The transition of human societies from high mobility to sedentary lifestyles had a profound impact on subsistence,technology,and the origin of civilization.Sedentism was influenced by various factors such as climate c...The transition of human societies from high mobility to sedentary lifestyles had a profound impact on subsistence,technology,and the origin of civilization.Sedentism was influenced by various factors such as climate change,population growth,resource pressure,and technological innovation.The Tibetan Plateau,due to its alpine and hypoxic conditions,is an ideal region to study human adaptation to extreme environments.However,the prehistoric process of sedentism on the Tibetan Plateau is unclear and the chronological sequence and driving mechanism of sedentism on the Tibetan Plateau are still controversial.Previous studies have focused on the diffusion of agriculture from low to high elevation areas,with little attention given to the role of animal resources in sedentism.Seasonality analysis using animal remains is crucial in determining whether a site was occupied year-round.To establish the seasonal calendar of animal resource utilization,it is recommended to create a database of skeletal morphology,whole genome,and proteome of contemporary Tibetan Plateau fauna to aid in the identification of animal remains from archaeological sites.Thus,intricate web of human-animal-environment relationship and the role of animal resources in human sedentism on the Tibetan Plateau can then be evaluated.展开更多
目的:定量分析9种单一中医体质的体积骨密度(volume bone mineral density,vBMD)及骨代谢指标差异,为骨量异常的临床管理提供参考。方法:纳入45~80周岁的健康体检受试者151例,采集中医体质、vBMD及骨代谢指标,包括骨钙素(osteocalcin,OC...目的:定量分析9种单一中医体质的体积骨密度(volume bone mineral density,vBMD)及骨代谢指标差异,为骨量异常的临床管理提供参考。方法:纳入45~80周岁的健康体检受试者151例,采集中医体质、vBMD及骨代谢指标,包括骨钙素(osteocalcin,OC)、全段甲状旁腺激素(intact parathyroid hormone,iPTH)、25-羟维生素D 3[25-hydroxy vitamin D 3,25-(OH)D 3]、β-胶原降解产物(β-collagen degradation product,β-CTX)、总I型胶原氨基端延长肽(total typeⅠcollagen terminal extension peptide,Total-P1NP)等。使用倾向性评分匹配控制年龄及性别等混杂因素后,观察9种体质不同骨量的分布特点及vBMD、骨代谢指标的定量差异。结果:特禀质组vBMD高于于非特禀质组(P<0.05);平和质组OC、25-(OH)D 3、β-CTX、Total-P1NP低于非平和质组(P<0.05);阴虚质组iPTH低于非阴虚质组(P<0.05),Total-P1NP高于非阴虚质组(P<0.05);阳虚质组Total-P1NP高于非阳虚质组(P<0.05);血瘀质组OC高于非血瘀质组(P<0.05);特禀质组25-(OH)D 3低于非特禀质组(P<0.05)。相关分析显示:年龄与vBMD呈显著负相关(r s=-0.49,P<0.001),与25-(OH)D 3呈显著正相关(r s=0.31,P<0.001)。结论:平和质、阴虚质、阳虚质、血瘀质及特禀质vBMD及骨代谢指标存在定量差异。展开更多
基金National Natural Science Foundation of China,No.41930323The Second Tibetan Plateau Scientific Expedition and Research Program,No.2019QZKK0601。
文摘The transition of human societies from high mobility to sedentary lifestyles had a profound impact on subsistence,technology,and the origin of civilization.Sedentism was influenced by various factors such as climate change,population growth,resource pressure,and technological innovation.The Tibetan Plateau,due to its alpine and hypoxic conditions,is an ideal region to study human adaptation to extreme environments.However,the prehistoric process of sedentism on the Tibetan Plateau is unclear and the chronological sequence and driving mechanism of sedentism on the Tibetan Plateau are still controversial.Previous studies have focused on the diffusion of agriculture from low to high elevation areas,with little attention given to the role of animal resources in sedentism.Seasonality analysis using animal remains is crucial in determining whether a site was occupied year-round.To establish the seasonal calendar of animal resource utilization,it is recommended to create a database of skeletal morphology,whole genome,and proteome of contemporary Tibetan Plateau fauna to aid in the identification of animal remains from archaeological sites.Thus,intricate web of human-animal-environment relationship and the role of animal resources in human sedentism on the Tibetan Plateau can then be evaluated.
