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不同情况下Bite Turbos对上颌中切牙作用的三维有限元分析
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作者 王玉琛 林新平 +2 位作者 邹明媛 弓国梁 余飞 《口腔医学研究》 北大核心 2025年第4期320-326,共7页
目的:通过分析不同情况下咬合垫(Bite Turbos)在打开前牙咬合时上颌中切牙的移动变化来探究影响上颌中切牙唇倾度的相关因素。方法:利用Minics、Geomagic Wrap 2017、SolidWork等软件进行模型的制作,用Workbench对模型设置运行条件,计... 目的:通过分析不同情况下咬合垫(Bite Turbos)在打开前牙咬合时上颌中切牙的移动变化来探究影响上颌中切牙唇倾度的相关因素。方法:利用Minics、Geomagic Wrap 2017、SolidWork等软件进行模型的制作,用Workbench对模型设置运行条件,计算出上颌中切牙的位移距离及方向。结果:作用位点Bite Turbos咬合面后1/3各组模型上中切牙均表现为舌倾改变,Turbos咬合面前1/3各组上中切牙均为唇倾改变;较标准唇倾度中切牙组,唇倾组中模型D1、E1、F1上中切牙更多舌倾变化,其余6组更多唇倾变化,舌倾组中G3、H3、I3表现为更少唇倾变化,其余6组多数表现更多舌倾;Turbos咬合面唇向倾斜,较水平组而言,各组模型上中切牙均表现更舌倾,而咬合面舌向倾斜所有模型表现均更唇倾;垂直向各组模型上中切牙整体表现为压低,除H1上中切牙切缘少量伸长(0.002 mm)外,其余各组切缘及根尖均压低表现。结论:Bite Turbos打开咬合时,上颌中切牙唇倾度的变化与其自身的唇倾度、Bite Turbos咬合面倾斜度及其咬合接触点密切相关。咬合力的作用力线及阻抗中心位置的关系影响上颌中切牙的唇倾度变化。 展开更多
关键词 三维有限元 bite Turbos 生物力学机制 深覆[牙合] 上颌中切牙唇倾度
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Spinal cord ischemia:The“snake bite sign”
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作者 Nikolaos-Achilleas Arkoudis Anastasia Karachaliou +3 位作者 George Triantafyllou Andreas Papadopoulos Christos Koutserimpas Georgios Velonakis 《World Journal of Radiology》 2025年第7期87-90,共4页
Descriptive signs in radiology can aid in easier pattern recognition and quicker diagnosis.In spinal cord ischemia,paired anterior-horn T2-hyperintensities have traditionally been known as the“owl’s eyes”or“snake ... Descriptive signs in radiology can aid in easier pattern recognition and quicker diagnosis.In spinal cord ischemia,paired anterior-horn T2-hyperintensities have traditionally been known as the“owl’s eyes”or“snake eyes”sign.We discuss how these signs,while visually apt,convey no pathophysiologic context and propose renaming this finding the“snake bite sign”.The image still evokes two punctate marks,yet the metaphor extends to a snake bite(two fang-like dots)rather than two bright foci(eyes)staring back at the viewer.Moreover,besides the sign metaphorically resembling a traumatic puncture of the two fangs,on the occasion of a venomous snake bite occurring elsewhere,additional neurological consequences may occur,paralleling the neurological deficits seen in anterior spinal artery infarction and several mimicking myelopathies,thus further high-lighting the analogy.Such clinically driven terminology may facilitate teaching,enable diagnostic recall,and improve interdisciplinary communication. 展开更多
关键词 RADIOLOGY NEUROIMAGING NEURORADIOLOGY Spinal CORD Ischemia SNAKE bite Eyes Owl
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Sexual differences in bite force are not related to testosterone level in the wild-derived red junglefowl
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作者 Xiaodong Rao Daiping Wang Wei Liang 《Current Zoology》 2025年第1期33-39,共7页
Bite force is an important performance indicator of individual fitness that is closely related to food acquisition,male competition,and mating selection.It is also affected by a variety of factors and different mechan... Bite force is an important performance indicator of individual fitness that is closely related to food acquisition,male competition,and mating selection.It is also affected by a variety of factors and different mechanisms.Therefore,it is relatively difficult to understand the evolutionary driving forces of changes in bite force.In this study,the driving factors affecting the bite force of wild-derived red junglefowl(Gallus gallus jabouillei)were investigated from the aspects of morphological indicators and physiological characteristics.Results showed that the bite force of wild-derived red junglefowl was directly related to