A double-exposure fabrication method without any intensity shadow mask to fabricate arbitrarily apodized fiber Bragg gratings（ FBGs） with narrow bandwidth is demonstrated by controlling the total ultra violet （UV）...A double-exposure fabrication method without any intensity shadow mask to fabricate arbitrarily apodized fiber Bragg gratings（ FBGs） with narrow bandwidth is demonstrated by controlling the total ultra violet （UV） irradiation along the grating by varying the speed of a translation stage. The UV source used is a stable continuous intracavity frequency-doubled argonion laser. The parameters （such as length, apodization profile, average index change）of FBGs can be easily changed with this method. The total UV irradiation is kept constant in the doubleexposure process because of the precise control of the exposure time, which ensures that the apodized FBG＇s bandwidth can be extremely narrow. The full width at half maximum （FWHM） bandwidth of the 2-cm-long apodized FBG fabricated by this method is 0. 15 nm with a maximum reflectivity of more than 95%.展开更多
The point spread function(PSF)caused by a wavefront coding system with a cubic phase mask has big side-lobes which leads to bad image restoration.This paper proposes a novel apodized cubic phase mask to suppress the s...The point spread function(PSF)caused by a wavefront coding system with a cubic phase mask has big side-lobes which leads to bad image restoration.This paper proposes a novel apodized cubic phase mask to suppress the side-lobes of the PSF.Simulated annealing algorithm is used to optimize the cubic and the truncation parameter of the phase mask.The system with the novel phase mask has better performance in the modulation transfer function(MTF)especially in low-and-medium spatial frequency region.The simulation results show that the restored images with the novel phase mask are superior to the one with the classic cubic phase mask in contrast and ringing effect.The experimental results show that the side-lobes of the PSF are suppressed by using the apodized cubic phase mask.展开更多
Sensors play an important role in shaping and monitoring human health.Exploration of methods to use Fiber Bragg Grating(FBG)with enhanced sensitivity has attracted great interest in the field of medical research.In th...Sensors play an important role in shaping and monitoring human health.Exploration of methods to use Fiber Bragg Grating(FBG)with enhanced sensitivity has attracted great interest in the field of medical research.In this paper,a novel apodization function is proposed and performance evaluation and optimization of the same have been made.A comparison was conducted between various existing apodization functions and the proposed one based on optical characteristics and sensor parameters.The results evince the implementation of the proposed apodization function for vital sign measurement.The optical characteristics considered for evaluation are Peak Resonance Reflectivity level,Side Lobes Reflectivity level and FullWidth HalfMaximum(FWHM).The proposed novel apodization novel function has better FWHM,which is narrower than the FWHM of uniform FBG.Sensor characteristics like a quality parameter,detection accuracy and sensitivity also show improvement.The proposed novel apodization function is demonstrated to have a better shift in wavelength in terms of temperature and pulse measurement than the existing functions.The sensitivity of the proposed apodized function is enhanced with a Poly-dimethylsiloxane coating of varying thickness,which is 6 times and 5.14 times greater than uniform Fiber Bragg grating and FBG with the proposed novel apodization function,respectively,enhancing its utilization in the field of medicine.展开更多
Sparrow criterion of resolution is used for assessment of the resolution of two object points of apodized optical systems under incoherent illumination of light. Semicircular arrays of circular aperture with discrete ...Sparrow criterion of resolution is used for assessment of the resolution of two object points of apodized optical systems under incoherent illumination of light. Semicircular arrays of circular aperture with discrete asymmetric apodization have suppressed side-lobes and a narrower central peak in the image plane termed as PSF good side on alternatively the right and left of the strong spectral point facilitates to detect the presence of weak spectral point in the vicinity of bright spectral point. The results of investigations on optimum discrete pupil function with semicircular arrays on the intensity distributions in the composite image of two