Skin cancer remains the most commonly diagnosed malignancy worldwide,with basal cell carcinoma(BCC),cutaneous squamous cell carcinoma(cSCC),and melanoma representing the most clinically significant types.While traditi...Skin cancer remains the most commonly diagnosed malignancy worldwide,with basal cell carcinoma(BCC),cutaneous squamous cell carcinoma(cSCC),and melanoma representing the most clinically significant types.While traditional treatments are effective for early-stage disease,advanced or metastatic cases often pose significant therapeutic challenges.Patients with high-risk or recurrent disease face limited options and poor prognoses.The emergence of immunotherapy has dramatically transformed the treatment landscape across multiple cancer types,including cutaneous malignancies.This review highlights recent advancements in immunotherapeutic strategies for BCC,cSCC,and melanoma,underscoring their growing importance in dermatologic oncology.We synthesize current evidence and ongoing clinical trials for immunotherapy across these three skin cancer types.We also explore the molecular mechanisms underpinning immune responsiveness and potential biomarkers of response.As immunotherapy continues to expand within dermatology,understanding its role,limitations,and future directions is essential for optimizing patient care.The integration of immunotherapy into dermatologic practice represents not only a therapeutic innovation but also a shift toward precision medicine in cutaneous oncology.展开更多
The dynamics of calcium(Ca)and magnesium(Mg)in the forest floor and topsoil caused by anthropogenic and natural processes continue to be a concern in temperate forests.However,the impacts of abiotic and biotic variabl...The dynamics of calcium(Ca)and magnesium(Mg)in the forest floor and topsoil caused by anthropogenic and natural processes continue to be a concern in temperate forests.However,the impacts of abiotic and biotic variables as well as their interactions remain unclear,especially in areas undergoing long-term forest restoration.In this study,Ca and Mg concentrations in the forest floor and topsoil from 239 forest plots across the Loess Plateau were measured,and the effects of forest types,climate,soil properties,stand characteristics and nitrogen deposition were explored.The results showed significantly higher Ca concentrations in the forest floor(20.68±8.04 mg/g)than in the topsoil(13.28±12.83 mg/g),whereas Mg exhibited the inverse pattern(3.64±1.09 and 10.11±2.51 mg/g,respectively).The effect of forest types was only significant on forest floor Ca,and Ca concentrations were higher in broadleaf and mixed forests than in coniferous forests.Overall,Ca and Mg concentrations in forest floor and topsoil increased with latitudes while decreased with elevations,and the significance of the trends varied among forest types.Forest floor Ca and Mg were mainly influenced by environmental variables aboveground,i.e.,basal area(BA)and mean annual precipitation(MAP),respectively;topsoil Ca and Mg were more affected by soil properties(soil C/N and pH,respectively).Those suggested a depletion of Ca belowground was associated with forest growth and enriched soil nitrogen,and the leaching of mobile Mg was correlated with rainfall and soil acidification.Besides,the impact of environmental variables on Ca-Mg balance(Ca/Mg ratio)belowground was primarily through the regulation of Ca.Elucidating the influence of environmental variables will improve our ability to predict future changes in base cations and thus forest soil health in the greening vegetated Loess Plateau.展开更多
The Yangtze finless porpoise(Neophocaena asiaeorientalis asiaeorientalis,Pilleri&Gihr,1972;YFP)is an exclusively freshwater cetacean species inhabiting the Yangtze River and its connecting large lakes.As the prima...The Yangtze finless porpoise(Neophocaena asiaeorientalis asiaeorientalis,Pilleri&Gihr,1972;YFP)is an exclusively freshwater cetacean species inhabiting the Yangtze River and its connecting large lakes.As the primary line of defense in maintaining physiological equilibrium,the epidermis of the porpoise is expected to have undergone structural adaptations due to the shift from the marine to the freshwater environment.This study compared the microstructural and ultrastructural features of the epidermis of YFP and its marine counterpart,the East Asian finless porpoise(Neophocaena asiaeorientalis sunameri,Pilleri&Gihr,1975;EAFP).Microscopic structural observations and statistical analyses of the epidermal thickness demonstrated no significant differences in the cell structure or distribution between the two porpoise species.However,the epidermis of the YFP contained more abundant stratum basale cells.The outermost lipid stratum corneum exhibited a thinner cell layer with wider neutral lipid droplets to resist the passive entry of water molecules in the hypotonic environment.In contrast,for the EAFp,a more uniformly arranged stratum basale in the epidermis led to denser keratin fibers and robust desmosomes within each epidermal layer at the ultrastructural level.This tight arrangement of cells can reduce transepidermal water loss(TEWL)in an environment with higher osmotic pressure.In conclusion,the 2 finless porpoise species appear to employ different epidermal mechanisms to adapt to their distinct osmotic environments.The YFP appears to possess a"lipid waterproofing"epidermal structure,while the EAFP possesses a"thick and compact water-retaining"epidermal structure to copewithpotentialwaterloss.展开更多
The globus pallidus plays a pivotal role in the basal ganglia circuit. Parkinson's disease is characterized by degeneration of dopamine-producing cells in the substantia nigra, which leads to dopamine deficiency i...The globus pallidus plays a pivotal role in the basal ganglia circuit. Parkinson's disease is characterized by degeneration of dopamine-producing cells in the substantia nigra, which leads to dopamine deficiency in the brain that subsequently manifests as various motor and non-motor symptoms. This review aims to summarize the involvement of the globus pallidus in both motor and non-motor manifestations of Parkinson's disease. The firing activities of parvalbumin neurons in the medial globus pallidus, including both the firing rate and pattern, exhibit strong correlations with the bradykinesia and rigidity associated with Parkinson's disease. Increased beta oscillations, which are highly correlated with bradykinesia and rigidity, are regulated by the lateral globus pallidus. Furthermore,bradykinesia and rigidity are strongly linked to the loss of dopaminergic projections within the cortical-basal ganglia-thalamocortical loop. Resting tremors are attributed to the transmission of pathological signals from the basal ganglia through the motor cortex to the cerebellum-ventral intermediate nucleus circuit. The cortico–striato–pallidal loop is responsible for mediating pallidi-associated sleep disorders. Medication and deep brain stimulation are the primary therapeutic strategies addressing the globus pallidus in Parkinson's disease. Medication is the primary treatment for motor symptoms in the early stages of Parkinson's disease, while deep brain stimulation has been clinically proven to be effective in alleviating symptoms in patients with advanced Parkinson's disease,particularly for the movement disorders caused by levodopa. Deep brain stimulation targeting the globus pallidus internus can improve motor function in patients with tremordominant and non-tremor-dominant Parkinson's disease, while deep brain stimulation targeting the globus pallidus externus can alter the temporal pattern of neural activity throughout the basal ganglia–thalamus network. Therefore, the composition of the globus pallidus neurons, the neurotransmitters that act on them, their electrical activity,and the neural circuits they form can guide the search for new multi-target drugs to treat Parkinson's disease in clinical practice. Examining the potential intra-nuclear and neural circuit mechanisms of deep brain stimulation associated with the globus pallidus can facilitate the management of both motor and non-motor symptoms while minimizing the side effects caused by deep brain stimulation.展开更多