sex,showing obvious sexual differences.However,there was no correlation between the plasma testosterone level and bite force.The bite force of males was significantly greater than that of females,and the body index(i.e.,PC1 of five body measures,namely body mass,body length,wing length,tail length,and tarsus length),the grasp index(i.e.,tomial length×bill width)of males were significantly greater than those of females.Sexual selection may have played a key role in the evolution of bite force in the red junglefowl.Future studies should examine other key factors affecting changes in bite force to verify the correlation between secondary sexual characteristics and bite force in red junglefowls. 展开更多
关键词 bite force evolution morphometric indices red junglefowl TESTOSTERONE
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Improved super-elastic Ti-Ni alloy wire for the angle class III patient with anterior open bite:A case report
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作者 Yu Fan Jian-Hong Yu Yuan-Hou Chen 《World Journal of Clinical Cases》 2025年第15期32-41,共10页
BACKGROUND Orthodontic treatment for open bite and crossbite cases is always challenging.In this paper,we demonstrate a skeletal class III patient with anterior open bite and crossbite whose problem was successfully c... BACKGROUND Orthodontic treatment for open bite and crossbite cases is always challenging.In this paper,we demonstrate a skeletal class III patient with anterior open bite and crossbite whose problem was successfully corrected with improved super-elastic Ti-Ni alloy wire(ISW).CASE SUMMARY A 19 years old male came to our clinic with a chief complaint of anterior open bite and crossbite and not able to chew food well.Clinical examination revealed an angle class III malocclusion with anterior open bite,crossbite and spaced arch.Ra-diographic and clinical examination showed a skeletal class III pattern.We used ISW to level the upper and lower arch and to correct the anterior open bite and crossbite.Intermaxillary elastics were also used to achieve a better interdigitation.Finally,adequate overbite,overjet and a desirable occlusion were achieved.The active treatment time took 2 years and 2 months.CONCLUSION In a case of class III angular malocclusion with open bite and crossbite in the ante-rior teeth,ideal results were achieved using the ISW technique and the patient was satisfied with the outcome. 展开更多
关键词 Dentistry Orthodontics Angle class III malocclusion Anterior open bite Anterior open bite Improved super-elastic Ti-Ni alloy wire Case report
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Application progresses of ultrasound for snakebites and relative complications 被引量:1
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作者 ZHENG Yiyin SHEN Yanyan BIN Wenkai 《中国医学影像技术》 CSCD 北大核心 2024年第8期1258-1261,共4页
Snakebite has become a serious public health problem with high mortality and disability rates.Ultrasound can provide imaging basis for diagnosis and treatment of snakebites and relative complications.The application p... Snakebite has become a serious public health problem with high mortality and disability rates.Ultrasound can provide imaging basis for diagnosis and treatment of snakebites and relative complications.The application progresses of ultrasound in snakebites and complications were reviewed in this article. 展开更多
关键词 snake bites ULTRASONOGRAPHY DIAGNOSIS
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A 10-year review and epidemiology of animal bite cases in Gerash city, south of Iran: A retrospective cross-sectional study
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作者 Mohammad-Rafi Bazrafshan Esmaeil Kavi +3 位作者 Negar Shahkarami Mohammad Nowrouzi Fereidoun Jahangir Hajar Haghshenas 《Journal of Acute Disease》 2024年第1期20-25,共6页