object points with widely varying in their intensities under various degree of coherence of illumination have been studied. Sparrow resolution limits and the dip in central intensity as function of degree of coherence of the illumination (γ), intensity ratio (α), degree of asymmetric apodization (b) and number of discrete elements in semicircular array (n). The efficiency of aperture functions is discussed in terms of these parameters. Pupil function capabilities in redistribution of energy in composite image of two object points in close vicinity have been verified for different considerations. Current study has found an improvement in two-point resolution characteristics compared to their unapodized counter part. Fourier analytical properties of an optical system are presented for evaluation of this practical problem.展开更多
An out-of-plane silicon grating coupler capable of mode-order conversion at the chip–fiber interface is designed and fabricated. Optimization of the structure is performed through finite-difference time-domain simula...An out-of-plane silicon grating coupler capable of mode-order conversion at the chip–fiber interface is designed and fabricated. Optimization of the structure is performed through finite-difference time-domain simulations,and the final device is characterized through far-field profile and transmission measurements. A coupling loss of 3.1 dB to a commercial two-mode fiber is measured for a single TE0→ LP11 mode conversion grating, which includes a conversion penalty of 1.3 dB. Far-field patterns of the excited LP11 mode profile are also reported.展开更多
Background:Alzheimer's disease(AD)is a progressive neurodegenerative disease with no effective therapies.It is well known that chronic neuroinflammation plays a critical role in the onset and progression of AD.Wel...Background:Alzheimer's disease(AD)is a progressive neurodegenerative disease with no effective therapies.It is well known that chronic neuroinflammation plays a critical role in the onset and progression of AD.Well-balanced neuronal-microglial interactions are essential for brain functions.However,determining the role of microglia—the primary immune cells in the brain—in neuroinflammation in AD and the associated molecular basis has been challenging.Methods:Inflammatory factors in the sera of AD patients were detected and their association with microglia activation was analyzed.The mechanism for microglial inflammation was investigated.IL6 and TNF-α were found to be significantly increased in the AD stage.Results:Our analysis revealed that microglia were extensively activated in AD cerebra,releasing sufficient amounts of cytokines to impair the neural stem cells(NSCs)function.Moreover,the ApoD-induced NLRC4 inflammasome was activated in microglia,which gave rise to the proinflammatory phenotype.Targeting the microglial ApoD promoted NSC self-renewal and inhibited neuron apoptosis.These findings demonstrate the critical role of ApoD in microglial inflammasome activation,and for the first time reveal that microglia-induced inflammation suppresses neuronal proliferation.Conclusion:Our studies establish the cellular basis for microglia activation in AD progression and shed light on cellular interactions important for AD treatment.展开更多
We analyze the effects of average index variation on the transmission characteristics of an index-apodized long-period fiber grating （LPFG） by the transfer matrix method and study how these effects depend on the gra...We analyze the effects of average index variation on the transmission characteristics of an index-apodized long-period fiber grating （LPFG） by the transfer matrix method and study how these effects depend on the grating length, the grating profile, the modal dispersion factor, and the duty cycle of the index modulation. Apart from shifting the resonance wavelength and modifying the rejection band, average index variation can give rise to significant side lobes that may appear on the short-wavelength or long-wavelength side of the rejection band, depending on the signs of the average index change and the modal dispersion factor. Our results provide general guidance for the writing of LPFGs for the minimization of side lobes. Our analysis compares well with published experimental results and should be useful for the design and fabrication of LPFGs.展开更多
