung-fire-clearing,phlegm-resolving and bowels-relaxing decoction in the treatment of lung cancer of phlegm-heat pattern.Methods:A total of 6 cases of lung cancer patients with phlegm-heat pattern were randomly selected from Inner Mongolia Baicaotang Qin's Zhong Meng Medical Hospital from March 2018 to December 2020 to conduct the study.They were divided into the reference group and the study group by using the digital table method.The patients in the reference group were treated with conventional Western medicine whereas the patients in the study group were treated with lung-fire-clearing,phlegm-resolving,and bowels-relaxing decoction to observe the curative effect.Results:There were no significant differences in the levels of the tumor markers between the two groups before treatment(P>0.05).However,after treatment,the levels of cytokeratin 19 soluble fragments(CYFRA21-1),carbohydrate antigen 125(CA125),and carcinoembryonic antigen(CEA)in the study group were lower than those in the control group(P<0.05).The effective rate and the quality of life score of the study group were higher than those of the reference group while the incidence of adverse reactions was lower than that of the reference group,P<0.05.Conclusion:Lung-fire-clearnig,phlegm-resolving,and bowels-relaxing decoction can effectively improve the symptoms of patients with lung cancer and improve their quality of life.
文摘In the time period 1996-2004, a case-control study on diet and cervical cancer was conducted at the National Cancer Institute in Uruguay. The study included 268 cases and 536 controls with non-neoplastic diseases. The foods and beverages in the food-frequency questionnaire were included in a factor analytic model. This method retained three factors which were labeled as the drinker, red meat, and prudent patterns. The model explained 60% of the variance. Whereas the red meat and drinker patterns were directly associated with the risk of cervical cancer (OR for red meat pattern 1.79, 95% CI 1.12-2.86), on the other hand, the prudent pattern was inversely associated with cervical cancer (OR 0.60, 95% CI 0.38-0.93). To our knowledge, this study was the first one using factor analysis in order to elucidate the role of the diet in relation with cervical cancer.
文摘<strong>Background:</strong><span><span><span style="font-family:""><span style="font-family:Verdana;"> In India approximately 20% of the patients with breast cancer are triple receptor negative. Owing to the aggressive nature and shorter disease-free survival judicious follow up and identification of failure pattern will benefit the patient. Similar studies have been conducted among non-Hispanic population and in China. This study aims to identify failure pattern in radically treated breast cancer patients who are triple receptor negative among Indian population. </span><b><span style="font-family:Verdana;">Methods</span></b><span style="font-family:Verdana;">: This prospective observational study was conducted in the Department of Radiation Oncology, a tertiary cancer centre in Kerala, India. The objective was to record the pattern of recurrence among triple negative breast cancer patients who completed their planned radical treatment. 171 patients with triple negative breast cancer were included in the study. Patients who completed the planned radical treatment were kept under regular follow up. Details of clinical examination and investigations during the follow up were recorded periodically. </span><b><span style="font-family:Verdana;">Results</span></b><span style="font-family:Verdana;">: Out of 171 patients 30 patients had </span></span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">a </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">recurrence of disease. Median age of the population was 53 years. Among the 30 patients who had </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">a </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">recurrence, 16 patients (53%) had systemic relapse and 14 patients (47%) had locoregional relapse. Lung was found to be the most common site of distant metastasis (37%). Ipsilateral chest wall was found to be the most common site of locoregional relapse (50%). 6 months disease free survival was found to be 91.8%</span></span></span><span><span><span style="font-family:""> </span></span></span><span><span><span style="font-family:""><span style="font-family:Verdana;">and 1-year disease free survival was found to be 70.2%. </span><b><span style="font-family:Verdana;">Conclusion</span></b><span style="font-family:Verdana;">: Among radically treated triple negative breast cancers relapses, systemic recurrence was more than locoregional recurrences.</span></span></span></span>
文摘This paper aims to propose the sequential pattern discovery method of Deoxyribonucleic Acid (DNA) sequence database in order to identify cancer disease. The DNA which is composed of amino acids of gene P53 is mutated. It effects to change of P53 formation. Sequential pattern discovery is a process of extracting data to generate knowledge about the series of events that has the sequences in a certain frequency so that it creates a pattern. PrefixSpan is to propose method to find a pattern of DNA sequence database. As a result, there are various selected patterns of DNA sequence. The pattem which has high similarity is used as biomarker to identify the breast cancer disease. The performance measure of support value average is 0.8. It means that the frequent sequence pattern is high. Another measure is confidence. All of the confidence values are 1. Then, the last performance measure is lift ratio at average more than 1. It means that the composed sequence items in the pattern has high dependency and relatedness. Futhermore, the selected patterns are applied as biomarker with accuracy as 100%.