Basal melting and calving are the main pathways for mass loss in Antarctic ice shelves.Basal channels,as detailed variations in basal melting,mutually promote basal melting and calving,thereby weakening the stability ...Basal melting and calving are the main pathways for mass loss in Antarctic ice shelves.Basal channels,as detailed variations in basal melting,mutually promote basal melting and calving,thereby weakening the stability of ice shelves.Therefore,it is necessary to calculate and statistically analyze basal melting,basal channels,and calving events across all Antarctic ice shelves and examine the correlation among these three factors.This study utilizes various data sources to calculate the Basal Channel Density(BCD)and average basal melt rate of all Antarctic ice shelves during 2010-2020,as well as the spatial correlation between basal melting,basal channels,and calving.We found that ice shelves along the Amundsen Sea and Bellingshausen Sea have higher basal melt rates and basal channel densities,while other sea areas have lower values.This is mainly influenced by seabed topography and Circumpolar Deep Water.Excluding(CDW)extreme calving events,there is a positive correlation among basal melting,basal channels,and calving in coastal ice shelves across different sea areas,with a correlation coefficient exceeding 0.67.This indicates that basal melting and basal channels are major factors causing ice shelf calving.Our results emphasize the importance of the impact of basal melting,basal channels,and calving on ice shelf stability,and they provide a significant reference for further research on ice shelf-ocean interactions.展开更多
Introduction: Biotin-thiamine-responsive basal ganglia disease (BTBGD) is a neuroregressive disorder associated with subacute encephalopathy, confusion, dysarthria, and dysphagia, as well as occasional external ophtha...Introduction: Biotin-thiamine-responsive basal ganglia disease (BTBGD) is a neuroregressive disorder associated with subacute encephalopathy, confusion, dysarthria, and dysphagia, as well as occasional external ophthalmoplegia or supranuclear facial nerve palsy. It may progress to severe rigidity, dystonia, and quadriparesis. Combination therapy of high-dose thiamine and biotin helps to control the symptoms and prevent progression of the disease. Methods: This retrospective, cross-sectional study was conducted at King Fahad Medical City in Riyadh, Saudi Arabia, to investigate the demographic, clinical features, treatment response, outcomes, and predictive factors of BTBGD in the pediatric population. Results: Twenty-five records of pediatric patients diagnosed with BTBGD were included in the study. The most common symptoms observed at presentation were ataxia in 13 patients (52%), followed by developmental regression in 11 patients (44%), and seizures in 7 patients (28%). Statistically significant associations were found between patient’s age of presentation, seizures at presentation, lactate level and their health outcomes. Multivariate logistic regression analysis revealed significant differences in patient outcomes (prognosis) based on their age at presentation, seizures, and lactate levels (p Conclusion: This study reported BTBGD in 25 pediatric patients in Saudi Arabia. Age at presentation, seizures, and lactate levels were found to be significantly associated with patient health outcomes. Increasing public awareness of the condition, particularly among parents and pediatricians, is imperative. Early diagnosis, along with timely management using biotin and thiamine supplementation, promotes improved health outcomes and prevents progressive neurodegeneration and death.展开更多
Food is a critical environmental factor that influences animal survival,especially for small passerines due to their high mass-specific metabolic rates.Basal metabolic rate(BMR)reflects the energy expended by endother...Food is a critical environmental factor that influences animal survival,especially for small passerines due to their high mass-specific metabolic rates.Basal metabolic rate(BMR)reflects the energy expended by endothermic animals for basic physiological processes and constitutes a major part of their daily energy budget.Some birds have been shown to employ compensatory mechanisms during food shortages,temporarily reducing these selfmaintenance expenditures without using hypothermia.However,the mechanisms of BMR adjustment remain unexplored.In the present study,we assessed the phenotypic variation in basal thermogenesis of Eurasian Tree Sparrows(Passer montanus)by comparing a control group to groups fasted for 6,12,18,and 24 h.We focused on the correlation between a reduction in energy metabolism and the alterations of cellular metabolic activities,mitochondrial substrate supply,and changes in serum thyroid hormones during fasting.Our data indicated that fasting groups had significantly lower body mass,BMR,body temperature,and body fat content.Furthermore,fasting groups had significantly lower glycogen levels,mitochondrial state 4 respiration and cytochrome c oxidase(CCO)activity in the liver,and CCO activity in pectoral muscle.The levels of avian uncoupling protein(avUCP)m RNA were significantly reduced,while the levels of myostatin protein in pectoral muscle were significantly increased in the fasting groups.Furthermore,the groups subjected to fasting exhibited significantly lower levels of serum glucose,triglyceride,thyroxine(T_(4)),and triiodothyronine(T_(3)).Positive correlations were observed between the following pairs of variables:log BMR and log body mass,log body mass and log body fat,log BMR and log state 4 respiration in the liver,log BMR and log CCO activity in the liver and muscle,log BMR and log av-UCP m RNA expression,whereas a negative correlation was observed between log BMR and log myostatin level.In addition,a positive correlation was also detected between log T_(3) and each of the following:log BMR,state 4 respiration,and log CCO activity in the liver.Our results suggested that decreased metabolic thermogenesis via down-regulation in cellular aerobic capacity of organs and serum thyroid hormones may be an important survival strategy for fasting Tree Sparrows to reduce energy expenditure.展开更多
Dear Editor,The primary motor cortex,also known as MOp in rodents,F1,or M1 in primates[1],plays a crucial role in autonomous motor control.It is interconnected with other motor control structures such as the basal gan...Dear Editor,The primary motor cortex,also known as MOp in rodents,F1,or M1 in primates[1],plays a crucial role in autonomous motor control.It is interconnected with other motor control structures such as the basal ganglia,thalamus,and brainstem.Among these connections,the corticostriatal system plays a significant role in functions including action selection,motor control,sequence learning,and habit formation[2].展开更多
Brain calcification is frequently detected by neuroimaging in patients with hereditary and nonhereditary disorders or in normal individuals with aging.Its prevalence ranges from approximately 1%in young people to over...Brain calcification is frequently detected by neuroimaging in patients with hereditary and nonhereditary disorders or in normal individuals with aging.Its prevalence ranges from approximately 1%in young people to over 20%in the elderly(Yamada et al.,2013),yet the underlying mechanisms of brain calcification remain poorly understood.Specifically,calcification in the basal ganglia is detected in approximately 5.5%-20%of CT scans in patients over 50 years old(Auffray-Calvier et al.,2020).展开更多
Models that predict a forest stand’s evolution are essential for developing plans for sustainable management.A simple mathematical framework was developed that con-siders the individual tree and stand basal area unde...Models that predict a forest stand’s evolution are essential for developing plans for sustainable management.A simple mathematical framework was developed that con-siders the individual tree and stand basal area under random resource competition and is based on two assumptions:(1)a sigmoid-type stochastic process governs tree and stand basal area dynamics of living and dying trees,and(2)the total area that a tree may potentially occupy determines the number of trees per hectare.The most effective method to satisfy these requirements is formalizing each tree diameter and potentially occupied area using Gompertz-type stochastic differential equations governed by fixed and mixed-effect parameters.Data from permanent experimental plots from long-term Lithuania experiments were used to construct the tree and stand basal area models.The new models were relatively unbiased for live trees of all species,including silver birch(Betula pen-dula Roth)and downy birch(Betula pubescens Ehrh.),[spruce(Picea abies),and pine(Pinus sylvestris)].Less reliable predic-tions were made for the basal area of dying trees.Pines gave the highest accuracy prediction of mean basal area among all live trees.The mean basal area prediction for all dying trees was lower than that for live trees.Among all species,pine also had the best average basal area prediction accuracy for live trees.Newly developed basal area growth and yield models can be recommended despite their complex formulation and implementation challenges,particularly in situations when data is scarce.This is because the newly observed plot provides sufficient information to calibrate random effects.展开更多