The primary mirrors of current and future large telescopes always employ a segmented mirror configuration.The small but non-negligible gaps between neighboring segments cause additional diffraction,which restricts the...The primary mirrors of current and future large telescopes always employ a segmented mirror configuration.The small but non-negligible gaps between neighboring segments cause additional diffraction,which restricts the performance of high-contrast coronagraph.To solve this problem,we propose a coronagraph system based on a single liquid crystal spatial light modulator(SLM).This spatial light modulator is used for amplitude apodization,and its feasibility and potential performance are demonstrated using a laboratory setup using the stochastic parallel gradient descent(SPGD)algorithm to control the spatial light modulator,which is based on point spread function(PSF)sensing and evaluation and optimized for maximum contrast in the discovery working area as a merit function.The system delivers a contrast in the order of 10−6,and shows excellent potential to be used in current and future large aperture telescopes,both on the ground and in space.展开更多
在采用高阶滤波器的三电平变流器中,载波同相层叠调制(phase disposition,PD)产生的开关频率次边带谐波易扩散到高阶滤波器固有谐振点附近,引起输出电流谐波增加或振荡,而载波交替反相层叠(alternative phase opposition disposition,AP...在采用高阶滤波器的三电平变流器中,载波同相层叠调制(phase disposition,PD)产生的开关频率次边带谐波易扩散到高阶滤波器固有谐振点附近,引起输出电流谐波增加或振荡,而载波交替反相层叠(alternative phase opposition disposition,APOD)所需滤波器总电感量较大。针对以上问题,在定量分析比较PD和APOD两种调制方式谐波分布及边带谐波扩散特点的基础上,给出了两种调制方式总电感量约束方程。为保有APOD调制谐波分布集中优点的同时减小APOD总电感量需求,研究了一种基于最优三次谐波注入的改进APOD调制策略,分析了不同三次谐波注入量对APOD电压谐波分布及总电感量需求的影响,进而给出了以总电感量需求最小为目标的三次谐波最优注入量的计算方法,该方法可以实时根据当前调制度自动计算需要注入的三次谐波最优幅值,实现最优三次谐波的在线注入。最后,仿真和实验结果表明,所提策略不仅可以有效地避开高阶滤波器的谐振点,而且可有效降低主导谐波电压幅值,从而减小所需滤波器总电感量。展开更多
A high-contrast coronagraph for direct imaging of an Earth-like exoplanet at the visible band needs a contrast of 10^-10 at a small angular separation of 4λ/D or less. Here we report our recent laboratory experiment ...A high-contrast coronagraph for direct imaging of an Earth-like exoplanet at the visible band needs a contrast of 10^-10 at a small angular separation of 4λ/D or less. Here we report our recent laboratory experiment that approaches these lim- its. Our test of a high-contrast imaging coronagraph is based on our step-transmission apodized filter. To achieve this goal, we use a liquid crystal array as a phase correc- tor to create a dark hole based on our dedicated algorithm. We have suppressed the diffraction and speckle noise near the point image of a star to a level of 1.68 × 10^-9 at 4λ/D, which can be used for direct imaging of Jupiter-like exoplanets. This demon- strates that a telescope incorporating a high-contrast coronagraph in space has the potential to detect and characterize Earth-like planets.展开更多
We propose a high-contrast coronagraph for direct imaging of young Jupiter-like planets orbiting nearby bright stars. The coronagraph employs a step- transmission filter in which the intensity is apodized with a finit...We propose a high-contrast coronagraph for direct imaging of young Jupiter-like planets orbiting nearby bright stars. The coronagraph employs a step- transmission filter in which the intensity is apodized with a finite number of steps with identical transmission in each step. It should be installed on a large ground-based telescope equipped with a state-of-the-art adaptive optics system. In this case, contrast ratios around 10-6 should be accessible within 0.1 arcsec of the central star. In recent progress, a coronagraph with a circular apodizing filter has been developed, which can be used for a ground-based telescope with a central obstruction and spider structure. It is shown that ground-based direct imaging of Jupiter-like planets is promising with current technology.展开更多
This paper numerically and analytically investigates the formation and propagation motion of optical soliton in the Bragg grating. We choose the fibre Bragg grating with hyperbolic tangent apodization in the middle se...This paper numerically and analytically investigates the formation and propagation motion of optical soliton in the Bragg grating. We choose the fibre Bragg grating with hyperbolic tangent apodization in the middle section in order to obtain slower solitons. Optical fibre soliton but not Bragg grating soliton is used as input pulse in the discussion, which is much more approximate to the light source for the practical purpose. We discuss in detail the effects of the soliton＇s velocity with some parameters in the process of transmission. The results show that by choosing special parameters, one can make the soliton slow-down with a little distortion and energy decay and obtain tunable time-delay on a small scale.展开更多
