肿瘤凋亡抑制因子IAP(Inhibitor of apoptosis protein)蛋白参与细胞凋亡、细胞内信号传导、细胞周期多种细胞功能。IAP家族有8个成员,cIAP-1是其中的重要成员之一,其主要功能是介导肿瘤坏死因子受体家族以发挥凋亡抑制作用以及通过直...肿瘤凋亡抑制因子IAP(Inhibitor of apoptosis protein)蛋白参与细胞凋亡、细胞内信号传导、细胞周期多种细胞功能。IAP家族有8个成员,cIAP-1是其中的重要成员之一,其主要功能是介导肿瘤坏死因子受体家族以发挥凋亡抑制作用以及通过直接结合于caspas-3和caspase-7,降解其凋亡作用的内源性细胞凋亡作用。近年来笔者对食道癌、宫颈癌、头颈部癌、舌鳞状细胞癌cIAP-1(Cellular inhibitor of apop-tosis protein 1)表达进行了相关报道,现将cIAP-1研究进展予以综述。展开更多
Hepatitis B virus (HBV)infection causes a wide spectrum of liver diseases in more than 240million people worldwide (Ott et al.2012).Patients with chronic hepatitis B (CHB)may progress to HBV-related end-stage liver di...Hepatitis B virus (HBV)infection causes a wide spectrum of liver diseases in more than 240million people worldwide (Ott et al.2012).Patients with chronic hepatitis B (CHB)may progress to HBV-related end-stage liver diseases,such as hepatic failure,cirrhosis or hepatocellular carcinoma (HCC)(Tang et al.2018).展开更多
文摘肿瘤凋亡抑制因子IAP(Inhibitor of apoptosis protein)蛋白参与细胞凋亡、细胞内信号传导、细胞周期多种细胞功能。IAP家族有8个成员,cIAP-1是其中的重要成员之一,其主要功能是介导肿瘤坏死因子受体家族以发挥凋亡抑制作用以及通过直接结合于caspas-3和caspase-7,降解其凋亡作用的内源性细胞凋亡作用。近年来笔者对食道癌、宫颈癌、头颈部癌、舌鳞状细胞癌cIAP-1(Cellular inhibitor of apop-tosis protein 1)表达进行了相关报道,现将cIAP-1研究进展予以综述。
基金partly supported by Grants from the National Natural Science Foundation of China(81641173)the Collaboration and Innovation Health Care Major Project of Guangzhou(201604020010)
文摘Hepatitis B virus (HBV)infection causes a wide spectrum of liver diseases in more than 240million people worldwide (Ott et al.2012).Patients with chronic hepatitis B (CHB)may progress to HBV-related end-stage liver diseases,such as hepatic failure,cirrhosis or hepatocellular carcinoma (HCC)(Tang et al.2018).