Objective:To determine the temporal trend and epidemiology of animal bite cases in Gerash City,Iran.Methods:This retrospective cross-sectional study analyzed 630 cases of people with animal bites between 2011 and 2021... Objective:To determine the temporal trend and epidemiology of animal bite cases in Gerash City,Iran.Methods:This retrospective cross-sectional study analyzed 630 cases of people with animal bites between 2011 and 2021 in Gerash City.The collected data were analyzed using Chi-square test.Results:The mean age of victims was(30.9±17.5)years.80.54%Of victims were male,39.70%were self-employed,and 64.60%were adults(≥18 years).Most cases of bites occurred in 2019(91 cases),2020(74 cases)and 2021(87 cases),and most of the bites were related to the upper limbs(62.70%).Most of the wounds were superficial(78%),most of the biting animals were domestic animals(91.74%),and most of the victims had Iranian nationality(97.62%).Conclusions:Given the increasing trend of animal bites in Gerash City,health authorities should carry out basic measures such as education and awareness among the public,especially at-risk groups such as adult males.Additionally,since most cases of bites are due to dogs,it seems necessary to plan for vaccination of dogs,especially those with owners. 展开更多
关键词 Animal bite Gerash Time trend Disease EPIDEMIOLOGY RABIES
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Spatial analysis of animal bites in Iran(2015-2020):A cross-sectional study
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作者 Hoda Amiri Khadijeh Yazdanparast +1 位作者 Mohsen Pourkhosravani Maryam Rastegar 《Journal of Acute Disease》 2024年第2期67-73,共7页
Objective:To investigate the distribution pattern of animal bites in Mirjaveh,Iran from 2015 to 2020.Methods:The data on animal bites were collected from the Department of Infectious Diseases,the provincial health cen... Objective:To investigate the distribution pattern of animal bites in Mirjaveh,Iran from 2015 to 2020.Methods:The data on animal bites were collected from the Department of Infectious Diseases,the provincial health center.Monthly climatic data on precipitation and temperature during the study period were also collected.The correlation between incidence and temperature,precipitation rate,land type,and altitude was also analyzed.Results:The results showed that men were more affected by animal bites than women(76.4%,P<0.001),and the highest incidence rate occurred in the age group of 5-19 years.The incidence rate of animal bites was found to be correlated with temperature and altitude.An increase in temperature was associated with a rise in the incidence rate of animal bites.The number of animal bites increased until 2019,possibly due to an increase in the number of dogs in the area.Conclusions:Targeted interventions should be implemented to reduce the incidence of animal bites,particularly among children,housewives,and students.Improving access to appropriate treatments,increasing public awareness of the hazards of animal bites,and increasing the number of vaccinated dogs in the area are essential strategies to be considered. 展开更多
关键词 Animal bites EPIDEMIOLOGY Zoonotic disease Iran
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Classification and a decade-long follow-up of rat bite injuries in the nasal region
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作者 Chu-Hsin Chen Yahong Chen +1 位作者 Peng Xu Kai Liu 《Chinese Journal of Plastic and Reconstructive Surgery》 2024年第1期28-33,共6页