Arogenate dehydratase(ADT)catalyzes the final step in phenylalanine synthesis and is crucial for plant development and metabolism.Previously,we demonstrated that the ADT/prephenate dehydratase ZmADT2 is essential for ...Arogenate dehydratase(ADT)catalyzes the final step in phenylalanine synthesis and is crucial for plant development and metabolism.Previously,we demonstrated that the ADT/prephenate dehydratase ZmADT2 is essential for maize resistance to Ustilago maydis and for overall plant development.In this study,we explored the role of ZmADT2 in maize kernel development.The mmsu mutant,a dysfunctional ZmADT2 variant,exhibits delayed embryo and endosperm development,along with deficiencies in carbohydrate and protein storage.Transcriptome analysis revealed differential expression of many kernel compartment-specific genes between mmsu and wild-type(WT)kernels,with impaired nutrient accumulation and auxin signaling pathway in the mmsu endosperm.Compared to WT,ZmADT2 mutation led to reduced auxin levels and smaller endosperm cell size.Exogenous auxin rescued the small kernel phenotype of mmsu.Additionally,auxin distribution was reduced in the basal endosperm transfer layer(BETL),causing defects in its development and function,including reduced transfer cell elongation,cell wall ingrowth and nutrient uptake.These findings suggest that ZmADT2 mediated mediates an auxin signaling pathway that is essential for maize kernel development.展开更多
A sparsely introduced basal intrinsic 2-type stacking fault(I_(2)-SF)with a dense segregation of clusters(cluster-arranged layer;CAL)inα-Mg exerts a sufficient strengthening effect with a reduced content of additive ...A sparsely introduced basal intrinsic 2-type stacking fault(I_(2)-SF)with a dense segregation of clusters(cluster-arranged layer;CAL)inα-Mg exerts a sufficient strengthening effect with a reduced content of additive elements.Moreover,the dynamic nucleation and growth of CALs during deformation largely improves the creep resistance.This paper analyzes the cosegregation behaviors of yttrium(Y)and zinc(Zn)atoms at an I_(2)-SF in bulk and at basal edge dislocations using density functional theory calculations.We also study the modification of the generalized stacking-fault energy(GSFE)curves associated with the cosegregation.The segregation energies of Y and Zn atoms in the I_(2)-SF are relatively small during the initial segregation of a cluster,but increases stepwise as the cluster grows.After introducing Y and Zn atoms in the I_(2)-SF in an energetically stable order,we obtain an L1_(2)-type cluster resembling that reported in the literature.Small structural changes driven by vacancy diffusion produce an exact L1_(2)-type cluster.Meanwhile,the core of the Shockley partial dislocation generates sufficient segregation energy for cluster nucleation.Migration of the Shockley partial dislocation and expansion of the I_(2)-SF part are observed at a specific cluster size.The migration is triggered by a large modification of the GSFE curve and destabilization of the hexagonal close-packed stacking(hcp)by the segregated atoms.At this point,the cluster has reached sufficient size and continues to follow the growth in the I_(2)-SF part.According to our findings,the CAL at elevated temperature is formed through repeated synchronized behavior of cluster nucleation at the Shockley partial dislocation,dislocation migration triggered by the destabilized hcp stacking,and following of cluster growth in the I_(2)-SF part of the dislocation.展开更多
Basal cell carcinoma(BCC)is the most prevalent form of skin cancer in the world,primarily affecting sun-exposed areas,including the periocular region.When BCC occurs near the eyes,surgical treatment becomes uniquely c...Basal cell carcinoma(BCC)is the most prevalent form of skin cancer in the world,primarily affecting sun-exposed areas,including the periocular region.When BCC occurs near the eyes,surgical treatment becomes uniquely complex.Excess excisions may cause detrimental effects to eyelid function and undesirable aesthetic outcomes.Conversely,adequate resection must occur to prevent further disease progression.Mohs micrographic surgery(MMS),a technique offering high remission rates,is often employed for periocular BCC.This method allows for precise cancer removal while preserving as much healthy tissue as possible,balancing the need for both effective treatment and aesthetic and functional preservation.Following Mohs surgery of periocular BCC,reconstruction methods vary and can be tailored based on the size of the resection and the functional requirements of the affected tissue.Amongst these methods,primary closure with and without secondary intentions,direct margin repair,local flap closure and advance flap,Tenzel flap,tarso-conjunctival flap,periocular skin grafting,and structural grafting are commonly utilized and each has its advantages and limitations.In the future,advancements in synthetic flaps and stabilizing glues in the periocular region may provide additional tools for post-Mohs reconstruction.However,these emerging techniques require further research to establish efficacy and safety,especially in more complex and sensitive regions like the periocular tissues.The primary purpose of this review is to provide a comprehensive analysis of periocular reconstructive techniques following Mohs surgery,comparing their efficacy,functional outcomes,and aesthetic considerations while addressing recent advancements such as synthetic flaps and stabilizing glues to guide clinical decision-making.展开更多
BACKGROUND Basal cell carcinoma(BCC)is the most prevalent skin cancer,characterized by indolent growth and low metastatic rates.When metastatic BCC(mBCC)does occur,it most commonly involves lymph nodes,lungs,and bones...BACKGROUND Basal cell carcinoma(BCC)is the most prevalent skin cancer,characterized by indolent growth and low metastatic rates.When metastatic BCC(mBCC)does occur,it most commonly involves lymph nodes,lungs,and bones,with metastases to other sites being exceptionally rare.This case reports the first documented instance of mBCC to the stomach,highlighting the importance of considering atypical metastatic sites,and the challenges associated with diagnosis and management.CASE SUMMARY A 52-year-old male with recurrent BCC and known mBCC to the bone presented with progressive dysphagia,cranial neuropathies and generalized weakness.He had been treated with immune checkpoint inhibitors,with intermittent therapy modifications due to treatment related toxicities.His past history was notable for malignant perineural invasion,radiotherapy for osseous metastases,immune checkpoint inhibitor-induced enteritis,and osteonecrosis of the jaw.Gastroscopy revealed subepithelial gastric lesions,and biopsies confirmed mBCC-a previously unreported site of disease dissemination.A multidisciplinary team involving gastroenterology,oncology,neurology,and palliative care guided his management.Given his declining functional status and poor prognosis,he was ultimately transitioned to hospice care.CONCLUSION Clinicians should consider atypical metastatic sites in advanced BCC.A multidisciplinary approach remains essential for timely diagnosis and coordinated management.展开更多
