Senile dementia（SD） is a syndrome characterized by progressive neurological deterioration. Treatment for the disease is still under investigation. Bamboo leaf extract（B-extract） has been known for its biological e...Senile dementia（SD） is a syndrome characterized by progressive neurological deterioration. Treatment for the disease is still under investigation. Bamboo leaf extract（B-extract） has been known for its biological efficacy in anti-oxidant and anti-cancer activities. However, study on B-extract for its protection against dementia is very limited. The effect of B-extract on a rat model with SD was examined. B-extract improved spatial learning ability of the dementia rats. The hippocampus of dementia model rats showed reduced levels of acetylcholine（ACh）, epinephrine（E）, norepinephrine（NE）, and dopamine（DA）, and increased activities of acetylcholine esterase（ACh E） and monoamine oxidase（MAO）. Treatment with B-extract 20 mg/（kg·d） for 7 weeks significantly inhibited the enzyme activity compared with untreated dementia rats, and raised the levels of ACh, E, and DA in the hippocampus. In addition, treatment with B-extract elevated the level of γ-aminobutyric acid（GABA）, but reduced the level of glutamate（Glu） in the brain. These data suggest that B-extract might be a potential drug in treating impairment of spatial memory in dementia rats by regulating the central neurotransmitter function.展开更多
竹叶提取物(Extract of bamboo leaves,Ebl)是我国新开发的一种植物类黄酮制剂,具有优良的抗自由基、抗氧化、抗衰老、抗菌、抗病毒及保护心脑血管,防治老年退行性疾病等生物学功效.就竹叶黄酮的提取、分离纯化及抗氧化活性的测定方法...竹叶提取物(Extract of bamboo leaves,Ebl)是我国新开发的一种植物类黄酮制剂,具有优良的抗自由基、抗氧化、抗衰老、抗菌、抗病毒及保护心脑血管,防治老年退行性疾病等生物学功效.就竹叶黄酮的提取、分离纯化及抗氧化活性的测定方法等方面做了详细的阐述,同时结合在实验过程中的一些经验,提出了一些看法.展开更多
基金Project supported by the Zhejiang Provincial Natural Science Foundation of China(No.LY14H090002)the National Undergraduate Training Programs for Innovation and Entrepreneurship of China(No.201313021016)
文摘Senile dementia（SD） is a syndrome characterized by progressive neurological deterioration. Treatment for the disease is still under investigation. Bamboo leaf extract（B-extract） has been known for its biological efficacy in anti-oxidant and anti-cancer activities. However, study on B-extract for its protection against dementia is very limited. The effect of B-extract on a rat model with SD was examined. B-extract improved spatial learning ability of the dementia rats. The hippocampus of dementia model rats showed reduced levels of acetylcholine（ACh）, epinephrine（E）, norepinephrine（NE）, and dopamine（DA）, and increased activities of acetylcholine esterase（ACh E） and monoamine oxidase（MAO）. Treatment with B-extract 20 mg/（kg·d） for 7 weeks significantly inhibited the enzyme activity compared with untreated dementia rats, and raised the levels of ACh, E, and DA in the hippocampus. In addition, treatment with B-extract elevated the level of γ-aminobutyric acid（GABA）, but reduced the level of glutamate（Glu） in the brain. These data suggest that B-extract might be a potential drug in treating impairment of spatial memory in dementia rats by regulating the central neurotransmitter function.
文摘竹叶提取物(Extract of bamboo leaves,Ebl)是我国新开发的一种植物类黄酮制剂,具有优良的抗自由基、抗氧化、抗衰老、抗菌、抗病毒及保护心脑血管,防治老年退行性疾病等生物学功效.就竹叶黄酮的提取、分离纯化及抗氧化活性的测定方法等方面做了详细的阐述,同时结合在实验过程中的一些经验,提出了一些看法.