Background:Nasal defects due to rat bites are frequently encountered in rural regions of China.In addition to serving as disease vectors,rats can also inflict bite injuries.In this study,we delineated the characterist... Background:Nasal defects due to rat bites are frequently encountered in rural regions of China.In addition to serving as disease vectors,rats can also inflict bite injuries.In this study,we delineated the characteristics of rat bite injuries in the nasal region and discussed the clinical features observed during a 10-year follow-up period.Methods:We retrospectively reviewed hospital records for patients admitted due to rat bites.This study outlines the demographics,clinical features,and follow-up outcomes supported by comprehensive photo documentation of the patients’progress.Results:Twenty-five patients,with a mean age of 29 years,were admitted due to rat bites.Treatment was provided for three distinct types of injuries:nasal tip defect(type Ⅰ),nasal defect(type Ⅱ),and full-thickness nasal defect with loss of surrounding tissues(type Ⅲ).All patients recovered fully.Conclusions:The treatment for rat bites should be based on the wound type.The long-term follow-up outcomes are more favorable when fewer subunits of the nose affected.We recommend early surgical intervention,along with psychological therapy,to prevent interference with growth and development. 展开更多
关键词 Rat bite Wound classification Nasal reconstruction
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Osteoarticular Lesions of the Shoulder Girdle by Hippopotamus Bite: Highly Septic Lesion
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作者 Jr Pierre Germain Ochou Achié Jean Régis Akobe +11 位作者 Yao Aboh Ganyn Robert Arnaud Assere Kouamé Jean-Eric Kouassi Adelaïde Aya Natacha Kouassi Ibrahim Soumahoro Zolopégué Marcel Soro Sédi Loues De Randolphe Akpro Gbalé Yannick Blé Kouamé Innocent M’bra Loukou Blaise Yao Bada Juste Léopold NiaoréSery Koffi Léopold Krah Michel Kodo 《Open Journal of Orthopedics》 2024年第2期114-121,共8页
Hippopotamus bites are rare in medical consultations, despite several studies exposing their aggressive character. A case of a hippopotamus bite on the shoulder of a fisherman has been reported. In addition to the ost... Hippopotamus bites are rare in medical consultations, despite several studies exposing their aggressive character. A case of a hippopotamus bite on the shoulder of a fisherman has been reported. In addition to the osteoarticular aspect representing a therapeutic problem, the infectious aspect was marked by sepsis, with a death in less than 48 hours. Based on this observation, a protocol for the initial management of large animal bites was submitted. 展开更多
关键词 bite HIPPOPOTAMUS Septic Shock
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新型双特异性单链抗体BiTEs及其在肿瘤治疗中的应用前景 被引量:2
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作者 于蕊 陈昭烈 《中国生物工程杂志》 CAS CSCD 2004年第4期1-6,共6页
BiTEs(bispecificTcellengagers)是一种以T细胞作为效应细胞的双特异性单链抗体 ,它具有两个抗原结合臂 ,可以同时和T细胞及靶细胞结合 ,并激活细胞毒性T细胞杀伤病变细胞。和其它双特异性抗体相比 ,BiTEs的分子柔韧性更好 ,能更好地促... BiTEs(bispecificTcellengagers)是一种以T细胞作为效应细胞的双特异性单链抗体 ,它具有两个抗原结合臂 ,可以同时和T细胞及靶细胞结合 ,并激活细胞毒性T细胞杀伤病变细胞。和其它双特异性抗体相比 ,BiTEs的分子柔韧性更好 ,能更好地促进CD3复合体和肿瘤靶标的连接 ,并且它不受T细胞受体和靶细胞上MHCⅠ类分子的约束 ,不需要共刺激分子的参与 ,是一种极具应用潜力的抗体形式。就BiTEs的结构、作用机理及其在肿瘤临床上的应用前景几个方面做一综述。 展开更多
关键词 biteS 双特异性单链抗体 细胞毒性T细胞 肿瘤 临床治疗
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基于MSFG的机载BITE故障定位算法研究 被引量:1
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作者 刘家学 杨梦娜 耿宏 《科学技术与工程》 北大核心 2016年第8期132-136,170,共6页
故障定位是机载BITE的重要功能,定位结果的准确性对维修测试有着重要影响。基于多信号流图模型,在构造故障-测试关联矩阵和故障-故障关联矩阵的基础上,引入故障信息矢量和故障定位矩阵,并给出适用于机载BITE故障定位的矢量描述和矩阵定... 故障定位是机载BITE的重要功能,定位结果的准确性对维修测试有着重要影响。基于多信号流图模型,在构造故障-测试关联矩阵和故障-故障关联矩阵的基础上,引入故障信息矢量和故障定位矩阵,并给出适用于机载BITE故障定位的矢量描述和矩阵定义,进而提出一种简单、有效的故障定位算法。实例验证表明,该算法能够对系统中的故障源进行准确定位。 展开更多