Objective:To analyze the therapeutic effect and prognosis of frameless stereotactic soft channel intracranial hematoma evacuation for severe basal ganglia hemorrhage.Methods:Clinical data of 411 patients with severe b...Objective:To analyze the therapeutic effect and prognosis of frameless stereotactic soft channel intracranial hematoma evacuation for severe basal ganglia hemorrhage.Methods:Clinical data of 411 patients with severe basal ganglia hemorrhage admitted to the Neurological Intensive Care Unit of Linyi People’s Hospital from January 2020 to December 2021 were collected.According to the modified Rankin Scale(mRS)score at 180 days after onset,the patients were divided into the good prognosis group and the poor prognosis group.The therapeutic effect of frameless stereotactic soft channel intracranial hematoma evacuation on severe basal ganglia hemorrhage was explored,and the influencing factors of prognosis were analyzed.Results:Multivariate Logistic regression analysis showed that the admission Glasgow Coma Scale(GCS)score was an independent protective factor for the prognosis of patients with severe basal ganglia hemorrhage,while age,preoperative hematoma volume,random blood glucose level,and mechanical ventilation were independent risk factors.Conclusion:Frameless stereotactic soft channel intracranial hematoma evacuation has a good therapeutic effect on severe basal ganglia hemorrhage.However,it is necessary to screen the patients’basic information before surgery and provide medical care based on their specific conditions to promote their rapid recovery.展开更多
BACKGROUND High-resolution optical coherence tomography(HR-OCT)has become an essential instrument in the screening and diagnosis of ocular surface neoplasms.Research demonstrates that HR-OCT possesses a diagnostic sen...BACKGROUND High-resolution optical coherence tomography(HR-OCT)has become an essential instrument in the screening and diagnosis of ocular surface neoplasms.Research demonstrates that HR-OCT possesses a diagnostic sensitivity ranging from 85%to 90%for ocular surface squamous neoplasia(OSSN).The connections between HR-OCT features and histological findings have consistently shown robustness,hence increasing the reliability of clinical diagnosis.AIM To examine the existing HR-OCT indicators employed in the identification of common non-benign ocular surface tumors,namely,basal cell carcinoma,OSSN,and melanocytic conjunctival lesions,and to assess their diagnostic efficacy,benefits,and prospective developments.METHODS A thorough literature review was performed to assess the published research on HR-OCT in the diagnosis of ocular surface cancers.Significant attention was given to research that compares HR-OCT characteristics with histopath-ologic validation,as well as on publications addressing the integration of emerging technologies and artificial intelligence in ocular oncology imaging.RESULTS HR-OCT exhibits elevated diagnostic sensitivity(85%-90%)for identifying OSSN and presents distinct imaging patterns that align closely with histology results.This approach has substantial clinical advantages due to its non-invasive characteristics,improved axial resolution,and real-time imaging capabilities.HR-OCT has demonstrated potential in assessing various lesions,including basal cell carcinoma and melanocytic conjunctival malignancies.CONCLUSION HR-OCT assumes an increasingly vital role in the early identification and clinical management of ocular surface malignancies.With advancements in imaging technology and the integration of artificial intelligence,HR-OCT is anticipated to enhance individualized diagnosis and treatment planning in ocular oncology,hence improving patient outcomes.展开更多
A tree's basal area(BA)and wood volume scale exponentially with tree diameter in species-specifc patterns.Recent observed increases in tree growth suggest these allometric relationships are shifting in response to...A tree's basal area(BA)and wood volume scale exponentially with tree diameter in species-specifc patterns.Recent observed increases in tree growth suggest these allometric relationships are shifting in response to climate change,rising CO_(2) levels,and/or changes in forest management.We analyzed 9,214 cores from nine conifer and 11 broadleaf species grown in managed mixed-species stands in the upper Midwest to quantify how well diameter(diameter at breast height(DBH))serves to predict BA growth and above-ground wood and carbon(C).These samples include many large trees.We ft mixed models to predict BA growth and above-ground biomass/C from diameter,tree height,and the BA of nearby trees while controlling for site effects.Models account for 55%–83%of the variance in log(recent growth),improving predictions over earlier models.Growth-diameter scaling exponents covary with certain leaf and stem(but not wood)functional traits,reflecting growth strategies.LogBA increment scales linearly with log(diameter)as trees grow bigger in 16/20 species and growth actually accelerates in Quercus rubra L.Three other species plateau in growth.Growth only decelerates in red pine,Pinus resinosa Ait.Growth in whole-tree,above-ground biomass,and C accelerate even more strongly with diameter(mean exponent:2.08 vs.1.30 for BA growth).Sustained BA growth and accelerating wood/C growth contradict the common assumption that tree growth declines in bigger trees.Yield tables and silvicultural guidelines should be updated to reflect these current relationships.Such revisions will favor delaying harvests in many managed stands to increase wood production and enhance ecosystem values including C fxation and storage.Further research may resolve the relative roles of thinning,climatic conditions,nitrogen inputs,and rising CO2 levels on changing patterns of tree growth.展开更多
Basal cell carcinoma(BCC)and cutaneous squamous cell carcinoma(cSCC),as certain forms of nonmelanoma skin cancer(NMSC)or keratinocyte carcinoma,are the most common forms of malignant neoplasms worldwide(Sharp et al.,2...Basal cell carcinoma(BCC)and cutaneous squamous cell carcinoma(cSCC),as certain forms of nonmelanoma skin cancer(NMSC)or keratinocyte carcinoma,are the most common forms of malignant neoplasms worldwide(Sharp et al.,2024).BCC and cSCC have been identified as two major components of NMSC,comprising one-third of all malignancies(Burton et al.,2016).Generally speaking,patients with NMSC tend to have relatively favorable survival outcomes,while different histopathological subtypes of NMSC exhibit distinct biological behaviors(Stătescu et al.,2023).展开更多
To understand metabolic adaptations,the basal metabolic rate（BMR） of Mrs Hume＇s Pheasant（Syrmaticus humiae） and Elliot＇s Pheasant（Syrmaticus ellioti） were investigated.Metabolic rate（MR）,body temperature（Tb...To understand metabolic adaptations,the basal metabolic rate（BMR） of Mrs Hume＇s Pheasant（Syrmaticus humiae） and Elliot＇s Pheasant（Syrmaticus ellioti） were investigated.Metabolic rate（MR）,body temperature（Tb） and thermal conductance（C） were determined in both species at a temperatrue range of 5-35 ℃,respectively.Oxygen consumption was measured with a closed circuit respirometer.The thermal neutral zones（TNZ） were 24.5-31.6 ℃,and 23.0-29.2 ℃,respectively.With a temperature range of 5-35 ℃,Mrs Hume＇s Pheasant and Elliot＇s Pheasant could maintained stable Tb at a mean of（40.47±0.64） and（40.36±0.10） ℃,respectively.Mean BMRs within TNZs were（1.36±0.84） mLO2/（g.h） for Mrs Hume＇s Pheasant and（2.03±0.12） mLO2/（g.h） for Elliot＇s Pheasant,which were 77% and 86% of the expected value based on their body mass,respectively.Thermal conductance of Mrs Hume＇s Pheasant and Elliot＇s Pheasant were（0.12±0.01） and（0.17±0.01） mLO2/（g.h.℃）,below the lower critical temperature,respectively,which were 119% and 124% of the expected value based on their body mass,respectively.The ecophysiological characteristics of these species were low metabolic rate,high body temperature,and high thermal conductance,which allow both species to better adapt to the warmer climate environment in south China.展开更多
文摘Skin cancer remains the most commonly diagnosed malignancy worldwide,with basal cell carcinoma(BCC),cutaneous squamous cell carcinoma(cSCC),and melanoma representing the most clinically significant types.While traditional treatments are effective for early-stage disease,advanced or metastatic cases often pose significant therapeutic challenges.Patients with high-risk or recurrent disease face limited options and poor prognoses.The emergence of immunotherapy has dramatically transformed the treatment landscape across multiple cancer types,including cutaneous malignancies.This review highlights recent advancements in immunotherapeutic strategies for BCC,cSCC,and melanoma,underscoring their growing importance in dermatologic oncology.We synthesize current evidence and ongoing clinical trials for immunotherapy across these three skin cancer types.We also explore the molecular mechanisms underpinning immune responsiveness and potential biomarkers of response.As immunotherapy continues to expand within dermatology,understanding its role,limitations,and future directions is essential for optimizing patient care.The integration of immunotherapy into dermatologic practice represents not only a therapeutic innovation but also a shift toward precision medicine in cutaneous oncology.