This paper exploits the Rayleigh integral method to simulate the propagation of transmitted ultrasonic waves and received echoes through various media. Performed simulations study the effect of apodization using diffe...This paper exploits the Rayleigh integral method to simulate the propagation of transmitted ultrasonic waves and received echoes through various media. Performed simulations study the effect of apodization using different types of windows and the effect of medium properties on the reflections obtained. All estimations are done using the Rayleigh integral method simplified by the Fresnel approximation. Five different interfaces are considered： tissue-bone-tissue, tissue-fat-bone, fat-muscle-bone, air-fat-bone and water-fat-bone. The apodization simulations show that the hamming window is more efficient than the rectangular and triangular windows for obtaining a more consistent beam. In the second set of simulations, reflections are mapped with respect to the depth from which these reflections are generated. It demonstrates that the solid and water media allow for the attainment of echoes from deeper regions as compared to the air medium. Matlab is used as the simulation framework.展开更多
Background:Breast cancer is the most common cancer,and abnormal lipid metabolism is associated with cancer.APOD expression is negatively correlated with various cancers related to tumor prognosis.DNA methylation may a...Background:Breast cancer is the most common cancer,and abnormal lipid metabolism is associated with cancer.APOD expression is negatively correlated with various cancers related to tumor prognosis.DNA methylation may affect APOD expression.Therefore,this paper aims to investigate the significance of APOD expression and APOD DNA methylation in breast cancer.Methods:This study utilized comprehensive bioinformatics analysis of APOD using Gene Expression database of Normal and Tumor tissues 2,UCSC Xena,etc.Clinical and survival information obtained from the The Cancer Genome Atlas and Gene Expression Omnibus datasets were extracted for data mining.Results:The correlation between APOD and breast cancer was examined,along with the connection between APOD DNA methylation and APOD expression.In the The Cancer Genome Atlas cohort,as well as GSE31448 and GSE65194 datasets,APOD expression decreased in breast cancer(P<0.0001).Clinical feature analysis results showed that APOD expression was correlated with the PAM50 subtype,with the lowest expression in the Basal subtype(P<0.0001).High APOD expression is a good prognostic marker for breast cancer(HR=0.71,P=0.037).APOD methylation level was significantly negatively correlated with expression level(R=−0.4770,P<0.001),and cg15231202,cg23720929,and cg05624196 were important regulatory targets.High APOD expression was associated with higher metabolism and extracellular matrix scores.Conclusion:APOD is an independent prognostic marker for breast cancer and is regulated by DNA methylation to modulate mRNA expression.展开更多
基金The Natural Science Foundation of Jiangsu Province(No.BK2004207)
文摘A double-exposure fabrication method without any intensity shadow mask to fabricate arbitrarily apodized fiber Bragg gratings（ FBGs） with narrow bandwidth is demonstrated by controlling the total ultra violet （UV） irradiation along the grating by varying the speed of a translation stage. The UV source used is a stable continuous intracavity frequency-doubled argonion laser. The parameters （such as length, apodization profile, average index change）of FBGs can be easily changed with this method. The total UV irradiation is kept constant in the doubleexposure process because of the precise control of the exposure time, which ensures that the apodized FBG＇s bandwidth can be extremely narrow. The full width at half maximum （FWHM） bandwidth of the 2-cm-long apodized FBG fabricated by this method is 0. 15 nm with a maximum reflectivity of more than 95%.
文摘The point spread function(PSF)caused by a wavefront coding system with a cubic phase mask has big side-lobes which leads to bad image restoration.This paper proposes a novel apodized cubic phase mask to suppress the side-lobes of the PSF.Simulated annealing algorithm is used to optimize the cubic and the truncation parameter of the phase mask.The system with the novel phase mask has better performance in the modulation transfer function(MTF)especially in low-and-medium spatial frequency region.The simulation results show that the restored images with the novel phase mask are superior to the one with the classic cubic phase mask in contrast and ringing effect.The experimental results show that the side-lobes of the PSF are suppressed by using the apodized cubic phase mask.