关键词 故障定位 多信号流图模型 机载bite系统 故障定位矩阵
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微环DNA表达抗EpCAM/抗CD3双特异BiTE分子的抗卵巢癌细胞体外实验研究 被引量:1
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作者 陈远群 谌平 +1 位作者 陈国创 韦枝红 《中国医药导报》 CAS 2019年第30期12-16,共5页
目的探讨抗EpCAM/抗CD3 BsAb分子蛋白对体外卵巢癌细胞生长的抑制效果。方法采用非病毒载体微环DNA表达抗EpCAM/抗CD3 BsAb分子蛋白。观察不同浓度(1×10^-3、1×10^-4、1×10^-5、1×10^-6、1×10^-7、1×10^-... 目的探讨抗EpCAM/抗CD3 BsAb分子蛋白对体外卵巢癌细胞生长的抑制效果。方法采用非病毒载体微环DNA表达抗EpCAM/抗CD3 BsAb分子蛋白。观察不同浓度(1×10^-3、1×10^-4、1×10^-5、1×10^-6、1×10^-7、1×10^-8μg/mL)抗EpCAM/抗CD3 BsAb分子蛋白加至卵巢癌细胞及T细胞中,经6 h和12 h培育后,利用倒置荧光显微镜观察活细胞与死亡细胞数量及形态变化。结果倒置显微镜下可见加抗体后卵巢癌细胞与T细胞明显聚集成块,周围见大量死亡细胞。相同时间下,随着浓度的增加,T细胞介导的卵巢癌肿瘤细胞的杀伤效果并不会一直增强。当浓度达到1×10^-4μg/mL时,培育6 h和12 h时的杀伤均达到最大,差异均有统计学意义(P<0.05)。结论新型的微环DNA表达系统所表达的抗EpCAM/抗CD3 BsAb对体外卵巢癌细胞生长具有抑制作用,未来可作为一种有效的抗卵巢癌肿瘤的靶向治疗药物。 展开更多
关键词 EPCAM CD3 双特异bite分子蛋白 卵巢癌 靶向治疗
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Bite turbo配合早期牵引治疗前牙反牙合的疗效分析
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作者 薛楠 赵阳 +1 位作者 戚琳 张扬 《口腔医学》 CAS 2016年第7期624-627,共4页
目的分析Bite turbo配合早期Ⅲ类牵引治疗前牙反牙合的临床效果。方法 16例恒牙期前牙反牙合且反覆牙合深的病例,下前牙舌侧粘接Bite turbo,并同时进行早期Ⅲ类牵引,观察其疗程及疗效。结果 16例病例均快速打开咬合并解除前牙反牙合。... 目的分析Bite turbo配合早期Ⅲ类牵引治疗前牙反牙合的临床效果。方法 16例恒牙期前牙反牙合且反覆牙合深的病例,下前牙舌侧粘接Bite turbo,并同时进行早期Ⅲ类牵引,观察其疗程及疗效。结果 16例病例均快速打开咬合并解除前牙反牙合。咬合打开后SNB减小、ANB增大,下颌平面角、下面高、下面高/全面高增大,上下磨牙均伸长、下切牙被压低,反覆盖解除,覆牙合减小。结论 Bite turbo配合早期Ⅲ类牵引可以快速打开咬合,解除前牙反牙合。 展开更多
关键词 bite TURBO 前牙反牙合 早期牵引
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双特异性单链抗体BiTE在肿瘤靶向治疗中的研究进展
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作者 董琼娜 蒋华 李宗海 《中国科技论文》 CAS 北大核心 2012年第12期963-966,共4页
BiTE(bispecificTcellengager)是一种以T细胞作为效应细胞的双特异性单链抗体,它具有2个抗原结合部位,可以同时结合T细胞及病变细胞表面的抗原分子,从而有效地激活静止的T细胞,达到杀伤病变细胞的目的。其分子量小,易穿透肿瘤组织,缺乏F... BiTE(bispecificTcellengager)是一种以T细胞作为效应细胞的双特异性单链抗体,它具有2个抗原结合部位,可以同时结合T细胞及病变细胞表面的抗原分子,从而有效地激活静止的T细胞,达到杀伤病变细胞的目的。其分子量小,易穿透肿瘤组织,缺乏Fc段,免疫源性低,是一种极具发展潜力的新型抗体形式。对BiTE的发展历程、结构和作用机制以及在肿瘤靶向治疗中的应用做简要综述。 展开更多
关键词 双特异性抗体 bite 定向杀伤 肿瘤靶向治疗
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共表达BiTE的溶瘤病毒对胶质瘤的抗肿瘤活性研究
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作者 许琼冠 欧阳一彬 谢镇明 《现代肿瘤医学》 CAS 北大核心 2022年第8期1354-1359,共6页
目的:探索编码BiTE的溶瘤病毒[分泌双特异性T细胞衔接器的单纯性孢疹病毒(herpes simplex virus-Bi-specific T-cell engagers,HSV-BiTE)]是否可以对胶质瘤产生显著的抗肿瘤活性。方法:荧光显微镜观察及Western blot检测HSV-BiTE对胶质... 目的:探索编码BiTE的溶瘤病毒[分泌双特异性T细胞衔接器的单纯性孢疹病毒(herpes simplex virus-Bi-specific T-cell engagers,HSV-BiTE)]是否可以对胶质瘤产生显著的抗肿瘤活性。方法:荧光显微镜观察及Western blot检测HSV-BiTE对胶质瘤细胞U118的感染能力及BiTE的表达情况;流式细胞术检测HSV-BiTE感染后U118的凋亡情况;小鼠移植瘤模型验证HSV-BiTE的体内抑瘤活性;免疫组化法检测肿瘤组织中Ki67和Cleaved Caspase3(Cl-Cas3)的表达;流式细胞术检测肿瘤浸润T细胞中IFN-γ和Granzyme B的表达情况。结果:HSV-BiTE可以有效感染U118细胞并表达BiTE;感染HSV-BiTE可以显著诱导U118细胞凋亡(P<0.001);HSV-BiTE较HSV而言可以有效抑制小鼠体内的肿瘤生长(P<0.001);HSV-BiTE治疗的小鼠较HSV治疗组可以降低肿瘤中Ki67的表达(P<0.01),同时增加Cl-Cas3的表达(P<0.01);HSV-BiTE治疗的小鼠较HSV治疗组可以显著提升肿瘤浸润T细胞中IFN-γ(P<0.001)和Granzyme B(P<0.0001)的表达水平。结论:HSV-BiTE在小鼠皮下移植瘤模型中显著抑制肿瘤生长,同时诱导肿瘤部位的T细胞发挥抗肿瘤功能。这种治疗方法优于未经改造的HSV治疗,支持进一步研究其在胶质瘤中的应用。 展开更多
关键词 胶质瘤 HSV bite 溶瘤病毒
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Habitat use by mountain nyala Tragelaphus buxtoni determined using stem bite diameters at point of browse, bite rates, and time budgets in the Bale Mountains National Park, Ethiopia
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作者 Solomon A. TADESSE Butt P. KOTLER 《Current Zoology》 SCIE CAS CSCD 2013年第6期707-717,共11页
