Objective To investigate the endoscopic and pathological features and the independent risk factors for early esophageal cancer combined with multiple primary cancer.Methods Endoscopic and pathological features of 324 ...Objective To investigate the endoscopic and pathological features and the independent risk factors for early esophageal cancer combined with multiple primary cancer.Methods Endoscopic and pathological features of 324 patients diagnosed as having early esophageal cancer from January 2013 to January 2022 in Beijing FriendshipHospital wereretrospectivelycollected.Independent risk factors for early esophageal cancer combined with multiple primary cancer were selected by multivariate logistic regression analysis.Results Among the 324 patients with early esophageal cancer,47(14.51%)patients(29 metachronous and 18 synchronous)had multiple primary cancer.Multivariate logistic regression analysis showed that alcohol drinking≥5 standard drinks/day(OR=6.23,95%CI:2.49-15.57,P<0.001),submucosal layer invasion(0R=2.80,95%Cl:1.07-7.30,P=0.036),lesion location at lower esophagus(0R=4.18,95%CI:1.98-8.97,P<0.001)and multiple lesions in esophagus(0R=3.30,95%CI:1.57-6.92,P=0.002)were independent risk factors for early esophageal cancer combined with multiple primary cancer.Conclusion Alcohol drinking≥5 standard drinks/day,submucosal layer invasion,lower lesions location,and multiple lesions in the esophagus are independent risk factors that are more likely to develop multiple primary cancer in patients with early esophageal cancer.It is recommended to prioritize monitoring patients with these factors,and enhance endoscopic follow-up and assessment.展开更多
文摘Objective To investigate the endoscopic and pathological features and the independent risk factors for early esophageal cancer combined with multiple primary cancer.Methods Endoscopic and pathological features of 324 patients diagnosed as having early esophageal cancer from January 2013 to January 2022 in Beijing FriendshipHospital wereretrospectivelycollected.Independent risk factors for early esophageal cancer combined with multiple primary cancer were selected by multivariate logistic regression analysis.Results Among the 324 patients with early esophageal cancer,47(14.51%)patients(29 metachronous and 18 synchronous)had multiple primary cancer.Multivariate logistic regression analysis showed that alcohol drinking≥5 standard drinks/day(OR=6.23,95%CI:2.49-15.57,P<0.001),submucosal layer invasion(0R=2.80,95%Cl:1.07-7.30,P=0.036),lesion location at lower esophagus(0R=4.18,95%CI:1.98-8.97,P<0.001)and multiple lesions in esophagus(0R=3.30,95%CI:1.57-6.92,P=0.002)were independent risk factors for early esophageal cancer combined with multiple primary cancer.Conclusion Alcohol drinking≥5 standard drinks/day,submucosal layer invasion,lower lesions location,and multiple lesions in the esophagus are independent risk factors that are more likely to develop multiple primary cancer in patients with early esophageal cancer.It is recommended to prioritize monitoring patients with these factors,and enhance endoscopic follow-up and assessment.