基金supported in part by Universiti Malaya,and ACU UK under Project No.IF063-2021.
文摘Sensors play an important role in shaping and monitoring human health.Exploration of methods to use Fiber Bragg Grating(FBG)with enhanced sensitivity has attracted great interest in the field of medical research.In this paper,a novel apodization function is proposed and performance evaluation and optimization of the same have been made.A comparison was conducted between various existing apodization functions and the proposed one based on optical characteristics and sensor parameters.The results evince the implementation of the proposed apodization function for vital sign measurement.The optical characteristics considered for evaluation are Peak Resonance Reflectivity level,Side Lobes Reflectivity level and FullWidth HalfMaximum(FWHM).The proposed novel apodization novel function has better FWHM,which is narrower than the FWHM of uniform FBG.Sensor characteristics like a quality parameter,detection accuracy and sensitivity also show improvement.The proposed novel apodization function is demonstrated to have a better shift in wavelength in terms of temperature and pulse measurement than the existing functions.The sensitivity of the proposed apodized function is enhanced with a Poly-dimethylsiloxane coating of varying thickness,which is 6 times and 5.14 times greater than uniform Fiber Bragg grating and FBG with the proposed novel apodization function,respectively,enhancing its utilization in the field of medicine.
文摘Sparrow criterion of resolution is used for assessment of the resolution of two object points of apodized optical systems under incoherent illumination of light. Semicircular arrays of circular aperture with discrete asymmetric apodization have suppressed side-lobes and a narrower central peak in the image plane termed as PSF good side on alternatively the right and left of the strong spectral point facilitates to detect the presence of weak spectral point in the vicinity of bright spectral point. The results of investigations on optimum discrete pupil function with semicircular arrays on the intensity distributions in the composite image of two object points with widely varying in their intensities under various degree of coherence of illumination have been studied. Sparrow resolution limits and the dip in central intensity as function of degree of coherence of the illumination (γ), intensity ratio (α), degree of asymmetric apodization (b) and number of discrete elements in semicircular array (n). The efficiency of aperture functions is discussed in terms of these parameters. Pupil function capabilities in redistribution of energy in composite image of two object points in close vicinity have been verified for different considerations. Current study has found an improvement in two-point resolution characteristics compared to their unapodized counter part. Fourier analytical properties of an optical system are presented for evaluation of this practical problem.
基金supported by the Engineering and Physical Sciences Research Council(EPSRC)UK through the Silicon Photonics for Future Systems(SPFS)Programme(EP/L00044X/1)the Photonic Phase Conjugation Systems(PHOS)(EP/S003436/1)
文摘An out-of-plane silicon grating coupler capable of mode-order conversion at the chip–fiber interface is designed and fabricated. Optimization of the structure is performed through finite-difference time-domain simulations,and the final device is characterized through far-field profile and transmission measurements. A coupling loss of 3.1 dB to a commercial two-mode fiber is measured for a single TE0→ LP11 mode conversion grating, which includes a conversion penalty of 1.3 dB. Far-field patterns of the excited LP11 mode profile are also reported.
基金supported by the Guiding Science and Technology Development Grant in the Social Sector of Luoyang(2101083A)。
文摘Background:Alzheimer's disease(AD)is a progressive neurodegenerative disease with no effective therapies.It is well known that chronic neuroinflammation plays a critical role in the onset and progression of AD.Well-balanced neuronal-microglial interactions are essential for brain functions.However,determining the role of microglia—the primary immune cells in the brain—in neuroinflammation in AD and the associated molecular basis has been challenging.Methods:Inflammatory factors in the sera of AD patients were detected and their association with microglia activation was analyzed.The mechanism for microglial inflammation was investigated.IL6 and TNF-α were found to be significantly increased in the AD stage.Results:Our analysis revealed that microglia were extensively activated in AD cerebra,releasing sufficient amounts of cytokines to impair the neural stem cells(NSCs)function.Moreover,the ApoD-induced NLRC4 inflammasome was activated in microglia,which gave rise to the proinflammatory phenotype.Targeting the microglial ApoD promoted NSC self-renewal and inhibited neuron apoptosis.These findings demonstrate the critical role of ApoD in microglial inflammasome activation,and for the first time reveal that microglia-induced inflammation suppresses neuronal proliferation.Conclusion:Our studies establish the cellular basis for microglia activation in AD progression and shed light on cellular interactions important for AD treatment.