We studied the habitat use of mountain nyala Tragelaphus buxtoni in the northern edge of the Bale Mountains Na- tional Park, Ethiopia. The aims of this study were to: (1) measure and quantify habitat-specific stem ... We studied the habitat use of mountain nyala Tragelaphus buxtoni in the northern edge of the Bale Mountains Na- tional Park, Ethiopia. The aims of this study were to: (1) measure and quantify habitat-specific stem bite diameters of mountain nyala foraging on common natural plant species in two major habitat types (i.e. grasslands versus woodlands), and (2) quantify the bite rates (number of bites per minute) and the activity time budgets of mountain nyala as functions of habitat type and sex-age category. We randomly laid out three transects in each habitat type. Following each transect, through focal animal obser- vations, we assessed and quantified stem diameters at point of browse (dpb), bite rates, and time budgets of mountain nyala in grasslands versus woodlands. Stem dpb provide a measure of natural giving-up densities (GUDs) and can be used to assess fora- ging costs and efficiencies, with greater stem dpb corresponding to lower costs and greater efficiencies. The results showed that stem dpb, bite rates, induced vigilance, and proportion of time spent in feeding differed between habitats. In particular, mountain nyala had greater stem dpb, higher bite rates, and spent a greater proportion of their time in feeding and less in induced vigilance in the grasslands. In addition, adult females had the highest bite rates, and the browse species Solanum marginatum had the greatest stem dpb. Generally, grasslands provide the mountain nyala with several advantages over the woodlands, including of- fering lower foraging costs, greater safety, and more time for foraging. The study advocates how behavioural indicators and natural GUDs are used to examine the habitat use of the endangered mountain nyala through applying non-invasive techniques. We conclude that the resulting measures are helpful for guiding conservation and management efforts and could be applicable to a number of endangered wildlife species including the mountain nyala . 展开更多
关键词 Behavioural indicators bite rates Mountain nyala Natural giving-up densities Non-invasive techniques Stem bite diameters Vigilance
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双特异性单链抗体BiTE的研究进展 被引量:2
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作者 周冲 于峰 +3 位作者 韩邦兴 周阳 刘黎琼 施海峰 《生物学杂志》 CAS CSCD 北大核心 2018年第4期76-80,共5页
癌症是严重威胁人类生存的重大疾病。BiTE(bispecific T-cell engager)所代表的一类具有显著抗肿瘤效应的双特异抗体,能够靶向性激活自身T细胞杀伤肿瘤细胞。BiTE由两个单链可变片段(scFv)组成,通过柔性融合接头串联连接。一个scFv识别... 癌症是严重威胁人类生存的重大疾病。BiTE(bispecific T-cell engager)所代表的一类具有显著抗肿瘤效应的双特异抗体,能够靶向性激活自身T细胞杀伤肿瘤细胞。BiTE由两个单链可变片段(scFv)组成,通过柔性融合接头串联连接。一个scFv识别T细胞表面蛋白CD3ε,而另一个scFv识别特异性肿瘤细胞表面抗原。BiTE的这种结构和特异性结合蛋白能力允许它将T细胞物理性地桥接肿瘤细胞而形成T细胞-BiTE-肿瘤细胞复合物,诱导免疫突触形成,刺激T细胞活化,产生杀伤肿瘤的细胞因子。近年来,BiTE在抗肿瘤研究中取得了显著进展,在临床上取得了理想的治疗效果。因此,对BiTE的结构、作用机制、临床应用以及创新性运用进行阐述。 展开更多
关键词 双特异性单链抗体 bite 免疫治疗
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The bonding bite plate combined with the face mask protracting maxilla to treat skeletal crossbite in the early mixed dentition
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作者 夜文敏 段银钟 +1 位作者 武俊杰 郭涛 《Journal of Medical Colleges of PLA(China)》 CAS 2007年第4期221-225,共5页
Objective: To evaluate the orthopedic effects of a new method to treat skeletal crossbite in the early mixed dentition. Methods :Twenty cases (5.8-7. 5 years old ) with skeletal crossbite were treated by bonding t... Objective: To evaluate the orthopedic effects of a new method to treat skeletal crossbite in the early mixed dentition. Methods :Twenty cases (5.8-7. 5 years old ) with skeletal crossbite were treated by bonding the bite plate combined with the face mask protracting the upper jaw. Cephalometric radiographs were taken and analyzed before and after treatments. Results: On average, in all 20 cases the maxilla was moved by 2.06 mm forwards the mandible was turned 2.45° downward and backwards the skeletal crossbites were corrected and the facial profiles were improved satisfactorily. The period of treatment was conducted for 1.7 months on average. Conclusion: A good effect can be achieved by bonding bite plate combined with the face mask protracting the upper jaw to treat skeletal crossbite in the early mixed dentition, which will benefit the craniofacial growth and the development of young children. 展开更多