基金supported by the National Natural Science Foundation of China(42401054)Natural Science Foundation of Hebei Province(D2024205019)Science and Technology Project of Hebei Education Department(BJ2025014).
文摘The dynamics of calcium(Ca)and magnesium(Mg)in the forest floor and topsoil caused by anthropogenic and natural processes continue to be a concern in temperate forests.However,the impacts of abiotic and biotic variables as well as their interactions remain unclear,especially in areas undergoing long-term forest restoration.In this study,Ca and Mg concentrations in the forest floor and topsoil from 239 forest plots across the Loess Plateau were measured,and the effects of forest types,climate,soil properties,stand characteristics and nitrogen deposition were explored.The results showed significantly higher Ca concentrations in the forest floor(20.68±8.04 mg/g)than in the topsoil(13.28±12.83 mg/g),whereas Mg exhibited the inverse pattern(3.64±1.09 and 10.11±2.51 mg/g,respectively).The effect of forest types was only significant on forest floor Ca,and Ca concentrations were higher in broadleaf and mixed forests than in coniferous forests.Overall,Ca and Mg concentrations in forest floor and topsoil increased with latitudes while decreased with elevations,and the significance of the trends varied among forest types.Forest floor Ca and Mg were mainly influenced by environmental variables aboveground,i.e.,basal area(BA)and mean annual precipitation(MAP),respectively;topsoil Ca and Mg were more affected by soil properties(soil C/N and pH,respectively).Those suggested a depletion of Ca belowground was associated with forest growth and enriched soil nitrogen,and the leaching of mobile Mg was correlated with rainfall and soil acidification.Besides,the impact of environmental variables on Ca-Mg balance(Ca/Mg ratio)belowground was primarily through the regulation of Ca.Elucidating the influence of environmental variables will improve our ability to predict future changes in base cations and thus forest soil health in the greening vegetated Loess Plateau.
基金supported by the National Key R&D Program of China(2021YFD1200304).
文摘The Yangtze finless porpoise(Neophocaena asiaeorientalis asiaeorientalis,Pilleri&Gihr,1972;YFP)is an exclusively freshwater cetacean species inhabiting the Yangtze River and its connecting large lakes.As the primary line of defense in maintaining physiological equilibrium,the epidermis of the porpoise is expected to have undergone structural adaptations due to the shift from the marine to the freshwater environment.This study compared the microstructural and ultrastructural features of the epidermis of YFP and its marine counterpart,the East Asian finless porpoise(Neophocaena asiaeorientalis sunameri,Pilleri&Gihr,1975;EAFP).Microscopic structural observations and statistical analyses of the epidermal thickness demonstrated no significant differences in the cell structure or distribution between the two porpoise species.However,the epidermis of the YFP contained more abundant stratum basale cells.The outermost lipid stratum corneum exhibited a thinner cell layer with wider neutral lipid droplets to resist the passive entry of water molecules in the hypotonic environment.In contrast,for the EAFp,a more uniformly arranged stratum basale in the epidermis led to denser keratin fibers and robust desmosomes within each epidermal layer at the ultrastructural level.This tight arrangement of cells can reduce transepidermal water loss(TEWL)in an environment with higher osmotic pressure.In conclusion,the 2 finless porpoise species appear to employ different epidermal mechanisms to adapt to their distinct osmotic environments.The YFP appears to possess a"lipid waterproofing"epidermal structure,while the EAFP possesses a"thick and compact water-retaining"epidermal structure to copewithpotentialwaterloss.
基金supported by the National Natural Science Foundation of China,No.31771143 (to QZ)Shanghai Municipal Science and Technology Major Project,ZJ Lab+1 种基金Shanghai Center for Brain Science and Brain-Inspired Technology,No.2018SHZDZX01 (to LC)Shanghai Zhou Liangfu Medical Development Foundation “Brain Science and Brain Diseases Youth Innovation Program”(to ZQ)。
文摘The globus pallidus plays a pivotal role in the basal ganglia circuit. Parkinson's disease is characterized by degeneration of dopamine-producing cells in the substantia nigra, which leads to dopamine deficiency in the brain that subsequently manifests as various motor and non-motor symptoms. This review aims to summarize the involvement of the globus pallidus in both motor and non-motor manifestations of Parkinson's disease. The firing activities of parvalbumin neurons in the medial globus pallidus, including both the firing rate and pattern, exhibit strong correlations with the bradykinesia and rigidity associated with Parkinson's disease. Increased beta oscillations, which are highly correlated with bradykinesia and rigidity, are regulated by the lateral globus pallidus. Furthermore,bradykinesia and rigidity are strongly linked to the loss of dopaminergic projections within the cortical-basal ganglia-thalamocortical loop. Resting tremors are attributed to the transmission of pathological signals from the basal ganglia through the motor cortex to the cerebellum-ventral intermediate nucleus circuit. The cortico–striato–pallidal loop is responsible for mediating pallidi-associated sleep disorders. Medication and deep brain stimulation are the primary therapeutic strategies addressing the globus pallidus in Parkinson's disease. Medication is the primary treatment for motor symptoms in the early stages of Parkinson's disease, while deep brain stimulation has been clinically proven to be effective in alleviating symptoms in patients with advanced Parkinson's disease,particularly for the movement disorders caused by levodopa. Deep brain stimulation targeting the globus pallidus internus can improve motor function in patients with tremordominant and non-tremor-dominant Parkinson's disease, while deep brain stimulation targeting the globus pallidus externus can alter the temporal pattern of neural activity throughout the basal ganglia–thalamus network. Therefore, the composition of the globus pallidus neurons, the neurotransmitters that act on them, their electrical activity,and the neural circuits they form can guide the search for new multi-target drugs to treat Parkinson's disease in clinical practice. Examining the potential intra-nuclear and neural circuit mechanisms of deep brain stimulation associated with the globus pallidus can facilitate the management of both motor and non-motor symptoms while minimizing the side effects caused by deep brain stimulation.