文摘We analyze the effects of average index variation on the transmission characteristics of an index-apodized long-period fiber grating （LPFG） by the transfer matrix method and study how these effects depend on the grating length, the grating profile, the modal dispersion factor, and the duty cycle of the index modulation. Apart from shifting the resonance wavelength and modifying the rejection band, average index variation can give rise to significant side lobes that may appear on the short-wavelength or long-wavelength side of the rejection band, depending on the signs of the average index change and the modal dispersion factor. Our results provide general guidance for the writing of LPFGs for the minimization of side lobes. Our analysis compares well with published experimental results and should be useful for the design and fabrication of LPFGs.
基金supported by the National Natural Science Foundation of China (U2031210 and 11827804)Science Research from the China Manned Space Project (CMS-CSST-2021-A11 and CMS-CSST-2021-B04).
文摘The primary mirrors of current and future large telescopes always employ a segmented mirror configuration.The small but non-negligible gaps between neighboring segments cause additional diffraction,which restricts the performance of high-contrast coronagraph.To solve this problem,we propose a coronagraph system based on a single liquid crystal spatial light modulator(SLM).This spatial light modulator is used for amplitude apodization,and its feasibility and potential performance are demonstrated using a laboratory setup using the stochastic parallel gradient descent(SPGD)algorithm to control the spatial light modulator,which is based on point spread function(PSF)sensing and evaluation and optimized for maximum contrast in the discovery working area as a merit function.The system delivers a contrast in the order of 10−6,and shows excellent potential to be used in current and future large aperture telescopes,both on the ground and in space.
文摘在采用高阶滤波器的三电平变流器中,载波同相层叠调制(phase disposition,PD)产生的开关频率次边带谐波易扩散到高阶滤波器固有谐振点附近,引起输出电流谐波增加或振荡,而载波交替反相层叠(alternative phase opposition disposition,APOD)所需滤波器总电感量较大。针对以上问题,在定量分析比较PD和APOD两种调制方式谐波分布及边带谐波扩散特点的基础上,给出了两种调制方式总电感量约束方程。为保有APOD调制谐波分布集中优点的同时减小APOD总电感量需求,研究了一种基于最优三次谐波注入的改进APOD调制策略,分析了不同三次谐波注入量对APOD电压谐波分布及总电感量需求的影响,进而给出了以总电感量需求最小为目标的三次谐波最优注入量的计算方法,该方法可以实时根据当前调制度自动计算需要注入的三次谐波最优幅值,实现最优三次谐波的在线注入。最后,仿真和实验结果表明,所提策略不仅可以有效地避开高阶滤波器的谐振点,而且可有效降低主导谐波电压幅值,从而减小所需滤波器总电感量。
基金Supported by the National Natural Science Foundation of China
文摘A high-contrast coronagraph for direct imaging of an Earth-like exoplanet at the visible band needs a contrast of 10^-10 at a small angular separation of 4λ/D or less. Here we report our recent laboratory experiment that approaches these lim- its. Our test of a high-contrast imaging coronagraph is based on our step-transmission apodized filter. To achieve this goal, we use a liquid crystal array as a phase correc- tor to create a dark hole based on our dedicated algorithm. We have suppressed the diffraction and speckle noise near the point image of a star to a level of 1.68 × 10^-9 at 4λ/D, which can be used for direct imaging of Jupiter-like exoplanets. This demon- strates that a telescope incorporating a high-contrast coronagraph in space has the potential to detect and characterize Earth-like planets.