关键词 bite plate face mask protracting upper jaw skeletal crossbite mixed dentition
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Culture Negative Disseminated Septic Polyarthritis Complicating Rat-Bite Fever in an Immunocompetent Adult
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作者 Mohammed Reda Sewilam Nasser Alhadhood 《Open Journal of Rheumatology and Autoimmune Diseases》 CAS 2022年第3期71-82,共12页
Rat-bite is uncommon worldwide, excluding developing countries. The history of a bite is usually missed if not meticulously asked for in history, proper exposure and examination. Today we report a case of culture-nega... Rat-bite is uncommon worldwide, excluding developing countries. The history of a bite is usually missed if not meticulously asked for in history, proper exposure and examination. Today we report a case of culture-negative rat-bite fever with poly septic arthritis resembling a rheumatoid arthritis-like picture in a 64-year-old gentleman. The presentation at first imitated an arthritis-like picture which was polyarthritis affecting the right ankle, right knee, right wrist, right proximal interphalangeal, left metacarpophalangeal and proximal interphalangeal joints. 展开更多
关键词 Rat-bite Fever Rat-bite Fever POLYARTHRITIS Culture-Negative Rheumatoid Arthritis Mimickers
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Root Resorption in Anterior Open Bite Malocclusions Due to Vertical Correction: A Radiometric Pilot Study
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作者 Suhina Kapoor David Briss +1 位作者 Shuying Jiang Thomas J. Cangialosi 《Open Journal of Orthopedics》 2023年第6期233-245,共13页
Introduction: One of the most common risks of fixed orthodontic therapy is the evidence of root resorption post orthodontic treatment ranging from mild root blunting to severe root resorption of significant portions o... Introduction: One of the most common risks of fixed orthodontic therapy is the evidence of root resorption post orthodontic treatment ranging from mild root blunting to severe root resorption of significant portions of the root structure. The etiology of apical root resorption is multifactorial but largely depends upon the type of orthodontic tooth movement and treatment duration. Study Objective: The primary aim of this study is to examine the association of external apical root resorption and vertical correction in anterior open bite malocclusions using panoramic radiographs for evaluation. Materials and Methods: Pre-treatment and post-treatment panoramic radiographs of 16 patients with anterior open bite malocclusions were scored to assess root resorption of anterior teeth (U/L 3-3). Initial and final root length and total tooth length for U/L 3-3 were measured on panoramic radiographs in Dolphin imaging. Results: Of the 24 pairs of measurements, 7 had a significant p-value (p Conclusions: A statistically significant amount of root resorption was observed, from pre-treatment to post-treatment radiographs. All mandibular anterior teeth except the mandibular right lateral incisors showed evidence of root resorption. 展开更多
关键词 Open bite malocclusion External apical root resorption Open bite closure
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