文摘目的探究肌层浸润性膀胱癌(muscle-invasive bladder cancer,MIBC)分子亚型特异性,为不同MIBC分子亚型患者的治疗提供指导。方法基于MIBC分子分型方法中的UNC分型法,应用转录组测序数据,将48例MIBC患者分为2种分子亚型即Basal型和Luminal型,并进行差异表达分析以探究MIBC特异性的lncRNAs,并进一步探讨其分子特征和临床意义。结合单细胞质谱流式细胞术(single-cell mass cytometry,CyTOF)和镜像质谱流式细胞术(imaging mass cytometry,IMC)分析MBNL1-AS1高表达组和低表达组Basal型MIBC患者的免疫微环境异质性。结果基于分子分型法筛选发现了在MIBC特异性表达的lncRNA MBNL1-AS1,其低表达与Basal型MIBC患者的不良预后密切相关(P=0.022)。且进一步分析转录组测序数据后发现,在Basal型MIBC中,MBNL1-AS1低表达组具有去分化(P=0.008)、高干性(P=0.020)和高增殖(P=0.010)的特征。MBNL1-AS1低表达组的Basal型MIBC患者的免疫评分与NK CD56bright细胞和Treg细胞的评分呈负相关(P<0.05),而MBNL1-AS1高表达组的B细胞和CD8+T细胞相关基因的表达水平较高。高维度单细胞蛋白质组学分析结果显示,MBNL1-AS1低表达的Basal型MIBC患者表现出较高的Treg细胞亚群丰度(P=0.016)。结论MBNL1-AS1低表达组的Basal型MIBC患者具有去分化、高干性、高增殖和免疫抑制的特点。MBNL1-AS1具有作为Basal型MIBC免疫响应生物标志物的潜能。
基金The National Natural Science Foundation of China No.42406251the Fundamental Research Funds for the Central Universities under contract No.2042025kf0079 and 2042025kf0080+2 种基金the Postdoctoral Fellowship Program of CPSF under contract No.GZC20241257the Postdoctoral Fellowship Program of CPSF under contract No.GZC20241257the Key Laboratory of Polar Environment Monitoring and Public Governance(Wuhan University),the Ministry of Education Open Fund under contract Nos 202403 and 202405.
文摘Basal melting and calving are the main pathways for mass loss in Antarctic ice shelves.Basal channels,as detailed variations in basal melting,mutually promote basal melting and calving,thereby weakening the stability of ice shelves.Therefore,it is necessary to calculate and statistically analyze basal melting,basal channels,and calving events across all Antarctic ice shelves and examine the correlation among these three factors.This study utilizes various data sources to calculate the Basal Channel Density(BCD)and average basal melt rate of all Antarctic ice shelves during 2010-2020,as well as the spatial correlation between basal melting,basal channels,and calving.We found that ice shelves along the Amundsen Sea and Bellingshausen Sea have higher basal melt rates and basal channel densities,while other sea areas have lower values.This is mainly influenced by seabed topography and Circumpolar Deep Water.Excluding(CDW)extreme calving events,there is a positive correlation among basal melting,basal channels,and calving in coastal ice shelves across different sea areas,with a correlation coefficient exceeding 0.67.This indicates that basal melting and basal channels are major factors causing ice shelf calving.Our results emphasize the importance of the impact of basal melting,basal channels,and calving on ice shelf stability,and they provide a significant reference for further research on ice shelf-ocean interactions.
文摘Introduction: Biotin-thiamine-responsive basal ganglia disease (BTBGD) is a neuroregressive disorder associated with subacute encephalopathy, confusion, dysarthria, and dysphagia, as well as occasional external ophthalmoplegia or supranuclear facial nerve palsy. It may progress to severe rigidity, dystonia, and quadriparesis. Combination therapy of high-dose thiamine and biotin helps to control the symptoms and prevent progression of the disease. Methods: This retrospective, cross-sectional study was conducted at King Fahad Medical City in Riyadh, Saudi Arabia, to investigate the demographic, clinical features, treatment response, outcomes, and predictive factors of BTBGD in the pediatric population. Results: Twenty-five records of pediatric patients diagnosed with BTBGD were included in the study. The most common symptoms observed at presentation were ataxia in 13 patients (52%), followed by developmental regression in 11 patients (44%), and seizures in 7 patients (28%). Statistically significant associations were found between patient’s age of presentation, seizures at presentation, lactate level and their health outcomes. Multivariate logistic regression analysis revealed significant differences in patient outcomes (prognosis) based on their age at presentation, seizures, and lactate levels (p Conclusion: This study reported BTBGD in 25 pediatric patients in Saudi Arabia. Age at presentation, seizures, and lactate levels were found to be significantly associated with patient health outcomes. Increasing public awareness of the condition, particularly among parents and pediatricians, is imperative. Early diagnosis, along with timely management using biotin and thiamine supplementation, promotes improved health outcomes and prevents progressive neurodegeneration and death.
基金financially supported by grants from the National Natural Science Foundation of China (Nos.32371573,32171497,and 31971420)。
文摘Food is a critical environmental factor that influences animal survival,especially for small passerines due to their high mass-specific metabolic rates.Basal metabolic rate(BMR)reflects the energy expended by endothermic animals for basic physiological processes and constitutes a major part of their daily energy budget.Some birds have been shown to employ compensatory mechanisms during food shortages,temporarily reducing these selfmaintenance expenditures without using hypothermia.However,the mechanisms of BMR adjustment remain unexplored.In the present study,we assessed the phenotypic variation in basal thermogenesis of Eurasian Tree Sparrows(Passer montanus)by comparing a control group to groups fasted for 6,12,18,and 24 h.We focused on the correlation between a reduction in energy metabolism and the alterations of cellular metabolic activities,mitochondrial substrate supply,and changes in serum thyroid hormones during fasting.Our data indicated that fasting groups had significantly lower body mass,BMR,body temperature,and body fat content.Furthermore,fasting groups had significantly lower glycogen levels,mitochondrial state 4 respiration and cytochrome c oxidase(CCO)activity in the liver,and CCO activity in pectoral muscle.The levels of avian uncoupling protein(avUCP)m RNA were significantly reduced,while the levels of myostatin protein in pectoral muscle were significantly increased in the fasting groups.Furthermore,the groups subjected to fasting exhibited significantly lower levels of serum glucose,triglyceride,thyroxine(T_(4)),and triiodothyronine(T_(3)).Positive correlations were observed between the following pairs of variables:log BMR and log body mass,log body mass and log body fat,log BMR and log state 4 respiration in the liver,log BMR and log CCO activity in the liver and muscle,log BMR and log av-UCP m RNA expression,whereas a negative correlation was observed between log BMR and log myostatin level.In addition,a positive correlation was also detected between log T_(3) and each of the following:log BMR,state 4 respiration,and log CCO activity in the liver.Our results suggested that decreased metabolic thermogenesis via down-regulation in cellular aerobic capacity of organs and serum thyroid hormones may be an important survival strategy for fasting Tree Sparrows to reduce energy expenditure.
基金supported by the National Key R&D Program of China(2020YFE0205900 and 2022YEF0203200)the STI 2030-Major Project(2021ZD0200104 and 2022ZD0205203)+2 种基金the Shenzhen Science and Technology Program(RCYX20210706092100003,RCBS20221008093311027,and JCYJ20210324102006018)the Youth Innovation Promotion Association CAS(2022367)the Shenzhen Technological Research Center for Primate Translational Medicine grant(XMHT20220104005).
文摘Dear Editor,The primary motor cortex,also known as MOp in rodents,F1,or M1 in primates[1],plays a crucial role in autonomous motor control.It is interconnected with other motor control structures such as the basal ganglia,thalamus,and brainstem.Among these connections,the corticostriatal system plays a significant role in functions including action selection,motor control,sequence learning,and habit formation[2].
基金supported by the Natural Science Foundation of China(32270663 and 31230045 to J.Y.L.)China Postdoctoral Science Foundation(2024M762007 and GZB20240453 to J.L.)Shanghai Municipal Science and Technology Major Project(2018SHZDZX05 to J.Y.L.).
文摘Brain calcification is frequently detected by neuroimaging in patients with hereditary and nonhereditary disorders or in normal individuals with aging.Its prevalence ranges from approximately 1%in young people to over 20%in the elderly(Yamada et al.,2013),yet the underlying mechanisms of brain calcification remain poorly understood.Specifically,calcification in the basal ganglia is detected in approximately 5.5%-20%of CT scans in patients over 50 years old(Auffray-Calvier et al.,2020).
