摘要
目的基于《苗族抗肿瘤药物集》药物,挖掘探索苗族医学干预癌性疼痛的用药规律。方法选取《苗族抗肿瘤药物集》药物,拟定关键词对中国知网、维普数据库、万方数据库、中国生物医学文献数据库、Pubmed、Embase、Web of Science、Cochrane library依次进行检索,纳入明确具有镇痛、止痛的药物并建立数据库进行分析。结果133味苗族抗肿瘤药物筛选后共纳入83味药物,科属分布中菊科频数最多,占9.64%;来源属性以土性药为主,占77.11%;走关以中、里关居多,共占85.63%;九架均有涉及,位居前三的为身架、肚架、肺架;药性以冷药最多,占74.70%;药味以苦、辣、甜为主,共占72.26%;归经主要集中在热经、冷经上,共占89.25%;功效以治毒药、补体药为主,共占69.88%;毒性以无毒药物居多,高达63味。结论苗族医学干预癌性疼痛以土性冷药为主,多归热经,多走中、里关,多入身架、肚架、肺架,用药虽以治毒为主,但无毒药物居多。
Objective To explore the medication patterns of Miao medicine in the intervention of cancer pain based on drugs from the Miao Medicine Antitumor Drug Collection.Methods Drugs from the Miao Medicine Antitumor Drug Collection were selected,and keywords were used to systematically search the China National Knowledge Infrastructure,VIP Chinese Journal Database,Wanfang Database,China Biomedical Literature Database,PubMed,Embase,Web of Science,and Cochrane Library.Drugs with definite analgesic efficacy were included,and a database was established for analysis.Results Among the 133 species of Miao antitumor drugs screened,83 drugs were ultimately included.Regarding the distribution of plant families,Asteraceae showed the highest frequency,accounting for 9.64%.Among the source attributes,earth-sourced drugs were predominant,accounting for 77.11%.Most drugs acted on the middle pass(Zhongguan)and inner pass(Liguan),accounting for 85.63%.All nine body frameworks(Jiujia)were involved,with the top three being body framework(Shenjia),abdominal framework(Dujia),and lung framework(Feijia).Regarding drug property,cold-natured drugs were most abundant,accounting for 74.70%.In drug flavor,bitter,acrid,and sweet flavors were predominant,accounting for 72.26%.The meridian tropisms were mainly concentrated in hot meridian and cold meridian,accounting for 89.25%.The main efficacy of drugs was toxin-resolving and body-supplementing,accounting for 69.88%.In toxicity profile,non-toxic drugs were most abundant,reaching 63 drugs.Conclusion Miao medicine intervention for cancer pain primarily employs cold-natured and earth-sourced drugs that predominantly attribute to hot meridians,target the middle and interior passes,and principally enter body framework,abdominal framework,and lung framework.Although toxin-resolving drugs form the main therapeutic strategy,the majority of medicines used are actually non-toxic.
作者
税会利
吴文宇
黄雯琪
杨兵
唐东昕
SHUI Huili;WU Wenyu;HUANG Wenqi;YANG Bing;TANG Dongxin(Graduate School,Guizhou University of Traditional Chinese Medicine,Guiyang 550025 Guizhou,China;Clinical Medical Research Center,The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine,Guiyang 550001 Guizhou,China;Guizhou Province Talent Base for Inheritance and Scientific and Technological Innovation of Chinese Medicine Oncology,Guiyang 550002 Guizhou,China)
出处
《中医肿瘤学杂志》
2026年第1期91-97,共7页
Journal of Oncology in Chinese Medicine
基金
国家自然科学基金(编号:82460959)
贵州省中医药管理局中医药、民族医药科学技术研究课题(编号:QZYY-2021-043)。
关键词
苗族医学
癌性疼痛
药物规律
文献研究
Miao medicine
cancer pain
medication pattern
literature study