文摘Background: Triple negative breast cancer (TNBC) tends to present aggressively with rapid progression and poor survival. Methods: We retrospectively reviewed patients’ files to define TNBC patients’ characteristics, predictive and prognostic factors, pattern of recurrence and survival. Results: 965 cases were identified. 147 patients (15.2%) were TNBC. 71.1% patients were premenopausal. T2, T3, T4 tumors represented 46.1%, 32% and 14.1%, respectively. N0, N1, N2, N3 disease represented 18.5%, 50.9%, 27.8% and 2.8%, respectively. Stages II, III & IV constituted 34.1%, 44.2% and 15.5%, respectively. 31.5% patients received neoadjuvant chemotherapy with 17.7% complete pathological response. 19.5%, 35.9%, 44.6% patients had unknown, ≤20 and >20 Ki67, respectively. Among non-metastatic patients (n = 108), 21.3% patients developed relapse with median time to relapse of 11 months. 78.3% of them had visceral (88.3% lung) metastasis, 13% bone metastasis, 21.7% brain metastasis and 13% LRR. There is significantly high risk of relapse in patients with large tumor size [T4: 66.75%, T3: 22.9%, T2: 16.7%, T1: 0% (p = 0.002)], positive LNs [N3: 100%, N2: 37.9%, N1: 15.1%, N0: 4.3% (p 0.001)] and Ki67 [>20: 31.6% versus 10.8% for Ki67 ≤ 20 (P = 0.007)]. Multivariate analysis revealed only T4 and N2-3 were significantly associated with high probability for relapse (P = 0.022 & 0.038). The 3-year DFS and OS were 73.2% and 75% respectively. For metastatic patients (n = 20), the m PFS was 7 months and m OS 1.5 years. Conclusion: Our data confirms the aggressive nature of TNBC with significant risk of relapse for patients with large tumor and positive lymph nodes. Maintenance metronomic capecitabine, neoadjuvant/adjuvant immunotherapy could be beneficial for non-metastatic patients. Lungs and brain were the most common sites of distant failure with poor survival that necessitates administration of molecular biomarkers (BRCA mutations, PD-L1 expression and microsatellite instability) for patients’ selection for novel targeted therapy.
文摘Raman spectroscopy was used to distinguish the serums from lung cancer patients and healthy people, through spectral pretreatment method combined with pattern recognition methods including principal component analysis (PCA), partial least squares-discriminant analysis (PLS-DA), un-correlated linear discriminant analysis (ULDA), etc. Through the comparisons of the results, it can be found that ULDA and LDA combined with multiple scatter correction (MSC) pretreatment method successfully distinguish the patients of lung cancer and healthy people. The method has academic significance and promising clinical application value.
文摘Introduction: Colorectal cancer (CRC) is the third most commonly diagnosed cancer and the third leading cause of cancer deaths in the United States. The goal of this study was to understand treatment patterns, biomarker testing practices, treatment adherence, and the clinical and economic outcomes associated with chemotherapy for metastatic disease. Methods and Materials: We retrospectively examined electronic health records of patients with metastatic CRC who initiated chemotherapy between 01 January 2007 and 30 June 2011, with follow-up to 30 June 2012. Parameters analyzed included demographics and clinical characteristics, treatment patterns, clinical outcomes, and health care resource utilization. Results: In the analysis, 756 patients were included;median age was 61 years (55% male) at start of first line therapy. The most commonly used regimens in the first, second, and third line were FOLFOX + bevacizumab (46%), FOLFIRI + bevacizumab (23%), and irinotecan + cetuximab (23%) respectively. Adherence to guidelines decreased with increasing line of therapy. When assessed by treatment backbone categories in the third line, outcome measures including overall survival (OS), and time to treatment discontinuation (TTD) were not statistically different between groups. In the multivariable model, body mass index (BMI), performance status, and KRAS were significant predictors of survival. Conclusions: This study provides insight into patterns of care and outcomes of mCRC patients for the aforementioned time period. As treatment options for mCRC evolve, it is valuable to understand the continuum of care to help inform future treatment among candidates for continued therapy.