基金supported by the Horizon Europe Framework Programme(HORIZON),call Teaming for Excellence(HORIZONWIDERA-2022-ACCESS-01-two-stage)-Creation of the Centre of Excellence in Smart Forestry“Forest 4.0”No.101059985″This research was cofunded by FOREST 4.0-“Ekscelencijos centras tvariai miško bioekonomikai vystyti”(Nr.10-042-P-0002).
文摘Models that predict a forest stand’s evolution are essential for developing plans for sustainable management.A simple mathematical framework was developed that con-siders the individual tree and stand basal area under random resource competition and is based on two assumptions:(1)a sigmoid-type stochastic process governs tree and stand basal area dynamics of living and dying trees,and(2)the total area that a tree may potentially occupy determines the number of trees per hectare.The most effective method to satisfy these requirements is formalizing each tree diameter and potentially occupied area using Gompertz-type stochastic differential equations governed by fixed and mixed-effect parameters.Data from permanent experimental plots from long-term Lithuania experiments were used to construct the tree and stand basal area models.The new models were relatively unbiased for live trees of all species,including silver birch(Betula pen-dula Roth)and downy birch(Betula pubescens Ehrh.),[spruce(Picea abies),and pine(Pinus sylvestris)].Less reliable predic-tions were made for the basal area of dying trees.Pines gave the highest accuracy prediction of mean basal area among all live trees.The mean basal area prediction for all dying trees was lower than that for live trees.Among all species,pine also had the best average basal area prediction accuracy for live trees.Newly developed basal area growth and yield models can be recommended despite their complex formulation and implementation challenges,particularly in situations when data is scarce.This is because the newly observed plot provides sufficient information to calibrate random effects.
基金funded by the National Natural Science Foundation of China(32071921)Key R&D Program of Shandong Province,China(2021LZGC022)Taishan Scholars Project(ts201712024).
文摘Arogenate dehydratase(ADT)catalyzes the final step in phenylalanine synthesis and is crucial for plant development and metabolism.Previously,we demonstrated that the ADT/prephenate dehydratase ZmADT2 is essential for maize resistance to Ustilago maydis and for overall plant development.In this study,we explored the role of ZmADT2 in maize kernel development.The mmsu mutant,a dysfunctional ZmADT2 variant,exhibits delayed embryo and endosperm development,along with deficiencies in carbohydrate and protein storage.Transcriptome analysis revealed differential expression of many kernel compartment-specific genes between mmsu and wild-type(WT)kernels,with impaired nutrient accumulation and auxin signaling pathway in the mmsu endosperm.Compared to WT,ZmADT2 mutation led to reduced auxin levels and smaller endosperm cell size.Exogenous auxin rescued the small kernel phenotype of mmsu.Additionally,auxin distribution was reduced in the basal endosperm transfer layer(BETL),causing defects in its development and function,including reduced transfer cell elongation,cell wall ingrowth and nutrient uptake.These findings suggest that ZmADT2 mediated mediates an auxin signaling pathway that is essential for maize kernel development.
基金supported by the Japan Science and Technology Agency(JST),CREST(grant number JapanJPR2094)。
文摘A sparsely introduced basal intrinsic 2-type stacking fault(I_(2)-SF)with a dense segregation of clusters(cluster-arranged layer;CAL)inα-Mg exerts a sufficient strengthening effect with a reduced content of additive elements.Moreover,the dynamic nucleation and growth of CALs during deformation largely improves the creep resistance.This paper analyzes the cosegregation behaviors of yttrium(Y)and zinc(Zn)atoms at an I_(2)-SF in bulk and at basal edge dislocations using density functional theory calculations.We also study the modification of the generalized stacking-fault energy(GSFE)curves associated with the cosegregation.The segregation energies of Y and Zn atoms in the I_(2)-SF are relatively small during the initial segregation of a cluster,but increases stepwise as the cluster grows.After introducing Y and Zn atoms in the I_(2)-SF in an energetically stable order,we obtain an L1_(2)-type cluster resembling that reported in the literature.Small structural changes driven by vacancy diffusion produce an exact L1_(2)-type cluster.Meanwhile,the core of the Shockley partial dislocation generates sufficient segregation energy for cluster nucleation.Migration of the Shockley partial dislocation and expansion of the I_(2)-SF part are observed at a specific cluster size.The migration is triggered by a large modification of the GSFE curve and destabilization of the hexagonal close-packed stacking(hcp)by the segregated atoms.At this point,the cluster has reached sufficient size and continues to follow the growth in the I_(2)-SF part.According to our findings,the CAL at elevated temperature is formed through repeated synchronized behavior of cluster nucleation at the Shockley partial dislocation,dislocation migration triggered by the destabilized hcp stacking,and following of cluster growth in the I_(2)-SF part of the dislocation.
文摘Basal cell carcinoma(BCC)is the most prevalent form of skin cancer in the world,primarily affecting sun-exposed areas,including the periocular region.When BCC occurs near the eyes,surgical treatment becomes uniquely complex.Excess excisions may cause detrimental effects to eyelid function and undesirable aesthetic outcomes.Conversely,adequate resection must occur to prevent further disease progression.Mohs micrographic surgery(MMS),a technique offering high remission rates,is often employed for periocular BCC.This method allows for precise cancer removal while preserving as much healthy tissue as possible,balancing the need for both effective treatment and aesthetic and functional preservation.Following Mohs surgery of periocular BCC,reconstruction methods vary and can be tailored based on the size of the resection and the functional requirements of the affected tissue.Amongst these methods,primary closure with and without secondary intentions,direct margin repair,local flap closure and advance flap,Tenzel flap,tarso-conjunctival flap,periocular skin grafting,and structural grafting are commonly utilized and each has its advantages and limitations.In the future,advancements in synthetic flaps and stabilizing glues in the periocular region may provide additional tools for post-Mohs reconstruction.However,these emerging techniques require further research to establish efficacy and safety,especially in more complex and sensitive regions like the periocular tissues.The primary purpose of this review is to provide a comprehensive analysis of periocular reconstructive techniques following Mohs surgery,comparing their efficacy,functional outcomes,and aesthetic considerations while addressing recent advancements such as synthetic flaps and stabilizing glues to guide clinical decision-making.
基金Supported by the Kelowna General Hospital Foundation,No.2025-1441.
文摘BACKGROUND Basal cell carcinoma(BCC)is the most prevalent skin cancer,characterized by indolent growth and low metastatic rates.When metastatic BCC(mBCC)does occur,it most commonly involves lymph nodes,lungs,and bones,with metastases to other sites being exceptionally rare.This case reports the first documented instance of mBCC to the stomach,highlighting the importance of considering atypical metastatic sites,and the challenges associated with diagnosis and management.CASE SUMMARY A 52-year-old male with recurrent BCC and known mBCC to the bone presented with progressive dysphagia,cranial neuropathies and generalized weakness.He had been treated with immune checkpoint inhibitors,with intermittent therapy modifications due to treatment related toxicities.His past history was notable for malignant perineural invasion,radiotherapy for osseous metastases,immune checkpoint inhibitor-induced enteritis,and osteonecrosis of the jaw.Gastroscopy revealed subepithelial gastric lesions,and biopsies confirmed mBCC-a previously unreported site of disease dissemination.A multidisciplinary team involving gastroenterology,oncology,neurology,and palliative care guided his management.Given his declining functional status and poor prognosis,he was ultimately transitioned to hospice care.CONCLUSION Clinicians should consider atypical metastatic sites in advanced BCC.A multidisciplinary approach remains essential for timely diagnosis and coordinated management.