基金supported by the National Natural Science Foundation of China (NSFC) (Grant No. 10873024)
文摘We propose a high-contrast coronagraph for direct imaging of young Jupiter-like planets orbiting nearby bright stars. The coronagraph employs a step- transmission filter in which the intensity is apodized with a finite number of steps with identical transmission in each step. It should be installed on a large ground-based telescope equipped with a state-of-the-art adaptive optics system. In this case, contrast ratios around 10-6 should be accessible within 0.1 arcsec of the central star. In recent progress, a coronagraph with a circular apodizing filter has been developed, which can be used for a ground-based telescope with a central obstruction and spider structure. It is shown that ground-based direct imaging of Jupiter-like planets is promising with current technology.
基金supported by the National Natural Science Foundation of China (Grant No. 60677003)
文摘This paper numerically and analytically investigates the formation and propagation motion of optical soliton in the Bragg grating. We choose the fibre Bragg grating with hyperbolic tangent apodization in the middle section in order to obtain slower solitons. Optical fibre soliton but not Bragg grating soliton is used as input pulse in the discussion, which is much more approximate to the light source for the practical purpose. We discuss in detail the effects of the soliton＇s velocity with some parameters in the process of transmission. The results show that by choosing special parameters, one can make the soliton slow-down with a little distortion and energy decay and obtain tunable time-delay on a small scale.
文摘This paper exploits the Rayleigh integral method to simulate the propagation of transmitted ultrasonic waves and received echoes through various media. Performed simulations study the effect of apodization using different types of windows and the effect of medium properties on the reflections obtained. All estimations are done using the Rayleigh integral method simplified by the Fresnel approximation. Five different interfaces are considered： tissue-bone-tissue, tissue-fat-bone, fat-muscle-bone, air-fat-bone and water-fat-bone. The apodization simulations show that the hamming window is more efficient than the rectangular and triangular windows for obtaining a more consistent beam. In the second set of simulations, reflections are mapped with respect to the depth from which these reflections are generated. It demonstrates that the solid and water media allow for the attainment of echoes from deeper regions as compared to the air medium. Matlab is used as the simulation framework.
基金The study design,data collection,data analysis,manuscript preparation,and publication decisions of this work were supported by the Science and Technology Program of Zhejiang Province Traditional Chinese Medicine(2023ZL056,2023ZL409)the Foundation Project of Zhejiang Chinese Medical University(2022JKZKTS26,2022JKJNTZ16,2022JKJNTZ23).
文摘Background:Breast cancer is the most common cancer,and abnormal lipid metabolism is associated with cancer.APOD expression is negatively correlated with various cancers related to tumor prognosis.DNA methylation may affect APOD expression.Therefore,this paper aims to investigate the significance of APOD expression and APOD DNA methylation in breast cancer.Methods:This study utilized comprehensive bioinformatics analysis of APOD using Gene Expression database of Normal and Tumor tissues 2,UCSC Xena,etc.Clinical and survival information obtained from the The Cancer Genome Atlas and Gene Expression Omnibus datasets were extracted for data mining.Results:The correlation between APOD and breast cancer was examined,along with the connection between APOD DNA methylation and APOD expression.In the The Cancer Genome Atlas cohort,as well as GSE31448 and GSE65194 datasets,APOD expression decreased in breast cancer(P<0.0001).Clinical feature analysis results showed that APOD expression was correlated with the PAM50 subtype,with the lowest expression in the Basal subtype(P<0.0001).High APOD expression is a good prognostic marker for breast cancer(HR=0.71,P=0.037).APOD methylation level was significantly negatively correlated with expression level(R=−0.4770,P<0.001),and cg15231202,cg23720929,and cg05624196 were important regulatory targets.High APOD expression was associated with higher metabolism and extracellular matrix scores.Conclusion:APOD is an independent prognostic marker for breast cancer and is regulated by DNA methylation to modulate mRNA expression.