文摘Background: The purpose of this study was to evaluate the use of 18FDG-PET/CT in staging procedure, the pattern of failure and survival in patients with small-cell lung cancer limited disease (LD-SCLC) undergoing chemo-radiotherapy. Methods: A total of 79 LD-SCLC patients were treated with a combination of chemotherapy and chest radiotherapy. Radiotherapy of the tumour and the pathological lymph nodes was performed either as 45 Gy twice-daily or 46 - 50 Gy once-daily. 18Fluro-2-deoxy-D-glucose (18FDG)-PET/CT was performed in 35 patients as part of the staging procedure. Results: With a median follow-up time of 17 months 6% developed isolated loco-regional failures while 57% developed distant metastases. No isolated regional failures were seen. Median overall survival was 22 months. Patients staged with a 18FDG-PET/CT had a significantly lower incidence of distant failures and a significantly improved overall survival compared with patients only staged with a CT scan (p = 0.03) (median overall survival of 34 versus 17 months, respectively). Conclusion: The pattern of failure showed a high risk of distant metastases but a low incidence of isolated loco-regional failures. Patients staged with an 18FDG-PET/CT had a significantly lower incidence of distant failures and better overall survival, indicating that 18FDG-PET could be beneficial in patients with LD-SCLC before deciding on treatment regimen.
文摘目的基于《苗族抗肿瘤药物集》药物,挖掘探索苗族医学干预癌性疼痛的用药规律。方法选取《苗族抗肿瘤药物集》药物,拟定关键词对中国知网、维普数据库、万方数据库、中国生物医学文献数据库、Pubmed、Embase、Web of Science、Cochrane library依次进行检索,纳入明确具有镇痛、止痛的药物并建立数据库进行分析。结果133味苗族抗肿瘤药物筛选后共纳入83味药物,科属分布中菊科频数最多,占9.64%;来源属性以土性药为主,占77.11%;走关以中、里关居多,共占85.63%;九架均有涉及,位居前三的为身架、肚架、肺架;药性以冷药最多,占74.70%;药味以苦、辣、甜为主,共占72.26%;归经主要集中在热经、冷经上,共占89.25%;功效以治毒药、补体药为主,共占69.88%;毒性以无毒药物居多,高达63味。结论苗族医学干预癌性疼痛以土性冷药为主,多归热经,多走中、里关,多入身架、肚架、肺架,用药虽以治毒为主,但无毒药物居多。
文摘目的系统整理并归纳总结乳腺癌的中医证候分布及临床组方用药论治规律,为临床应用中医药治疗乳腺癌提供选方用药思路借鉴。方法检索建库至2024年6月30日中国知网(CNKI)、万方医学网(WANFANG MED ONLINE)、维普网(VIP)、中国生物医学服务系统(SinoMed)文献数据库有关中医诊治乳腺癌的文献资料,建立数据库,通过Excel、SPSS Statistics、SPSS Modeler软件对证型、症状、方剂、药物进行频数统计、系统聚类和Apriori关联规则分析。结果共筛选得到文献164篇,中医证型36个,其中气血两虚、肝郁脾虚、肝郁气滞、气阴两虚、肝肾阴虚、瘀毒互结为常见证型;包含方剂257首,其中成方47首,以逍遥散、八珍汤、六君子汤为主;涉及中药281味,高频中药有白术、茯苓、甘草、黄芪、当归、柴胡、白芍、陈皮、白花蛇舌草等,功效以补虚药、清热药、活血化瘀药、理气药为主,主归肝、脾、肾经;45味高频中药系统聚类分析得到4个聚类方;关联规则分析得到20个药物组合。结论乳腺癌患者以气血两虚、肝郁脾虚、肝郁气滞证为主,在遣方用药上以益气健脾、滋阴养血为基本治法,同时辅以行气活血、清热解毒散结等药物辨证论治。