基金Shandong Provincial Medical and Health Science and Technology Development Program,Clinical Study on Modified Stereotactic Soft Channel Intracranial Hematoma Evacuation for Severe Basal Ganglia Hemorrhage(Project No.:202203071107)。
文摘Objective:To analyze the therapeutic effect and prognosis of frameless stereotactic soft channel intracranial hematoma evacuation for severe basal ganglia hemorrhage.Methods:Clinical data of 411 patients with severe basal ganglia hemorrhage admitted to the Neurological Intensive Care Unit of Linyi People’s Hospital from January 2020 to December 2021 were collected.According to the modified Rankin Scale(mRS)score at 180 days after onset,the patients were divided into the good prognosis group and the poor prognosis group.The therapeutic effect of frameless stereotactic soft channel intracranial hematoma evacuation on severe basal ganglia hemorrhage was explored,and the influencing factors of prognosis were analyzed.Results:Multivariate Logistic regression analysis showed that the admission Glasgow Coma Scale(GCS)score was an independent protective factor for the prognosis of patients with severe basal ganglia hemorrhage,while age,preoperative hematoma volume,random blood glucose level,and mechanical ventilation were independent risk factors.Conclusion:Frameless stereotactic soft channel intracranial hematoma evacuation has a good therapeutic effect on severe basal ganglia hemorrhage.However,it is necessary to screen the patients’basic information before surgery and provide medical care based on their specific conditions to promote their rapid recovery.
文摘BACKGROUND High-resolution optical coherence tomography(HR-OCT)has become an essential instrument in the screening and diagnosis of ocular surface neoplasms.Research demonstrates that HR-OCT possesses a diagnostic sensitivity ranging from 85%to 90%for ocular surface squamous neoplasia(OSSN).The connections between HR-OCT features and histological findings have consistently shown robustness,hence increasing the reliability of clinical diagnosis.AIM To examine the existing HR-OCT indicators employed in the identification of common non-benign ocular surface tumors,namely,basal cell carcinoma,OSSN,and melanocytic conjunctival lesions,and to assess their diagnostic efficacy,benefits,and prospective developments.METHODS A thorough literature review was performed to assess the published research on HR-OCT in the diagnosis of ocular surface cancers.Significant attention was given to research that compares HR-OCT characteristics with histopath-ologic validation,as well as on publications addressing the integration of emerging technologies and artificial intelligence in ocular oncology imaging.RESULTS HR-OCT exhibits elevated diagnostic sensitivity(85%-90%)for identifying OSSN and presents distinct imaging patterns that align closely with histology results.This approach has substantial clinical advantages due to its non-invasive characteristics,improved axial resolution,and real-time imaging capabilities.HR-OCT has demonstrated potential in assessing various lesions,including basal cell carcinoma and melanocytic conjunctival malignancies.CONCLUSION HR-OCT assumes an increasingly vital role in the early identification and clinical management of ocular surface malignancies.With advancements in imaging technology and the integration of artificial intelligence,HR-OCT is anticipated to enhance individualized diagnosis and treatment planning in ocular oncology,hence improving patient outcomes.
文摘A tree's basal area(BA)and wood volume scale exponentially with tree diameter in species-specifc patterns.Recent observed increases in tree growth suggest these allometric relationships are shifting in response to climate change,rising CO_(2) levels,and/or changes in forest management.We analyzed 9,214 cores from nine conifer and 11 broadleaf species grown in managed mixed-species stands in the upper Midwest to quantify how well diameter(diameter at breast height(DBH))serves to predict BA growth and above-ground wood and carbon(C).These samples include many large trees.We ft mixed models to predict BA growth and above-ground biomass/C from diameter,tree height,and the BA of nearby trees while controlling for site effects.Models account for 55%–83%of the variance in log(recent growth),improving predictions over earlier models.Growth-diameter scaling exponents covary with certain leaf and stem(but not wood)functional traits,reflecting growth strategies.LogBA increment scales linearly with log(diameter)as trees grow bigger in 16/20 species and growth actually accelerates in Quercus rubra L.Three other species plateau in growth.Growth only decelerates in red pine,Pinus resinosa Ait.Growth in whole-tree,above-ground biomass,and C accelerate even more strongly with diameter(mean exponent:2.08 vs.1.30 for BA growth).Sustained BA growth and accelerating wood/C growth contradict the common assumption that tree growth declines in bigger trees.Yield tables and silvicultural guidelines should be updated to reflect these current relationships.Such revisions will favor delaying harvests in many managed stands to increase wood production and enhance ecosystem values including C fxation and storage.Further research may resolve the relative roles of thinning,climatic conditions,nitrogen inputs,and rising CO2 levels on changing patterns of tree growth.
基金supported by the National Natural Science Foundation of China(No.82003372)the Medical and Health Technology Project of Zhejiang Province(No.2024KY984),China.
文摘Basal cell carcinoma(BCC)and cutaneous squamous cell carcinoma(cSCC),as certain forms of nonmelanoma skin cancer(NMSC)or keratinocyte carcinoma,are the most common forms of malignant neoplasms worldwide(Sharp et al.,2024).BCC and cSCC have been identified as two major components of NMSC,comprising one-third of all malignancies(Burton et al.,2016).Generally speaking,patients with NMSC tend to have relatively favorable survival outcomes,while different histopathological subtypes of NMSC exhibit distinct biological behaviors(Stătescu et al.,2023).
基金the National Natural Science Foundation of China (30760039)the Key Laboratory of Ecology of Rare and Endangered Species and Environmental Protection (Guangxi Normal University)Ministry of Education, China, and the projects of Science and Technology Bureau of Yongzhou, Hunan (201019)
文摘To understand metabolic adaptations,the basal metabolic rate（BMR） of Mrs Hume＇s Pheasant（Syrmaticus humiae） and Elliot＇s Pheasant（Syrmaticus ellioti） were investigated.Metabolic rate（MR）,body temperature（Tb） and thermal conductance（C） were determined in both species at a temperatrue range of 5-35 ℃,respectively.Oxygen consumption was measured with a closed circuit respirometer.The thermal neutral zones（TNZ） were 24.5-31.6 ℃,and 23.0-29.2 ℃,respectively.With a temperature range of 5-35 ℃,Mrs Hume＇s Pheasant and Elliot＇s Pheasant could maintained stable Tb at a mean of（40.47±0.64） and（40.36±0.10） ℃,respectively.Mean BMRs within TNZs were（1.36±0.84） mLO2/（g.h） for Mrs Hume＇s Pheasant and（2.03±0.12） mLO2/（g.h） for Elliot＇s Pheasant,which were 77% and 86% of the expected value based on their body mass,respectively.Thermal conductance of Mrs Hume＇s Pheasant and Elliot＇s Pheasant were（0.12±0.01） and（0.17±0.01） mLO2/（g.h.℃）,below the lower critical temperature,respectively,which were 119% and 124% of the expected value based on their body mass,respectively.The ecophysiological characteristics of these species were low metabolic rate,high body temperature,and high thermal conductance,which allow both species to better adapt to the warmer climate environment in south China.
