摘要
BiTEs(bispecificTcellengagers)是一种以T细胞作为效应细胞的双特异性单链抗体 ,它具有两个抗原结合臂 ,可以同时和T细胞及靶细胞结合 ,并激活细胞毒性T细胞杀伤病变细胞。和其它双特异性抗体相比 ,BiTEs的分子柔韧性更好 ,能更好地促进CD3复合体和肿瘤靶标的连接 ,并且它不受T细胞受体和靶细胞上MHCⅠ类分子的约束 ,不需要共刺激分子的参与 ,是一种极具应用潜力的抗体形式。就BiTEs的结构、作用机理及其在肿瘤临床上的应用前景几个方面做一综述。
BiTEs is a kind of bispecific single-chain antibodies that is capable of very potently activating resting T cells.It not only can link T cells and pathogenic cells,but also can efficiently stimulate cytotoxic T cells and induce target cell destruction.Compared to other bispecific formats,BiTEs has higher flexibility between the two binding arms suggesting that higher flexibility may facilitate the process of cross-linking of CD3 complex and tumor target.It is independent from a T cell’s receptor specificity and the presence of MHC class Ⅰ on target cells,without the need for costimulation of T cells.BiTEs has been thought as an potent and attractive concept in cancer therapy.This review describes the construction of BiTEs,its mechanism of action and prospect in cancer clinical trials.;
出处
《中国生物工程杂志》
CAS
CSCD
2004年第4期1-6,共6页
China Biotechnology
